NO872812L - 4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmŸte for deres fremstilling. - Google Patents

4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmŸte for deres fremstilling.

Info

Publication number
NO872812L
NO872812L NO872812A NO872812A NO872812L NO 872812 L NO872812 L NO 872812L NO 872812 A NO872812 A NO 872812A NO 872812 A NO872812 A NO 872812A NO 872812 L NO872812 L NO 872812L
Authority
NO
Norway
Prior art keywords
compounds
substituted
isokinolinol
nitrogen
procedure
Prior art date
Application number
NO872812A
Other languages
English (en)
Norwegian (no)
Other versions
NO872812D0 (no
Inventor
Ramesh M Kanojia
Robert Falotico
Alfonso J Tobia
Jeffery B Press
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of NO872812D0 publication Critical patent/NO872812D0/no
Publication of NO872812L publication Critical patent/NO872812L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO872812A 1986-07-07 1987-07-06 4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmŸte for deres fremstilling. NO872812L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/882,655 US4714705A (en) 1986-07-07 1986-07-07 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties

Publications (2)

Publication Number Publication Date
NO872812D0 NO872812D0 (no) 1987-07-06
NO872812L true NO872812L (no) 1988-01-08

Family

ID=25381064

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872812A NO872812L (no) 1986-07-07 1987-07-06 4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmŸte for deres fremstilling.

Country Status (22)

Country Link
US (1) US4714705A (ja)
EP (1) EP0252721B1 (ja)
JP (1) JPS6322562A (ja)
KR (1) KR880001603A (ja)
CN (1) CN87105724A (ja)
AT (1) ATE67992T1 (ja)
AU (1) AU597083B2 (ja)
DE (1) DE3773438D1 (ja)
DK (1) DK348087A (ja)
ES (1) ES2040750T3 (ja)
FI (1) FI872980A (ja)
GR (1) GR3002829T3 (ja)
HK (1) HK107591A (ja)
HU (1) HU196966B (ja)
IL (1) IL83088A (ja)
MY (1) MY101961A (ja)
NO (1) NO872812L (ja)
NZ (1) NZ220967A (ja)
PH (1) PH22571A (ja)
PT (1) PT85271B (ja)
SG (1) SG95491G (ja)
ZA (1) ZA874894B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880817A (en) * 1987-06-09 1989-11-14 Ortho Pharmaceutical Corporation O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
CA2270118A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1424348A (en) * 1972-11-30 1976-02-11 Wyeth John & Brother Ltd Isoquinoline derivatives
JPS625963A (ja) * 1985-07-02 1987-01-12 Mitsui Toatsu Chem Inc イソキノリン誘導体

Also Published As

Publication number Publication date
CN87105724A (zh) 1988-03-09
ZA874894B (en) 1989-02-22
EP0252721B1 (en) 1991-10-02
IL83088A0 (en) 1987-12-31
MY101961A (en) 1992-02-29
AU597083B2 (en) 1990-05-24
GR3002829T3 (en) 1993-01-25
KR880001603A (ko) 1988-04-25
HU196966B (en) 1989-02-28
DE3773438D1 (de) 1991-11-07
EP0252721A1 (en) 1988-01-13
IL83088A (en) 1991-08-16
NO872812D0 (no) 1987-07-06
FI872980A0 (fi) 1987-07-06
ATE67992T1 (de) 1991-10-15
PH22571A (en) 1988-10-17
HK107591A (en) 1992-01-03
FI872980A (fi) 1988-01-08
NZ220967A (en) 1990-07-26
ES2040750T3 (es) 1993-11-01
AU7527387A (en) 1988-01-14
JPS6322562A (ja) 1988-01-30
PT85271B (pt) 1990-03-30
HUT44515A (en) 1988-03-28
DK348087A (da) 1988-01-08
PT85271A (en) 1987-08-01
US4714705A (en) 1987-12-22
SG95491G (en) 1991-12-13
DK348087D0 (da) 1987-07-06

Similar Documents

Publication Publication Date Title
EA200000723A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
IT1177803B (it) Procedimento per il trattamento di elementi strutturali poliglolici per uso chirurgico per modificarne le proprieta' fisiche in-vivo
ES2075845T3 (es) 3,5-di-terc-butil-4-hidroxifenil-1,3,4-tiadiazoles, oxadiazoles y 3,5-di-terc-butil-4-hidroxifenil-1,2,4-tiadiazoles, oxadiazoles y triazoles como agentes antiinflamatorios.
NO871588D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske karboksamider.
NO920395L (no) Terapeutisk aktive benzyloksyfenyl-derivater og fremgangsmaate for deres fremstilling
DK0434057T3 (da) Indocarbazol-derivater, fremgangsmåder til deres fremstilling og deres anvendelse
NO871044D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive pyrimidinderivater.
NO872812L (no) 4-nitrogensubstituerte isokinolinolforbindelser med terapeutisk aktivitet og fremgangsmŸte for deres fremstilling.
NO884175L (no) Fremgangsmaate for fremstilling av terapeutiske aktive heterocykliske derivater.
DK148288D0 (da) N-phenethylaminoalkyl-benzamid-forbindelser, deres anvendelse til fremstilling af antiarrhythmia-laegemidler og farmaceutiske praeparater indeholdende forbindelserne
NO853551L (no) Fremgangsmaate ved fremstilling av prolinderivater og lignende forbindelser med antihypertensiv aktivitet.
ATE75399T1 (de) Therapeutikum zur behandlung von magengeschwueren.
NO873727D0 (no) Fremgangsmaate for fremstilling av benzoxazoninforbindelser med terapeutisk aktivitet.
ES2053808T3 (es) Nuevos compuestos azolicos.
ATE95697T1 (de) Uricosuretische zusammensetzung.
NO164544C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydrazonderivater med morfinan-skjelett.
NO870499L (no) Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
NO870919D0 (no) L-vinsyre-o-monoestere av 3-morfolino-4-(3'-tert-butylamino-2'-hydroksypropoksy)-1,2,5-tiadiazol og fremgangsmaate for deres fremstilling.