NO853408L - Paavisning av polynukleotider. - Google Patents
Paavisning av polynukleotider.Info
- Publication number
- NO853408L NO853408L NO853408A NO853408A NO853408L NO 853408 L NO853408 L NO 853408L NO 853408 A NO853408 A NO 853408A NO 853408 A NO853408 A NO 853408A NO 853408 L NO853408 L NO 853408L
- Authority
- NO
- Norway
- Prior art keywords
- polynucleotide sequence
- interest
- polynucleotide
- mixture
- labeled
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title claims abstract description 318
- 239000002157 polynucleotide Substances 0.000 title claims abstract description 318
- 108091033319 polynucleotide Proteins 0.000 title claims abstract description 317
- 238000000034 method Methods 0.000 claims abstract description 39
- 238000001514 detection method Methods 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims description 62
- 238000009396 hybridization Methods 0.000 claims description 44
- 239000003550 marker Substances 0.000 claims description 44
- 230000000295 complement effect Effects 0.000 claims description 43
- 239000013598 vector Substances 0.000 claims description 22
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 14
- 241000700584 Simplexvirus Species 0.000 claims description 6
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 5
- 210000000349 chromosome Anatomy 0.000 claims description 2
- 241000588832 Bordetella pertussis Species 0.000 claims 1
- 241000589567 Brucella abortus Species 0.000 claims 1
- 241001136175 Burkholderia pseudomallei Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 229940056450 brucella abortus Drugs 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract description 5
- 230000002068 genetic effect Effects 0.000 abstract description 4
- 238000012252 genetic analysis Methods 0.000 abstract description 3
- 230000005856 abnormality Effects 0.000 abstract description 2
- 238000003745 diagnosis Methods 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 108020004414 DNA Proteins 0.000 description 87
- 239000000523 sample Substances 0.000 description 50
- 239000012634 fragment Substances 0.000 description 22
- 241000588650 Neisseria meningitidis Species 0.000 description 20
- 239000013612 plasmid Substances 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 239000000020 Nitrocellulose Substances 0.000 description 9
- 229920001220 nitrocellulos Polymers 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 241000606153 Chlamydia trachomatis Species 0.000 description 7
- 101150072055 PAL1 gene Proteins 0.000 description 7
- 229940038705 chlamydia trachomatis Drugs 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 6
- 206010018612 Gonorrhoea Diseases 0.000 description 6
- 230000029087 digestion Effects 0.000 description 6
- 102000053602 DNA Human genes 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 241000588653 Neisseria Species 0.000 description 5
- 241000700605 Viruses Species 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 238000013519 translation Methods 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 4
- 239000013611 chromosomal DNA Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 241000606161 Chlamydia Species 0.000 description 3
- 241000498849 Chlamydiales Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000009889 Herpes Simplex Diseases 0.000 description 3
- 239000011543 agarose gel Substances 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001502 gel electrophoresis Methods 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 229920002477 rna polymer Polymers 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 210000001541 thymus gland Anatomy 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102000004594 DNA Polymerase I Human genes 0.000 description 2
- 108010017826 DNA Polymerase I Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- 230000005574 cross-species transmission Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 102000013415 peroxidase activity proteins Human genes 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OVOJUAKDTOOXRF-UHFFFAOYSA-N 2,4-dinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O OVOJUAKDTOOXRF-UHFFFAOYSA-N 0.000 description 1
- 108010006591 Apoenzymes Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 241000726445 Viroids Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 239000012637 allosteric effector Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- SUYVUBYJARFZHO-RRKCRQDMSA-N dATP Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-RRKCRQDMSA-N 0.000 description 1
- SUYVUBYJARFZHO-UHFFFAOYSA-N dATP Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 SUYVUBYJARFZHO-UHFFFAOYSA-N 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000004033 diameter control Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- -1 nucleoside triphosphates Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/646,171 US4755458A (en) | 1984-08-30 | 1984-08-30 | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO853408L true NO853408L (no) | 1986-03-03 |
Family
ID=24592052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO853408A NO853408L (no) | 1984-08-30 | 1985-08-29 | Paavisning av polynukleotider. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4755458A (da) |
| EP (1) | EP0173339B1 (da) |
| JP (1) | JPH0634758B2 (da) |
| AT (1) | ATE71982T1 (da) |
| AU (1) | AU597874B2 (da) |
| CA (1) | CA1260368A (da) |
| DE (1) | DE3585249D1 (da) |
| DK (1) | DK391985A (da) |
