NO942757L - 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater - Google Patents

4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater

Info

Publication number
NO942757L
NO942757L NO942757A NO942757A NO942757L NO 942757 L NO942757 L NO 942757L NO 942757 A NO942757 A NO 942757A NO 942757 A NO942757 A NO 942757A NO 942757 L NO942757 L NO 942757L
Authority
NO
Norway
Prior art keywords
formula
nitrogen
group
compounds
optionally substituted
Prior art date
Application number
NO942757A
Other languages
English (en)
Other versions
NO942757D0 (no
Inventor
Ernest S Hamanaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO942757D0 publication Critical patent/NO942757D0/no
Publication of NO942757L publication Critical patent/NO942757L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med formel (I) hvor hver m uavhengig er O til 4; R2 er hydrogen eller (C^J alkyl; hver R3 og R* er uavhengig halogen, (Cj.Jalkyl eventuelt substituert med ett eller flere halogenatomer, (C^j) alkoksy eventuelt substituert med ett eller flere halogenatomer, (Cj.J alkyltio eventuelt substituert med ett eller flere halogenatomer; nitro, karboksyl eventuelt forestret med en (Cj.J alkylgruppe; hydroksyl, (Ct.J acyloksy eller (Cj.jjacyl; X er svovel eller oksygen; og Q er en gruppe med formel (XIV), (XV) eller (XVI) hvor m er som angitt oven- for; n er O eller 1; hver l er uavhengig O til 3; hver R6 og R7 er som angitt i beskrivelsen; B, D, E og G er nitrogen eller karbon, med det forbehold at en eller flere av B> D og E er nitrogen, og med det forbehold at når G er nitrogen,:er grup- pen XVI bundet til nitrogenet i formel (I) i 4- eller 5-stil- ling i pyrimidin-ringen (betegnet a og b) hvor hvilke som helst av nitrogenatomene kan være oksydert, eller farmasøytisk, godtagbare salter derav, og mellomprodukter med formel (IV) som anvendes for syntese av forbindelsene. Forbindelsene med formel (I) er inhibitorer for acyl coenzym A: cholesterol . acyltransferase (ACAT) og er nyttige som hypolipidemiske og antiaterosklerotiske midler.
NO942757A 1992-01-23 1994-07-22 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater NO942757L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82463992A 1992-01-23 1992-01-23
PCT/US1992/010886 WO1993015058A1 (en) 1992-01-23 1992-12-21 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents

Publications (2)

Publication Number Publication Date
NO942757D0 NO942757D0 (no) 1994-07-22
NO942757L true NO942757L (no) 1994-07-22

Family

ID=25241935

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942757A NO942757L (no) 1992-01-23 1994-07-22 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater

Country Status (16)

Country Link
EP (1) EP0623112B1 (no)
JP (1) JP2668163B2 (no)
KR (1) KR950700284A (no)
AT (1) ATE175196T1 (no)
AU (1) AU3323393A (no)
CA (1) CA2128093C (no)
DE (1) DE69228069T2 (no)
DK (1) DK0623112T3 (no)
ES (1) ES2125325T3 (no)
FI (2) FI930264A (no)
HU (1) HUT63625A (no)
IL (1) IL104420A0 (no)
MX (1) MX9300361A (no)
NO (1) NO942757L (no)
WO (1) WO1993015058A1 (no)
ZA (1) ZA93482B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133326A (en) * 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
AU2547399A (en) 1998-02-25 1999-09-15 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for producing the same
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
ES2239145T3 (es) 2000-02-02 2005-09-16 Warner-Lambert Company Llc Inhibidor doble de la sintesis de ester de colesterilo y de ester de cera avasimibe para el tratamiento de trastornos de la glandula sebacea.
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
BRPI0514381A (pt) * 2004-07-30 2008-06-10 Palumed Sa compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
TW205037B (no) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
US5278186A (en) * 1990-02-10 1994-01-11 Takeda Chemical Industries, Ltd. Chromene derivatives, their production and use
BR9205939A (pt) * 1991-04-26 1994-09-27 Pfizer Derivados de 4-aril-3-(heteroalilureído)quinolina

Also Published As

Publication number Publication date
ES2125325T3 (es) 1999-03-01
ATE175196T1 (de) 1999-01-15
MX9300361A (es) 1994-06-30
ZA93482B (en) 1994-07-22
HU9300197D0 (en) 1993-04-28
NO942757D0 (no) 1994-07-22
EP0623112B1 (en) 1998-12-30
KR950700284A (ko) 1995-01-16
IL104420A0 (en) 1993-05-13
HUT63625A (en) 1993-09-28
DE69228069T2 (de) 1999-05-20
AU3323393A (en) 1993-09-01
CA2128093C (en) 1998-02-03
FI930264A (fi) 1993-07-24
FI930264A0 (fi) 1993-01-22
JP2668163B2 (ja) 1997-10-27
DK0623112T3 (da) 1999-08-30
CA2128093A1 (en) 1993-08-05
JPH07503712A (ja) 1995-04-20
FI20010074A (fi) 2001-01-12
WO1993015058A1 (en) 1993-08-05
DE69228069D1 (de) 1999-02-11
EP0623112A1 (en) 1994-11-09

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