NO941986L - Anti-kreft immunoterapeutisk vektorkonstruksjoner - Google Patents
Anti-kreft immunoterapeutisk vektorkonstruksjonerInfo
- Publication number
- NO941986L NO941986L NO941986A NO941986A NO941986L NO 941986 L NO941986 L NO 941986L NO 941986 A NO941986 A NO 941986A NO 941986 A NO941986 A NO 941986A NO 941986 L NO941986 L NO 941986L
- Authority
- NO
- Norway
- Prior art keywords
- altered
- expression
- vector constructs
- recombinant virus
- altered cellular
- Prior art date
Links
- 230000001093 anti-cancer Effects 0.000 title 1
- 230000001024 immunotherapeutic effect Effects 0.000 title 1
- 230000001413 cellular effect Effects 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 102000044159 Ubiquitin Human genes 0.000 abstract 1
- 108090000848 Ubiquitin Proteins 0.000 abstract 1
- 108700025700 Wilms Tumor Genes Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000000381 tumorigenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en fremgangsmåte for å ødelegge selekterte tumorceller, som omfatter at det til et varmblodig dyr administreres en vektorkonstruksjon som styrer ekspresjonen av minst en immunogen, ikke-tumorogen form av en endret cellulær komponent som normalt er assosiert med de selekterte tumorceller. Det tilveiebringes også vektor- konstruksjoner som styrer ekspresjonen av endrede cellulære komponenter. Representative endrede cellulære komponenter innbefatter ras', p53", Kb", endret protein som kodes av Wilms tumorgenet, ubikvitin", DCC, APC, MCC, neu, en endret reseptor og bcr/abl. Det tilveiebringes også rekombinante virus som er bærere av en vektorkonstruksjon, målceller infisert med det rekombinante virus og farmasøytiske preparater som omfatter det rekombinante virus og et farmasøytisk akseptabelt bærer- eller fortynningsmiddel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80032891A | 1991-11-29 | 1991-11-29 | |
PCT/US1992/010309 WO1993010814A1 (en) | 1991-11-29 | 1992-11-30 | Anti-cancer immunotherapeutic vector constructs |
Publications (2)
Publication Number | Publication Date |
---|---|
NO941986D0 NO941986D0 (no) | 1994-05-27 |
NO941986L true NO941986L (no) | 1994-07-27 |
Family
ID=25178122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO941986A NO941986L (no) | 1991-11-29 | 1994-05-27 | Anti-kreft immunoterapeutisk vektorkonstruksjoner |
Country Status (10)
Country | Link |
---|---|
US (1) | US5693522A (no) |
EP (1) | EP0615453B1 (no) |
JP (1) | JPH07501942A (no) |
AT (1) | ATE152915T1 (no) |
AU (1) | AU671971B2 (no) |
CA (1) | CA2117303C (no) |
DE (1) | DE69219787T2 (no) |
FI (1) | FI942503A0 (no) |
NO (1) | NO941986L (no) |
WO (1) | WO1993010814A1 (no) |
Families Citing this family (59)
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US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
ATE261314T1 (de) * | 1992-07-22 | 2004-03-15 | Univ Princeton | P53 impfstoff |
US20030086935A1 (en) * | 1992-07-22 | 2003-05-08 | Levine Arnold J. | p53 vaccine |
AU676204B2 (en) | 1992-09-18 | 1997-03-06 | Canji, Inc. | Gene therapy by retroviral vector with tumor suppressive gene |
US6953573B1 (en) | 1993-03-17 | 2005-10-11 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US5700657A (en) * | 1993-12-13 | 1997-12-23 | Genzyme Corporation | Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby |
US5629192A (en) * | 1994-02-04 | 1997-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | ETS1 gene: a human tumor suppressor gene |
KR970702915A (ko) * | 1994-04-29 | 1997-06-10 | 린다 버겐 | 종양 세포의 치료 감응성 향상 방법(Enhancing The Sensitivity of Tumor Cells to Therapies) |
ATE381624T1 (de) | 1994-05-09 | 2008-01-15 | Oxford Biomedica Ltd | Retrovirale vektoren mit verminderter rekombinationsrate |
