DE69000645T2 - Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung. - Google Patents

Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.

Info

Publication number
DE69000645T2
DE69000645T2 DE9090201353T DE69000645T DE69000645T2 DE 69000645 T2 DE69000645 T2 DE 69000645T2 DE 9090201353 T DE9090201353 T DE 9090201353T DE 69000645 T DE69000645 T DE 69000645T DE 69000645 T2 DE69000645 T2 DE 69000645T2
Authority
DE
Germany
Prior art keywords
production
refrigerant temperature
stable aqueous
solution
folinate solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE9090201353T
Other languages
English (en)
Other versions
DE69000645D1 (de
Inventor
Alfred James Nijker
Johanna Maria Pieterne Vermeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmachemie BV
Original Assignee
Pharmachemie BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie BV filed Critical Pharmachemie BV
Application granted granted Critical
Publication of DE69000645D1 publication Critical patent/DE69000645D1/de
Publication of DE69000645T2 publication Critical patent/DE69000645T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
DE9090201353T 1989-06-06 1990-05-28 Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung. Expired - Lifetime DE69000645T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8901432A NL8901432A (nl) 1989-06-06 1989-06-06 Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.

Publications (2)

Publication Number Publication Date
DE69000645D1 DE69000645D1 (de) 1993-02-04
DE69000645T2 true DE69000645T2 (de) 1993-05-13

Family

ID=19854784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE9090201353T Expired - Lifetime DE69000645T2 (de) 1989-06-06 1990-05-28 Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.

Country Status (13)

Country Link
US (1) US5177076A (de)
EP (1) EP0401895B1 (de)
JP (1) JP2945718B2 (de)
AT (1) ATE83660T1 (de)
AU (1) AU626421B2 (de)
CA (1) CA2018230C (de)
DE (1) DE69000645T2 (de)
DK (1) DK0401895T3 (de)
ES (1) ES2036396T3 (de)
FI (1) FI96275C (de)
IL (1) IL92370A0 (de)
NL (1) NL8901432A (de)
NO (1) NO176389C (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
KR100188318B1 (ko) * 1993-04-28 1999-06-01 고오야 마사시 안정화된 주사제 및 주사제의 안정화법
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
US20020032160A1 (en) * 1995-02-24 2002-03-14 Nyce Jonathan W. Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US5660835A (en) * 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US5980882A (en) * 1997-04-16 1999-11-09 Medeva Pharmaceuticals Manufacturing Drug-resin complexes stabilized by chelating agents
AU2002303427A1 (en) * 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
AU2002303425A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
US7405207B2 (en) * 2002-06-17 2008-07-29 Epigenesis Pharmaceuticals, Inc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
EP1553954A4 (de) * 2002-06-17 2009-12-23 Epigenesis Pharmaceuticals Llc Dihydrat-dehydroepiandrosteron und verfahren zur behandlung von asthma oder chronisch obstruktiver lungenerkrankung mit zusammensetzungen daraus
US20050043282A1 (en) * 2003-07-31 2005-02-24 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) * 2003-07-31 2009-10-22 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) * 2003-07-31 2005-05-26 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20090274676A1 (en) * 2003-07-31 2009-11-05 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050085430A1 (en) * 2003-07-31 2005-04-21 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026848A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090285900A1 (en) * 2003-07-31 2009-11-19 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
DE602005026352D1 (de) * 2004-09-15 2011-03-31 Nipro Corp Wässrige, stabile (6S)-Folinsäurelösung zur Injektion
US9713616B2 (en) 2012-08-06 2017-07-25 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising L-leucovorin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
US4344940A (en) * 1981-11-30 1982-08-17 E. R. Squibb & Sons, Inc. Steroid formulation containing dipotassium EDTA
US4436738A (en) * 1982-03-15 1984-03-13 Mead Johnson & Company Stabilized estradiol cream composition

Also Published As

Publication number Publication date
NO902487L (no) 1990-12-07
JP2945718B2 (ja) 1999-09-06
ES2036396T3 (es) 1993-05-16
NO902487D0 (no) 1990-06-05
US5177076A (en) 1993-01-05
JPH0356418A (ja) 1991-03-12
ATE83660T1 (de) 1993-01-15
NO176389B (no) 1994-12-19
CA2018230C (en) 1996-04-16
EP0401895B1 (de) 1992-12-23
NO176389C (no) 1995-03-29
FI96275C (fi) 1996-06-10
AU5629790A (en) 1990-12-13
NL8901432A (nl) 1991-01-02
FI96275B (fi) 1996-02-29
DK0401895T3 (da) 1993-04-13
FI902712A0 (fi) 1990-05-31
AU626421B2 (en) 1992-07-30
EP0401895A1 (de) 1990-12-12
DE69000645D1 (de) 1993-02-04
IL92370A0 (en) 1990-07-26
CA2018230A1 (en) 1990-12-06

Similar Documents

Publication Publication Date Title
DE69000645T2 (de) Bei kuehlschranktemperatur stabile waessrige folinatloesung sowie verfahren zu deren herstellung.
ATE39928T1 (de) 4-dimethylamino-1-hydroxybutan-1,1diphosphons|ure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung.
DE69429526T2 (de) Selbsthärtende calciumphosphatzemente und verfahren zu deren herstellung und verwendung
IL107533A0 (en) N'-substituted-n, n'-diacylhydrazines their preparation and their use as insecticides
AU2644688A (en) Polyphenylene sulfide composition and method of producing the same
CA2027753A1 (en) Deodorizing and cleaning compositions and method
DE69433010D1 (de) Verfahren zur darstellung von oligonukleotiden
CA2140923A1 (en) Lowering the pH of Textile Processing Solution with an Acid/Base Salt as a pH Adjusting Agent
HUT52685A (en) Pesticide compositions containing non-volatile salts as active components and process for producing these salts
HUT59139A (en) Process for producing tricyclic compounds and antimicrobial pharmaceutical compositions comprising same
SG46464A1 (en) Biocidal composition
HU9301478D0 (en) Method for producing methylole-hydantoine derivatives with low free formaldehyde content and preparatives containing it
HUT57725A (en) 2,3-pyridinedicarboxylate derivatives and process for producing same
DE3668621D1 (de) Verfahren zur herstellung von pteridinderivaten.
EP0288254A3 (de) Polyoxymethylenzusammensetzung und Verfahren zu ihrer Herstellung
GB9220327D0 (en) Process
ES8301928A1 (es) Un procedimiento para preparar 4-(2-4-dicloro-3-metilbenzoil)-1,3-dimetil-5-fenaciloxipirazol).
DE68903177D1 (de) Plastifizierungsmittel, verfahren zu seiner herstellung sowie seine verwendung.
DK0407815T3 (da) Præparat indeholdende polyprenylforbindelser til bløde kapsler
HUT47792A (en) Herbicide compositions containing 2,6-substituted-pyridine-carboxylic acid derivatives as active components and process for producing the active components
HU9202103D0 (en) Method for producing inosite-phosphate analogues and pharmaceutical preparatives containing these compounds
FR2702678B1 (fr) Procédé de réalisation d'un composite actif.
JPS6470062A (en) Bacteriostatic deodorizing composition
HU9600300D0 (en) Thiocarbamoyl derivatives using as antimicrobial agents and process for producing of these
ZA891077B (en) Process for the preparation of 1,2-disulfone compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition