NO940130L - Benzimidazolderivater, fremgangsmåte for deres fremstilling og terapeutisk anvendelse derav - Google Patents
Benzimidazolderivater, fremgangsmåte for deres fremstilling og terapeutisk anvendelse deravInfo
- Publication number
- NO940130L NO940130L NO940130A NO940130A NO940130L NO 940130 L NO940130 L NO 940130L NO 940130 A NO940130 A NO 940130A NO 940130 A NO940130 A NO 940130A NO 940130 L NO940130 L NO 940130L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- alkyl
- therapeutic use
- groups
- type
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- -1 cyano, aminocarbonyl Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- VNZKTXZTVRKWEB-UHFFFAOYSA-N 2-(4h-imidazo[1,2-a]benzimidazol-1-yl)acetamide Chemical class C1=CC=C2N3C(CC(=O)N)=CN=C3NC2=C1 VNZKTXZTVRKWEB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
9H-imidazo[l,2-a]benzimidazol-3-acetamidforbindelser med den generelle formel (I) (I) hvori X står for ett eller flere atomer eller grupper valgt blant hydrogen, halogenene, grupper av type alkyl, trifluormetyl alkoksy, alkyltio, metylsulfonyl, cyano, aminokarbonyl og karboksy, Y står for ett eller flere atomer eller grupper valgt blant hydrogen, halogenene, grupper av type alkyl, trifluormetyl, metoksy og trifluormetoksy, Rj står for hydrogen, eller en gruppe av type alkyl, fenylmetyl, 2- fenyletyl, acetyl eller alkoksykarbonyl, R2 og R3 står hver for hydrogen eller eventuelt substituert alkyl, prop-2enyl, prop-2-ynyl, fenyl, l-(fenylmetyl)piperidin-4-yl, l-[(cyklo- heksen-1-yl)metyl]piperidin-4-yl, eller også danner R2 og R3 sammen med det nitrogenatom som bærer dem en event- uelt hetrocyklisk gruppe. Forbindelsene har terapeutisk anvendelse, er beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9300337A FR2700544B1 (fr) | 1993-01-15 | 1993-01-15 | Dérivés de 9H-imidazo[1,2-a]benzimidazole-3-acétamide, leur préparation et leur application en thérapeutique. |
FR9309013A FR2707987B1 (fr) | 1993-07-22 | 1993-07-22 | Dérivés de 9H-imidazo[1,2-a]benzimidazole-3-acétamide, leur préparation et leur application en thérapeutique . |
Publications (2)
Publication Number | Publication Date |
---|---|
NO940130D0 NO940130D0 (no) | 1994-01-14 |
NO940130L true NO940130L (no) | 1994-07-18 |
Family
ID=26230029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO940130A NO940130L (no) | 1993-01-15 | 1994-01-14 | Benzimidazolderivater, fremgangsmåte for deres fremstilling og terapeutisk anvendelse derav |
Country Status (16)
Country | Link |
---|---|
US (1) | US5466706A (no) |
EP (1) | EP0607076A1 (no) |
JP (1) | JPH06271575A (no) |
CN (1) | CN1097743A (no) |
AU (1) | AU665137B2 (no) |
CA (1) | CA2113490A1 (no) |
CZ (1) | CZ9394A3 (no) |
FI (1) | FI940186A (no) |
HU (1) | HUT70407A (no) |
IL (1) | IL108343A0 (no) |
NO (1) | NO940130L (no) |
NZ (1) | NZ250679A (no) |
PL (1) | PL301901A1 (no) |
RU (1) | RU94000725A (no) |
SK (1) | SK4694A3 (no) |
TW (1) | TW253886B (no) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2719843B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Dérivés de 5,6-dihydro-4h-imidazo [2',1':2,3] imidazo-[4,5,1-ij] quinoléine et de 4,5-dihydroimidazo [1,2-a] pyrrolo-[1,2,3-cd] benzimidazole, leur préparation et leur application en thérapeutique. |
FR2741073B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives de 4,5-dihydroimidazo(1,2-a)pyrrolo(1,2,3-cd) benzimidazole, leur preparation et leur application en therapeutique |
