NO901989L - Fremgangsmaate for fremstilling av maleinimidderivater. - Google Patents
Fremgangsmaate for fremstilling av maleinimidderivater.Info
- Publication number
- NO901989L NO901989L NO90901989A NO901989A NO901989L NO 901989 L NO901989 L NO 901989L NO 90901989 A NO90901989 A NO 90901989A NO 901989 A NO901989 A NO 901989A NO 901989 L NO901989 L NO 901989L
- Authority
- NO
- Norway
- Prior art keywords
- preparing
- procedure
- derivatives
- maleinimide
- maleinimide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Image Processing (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3914764A DE3914764A1 (de) | 1989-05-05 | 1989-05-05 | Maleinimid-derivate und deren verwendung als arzneimittel |
DE19893942991 DE3942991A1 (de) | 1989-12-27 | 1989-12-27 | Maleinimid-derivate und deren verwendung als arzneimittel |
Publications (4)
Publication Number | Publication Date |
---|---|
NO901989D0 NO901989D0 (no) | 1990-05-04 |
NO901989L true NO901989L (no) | 1990-11-06 |
NO179748B NO179748B (no) | 1996-09-02 |
NO179748C NO179748C (no) | 1996-12-11 |
Family
ID=25880591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO901989A NO179748C (no) | 1989-05-05 | 1990-05-04 | Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-(1H-indol-3-yl)-maleinimidderivater |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0397060B1 (no) |
JP (1) | JP2983248B2 (no) |
KR (1) | KR900018080A (no) |
AT (1) | ATE209202T1 (no) |
AU (1) | AU634541B2 (no) |
CA (1) | CA2015996C (no) |
DE (1) | DE59010927D1 (no) |
DK (1) | DK0397060T3 (no) |
ES (1) | ES2169719T3 (no) |
FI (1) | FI902251A0 (no) |
HU (1) | HU207727B (no) |
IL (1) | IL94274A0 (no) |
NO (1) | NO179748C (no) |
NZ (1) | NZ233560A (no) |
PT (1) | PT93947B (no) |
YU (1) | YU87990A (no) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
AU3761393A (en) * | 1992-03-20 | 1993-10-21 | Wellcome Foundation Limited, The | Indole derivatives with antiviral activity |
DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
DK0657411T3 (da) * | 1993-12-07 | 1999-11-15 | Lilly Co Eli | Forbedret syntese af bisindolylmaleimider |
PT657458E (pt) * | 1993-12-07 | 2002-02-28 | Lilly Co Eli | Inibidores de proteina cinase c |
ATE456367T1 (de) | 1993-12-23 | 2010-02-15 | Lilly Co Eli | Proteinkinase c inhibitoren |
PT760375E (pt) * | 1994-05-09 | 2004-04-30 | Banyu Pharma Co Ltd | Derivado de indolopiprolocarbazole anti-tumoral |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
PL184728B1 (pl) * | 1995-11-20 | 2002-12-31 | Lilly Co Eli | Nowe pochodne bisindolilomaleimidu z mostkiem N,N'i środek farmaceutyczny |
PE91498A1 (es) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | Pirroles sustituidos |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
CA2268399C (en) * | 1996-10-31 | 2008-08-19 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
WO1999042100A1 (fr) * | 1998-02-23 | 1999-08-26 | Sagami Chemical Research Center | Inhibiteurs de la mort cellulaire |
ATE277010T1 (de) | 1998-07-08 | 2004-10-15 | Harbor Branch Oceanographic | Bis-indolederivate und ihre verwendung als entzündungshemmende mittel |
US6589977B1 (en) | 1999-02-09 | 2003-07-08 | Sagami Chemical Research Center | Pyrrole derivatives and cell death inhibitors |
US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
DE10109280A1 (de) * | 2001-02-26 | 2002-09-05 | Peter Mayser | Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen |
TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
CN1582150B (zh) * | 2001-10-30 | 2011-09-07 | 诺瓦提斯公司 | 作为flt3受体酪氨酸激酶活性抑制剂的星形孢菌素衍生物 |
CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
CA2522712A1 (en) * | 2003-04-18 | 2004-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Nerve regenerating drug |
EP2289892B1 (en) | 2005-02-09 | 2012-08-22 | ArQule, Inc. | Maleimide derivatives, pharmaceutical compositions amd methods for treatment of cancer |
AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
US8513292B2 (en) | 2007-06-22 | 2013-08-20 | Arqule, Inc. | Compositions and methods for the treatment of cancer |
JP5425060B2 (ja) | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
WO2010144780A1 (en) * | 2009-06-12 | 2010-12-16 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
JP2017524739A (ja) | 2014-07-17 | 2017-08-31 | アンセルムInserm | 神経筋接合部関連疾患の処置方法 |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
-
1990
- 1990-05-03 CA CA002015996A patent/CA2015996C/en not_active Expired - Fee Related
- 1990-05-03 IL IL9094274A patent/IL94274A0/xx unknown
- 1990-05-03 PT PT93947A patent/PT93947B/pt active IP Right Grant
- 1990-05-04 KR KR1019900006359A patent/KR900018080A/ko not_active Application Discontinuation
- 1990-05-04 NO NO901989A patent/NO179748C/no unknown
- 1990-05-04 EP EP90108468A patent/EP0397060B1/de not_active Expired - Lifetime
- 1990-05-04 YU YU87990A patent/YU87990A/sh unknown
- 1990-05-04 DK DK90108468T patent/DK0397060T3/da active
- 1990-05-04 FI FI902251A patent/FI902251A0/fi not_active Application Discontinuation
- 1990-05-04 HU HU902681A patent/HU207727B/hu not_active IP Right Cessation
- 1990-05-04 ES ES90108468T patent/ES2169719T3/es not_active Expired - Lifetime
- 1990-05-04 AU AU54666/90A patent/AU634541B2/en not_active Ceased
- 1990-05-04 NZ NZ233560A patent/NZ233560A/xx unknown
- 1990-05-04 DE DE59010927T patent/DE59010927D1/de not_active Expired - Fee Related
- 1990-05-04 AT AT90108468T patent/ATE209202T1/de not_active IP Right Cessation
- 1990-05-07 JP JP2115916A patent/JP2983248B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE59010927D1 (de) | 2002-01-03 |
AU5466690A (en) | 1990-11-08 |
AU634541B2 (en) | 1993-02-25 |
HU902681D0 (en) | 1990-09-28 |
PT93947B (pt) | 1996-11-29 |
EP0397060A3 (de) | 1992-01-02 |
NO179748B (no) | 1996-09-02 |
HU207727B (en) | 1993-05-28 |
EP0397060B1 (de) | 2001-11-21 |
NO901989D0 (no) | 1990-05-04 |
NZ233560A (en) | 1992-01-29 |
DK0397060T3 (da) | 2002-05-21 |
ATE209202T1 (de) | 2001-12-15 |
YU87990A (sh) | 1992-07-20 |
HUT53902A (en) | 1990-12-28 |
CA2015996A1 (en) | 1990-11-05 |
FI902251A0 (fi) | 1990-05-04 |
KR900018080A (ko) | 1990-12-20 |
JPH02306974A (ja) | 1990-12-20 |
CA2015996C (en) | 2001-08-28 |
JP2983248B2 (ja) | 1999-11-29 |
ES2169719T3 (es) | 2002-07-16 |
IL94274A0 (en) | 1991-03-10 |
NO179748C (no) | 1996-12-11 |
PT93947A (pt) | 1991-01-08 |
EP0397060A2 (de) | 1990-11-14 |
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