ATE399022T1 (de) * | 1995-10-20 | 2008-07-15 | Univ Nebraska | Zusammensetzung und verfahren zur verstärkung der immunantwort antigen-präsentierender zellen |
EP0871747A1 (en) * | 1996-01-02 | 1998-10-21 | Chiron Viagene, Inc. | Immunostimulation mediated by gene-modified dendritic cells |
US6365151B1 (en) * | 1996-01-19 | 2002-04-02 | Philadelphia Health And Educational Corporation | Cellular immunogens comprising cognate proto-oxogenes |
US6942862B2 (en) * | 1996-04-01 | 2005-09-13 | University Of Washington | Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins |
EP0907746B1 (en) | 1996-04-05 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
JP2001500738A (ja) * | 1996-09-17 | 2001-01-23 | カイロン コーポレイション | 細胞内疾患を処置するための組成物および方法 |
US20040202680A1 (en) * | 1997-01-30 | 2004-10-14 | O'hagan Derek | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
DK0991403T3 (da) * | 1997-01-30 | 2003-07-28 | Chiron Corp | Anvendelse af mikropartikler med adsorberet antigen til stimulering af immunresponser |
US6884435B1 (en) * | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
EP0984813A1 (en) | 1997-05-13 | 2000-03-15 | Stuart D. Edwards | Global medical treatment method and apparatus |
FR2775601B1 (fr) * | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
US20030235557A1 (en) * | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
US7144581B2 (en) * | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
US20030039635A1 (en) * | 1998-09-30 | 2003-02-27 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
EP1123086B1 (en) | 1998-10-20 | 2010-03-03 | Androclus Technologies S.r.l. in liquidazione | Artificial antigen-specific cells and related methods |
US6787154B2 (en) * | 1998-10-20 | 2004-09-07 | Salvatore Albani | Artificial antigen presenting cells |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
US8647864B2 (en) | 1999-04-14 | 2014-02-11 | Novartis Ag | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
AU5003200A (en) | 1999-05-14 | 2000-12-05 | United States Of America As Represented By The Department Of Veterans Affairs, The | Isolation and characterization of epidermal growth factor related protein |
US7049410B2 (en) * | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
WO2001016167A2 (en) * | 1999-09-01 | 2001-03-08 | The Johns Hopkins University | Beta-catenin, tcf-4, and apc interact to prevent cancer |
US9289487B2 (en) * | 1999-09-14 | 2016-03-22 | Antigen Express, Inc. | II-key/antigenic epitope hybrid peptide vaccines |
US20030235594A1 (en) * | 1999-09-14 | 2003-12-25 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
US6432409B1 (en) | 1999-09-14 | 2002-08-13 | Antigen Express, Inc. | Hybrid peptides modulate the immune response |
US6656718B2 (en) | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
EP1356048A2 (en) | 2000-12-04 | 2003-10-29 | Argonex Pharmaceuticals | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
EP2305299B1 (en) | 2001-05-31 | 2017-03-01 | GlaxoSmithKline Biologicals SA | Chimeric alphavirus replicon particles |
US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
US7179645B2 (en) * | 2002-09-24 | 2007-02-20 | Antigen Express, Inc. | Ii-Key/antigenic epitope hybrid peptide vaccines |
EP1556072B1 (en) | 2002-09-17 | 2010-05-19 | Antigen Express, Inc. | Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES |
WO2005087260A1 (en) * | 2004-03-04 | 2005-09-22 | Corixa Corporation | Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof |
JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 免疫増強用の化合物 |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
JP2009511636A (ja) | 2005-10-18 | 2009-03-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | アルファウイルスレプリコン粒子による粘膜免疫および全身免疫 |
CA2646539A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
