DE69420361D1 - Zyklische Hexapeptide mit Endothelin antagonistischer Aktivität - Google Patents

Zyklische Hexapeptide mit Endothelin antagonistischer Aktivität

Info

Publication number
DE69420361D1
DE69420361D1 DE69420361T DE69420361T DE69420361D1 DE 69420361 D1 DE69420361 D1 DE 69420361D1 DE 69420361 T DE69420361 T DE 69420361T DE 69420361 T DE69420361 T DE 69420361T DE 69420361 D1 DE69420361 D1 DE 69420361D1
Authority
DE
Germany
Prior art keywords
alkyl
cycloalkyl
alkoxy
alpha
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69420361T
Other languages
English (en)
Other versions
DE69420361T2 (de
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Akira Kawada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69420361D1 publication Critical patent/DE69420361D1/de
Publication of DE69420361T2 publication Critical patent/DE69420361T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69420361T 1993-11-08 1994-11-05 Zyklische Hexapeptide mit Endothelin antagonistischer Aktivität Expired - Fee Related DE69420361T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27872293 1993-11-08
JP11236594 1994-05-26

Publications (2)

Publication Number Publication Date
DE69420361D1 true DE69420361D1 (de) 1999-10-07
DE69420361T2 DE69420361T2 (de) 1999-12-16

Family

ID=26451544

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420361T Expired - Fee Related DE69420361T2 (de) 1993-11-08 1994-11-05 Zyklische Hexapeptide mit Endothelin antagonistischer Aktivität

Country Status (7)

Country Link
US (1) US5948754A (de)
EP (1) EP0655463B1 (de)
AT (1) ATE184021T1 (de)
CA (1) CA2135151A1 (de)
DE (1) DE69420361T2 (de)
FI (1) FI945227A (de)
NO (1) NO944241L (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714909A1 (de) * 1994-12-01 1996-06-05 Takeda Chemical Industries, Ltd. Zusammensetzung zur Vorbeugung und Behandlung von Lungen-Kreislauferkrankungen
EP0815870A3 (de) * 1996-06-27 2000-05-03 Takeda Chemical Industries, Ltd. Zubereitung für die Vorbeugung und Behandlung des Schlaganfalls
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
DK2060259T3 (da) 2001-11-01 2010-05-17 Spectrum Pharmaceuticals Inc Medicinske sammensætninger til intravesikal behandling af blærecancer
US8217010B2 (en) 2002-10-24 2012-07-10 The Board Of Trustees Of The University Of Illinois Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors
US8026216B2 (en) 2002-10-24 2011-09-27 Spectrum Pharmaceuticals, Inc. Methods and compositions for contributing to the treatment of cancers
JP2006508086A (ja) * 2002-10-24 2006-03-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ 固形腫瘍を予防および治療するための方法および組成物
US20070032422A1 (en) 2002-10-24 2007-02-08 Spectrum Pharmaceuticals, Inc. Methods, compositions and articles of manufacture for contributing to the treatment of cancers
BRPI0722292A2 (pt) 2006-08-31 2014-04-15 Spectrum Pharmaceuticals Inc Sensibilização de células de tumor à terapia com radiação pela administração de agonistas de endotelina
US9308235B2 (en) 2012-05-09 2016-04-12 Spectrum Pharmaceuticals, Inc. Treatment of primary and metastatic carcinoma

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
DK0528312T3 (da) * 1991-08-13 1997-12-29 Takeda Chemical Industries Ltd Cykliske peptider og anvendelse deraf
ES2133295T3 (es) * 1991-11-19 1999-09-16 Takeda Chemical Industries Ltd Peptidos ciclicos y su uso.
TW217417B (de) * 1991-12-04 1993-12-11 Manyu Seiyaku Kk

Also Published As

Publication number Publication date
DE69420361T2 (de) 1999-12-16
NO944241D0 (no) 1994-11-07
NO944241L (no) 1995-05-09
CA2135151A1 (en) 1995-05-09
US5948754A (en) 1999-09-07
FI945227A (fi) 1995-05-09
EP0655463B1 (de) 1999-09-01
FI945227A0 (fi) 1994-11-07
EP0655463A1 (de) 1995-05-31
ATE184021T1 (de) 1999-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee