NO902487L - Vandig folinatloesning stabil ved kjoeleskapstemperatur og fremgangsmaate ved fremstilling derav. - Google Patents

Vandig folinatloesning stabil ved kjoeleskapstemperatur og fremgangsmaate ved fremstilling derav.

Info

Publication number
NO902487L
NO902487L NO90902487A NO902487A NO902487L NO 902487 L NO902487 L NO 902487L NO 90902487 A NO90902487 A NO 90902487A NO 902487 A NO902487 A NO 902487A NO 902487 L NO902487 L NO 902487L
Authority
NO
Norway
Prior art keywords
preparing
procedure
refrigerator temperature
solution stable
aqueous
Prior art date
Application number
NO90902487A
Other languages
English (en)
Other versions
NO176389B (no
NO176389C (no
NO902487D0 (no
Inventor
Alfred James Nijkerk
Johanna Maria Pieterne Vermeer
Original Assignee
Pharmachemie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv
Publication of NO902487D0 publication Critical patent/NO902487D0/no
Publication of NO902487L publication Critical patent/NO902487L/no
Publication of NO176389B publication Critical patent/NO176389B/no
Publication of NO176389C publication Critical patent/NO176389C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
NO902487A 1989-06-06 1990-06-05 Fremgangsmåte ved fremstilling av vandig folinatlösning stabil ved kjöleskapstemperatur NO176389C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8901432A NL8901432A (nl) 1989-06-06 1989-06-06 Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.

Publications (4)

Publication Number Publication Date
NO902487D0 NO902487D0 (no) 1990-06-05
NO902487L true NO902487L (no) 1990-12-07
NO176389B NO176389B (no) 1994-12-19
NO176389C NO176389C (no) 1995-03-29

Family

ID=19854784

Family Applications (1)

Application Number Title Priority Date Filing Date
NO902487A NO176389C (no) 1989-06-06 1990-06-05 Fremgangsmåte ved fremstilling av vandig folinatlösning stabil ved kjöleskapstemperatur

Country Status (13)

Country Link
US (1) US5177076A (no)
EP (1) EP0401895B1 (no)
JP (1) JP2945718B2 (no)
AT (1) ATE83660T1 (no)
AU (1) AU626421B2 (no)
CA (1) CA2018230C (no)
DE (1) DE69000645T2 (no)
DK (1) DK0401895T3 (no)
ES (1) ES2036396T3 (no)
FI (1) FI96275C (no)
IL (1) IL92370A0 (no)
NL (1) NL8901432A (no)
NO (1) NO176389C (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
WO1994025032A1 (en) * 1993-04-28 1994-11-10 Yoshitomi Pharmaceutical Industries, Ltd. Stabilized injection and method of stabilizing injection
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
US5660835A (en) * 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
AU2002303425A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
WO2002085297A2 (en) * 2001-04-24 2002-10-31 East Carolina University Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease
US7405207B2 (en) * 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
CN100540007C (zh) * 2002-06-17 2009-09-16 埃匹吉尼斯医药有限公司 二水合脱氢表雄酮和采用其组合物治疗哮喘或慢性阻塞性肺部疾病的方法
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026848A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
ATE498401T1 (de) * 2004-09-15 2011-03-15 Nipro Corp Wässrige, stabile (6s)-folinsäurelösung zur injektion
WO2014025807A1 (en) 2012-08-06 2014-02-13 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising l-leucovorin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
US4436738A (en) * 1982-03-15 1984-03-13 Mead Johnson & Company Stabilized estradiol cream composition

Also Published As

Publication number Publication date
DK0401895T3 (da) 1993-04-13
AU5629790A (en) 1990-12-13
CA2018230A1 (en) 1990-12-06
FI96275B (fi) 1996-02-29
IL92370A0 (en) 1990-07-26
DE69000645D1 (de) 1993-02-04
DE69000645T2 (de) 1993-05-13
ATE83660T1 (de) 1993-01-15
EP0401895B1 (en) 1992-12-23
US5177076A (en) 1993-01-05
ES2036396T3 (es) 1993-05-16
JPH0356418A (ja) 1991-03-12
JP2945718B2 (ja) 1999-09-06
NO176389B (no) 1994-12-19
AU626421B2 (en) 1992-07-30
EP0401895A1 (en) 1990-12-12
NO176389C (no) 1995-03-29
NO902487D0 (no) 1990-06-05
FI902712A0 (fi) 1990-05-31
NL8901432A (nl) 1991-01-02
FI96275C (fi) 1996-06-10
CA2018230C (en) 1996-04-16

Similar Documents

Publication Publication Date Title
NO902487D0 (no) Vandig folinatloesning stabil ved kjoeleskapstemperatur og fremgangsmaate ved fremstilling derav.
AU5777490A (en) Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
NZ250170A (en) Insecticidal n,n'-diacylhydrazines and compositions
DK0411153T3 (no)
DE69133125T2 (de) Konservierungslösung für Zellen
GB2316006A (en) Stomach-action molluscicides
EP0337103A3 (en) Biocidal composition
ZA916268B (en) Tricyclic compound or salts thereof,method for producing the same and antimicrobial agent containing the same
SG46464A1 (en) Biocidal composition
HU9301478D0 (en) Method for producing methylole-hydantoine derivatives with low free formaldehyde content and preparatives containing it
JPS6445712A (en) Synthesis of zeolite l
IL105577A0 (en) Fungicidal compositions containing 3-hydroxy-5-methylisoxazole or salts thereof and methods for the preparation thereof
CA2036507A1 (en) 2'-deoxy-2'-methylidenecytidine dihydrate, methods for its production and compositions
AU2415699A (en) 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid
PL151373B2 (no)
NO960700L (no) Isotiazolonmateriale og fremgangsmåte til stabilisering av vandig isotiazolonlösning
HUT50132A (en) Process for producing 2-cyano-2-phenyl-1-/azol-1-yl/-ethan derivatives, and fungicide compositions containing them as active components
NO901209L (no) Stabiliserte polyprenylholdige preparater, deres fremstilling og anvendelse.
ES8207516A1 (es) Procedimiento para la obtencion de acido acetilaminometil- fosfonico

Legal Events

Date Code Title Description
MK1K Patent expired