NO901989L - PROCEDURE FOR PREPARING MALEINIMIDE DERIVATIVES. - Google Patents
PROCEDURE FOR PREPARING MALEINIMIDE DERIVATIVES.Info
- Publication number
- NO901989L NO901989L NO90901989A NO901989A NO901989L NO 901989 L NO901989 L NO 901989L NO 90901989 A NO90901989 A NO 90901989A NO 901989 A NO901989 A NO 901989A NO 901989 L NO901989 L NO 901989L
- Authority
- NO
- Norway
- Prior art keywords
- preparing
- procedure
- derivatives
- maleinimide
- maleinimide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
- Image Processing (AREA)
Abstract
The invention relates to novel bis(1H-indol-3-yl)maleimide derivatives, a process for their preparation, pharmaceuticals containing these compounds and their use for the treatment of cardiac and vascular diseases such as thromboses, arteriosclerosis, hypertension, inflammatory processes, allergies, cancer and certain types of degenerative damage of the central nervous system and also disorders of the immune system and viral diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3914764A DE3914764A1 (en) | 1989-05-05 | 1989-05-05 | New bis(1H-indol-3-yl) maleinimide derivs. - are inhibitors of protein kinase C for treatment of cardiovascular, CNS and immune system disorders |
DE19893942991 DE3942991A1 (en) | 1989-12-27 | 1989-12-27 | New 2,3-bis:indolyl-maleimide derivs. |
Publications (4)
Publication Number | Publication Date |
---|---|
NO901989D0 NO901989D0 (en) | 1990-05-04 |
NO901989L true NO901989L (en) | 1990-11-06 |
NO179748B NO179748B (en) | 1996-09-02 |
NO179748C NO179748C (en) | 1996-12-11 |
Family
ID=25880591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO901989A NO179748C (en) | 1989-05-05 | 1990-05-04 | Analogous Process for Preparation of Therapeutically Active Bis- (1H-Indol-3-yl) -maleinimide Derivatives |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0397060B1 (en) |
JP (1) | JP2983248B2 (en) |
KR (1) | KR900018080A (en) |
AT (1) | ATE209202T1 (en) |
AU (1) | AU634541B2 (en) |
CA (1) | CA2015996C (en) |
DE (1) | DE59010927D1 (en) |
DK (1) | DK0397060T3 (en) |
ES (1) | ES2169719T3 (en) |
FI (1) | FI902251A0 (en) |
HU (1) | HU207727B (en) |
IL (1) | IL94274A0 (en) |
NO (1) | NO179748C (en) |
NZ (1) | NZ233560A (en) |
PT (1) | PT93947B (en) |
YU (1) | YU87990A (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
DE4005970A1 (en) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | NEW TRISUBSTITUTED MALEINIMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
EP0630241A1 (en) * | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
DE4243321A1 (en) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Amino acid derivatives of heterocycles as PKC inhibitors |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
ES2134910T3 (en) * | 1993-12-07 | 1999-10-16 | Lilly Co Eli | SYNTHESIS OF BISINDOLILMALEIMIDAS. |
HU219709B (en) * | 1993-12-07 | 2001-06-28 | Eli Lilly And Co. | Condensed indole derivatives of protein kinase c inhibitor activity, process for preparing them and pharmaceutical compositions containing them |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
PT817627E (en) | 1993-12-23 | 2005-07-29 | Lilly Co Eli | PROTEIN INHIBITORS CINASE C |
ES2230433T3 (en) * | 1994-05-09 | 2005-05-01 | Banyu Pharmaceutical Co., Ltd. | PROCEDURES FOR THE PREPARATION OF INDOLOPIRROLOCARBAZOL DERIVATIVES. |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
EA000639B1 (en) * | 1995-11-20 | 1999-12-29 | Эли Лилли Энд Компани | Novel intermediates and their use to prepare n,n'-bridged bisindolymaleimides |
PE91698A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
PE91498A1 (en) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
PE91598A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
SE9603283D0 (en) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
ATE258050T1 (en) * | 1996-10-31 | 2004-02-15 | Harbor Branch Oceanographic | USE OF NEUROGENIC ANTI-INFLAMMATORY COMPOUNDS AND COMPOSITIONS |
EP1057484A4 (en) * | 1998-02-23 | 2002-11-20 | Sagami Chem Res | Cell death inhibitors |
CA2335254A1 (en) | 1998-07-08 | 2000-01-20 | Harbor Branch Oceanographic Institution, Inc. | Bis-indole derivatives and their use as antiinflammatory agents |
US6589977B1 (en) | 1999-02-09 | 2003-07-08 | Sagami Chemical Research Center | Pyrrole derivatives and cell death inhibitors |
US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
DE10109280A1 (en) * | 2001-02-26 | 2002-09-05 | Peter Mayser | Indole derivatives with inhibitory effects on protein kinases |
TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
CN1582150B (en) * | 2001-10-30 | 2011-09-07 | 诺瓦提斯公司 | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity |
CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
EP1645286A1 (en) * | 2003-04-18 | 2006-04-12 | Kyowa Hakko Kogyo Co., Ltd. | Drug for nerve regeneration |
EP1846406B9 (en) | 2005-02-09 | 2012-01-11 | ArQule, Inc. | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
CN101801969B (en) | 2007-06-22 | 2014-10-29 | 艾科尔公司 | Indolyl pyrrolidines for the treatment of cancer |
EP2170870B1 (en) | 2007-06-22 | 2014-03-05 | ArQule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
JP2010530885A (en) | 2007-06-22 | 2010-09-16 | アークル インコーポレイテッド | Quinazolinone compounds and methods of use thereof |
WO2010144780A1 (en) * | 2009-06-12 | 2010-12-16 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
JP2017524739A (en) | 2014-07-17 | 2017-08-31 | アンセルムInserm | Method for treating neuromuscular junction related diseases |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
-
1990
- 1990-05-03 IL IL9094274A patent/IL94274A0/en unknown
- 1990-05-03 PT PT93947A patent/PT93947B/en active IP Right Grant
- 1990-05-03 CA CA002015996A patent/CA2015996C/en not_active Expired - Fee Related
- 1990-05-04 YU YU87990A patent/YU87990A/en unknown
- 1990-05-04 DE DE59010927T patent/DE59010927D1/en not_active Expired - Fee Related
- 1990-05-04 NZ NZ233560A patent/NZ233560A/en unknown
- 1990-05-04 AU AU54666/90A patent/AU634541B2/en not_active Ceased
- 1990-05-04 EP EP90108468A patent/EP0397060B1/en not_active Expired - Lifetime
- 1990-05-04 HU HU902681A patent/HU207727B/en not_active IP Right Cessation
- 1990-05-04 NO NO901989A patent/NO179748C/en unknown
- 1990-05-04 FI FI902251A patent/FI902251A0/en not_active Application Discontinuation
- 1990-05-04 DK DK90108468T patent/DK0397060T3/en active
- 1990-05-04 AT AT90108468T patent/ATE209202T1/en not_active IP Right Cessation
- 1990-05-04 ES ES90108468T patent/ES2169719T3/en not_active Expired - Lifetime
- 1990-05-04 KR KR1019900006359A patent/KR900018080A/en not_active Application Discontinuation
- 1990-05-07 JP JP2115916A patent/JP2983248B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2983248B2 (en) | 1999-11-29 |
DK0397060T3 (en) | 2002-05-21 |
DE59010927D1 (en) | 2002-01-03 |
EP0397060A3 (en) | 1992-01-02 |
AU634541B2 (en) | 1993-02-25 |
ATE209202T1 (en) | 2001-12-15 |
AU5466690A (en) | 1990-11-08 |
HUT53902A (en) | 1990-12-28 |
JPH02306974A (en) | 1990-12-20 |
FI902251A0 (en) | 1990-05-04 |
PT93947A (en) | 1991-01-08 |
HU902681D0 (en) | 1990-09-28 |
NO901989D0 (en) | 1990-05-04 |
YU87990A (en) | 1992-07-20 |
ES2169719T3 (en) | 2002-07-16 |
NO179748C (en) | 1996-12-11 |
CA2015996C (en) | 2001-08-28 |
NZ233560A (en) | 1992-01-29 |
CA2015996A1 (en) | 1990-11-05 |
EP0397060B1 (en) | 2001-11-21 |
HU207727B (en) | 1993-05-28 |
IL94274A0 (en) | 1991-03-10 |
EP0397060A2 (en) | 1990-11-14 |
KR900018080A (en) | 1990-12-20 |
NO179748B (en) | 1996-09-02 |
PT93947B (en) | 1996-11-29 |
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