CA2647100A1 (en) * | 2006-03-23 | 2007-09-27 | Novartis Ag | Methods for the preparation of imidazole-containing compounds |
US8063063B2 (en) * | 2006-03-23 | 2011-11-22 | Novartis Ag | Immunopotentiating compounds |
CA2999337C (en) * | 2008-01-28 | 2023-03-07 | Implantica Patent Ltd. | An implantable drainage device |
CA2750922A1 (en) * | 2009-01-28 | 2010-08-05 | Antigen Express, Inc. | Li-key hybrid peptides that modulate the immune response to influenza |
CN102933267B (zh) | 2010-05-28 | 2015-05-27 | 泰特里斯在线公司 | 交互式混合异步计算机游戏基础结构 |
CA2954892A1 (en) | 2016-01-19 | 2017-07-19 | Pfizer Inc. | Immunogens derived from tumor-associated antigens or nucleic acid molecules encoding the immunogens |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4405712A (en) * | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
US4965196A (en) * | 1983-01-19 | 1990-10-23 | Genentech, Inc. | Polycistronic expression vector construction |
GB8424757D0 (en) * | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4871838A (en) * | 1985-07-23 | 1989-10-03 | The Board Of Rijks Universiteit Leiden | Probes and methods for detecting activated ras oncogenes |
US4931275A (en) * | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
CA1310924C (en) * | 1986-04-24 | 1992-12-01 | Francis P. Mccormick | Infective drug delivery system |
US4861719A (en) * | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US4980289A (en) * | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
DE3854313D1 (de) * | 1987-05-29 | 1995-09-21 | Dana Farber Cancer Inst Inc | Cis-Wirkung-Repressionen-Sequenzen, Cis-Wirkung-Antirepressionen-Sequenzen, Vektoren, Verfahren zur Vorbereitung und Anwendung. |
WO1989001973A2 (en) * | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
JP3015383B2 (ja) * | 1987-09-11 | 2000-03-06 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 形質導入した線維芽およびそれらの使用 |
WO1989005349A1 (en) * | 1987-12-09 | 1989-06-15 | The Australian National University | Method of combating viral infections |
US4957859A (en) * | 1988-02-16 | 1990-09-18 | Hoffmann-La Roche Inc. | Antibodies for transforming ras protein |
CA1339354C (en) * | 1988-09-01 | 1997-08-26 | The Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
WO1990011092A1 (en) * | 1989-03-21 | 1990-10-04 | Vical, Inc. | Expression of exogenous polynucleotide sequences in a vertebrate |
CA2055441C (en) * | 1989-05-19 | 2003-01-07 | Robert M. Hudziak | Her2 extracellular domain |
FR2668064B1 (fr) * | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
-
1992
- 1992-11-30 EP EP93900751A patent/EP0615453B1/en not_active Expired - Lifetime
- 1992-11-30 AU AU32297/93A patent/AU671971B2/en not_active Ceased
- 1992-11-30 JP JP5510289A patent/JPH07501942A/ja active Pending
- 1992-11-30 CA CA002117303A patent/CA2117303C/en not_active Expired - Fee Related
- 1992-11-30 AT AT93900751T patent/ATE152915T1/de not_active IP Right Cessation
- 1992-11-30 WO PCT/US1992/010309 patent/WO1993010814A1/en active IP Right Grant
- 1992-11-30 DE DE69219787T patent/DE69219787T2/de not_active Expired - Fee Related
-
1994
- 1994-05-27 FI FI942503A patent/FI942503A0/fi unknown
- 1994-05-27 NO NO941986A patent/NO941986L/no unknown
-
1995
- 1995-01-11 US US08/371,922 patent/US5693522A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0615453A1 (en) | 1994-09-21 |
WO1993010814A1 (en) | 1993-06-10 |
JPH07501942A (ja) | 1995-03-02 |
FI942503A (fi) | 1994-05-27 |
FI942503A0 (fi) | 1994-05-27 |
AU3229793A (en) | 1993-06-28 |
ATE152915T1 (de) | 1997-05-15 |
EP0615453B1 (en) | 1997-05-14 |
AU671971B2 (en) | 1996-09-19 |
US5693522A (en) | 1997-12-02 |
CA2117303A1 (en) | 1993-06-10 |
CA2117303C (en) | 2000-10-17 |
NO941986D0 (no) | 1994-05-27 |
DE69219787T2 (de) | 1997-08-28 |
DE69219787D1 (de) | 1997-06-19 |
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