NO883072L - Fremgangsmaate til fremstilling av 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-hept-6-ensyrer, 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-heptansyrer, samt deres mellomprodukter. - Google Patents
Fremgangsmaate til fremstilling av 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-hept-6-ensyrer, 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-heptansyrer, samt deres mellomprodukter.Info
- Publication number
- NO883072L NO883072L NO88883072A NO883072A NO883072L NO 883072 L NO883072 L NO 883072L NO 88883072 A NO88883072 A NO 88883072A NO 883072 A NO883072 A NO 883072A NO 883072 L NO883072 L NO 883072L
- Authority
- NO
- Norway
- Prior art keywords
- pyrrol
- substituted
- dihydroxy
- encydrices
- heptans
- Prior art date
Links
- -1 1H-PYRROL-3-YL Chemical group 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title 1
- 125000000422 delta-lactone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873722806 DE3722806A1 (de) | 1987-07-10 | 1987-07-10 | 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-hept-6-ensaeuren, 7-(1h-pyrrol-3-yl)-substituierte 3,5-dihydroxy-heptansaeuren, ihre entsprechenden (delta)-lactone und salze, verfahren zu ihrer herstellung ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO883072D0 NO883072D0 (no) | 1988-07-08 |
| NO883072L true NO883072L (no) | 1989-01-11 |
Family
ID=6331291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO88883072A NO883072L (no) | 1987-07-10 | 1988-07-08 | Fremgangsmaate til fremstilling av 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-hept-6-ensyrer, 7-(1h-pyrrol-3-yl)-substituerte 3,5-dihydroksy-heptansyrer, samt deres mellomprodukter. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5055484A (da) |
| EP (1) | EP0300249B1 (da) |
| JP (1) | JPS6434959A (da) |
| KR (1) | KR890002135A (da) |
| AT (1) | ATE85324T1 (da) |
| AU (1) | AU1888088A (da) |
| DE (2) | DE3722806A1 (da) |
| DK (1) | DK384288A (da) |
| ES (1) | ES2043736T3 (da) |
| FI (1) | FI883247A (da) |
| GR (1) | GR3007611T3 (da) |
| HU (1) | HU208672B (da) |
| IE (1) | IE63205B1 (da) |
| IL (1) | IL87036A0 (da) |
| NO (1) | NO883072L (da) |
| NZ (1) | NZ225342A (da) |
| PH (1) | PH26375A (da) |
| PT (1) | PT87927B (da) |
| ZA (1) | ZA884918B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3826814A1 (de) * | 1988-08-06 | 1990-02-08 | Hoechst Ag | Neue 6-fluor-3,5-dihydroxycarbonsaeuren und deren derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| IT1237793B (it) * | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5128366A (en) * | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
| DE4243279A1 (de) * | 1992-12-21 | 1994-06-23 | Bayer Ag | Substituierte Triole |
| US7250444B2 (en) * | 2003-08-11 | 2007-07-31 | Pfizer Inc. | Pyrrole-based HMG-CoA reductase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928380A (en) * | 1973-03-29 | 1975-12-23 | Sterling Drug Inc | 1,1{40 -Spirobis(cyclopenta-{8 4,5-c{9 pyrroles) |
| US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
| US4851427A (en) * | 1985-10-25 | 1989-07-25 | Sandoz Pharm. Corp. | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use |
| KR900001212B1 (ko) * | 1985-10-25 | 1990-02-28 | 산도즈 파마슈티칼스 코오포레이숀 | 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도 |
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| NO881411L (no) * | 1987-04-14 | 1988-10-17 | Bayer Ag | Substituerte pyrroler. |
-
1987
- 1987-07-10 DE DE19873722806 patent/DE3722806A1/de not_active Withdrawn
-
1988
- 1988-07-01 ES ES88110533T patent/ES2043736T3/es not_active Expired - Lifetime
- 1988-07-01 DE DE8888110533T patent/DE3878067D1/de not_active Expired - Fee Related
- 1988-07-01 EP EP88110533A patent/EP0300249B1/de not_active Expired - Lifetime
- 1988-07-01 AT AT88110533T patent/ATE85324T1/de not_active IP Right Cessation
- 1988-07-07 FI FI883247A patent/FI883247A/fi not_active Application Discontinuation
- 1988-07-07 PT PT87927A patent/PT87927B/pt not_active IP Right Cessation
- 1988-07-08 IL IL87036A patent/IL87036A0/xx unknown
- 1988-07-08 AU AU18880/88A patent/AU1888088A/en not_active Abandoned
- 1988-07-08 NO NO88883072A patent/NO883072L/no unknown
- 1988-07-08 HU HU883600A patent/HU208672B/hu not_active IP Right Cessation
- 1988-07-08 JP JP63169159A patent/JPS6434959A/ja active Pending
- 1988-07-08 PH PH37199A patent/PH26375A/en unknown
- 1988-07-08 ZA ZA884918A patent/ZA884918B/xx unknown
- 1988-07-08 US US07/216,423 patent/US5055484A/en not_active Expired - Fee Related
- 1988-07-08 NZ NZ225342A patent/NZ225342A/en unknown
- 1988-07-08 DK DK384288A patent/DK384288A/da not_active Application Discontinuation
- 1988-07-08 IE IE209788A patent/IE63205B1/en not_active IP Right Cessation
- 1988-07-09 KR KR1019880008546A patent/KR890002135A/ko not_active Application Discontinuation
-
1993
- 1993-04-09 GR GR930400426T patent/GR3007611T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5055484A (en) | 1991-10-08 |
| ES2043736T3 (es) | 1994-01-01 |
| PT87927B (pt) | 1995-03-01 |
| DE3878067D1 (de) | 1993-03-18 |
| FI883247A0 (fi) | 1988-07-07 |
| EP0300249B1 (de) | 1993-02-03 |
| DK384288A (da) | 1989-01-11 |
| AU1888088A (en) | 1989-01-12 |
| EP0300249A1 (de) | 1989-01-25 |
| HU208672B (en) | 1993-12-28 |
| IE882097L (en) | 1989-01-10 |
| JPS6434959A (en) | 1989-02-06 |
| ATE85324T1 (de) | 1993-02-15 |
| NO883072D0 (no) | 1988-07-08 |
| IE63205B1 (en) | 1995-04-05 |
| KR890002135A (ko) | 1989-04-08 |
| PH26375A (en) | 1992-06-01 |
| IL87036A0 (en) | 1988-12-30 |
| ZA884918B (en) | 1989-01-18 |
| FI883247A (fi) | 1989-01-11 |
| DE3722806A1 (de) | 1989-01-19 |
| DK384288D0 (da) | 1988-07-08 |
| GR3007611T3 (da) | 1993-08-31 |
| PT87927A (pt) | 1989-06-30 |
| HUT48580A (en) | 1989-06-28 |
| NZ225342A (en) | 1991-03-26 |
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