AU5466690A - Maleinimide-derivatives and their use as pharmaceuticals - Google Patents
Maleinimide-derivatives and their use as pharmaceuticalsInfo
- Publication number
- AU5466690A AU5466690A AU54666/90A AU5466690A AU5466690A AU 5466690 A AU5466690 A AU 5466690A AU 54666/90 A AU54666/90 A AU 54666/90A AU 5466690 A AU5466690 A AU 5466690A AU 5466690 A AU5466690 A AU 5466690A
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceuticals
- derivatives
- maleinimide
- thromboses
- indol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Aerodynamic Tests, Hydrodynamic Tests, Wind Tunnels, And Water Tanks (AREA)
- Image Processing (AREA)
Abstract
The invention relates to novel bis(1H-indol-3-yl)maleimide derivatives, a process for their preparation, pharmaceuticals containing these compounds and their use for the treatment of cardiac and vascular diseases such as thromboses, arteriosclerosis, hypertension, inflammatory processes, allergies, cancer and certain types of degenerative damage of the central nervous system and also disorders of the immune system and viral diseases.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3914764A DE3914764A1 (en) | 1989-05-05 | 1989-05-05 | New bis(1H-indol-3-yl) maleinimide derivs. - are inhibitors of protein kinase C for treatment of cardiovascular, CNS and immune system disorders |
DE3914764 | 1989-05-05 | ||
DE19893942991 DE3942991A1 (en) | 1989-12-27 | 1989-12-27 | New 2,3-bis:indolyl-maleimide derivs. |
DE3942991 | 1989-12-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5466690A true AU5466690A (en) | 1990-11-08 |
AU634541B2 AU634541B2 (en) | 1993-02-25 |
Family
ID=25880591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU54666/90A Ceased AU634541B2 (en) | 1989-05-05 | 1990-05-04 | Maleinimide-derivatives and their use as pharmaceuticals |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0397060B1 (en) |
JP (1) | JP2983248B2 (en) |
KR (1) | KR900018080A (en) |
AT (1) | ATE209202T1 (en) |
AU (1) | AU634541B2 (en) |
CA (1) | CA2015996C (en) |
DE (1) | DE59010927D1 (en) |
DK (1) | DK0397060T3 (en) |
ES (1) | ES2169719T3 (en) |
FI (1) | FI902251A0 (en) |
HU (1) | HU207727B (en) |
IL (1) | IL94274A0 (en) |
NO (1) | NO179748C (en) |
NZ (1) | NZ233560A (en) |
PT (1) | PT93947B (en) |
YU (1) | YU87990A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU623630B2 (en) * | 1988-02-10 | 1992-05-21 | F. Hoffmann-La Roche Ag | 3 (3-indoyl) pyrrole-2,5-dione derivatives |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4005970A1 (en) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | NEW TRISUBSTITUTED MALEINIMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
EP0630241A1 (en) * | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indole derivatives with antiviral activity |
DE4243321A1 (en) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Amino acid derivatives of heterocycles as PKC inhibitors |
US5405864A (en) * | 1993-10-15 | 1995-04-11 | Syntex (U.S.A.) Inc. | Chemotherapeutic maleimides |
BR9404831A (en) * | 1993-12-07 | 1995-08-08 | Lilly Co Eli | Compound, pharmaceutical formulation and process for preparing a compound |
US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
DK0657411T3 (en) * | 1993-12-07 | 1999-11-15 | Lilly Co Eli | Improved synthesis of bisindolylmaleimides |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
AU1339895A (en) | 1993-12-23 | 1995-07-10 | Eli Lilly And Company | Protein kinase c inhibitors |
ATE283863T1 (en) * | 1994-05-09 | 2004-12-15 | Banyu Pharma Co Ltd | METHOD FOR PRODUCING INDOLOPYRROLOCARBAZOLE DERIVATIVES |
US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
ES2145978T3 (en) * | 1995-11-20 | 2000-07-16 | Lilly Co Eli | INTERMEDIATES AND THEIR USE TO PREPARE BISINDOLYL MALEIMIDES WITH A BRIDGE N, N '. |
PE91498A1 (en) * | 1996-07-29 | 1998-12-22 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
PE91698A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
PE91598A1 (en) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | SUBSTITUTED PYRROLES |
