FI902251A0 - MALEINIMIDDERIVAT OCH DERAS ANVAENDNING SOM CEILING MODEL. - Google Patents

MALEINIMIDDERIVAT OCH DERAS ANVAENDNING SOM CEILING MODEL.

Info

Publication number
FI902251A0
FI902251A0 FI902251A FI902251A FI902251A0 FI 902251 A0 FI902251 A0 FI 902251A0 FI 902251 A FI902251 A FI 902251A FI 902251 A FI902251 A FI 902251A FI 902251 A0 FI902251 A0 FI 902251A0
Authority
FI
Finland
Prior art keywords
maleinimidderivat
och deras
ceiling model
deras anvaendning
anvaendning som
Prior art date
Application number
FI902251A
Other languages
Finnish (fi)
Inventor
Hubert Barth
Johannes Hartenstein
Claus Rudolph
Christoph Schaechtele
Hans-Juergen Betche
Hartmut Osswald
Reinhard Reck
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3914764A external-priority patent/DE3914764A1/en
Priority claimed from DE19893942991 external-priority patent/DE3942991A1/en
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of FI902251A0 publication Critical patent/FI902251A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

The invention relates to novel bis(1H-indol-3-yl)maleimide derivatives, a process for their preparation, pharmaceuticals containing these compounds and their use for the treatment of cardiac and vascular diseases such as thromboses, arteriosclerosis, hypertension, inflammatory processes, allergies, cancer and certain types of degenerative damage of the central nervous system and also disorders of the immune system and viral diseases.
FI902251A 1989-05-05 1990-05-04 MALEINIMIDDERIVAT OCH DERAS ANVAENDNING SOM CEILING MODEL. FI902251A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3914764A DE3914764A1 (en) 1989-05-05 1989-05-05 New bis(1H-indol-3-yl) maleinimide derivs. - are inhibitors of protein kinase C for treatment of cardiovascular, CNS and immune system disorders
DE19893942991 DE3942991A1 (en) 1989-12-27 1989-12-27 New 2,3-bis:indolyl-maleimide derivs.

Publications (1)

Publication Number Publication Date
FI902251A0 true FI902251A0 (en) 1990-05-04

Family

ID=25880591

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902251A FI902251A0 (en) 1989-05-05 1990-05-04 MALEINIMIDDERIVAT OCH DERAS ANVAENDNING SOM CEILING MODEL.

Country Status (16)