GB9702524D0 (en) * | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
FR2759698B1 (fr) * | 1997-02-20 | 1999-03-19 | Synthelabo | Derives de 1,4-diphenylimidazole-5-acetamide, leur preparation et leur application en therapeutique |
WO2002022572A2 (en) * | 2000-09-11 | 2002-03-21 | Sepracor, Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission) |
PL368555A1 (en) * | 2001-01-26 | 2005-04-04 | Bristol-Myers Squibb Company | Imidazolyl derivatives as corticotropin releasing factor inhibitors |
WO2004058758A1 (en) * | 2002-12-18 | 2004-07-15 | Mallinckrodt Inc. | Synthesis of heteroaryl acetamides |
FR2870239B1 (fr) | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
US7498439B2 (en) * | 2004-06-22 | 2009-03-03 | Mallinckrodt Inc. | Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content |
NZ571566A (en) * | 2006-03-17 | 2011-07-29 | Ambit Biosciences Corp | Imidazolothiazole compounds for the treatment of disease |
CA2696776C (en) | 2007-09-19 | 2015-12-15 | Ambit Biosciences Corporation | Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3732243A (en) * | 1970-06-23 | 1973-05-08 | Sankyo Co | 2-(p-bromophenyl)-9-dimethyl-amino-propyl-9h-imidazo(1,2-a)benzimidazole |
GB1484615A (en) * | 1974-11-23 | 1977-09-01 | Lepetit Spa | Tricyclic n-containing derivatives |
FR2568879B1 (fr) * | 1984-08-07 | 1986-12-12 | Synthelabo | Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique |
US4675323A (en) * | 1985-08-06 | 1987-06-23 | Synthelabo | Imidazo(1,2-a)quinoline derivatives useful as anxiolytic agents |
US5240944A (en) * | 1988-12-28 | 1993-08-31 | Kotobuki Seiyaku Co. Ltd. | Cyclic guanidine derivatives, anti-ulceratives and method of manufacturing the same |
-
1994
- 1994-01-11 EP EP94400057A patent/EP0607076A1/fr not_active Withdrawn
- 1994-01-14 HU HU9400109A patent/HUT70407A/hu unknown
- 1994-01-14 US US08/180,998 patent/US5466706A/en not_active Expired - Fee Related
- 1994-01-14 RU RU94000725/04A patent/RU94000725A/ru unknown
- 1994-01-14 SK SK46-94A patent/SK4694A3/sk unknown
- 1994-01-14 NZ NZ250679A patent/NZ250679A/en unknown
- 1994-01-14 PL PL94301901A patent/PL301901A1/xx unknown
- 1994-01-14 JP JP6002463A patent/JPH06271575A/ja active Pending
- 1994-01-14 CN CN94100607A patent/CN1097743A/zh active Pending
- 1994-01-14 IL IL10834394A patent/IL108343A0/xx unknown
- 1994-01-14 NO NO940130A patent/NO940130L/no unknown
- 1994-01-14 CZ CZ9493A patent/CZ9394A3/cs unknown
- 1994-01-14 AU AU53177/94A patent/AU665137B2/en not_active Ceased
- 1994-01-14 CA CA002113490A patent/CA2113490A1/en not_active Abandoned
- 1994-01-14 FI FI940186A patent/FI940186A/fi unknown
- 1994-01-17 TW TW083100320A patent/TW253886B/zh active
Also Published As
Publication number | Publication date |
---|---|
NZ250679A (en) | 1995-07-26 |
FI940186A0 (fi) | 1994-01-14 |
AU665137B2 (en) | 1995-12-14 |
HUT70407A (en) | 1995-10-30 |
CN1097743A (zh) | 1995-01-25 |
RU94000725A (ru) | 1997-05-27 |
JPH06271575A (ja) | 1994-09-27 |
TW253886B (no) | 1995-08-11 |
AU5317794A (en) | 1995-05-25 |
HU9400109D0 (en) | 1994-05-30 |
FI940186A (fi) | 1994-07-16 |
SK4694A3 (en) | 1995-02-08 |
CZ9394A3 (en) | 1994-08-17 |
EP0607076A1 (fr) | 1994-07-20 |
PL301901A1 (en) | 1994-07-25 |
CA2113490A1 (en) | 1994-07-16 |
IL108343A0 (en) | 1994-04-12 |
NO940130D0 (no) | 1994-01-14 |
US5466706A (en) | 1995-11-14 |
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