SE9603283D0 (en) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
WO1998018466A2 (en) * | 1996-10-31 | 1998-05-07 | Harbor Branch Oceanographic Institution, Inc. | Anti-neurogenic inflammatory compounds and compositions and methods of use thereof |
EP1057484A4 (en) * | 1998-02-23 | 2002-11-20 | Sagami Chem Res | Cell death inhibitors |
DE69920455T2 (en) | 1998-07-08 | 2005-01-20 | Harbor Branch Oceanographic Institution Inc., Fort Pierce | BIS-INDOLEDERIVATE AND ITS USE AS AN INFLAMMATORY AGENT |
WO2000047575A1 (en) * | 1999-02-09 | 2000-08-17 | Sagami Chemical Research Center | Pyrrole derivatives and cell death inhibitors |
US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
DE10109280A1 (en) * | 2001-02-26 | 2002-09-05 | Peter Mayser | Indole derivatives with inhibitory effects on protein kinases |
TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
IL161156A0 (en) | 2001-10-30 | 2004-08-31 | Novartis Ag | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
JPWO2004091663A1 (en) * | 2003-04-18 | 2006-07-06 | 協和醗酵工業株式会社 | Nerve regeneration drug |
SI1846406T1 (en) | 2005-02-09 | 2011-02-28 | Arqule Inc | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
WO2009002806A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
WO2009002807A2 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
MX2009013815A (en) | 2007-06-22 | 2010-03-01 | Arqule Inc | Quinazolinone compounds and methods of use thereof. |
US8193235B2 (en) * | 2009-06-12 | 2012-06-05 | University Of Kansas | Compositions and methods for establishing and maintaining stem cells in an undifferentiated state |
EP3741375A1 (en) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
CZ280738B6 (en) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituted pyrroles, their use for preparing medicaments and medicaments based thereon |
-
1990
- 1990-05-03 CA CA002015996A patent/CA2015996C/en not_active Expired - Fee Related
- 1990-05-03 PT PT93947A patent/PT93947B/en active IP Right Grant
- 1990-05-03 IL IL9094274A patent/IL94274A0/en unknown
- 1990-05-04 ES ES90108468T patent/ES2169719T3/en not_active Expired - Lifetime
- 1990-05-04 AU AU54666/90A patent/AU634541B2/en not_active Ceased
- 1990-05-04 FI FI902251A patent/FI902251A0/en not_active Application Discontinuation
- 1990-05-04 DK DK90108468T patent/DK0397060T3/en active
- 1990-05-04 NO NO901989A patent/NO179748C/en unknown
- 1990-05-04 AT AT90108468T patent/ATE209202T1/en not_active IP Right Cessation
- 1990-05-04 EP EP90108468A patent/EP0397060B1/en not_active Expired - Lifetime
- 1990-05-04 KR KR1019900006359A patent/KR900018080A/en not_active Application Discontinuation
- 1990-05-04 DE DE59010927T patent/DE59010927D1/en not_active Expired - Fee Related
- 1990-05-04 YU YU87990A patent/YU87990A/en unknown
- 1990-05-04 HU HU902681A patent/HU207727B/en not_active IP Right Cessation
- 1990-05-04 NZ NZ233560A patent/NZ233560A/en unknown
- 1990-05-07 JP JP2115916A patent/JP2983248B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU623630B2 (en) * | 1988-02-10 | 1992-05-21 | F. Hoffmann-La Roche Ag | 3 (3-indoyl) pyrrole-2,5-dione derivatives |
Also Published As
Publication number | Publication date |
---|---|
HU902681D0 (en) | 1990-09-28 |
CA2015996A1 (en) | 1990-11-05 |
KR900018080A (en) | 1990-12-20 |
NO901989D0 (en) | 1990-05-04 |
NO179748C (en) | 1996-12-11 |
CA2015996C (en) | 2001-08-28 |
FI902251A0 (en) | 1990-05-04 |
EP0397060A3 (en) | 1992-01-02 |
EP0397060A2 (en) | 1990-11-14 |
EP0397060B1 (en) | 2001-11-21 |
PT93947A (en) | 1991-01-08 |
DK0397060T3 (en) | 2002-05-21 |
ES2169719T3 (en) | 2002-07-16 |
YU87990A (en) | 1992-07-20 |
NO179748B (en) | 1996-09-02 |
HU207727B (en) | 1993-05-28 |
ATE209202T1 (en) | 2001-12-15 |
PT93947B (en) | 1996-11-29 |
IL94274A0 (en) | 1991-03-10 |
JPH02306974A (en) | 1990-12-20 |
NZ233560A (en) | 1992-01-29 |
HUT53902A (en) | 1990-12-28 |
DE59010927D1 (en) | 2002-01-03 |
NO901989L (en) | 1990-11-06 |
AU634541B2 (en) | 1993-02-25 |
JP2983248B2 (en) | 1999-11-29 |
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