NO914825L - Analogifremgangsmaate for fremstilling av terapeutisk virksomme alfa-oxoacetamider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk virksomme alfa-oxoacetamider

Info

Publication number
NO914825L
NO914825L NO91914825A NO914825A NO914825L NO 914825 L NO914825 L NO 914825L NO 91914825 A NO91914825 A NO 91914825A NO 914825 A NO914825 A NO 914825A NO 914825 L NO914825 L NO 914825L
Authority
NO
Norway
Prior art keywords
oxoacetamides
alfa
preparation
therapeutically effective
analogy procedure
Prior art date
Application number
NO91914825A
Other languages
English (en)
Other versions
NO914825D0 (no
Inventor
Robin D Clark
Richard M Eglen
Joseph M Muchowski
William L Smith
Klaus K Weinholdt
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO914825D0 publication Critical patent/NO914825D0/no
Publication of NO914825L publication Critical patent/NO914825L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO91914825A 1990-12-07 1991-12-06 Analogifremgangsmaate for fremstilling av terapeutisk virksomme alfa-oxoacetamider NO914825L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/624,028 US5192770A (en) 1990-12-07 1990-12-07 Serotonergic alpha-oxoacetamides

Publications (2)

Publication Number Publication Date
NO914825D0 NO914825D0 (no) 1991-12-06
NO914825L true NO914825L (no) 1992-06-09

Family

ID=24500341

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91914825A NO914825L (no) 1990-12-07 1991-12-06 Analogifremgangsmaate for fremstilling av terapeutisk virksomme alfa-oxoacetamider

Country Status (16)

Country Link
US (1) US5192770A (no)
EP (1) EP0490263A1 (no)
JP (1) JPH04290884A (no)
KR (1) KR920012061A (no)
AU (1) AU644249B2 (no)
CA (1) CA2057181A1 (no)
FI (1) FI915736A (no)
HU (1) HUT60270A (no)
IE (1) IE914247A1 (no)
IL (1) IL100262A0 (no)
IT (1) ITTO910939A1 (no)
MX (1) MX9102436A (no)
NO (1) NO914825L (no)
PL (1) PL292669A1 (no)
PT (1) PT99705A (no)
ZA (1) ZA919660B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT675110E (pt) * 1994-04-01 2002-11-29 Lilly Co Eli 1h-indole-3-glioxilamidas inibidoras da spla2
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists
SE9603283D0 (sv) * 1996-09-10 1996-09-10 Astra Ab New compounds
TW472045B (en) * 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
EP1475377B1 (de) * 1998-04-28 2006-06-21 elbion AG Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4.
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6469006B1 (en) * 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
US6346625B1 (en) 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
EP1284732A2 (en) * 2000-05-18 2003-02-26 Glaxo Group Limited Method for treating functional dyspepsia using alosetron
IT1318641B1 (it) * 2000-07-25 2003-08-27 Novuspharma Spa Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
TWI323658B (en) * 2001-12-06 2010-04-21 Nat Health Research Institutes Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same
WO2004029050A1 (en) 2002-09-25 2004-04-08 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
JP4824578B2 (ja) 2003-12-22 2011-11-30 メモリー・ファーマシューティカルズ・コーポレイション インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用
CA2560741C (en) 2004-03-25 2013-08-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US7488737B2 (en) * 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
JP2007538011A (ja) * 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7625924B2 (en) * 2004-12-22 2009-12-01 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
MX2008000560A (es) 2005-07-11 2008-03-10 Mitsubishi Tanabe Pharma Corp Un derivado de oxima y sus preparaciones.
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
GB0817576D0 (en) * 2008-09-25 2008-11-05 Lectus Therapeutics Ltd Calcium ion channel modulators & uses thereof
GB0909441D0 (en) * 2009-06-02 2009-07-15 Univ Sheffield Novel indole derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146628A (en) * 1977-08-04 1979-03-27 Edna Oppenheimer Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
GB8520616D0 (en) * 1985-08-16 1985-09-25 Beecham Group Plc Compounds
GB8525844D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds
DE3687980T2 (de) * 1986-01-07 1993-06-17 Beecham Group Plc Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
US4722834A (en) * 1986-03-05 1988-02-02 A. H. Robins Company, Incorporated Method of using 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide-N-oxides to control emesis caused by anticancer drugs
EP0254584B1 (en) * 1986-07-25 1992-10-07 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
IT1231413B (it) * 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
EP0311724A1 (en) * 1987-10-16 1989-04-19 Synthelabo Anxiolytic-R-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides
AU5650890A (en) * 1989-05-24 1990-12-18 Nippon Shinyaku Co. Ltd. Indole derivatives and medicine

Also Published As

Publication number Publication date
FI915736A (fi) 1992-06-08
AU8885691A (en) 1992-06-11
PL292669A1 (en) 1992-08-10
ITTO910939A0 (it) 1991-12-04
HUT60270A (en) 1992-08-28
KR920012061A (ko) 1992-07-25
FI915736A0 (fi) 1991-12-05
ZA919660B (en) 1993-06-07
HU913836D0 (en) 1992-02-28
PT99705A (pt) 1992-10-30
IE914247A1 (en) 1992-06-17
NO914825D0 (no) 1991-12-06
US5192770A (en) 1993-03-09
AU644249B2 (en) 1993-12-02
ITTO910939A1 (it) 1992-06-08
IL100262A0 (en) 1992-09-06
CA2057181A1 (en) 1992-06-08
JPH04290884A (ja) 1992-10-15
EP0490263A1 (en) 1992-06-17
MX9102436A (es) 1992-06-01

Similar Documents

Publication Publication Date Title
NO914825D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme alfa-oxoacetamider
NO921777L (no) Fremgangsmaate for fremstilling av isoparaffiner
NO179448C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
NO910395L (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 4-isoxazolcarboxamidderivater.
NO914490D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme tricykliske forbindelser
NO912797L (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme karbostirilderivater.
NO930574L (no) Fremgangsmaate for fremstilling av desfluran
NO920049D0 (no) Fremgangsmaate for fremstilling av 3-eksometylencefamsulfoksydestere
NO914071D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser
NO914053L (no) Fremgangsmaate for fremstilling av 8-klorokinolonderivater
NO304428B1 (no) AnalogifremgangsmÕte for fremstilling av terapeutisk aktive vinylazoler
NO158376C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme rooperolforbindelser.
NO914985D0 (no) Fremgangsmaate for fremstilling av 15-nitro-tabersonin-derivater
NO903397D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme derivater av protocatechualdehyd.
NO302416B1 (no) Fremgangsmåte for fremstilling av pergolid
NO920849D0 (no) Fremgangsmaate for fremstilling av l-lysin ved fermentasjon
NO179909C (no) Analogifremgangsmåte for fremstilling av terapeutisk avtive 6-substituerte purinylpiperazinderivater
NO914452D0 (no) Fremgangsmaate for fremstilling av isokinolinderivater
NO904678D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme benzylpyrrolidenderivater.
NO174196C (no) Fremgangsmåte for fremstilling av omega-decenol
NO881036L (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme nafthalenderivater.
NO173140C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tieno-triazolo-diazepin-derivater
NO914586D0 (no) Fremgangsmaate for fremstilling av polyeterester
NO914560D0 (no) Fremgangsmaate for fremstilling av fiberformig magnesiumoksid
NO950203D0 (no) Fremgangsmåte for fremstilling av propargylazetidion-forbindelser