NO920057L - 6-(hydronaftyl-1-ethyl)-4-hydroksy-3,4,5,6-tetrahydro-2h-pyran-2-oner og de tilsvarende hydroksysyrer - Google Patents

6-(hydronaftyl-1-ethyl)-4-hydroksy-3,4,5,6-tetrahydro-2h-pyran-2-oner og de tilsvarende hydroksysyrer

Info

Publication number
NO920057L
NO920057L NO92920057A NO920057A NO920057L NO 920057 L NO920057 L NO 920057L NO 92920057 A NO92920057 A NO 92920057A NO 920057 A NO920057 A NO 920057A NO 920057 L NO920057 L NO 920057L
Authority
NO
Norway
Prior art keywords
hydroxy
hydronaftyl
pyrane
tetrahydro
ones
Prior art date
Application number
NO92920057A
Other languages
English (en)
Norwegian (no)
Other versions
NO920057D0 (no
Inventor
Christopher Norman Lewis
Alan Hornsby Davidson
Christopher David Floyd
Jonathan Philip Dickens
Original Assignee
British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology filed Critical British Bio Technology
Publication of NO920057D0 publication Critical patent/NO920057D0/no
Publication of NO920057L publication Critical patent/NO920057L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO92920057A 1989-07-04 1992-01-03 6-(hydronaftyl-1-ethyl)-4-hydroksy-3,4,5,6-tetrahydro-2h-pyran-2-oner og de tilsvarende hydroksysyrer NO920057L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898915280A GB8915280D0 (en) 1989-07-04 1989-07-04 Compounds
PCT/GB1990/001030 WO1991000280A1 (en) 1989-07-04 1990-07-04 6-(hydronaphtyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones and the corresponding hydroxy acids

Publications (2)

Publication Number Publication Date
NO920057D0 NO920057D0 (no) 1992-01-03
NO920057L true NO920057L (no) 1992-03-03

Family

ID=10659493

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92920057A NO920057L (no) 1989-07-04 1992-01-03 6-(hydronaftyl-1-ethyl)-4-hydroksy-3,4,5,6-tetrahydro-2h-pyran-2-oner og de tilsvarende hydroksysyrer

Country Status (14)

Country Link
US (1) US5308864A (ko)
EP (1) EP0480986A1 (ko)
JP (1) JPH04506523A (ko)
KR (1) KR920703563A (ko)
AU (1) AU631909B2 (ko)
CA (1) CA2060212A1 (ko)
FI (1) FI920036A0 (ko)
GB (1) GB8915280D0 (ko)
HU (1) HUT62254A (ko)
IE (1) IE902417A1 (ko)
NO (1) NO920057L (ko)
NZ (1) NZ234369A (ko)
PT (1) PT94584A (ko)
WO (1) WO1991000280A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9111192D0 (en) * 1991-05-23 1991-07-17 British Bio Technology Synthetic process
GB9115773D0 (en) * 1991-07-22 1991-09-04 British Bio Technology Synthetic process
GB9126144D0 (en) * 1991-12-10 1992-02-12 British Bio Technology Compounds
GB9208790D0 (en) * 1992-04-23 1992-06-10 British Bio Technology Compounds
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
US5990172A (en) * 1996-02-28 1999-11-23 Innapharma, Inc. Peptidomimetics for the treatment of HIV infection
US5925672A (en) 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
HUP0103021A3 (en) * 1998-12-10 2002-04-29 Kaneka Corp Process for producing simvastatin derivatives
US20050113445A1 (en) * 2003-02-20 2005-05-26 Daniele Piomelli Methods of treating mental diseases, inflammation and pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293496A (en) * 1980-02-04 1981-10-06 Merck & Co., Inc. 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4771071A (en) * 1986-05-05 1988-09-13 Merck & Co., Inc. Antihypercholesterolemic compounds
US4661483A (en) * 1986-05-05 1987-04-28 Merck & Co., Inc. Antihypercholesterolemic lactone compounds, compositions and use
PT85109A (en) * 1986-06-23 1987-07-01 Merck & Co Inc Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors

Also Published As

Publication number Publication date
AU6032290A (en) 1991-01-17
JPH04506523A (ja) 1992-11-12
KR920703563A (ko) 1992-12-18
PT94584A (pt) 1991-04-18
IE902417A1 (en) 1991-06-19
NZ234369A (en) 1991-10-25
CA2060212A1 (en) 1991-01-05
AU631909B2 (en) 1992-12-10
HUT62254A (en) 1993-04-28
WO1991000280A1 (en) 1991-01-10
EP0480986A1 (en) 1992-04-22
NO920057D0 (no) 1992-01-03
GB8915280D0 (en) 1989-08-23
FI920036A0 (fi) 1992-01-03
US5308864A (en) 1994-05-03
HU9200022D0 (en) 1992-07-28

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