Country Link
EP (1) EP0397060B1 (en)
JP (1) JP2983248B2 (en)
KR (1) KR900018080A (en)
AT (1) ATE209202T1 (en)
AU (1) AU634541B2 (en)
CA (1) CA2015996C (en)
DE (1) DE59010927D1 (en)
DK (1) DK0397060T3 (en)
ES (1) ES2169719T3 (en)
FI (1) FI902251A0 (en)
HU (1) HU207727B (en)
IL (1) IL94274A0 (en)
NO (1) NO179748C (en)
NZ (1) NZ233560A (en)
PT (1) PT93947B (en)
YU (1) YU87990A (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278989B6 (en) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituted pyrroles, their use for producing a drug, and the drug on their base
DE4005970A1 (en) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh NEW TRISUBSTITUTED MALEINIMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
JPH07504673A (en) * 1992-03-20 1995-05-25 ザ・ウエルカム・ファウンデーション・リミテッド Indole derivatives with antiviral activity
DE4243321A1 (en) * 1992-12-21 1994-06-23 Goedecke Ag Amino acid derivatives of heterocycles as PKC inhibitors
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
EP0657411B1 (en) * 1993-12-07 1999-06-09 Eli Lilly And Company Synthesis of bisindolylmaleimides
FI108138B (en) * 1993-12-07 2001-11-30 Lilly Co Eli Process for the preparation of therapeutically useful 3,4 [(N, N'-1,1 ') - substituted alkylene) bis (3,3'-indolyl)] 1H-pyrrole-2,5-dione derivatives
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
DE69434294T2 (en) * 1993-12-23 2005-12-29 Eli Lilly And Co., Indianapolis Protein kinase C inhibitors
DE69533833T2 (en) * 1994-05-09 2005-12-15 Banyu Pharmaceutical Co., Ltd. Process for the preparation of indolopyrrolocarbazole derivatives
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
NZ323282A (en) * 1995-11-20 1999-01-28 Lilly Co Eli N,n'-bridged bisindolylmaleimides and their use to prepare n,n'-bridged bisindolylmaleimides
PE91698A1 (en) * 1996-07-29 1998-12-24 Hoffmann La Roche SUBSTITUTED PYRROLES
PE91498A1 (en) * 1996-07-29 1998-12-22 Hoffmann La Roche SUBSTITUTED PYRROLES
PE91598A1 (en) * 1996-07-29 1998-12-24 Hoffmann La Roche SUBSTITUTED PYRROLES
SE9603283D0 (en) * 1996-09-10 1996-09-10 Astra Ab New compounds
WO1998018466A2 (en) * 1996-10-31 1998-05-07 Harbor Branch Oceanographic Institution, Inc. Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
AU2548699A (en) * 1998-02-23 1999-09-06 Rei Asakai Cell death inhibitors
JP2002520315A (en) 1998-07-08 2002-07-09 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． Bisindole derivatives and their use as anti-inflammatory agents
EP1152002A4 (en) 1999-02-09 2002-04-17 Sagami Chem Res Pyrrole derivatives and cell death inhibitors
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
DE10109280A1 (en) * 2001-02-26 2002-09-05 Peter Mayser Indole derivatives with inhibitory effects on protein kinases
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
NZ532136A (en) 2001-10-30 2006-08-31 Novartis Ag Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
WO2004091663A1 (en) * 2003-04-18 2004-10-28 Kyowa Hakko Kogyo Co., Ltd. Drug for nerve regeneration
JP4171061B2 (en) 2005-02-09 2008-10-22 アーキュール，インコーポレーテッド Maleimide derivatives, pharmaceutical compositions and their use for the treatment of cancer
WO2009002807A2 (en) 2007-06-22 2008-12-31 Arqule, Inc. Indolyl pyrrolidines for the treatment of cancer
KR20100024494A (en) 2007-06-22 2010-03-05 아르퀼 인코포레이티드 Quinazolinone compounds and methods of use thereof
EP2170870B1 (en) 2007-06-22 2014-03-05 ArQule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
US8193235B2 (en) * 2009-06-12 2012-06-05 University Of Kansas Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
US20170209488A1 (en) 2014-07-17 2017-07-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
SK278989B6 (en) * 1988-02-10 1998-05-06 F. Hoffmann-La Roche Ag Substituted pyrroles, their use for producing a drug, and the drug on their base

Also Published As

Publication number Publication date
JPH02306974A (en) 1990-12-20
DE59010927D1 (en) 2002-01-03
CA2015996C (en) 2001-08-28
PT93947A (en) 1991-01-08
ATE209202T1 (en) 2001-12-15
HUT53902A (en) 1990-12-28
ES2169719T3 (en) 2002-07-16
DK0397060T3 (en) 2002-05-21
NO179748C (en) 1996-12-11
HU207727B (en) 1993-05-28
EP0397060A2 (en) 1990-11-14
NZ233560A (en) 1992-01-29
KR900018080A (en) 1990-12-20
EP0397060B1 (en) 2001-11-21
CA2015996A1 (en) 1990-11-05
NO179748B (en) 1996-09-02
HU902681D0 (en) 1990-09-28
EP0397060A3 (en) 1992-01-02
JP2983248B2 (en) 1999-11-29
NO901989L (en) 1990-11-06
NO901989D0 (en) 1990-05-04
PT93947B (en) 1996-11-29
AU634541B2 (en) 1993-02-25
YU87990A (en) 1992-07-20
AU5466690A (en) 1990-11-08
IL94274A0 (en) 1991-03-10

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Owner name: GOEDECKE AKTIENGESELLSCHAFT