NO942757L - 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater - Google Patents
4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivaterInfo
- Publication number
- NO942757L NO942757L NO942757A NO942757A NO942757L NO 942757 L NO942757 L NO 942757L NO 942757 A NO942757 A NO 942757A NO 942757 A NO942757 A NO 942757A NO 942757 L NO942757 L NO 942757L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- nitrogen
- group
- compounds
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Forbindelser med formel (I) hvor hver m uavhengig er O til 4; R2 er hydrogen eller (C^J alkyl; hver R3 og R* er uavhengig halogen, (Cj.Jalkyl eventuelt substituert med ett eller flere halogenatomer, (C^j) alkoksy eventuelt substituert med ett eller flere halogenatomer, (Cj.J alkyltio eventuelt substituert med ett eller flere halogenatomer; nitro, karboksyl eventuelt forestret med en (Cj.J alkylgruppe; hydroksyl, (Ct.J acyloksy eller (Cj.jjacyl; X er svovel eller oksygen; og Q er en gruppe med formel (XIV), (XV) eller (XVI) hvor m er som angitt oven- for; n er O eller 1; hver l er uavhengig O til 3; hver R6 og R7 er som angitt i beskrivelsen; B, D, E og G er nitrogen eller karbon, med det forbehold at en eller flere av B> D og E er nitrogen, og med det forbehold at når G er nitrogen,:er grup- pen XVI bundet til nitrogenet i formel (I) i 4- eller 5-stil- ling i pyrimidin-ringen (betegnet a og b) hvor hvilke som helst av nitrogenatomene kan være oksydert, eller farmasøytisk, godtagbare salter derav, og mellomprodukter med formel (IV) som anvendes for syntese av forbindelsene. Forbindelsene med formel (I) er inhibitorer for acyl coenzym A: cholesterol . acyltransferase (ACAT) og er nyttige som hypolipidemiske og antiaterosklerotiske midler.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82463992A | 1992-01-23 | 1992-01-23 | |
| PCT/US1992/010886 WO1993015058A1 (en) | 1992-01-23 | 1992-12-21 | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO942757D0 NO942757D0 (no) | 1994-07-22 |
| NO942757L true NO942757L (no) | 1994-07-22 |
Family
ID=25241935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO942757A NO942757L (no) | 1992-01-23 | 1994-07-22 | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-okso-kinolin-derivater |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0623112B1 (no) |
| JP (1) | JP2668163B2 (no) |
| KR (1) | KR950700284A (no) |
| AT (1) | ATE175196T1 (no) |
| AU (1) | AU3323393A (no) |
| CA (1) | CA2128093C (no) |
| DE (1) | DE69228069T2 (no) |
| DK (1) | DK0623112T3 (no) |
| ES (1) | ES2125325T3 (no) |
| FI (2) | FI930264A (no) |
| HU (1) | HUT63625A (no) |
| IL (1) | IL104420A0 (no) |
| MX (1) | MX9300361A (no) |
| NO (1) | NO942757L (no) |
| WO (1) | WO1993015058A1 (no) |
| ZA (1) | ZA93482B (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133326A (en) * | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| AU2547399A (en) | 1998-02-25 | 1999-09-15 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for producing the same |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| ES2239145T3 (es) | 2000-02-02 | 2005-09-16 | Warner-Lambert Company Llc | Inhibidor doble de la sintesis de ester de colesterilo y de ester de cera avasimibe para el tratamiento de trastornos de la glandula sebacea. |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| BRPI0514381A (pt) * | 2004-07-30 | 2008-06-10 | Palumed Sa | compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes |
| FR2874922A1 (fr) * | 2004-07-30 | 2006-03-10 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| TW205037B (no) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| US5278186A (en) * | 1990-02-10 | 1994-01-11 | Takeda Chemical Industries, Ltd. | Chromene derivatives, their production and use |
| BR9205939A (pt) * | 1991-04-26 | 1994-09-27 | Pfizer | Derivados de 4-aril-3-(heteroalilureído)quinolina |
-
1992
- 1992-12-21 ES ES93901257T patent/ES2125325T3/es not_active Expired - Lifetime
- 1992-12-21 WO PCT/US1992/010886 patent/WO1993015058A1/en active IP Right Grant
- 1992-12-21 AT AT93901257T patent/ATE175196T1/de not_active IP Right Cessation
- 1992-12-21 JP JP5513207A patent/JP2668163B2/ja not_active Expired - Fee Related
- 1992-12-21 AU AU33233/93A patent/AU3323393A/en not_active Abandoned
- 1992-12-21 CA CA002128093A patent/CA2128093C/en not_active Expired - Fee Related
- 1992-12-21 DK DK93901257T patent/DK0623112T3/da active
- 1992-12-21 DE DE69228069T patent/DE69228069T2/de not_active Expired - Fee Related
- 1992-12-21 EP EP93901257A patent/EP0623112B1/en not_active Expired - Lifetime
-
1993
- 1993-01-18 IL IL104420A patent/IL104420A0/xx unknown
- 1993-01-22 MX MX9300361A patent/MX9300361A/es unknown
- 1993-01-22 HU HU9300197A patent/HUT63625A/hu unknown
- 1993-01-22 ZA ZA93482A patent/ZA93482B/xx unknown
- 1993-01-22 FI FI930264A patent/FI930264A/fi unknown
-
1994
- 1994-07-22 KR KR1019940702519A patent/KR950700284A/ko not_active Application Discontinuation
- 1994-07-22 NO NO942757A patent/NO942757L/no unknown
-
2001
- 2001-01-12 FI FI20010074A patent/FI20010074A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2125325T3 (es) | 1999-03-01 |
| ATE175196T1 (de) | 1999-01-15 |
| MX9300361A (es) | 1994-06-30 |
| ZA93482B (en) | 1994-07-22 |
| HU9300197D0 (en) | 1993-04-28 |
| NO942757D0 (no) | 1994-07-22 |
| EP0623112B1 (en) | 1998-12-30 |
| KR950700284A (ko) | 1995-01-16 |
| IL104420A0 (en) | 1993-05-13 |
| HUT63625A (en) | 1993-09-28 |
| DE69228069T2 (de) | 1999-05-20 |
| AU3323393A (en) | 1993-09-01 |
| CA2128093C (en) | 1998-02-03 |
| FI930264A (fi) | 1993-07-24 |
| FI930264A0 (fi) | 1993-01-22 |
| JP2668163B2 (ja) | 1997-10-27 |
| DK0623112T3 (da) | 1999-08-30 |
| CA2128093A1 (en) | 1993-08-05 |
| JPH07503712A (ja) | 1995-04-20 |
| FI20010074A (fi) | 2001-01-12 |
| WO1993015058A1 (en) | 1993-08-05 |
| DE69228069D1 (de) | 1999-02-11 |
| EP0623112A1 (en) | 1994-11-09 |
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