| ES (1) | ES8703934A1 (da) |
| IL (1) | IL76143A (da) |
| NO (1) | NO853408L (da) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
| US5008182A (en) * | 1986-01-10 | 1991-04-16 | Cetus Corporation | Detection of AIDS associated virus by polymerase chain reaction |
| US5176995A (en) * | 1985-03-28 | 1993-01-05 | Hoffmann-La Roche Inc. | Detection of viruses by amplification and hybridization |
| US4868105A (en) * | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
| US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
| US6872817B1 (en) | 1986-01-16 | 2005-03-29 | The Regents Of The Univ. Of California | Method of staining target interphase chromosomal DNA |
| US6280929B1 (en) | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| US6475720B1 (en) | 1986-01-16 | 2002-11-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US5756696A (en) * | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| US7115709B1 (en) * | 1986-01-16 | 2006-10-03 | The Regents Of The University Of California | Methods of staining target chromosomal DNA employing high complexity nucleic acid probes |
| US6344315B1 (en) | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US4900659A (en) * | 1986-01-30 | 1990-02-13 | Enzo Biochem, Inc. | Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group |
| US5281518A (en) * | 1986-05-01 | 1994-01-25 | Washington Research Foundation | Detection of a unique chlamydia strain associated with acute respiratory disease |
| US5714380A (en) | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
| US7090972B1 (en) | 1986-11-24 | 2006-08-15 | Gen-Probe Incorporated | Methods for determining the presence of non-viral organisms in a sample |
| US7087742B1 (en) | 1986-11-24 | 2006-08-08 | Gen-Probe Incorporated | Oligonucleotide probes for the detection and/or quantitation of non-viral organisms |
| US5079351A (en) * | 1986-11-26 | 1992-01-07 | Cetus Corporation | Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization |
| US5225324A (en) * | 1987-04-24 | 1993-07-06 | Bioscience International, Inc. | Diagnostics for mycobacteria in public health, medical, and veterinary practice |
| GB8709803D0 (en) * | 1987-04-24 | 1987-05-28 | Mcfadden J J | Treatment of crohn's disease &c |
| JPH02503983A (ja) * | 1987-06-26 | 1990-11-22 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 捕捉ビーズを用いる組み換えクローン化ｎａからの混入配列のアフイニテイ除去 |
| ES2063038T3 (es) * | 1987-07-31 | 1995-01-01 | Gen Probe Inc | Analisis de polinucleotidos empleando oligonucleotidos para eliminar reacciones cruzadas indeseables. |
| US5359100A (en) * | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| CA1339351C (en) * | 1987-10-15 | 1997-08-26 | Michael S. Urdea | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5099011A (en) * | 1988-08-02 | 1992-03-24 | Ortho Diagnostic Systems Inc. | Nucleic acid probe for detection of Neisseria gonorrhoea |
| US5108895A (en) * | 1988-08-02 | 1992-04-28 | Ortho Diagnostic System Inc. | Nucleic acid probe for detection of Neisseria gonorrhoea |
| US6203977B1 (en) * | 1988-11-15 | 2001-03-20 | Yale University | Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization |
| US7172863B1 (en) | 1988-12-09 | 2007-02-06 | Gen-Probe Incorporated | Nucleic acid probes and methods for detecting Neisseria gonorrhoeae |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US6406844B1 (en) | 1989-06-07 | 2002-06-18 | Affymetrix, Inc. | Very large scale immobilized polymer synthesis |
| US6955915B2 (en) | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6919211B1 (en) | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6379895B1 (en) | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| GB2241242A (en) * | 1990-01-10 | 1991-08-28 | Univ Surrey | DNA probe for Neisseria meningitidis |
| US6506558B1 (en) | 1990-03-07 | 2003-01-14 | Affymetrix Inc. | Very large scale immobilized polymer synthesis |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4717653A (en) * | 1981-09-25 | 1988-01-05 | Webster John A Jr | Method for identifying and characterizing organisms |
| FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
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1984
- 1984-08-30 US US06/646,171 patent/US4755458A/en not_active Expired - Lifetime
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1985
- 1985-08-20 IL IL76143A patent/IL76143A/xx unknown
- 1985-08-20 AU AU46466/85A patent/AU597874B2/en not_active Ceased
- 1985-08-20 CA CA000489090A patent/CA1260368A/en not_active Expired
- 1985-08-29 NO NO853408A patent/NO853408L/no unknown
- 1985-08-29 EP EP85110910A patent/EP0173339B1/en not_active Expired - Lifetime
- 1985-08-29 ES ES546536A patent/ES8703934A1/es not_active Expired
- 1985-08-29 DE DE8585110910T patent/DE3585249D1/de not_active Expired - Lifetime
- 1985-08-29 DK DK391985A patent/DK391985A/da not_active Application Discontinuation
- 1985-08-29 JP JP60188690A patent/JPH0634758B2/ja not_active Expired - Lifetime
- 1985-08-29 AT AT85110910T patent/ATE71982T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE71982T1 (de) | 1992-02-15 |
| EP0173339A3 (en) | 1987-12-23 |
| DK391985D0 (da) | 1985-08-29 |
| ES546536A0 (es) | 1987-03-01 |
| ES8703934A1 (es) | 1987-03-01 |
| DK391985A (da) | 1986-03-01 |
| IL76143A0 (en) | 1985-12-31 |
| AU4646685A (en) | 1986-03-06 |
| EP0173339A2 (en) | 1986-03-05 |
| DE3585249D1 (de) | 1992-03-05 |
| JPS6165163A (ja) | 1986-04-03 |
| IL76143A (en) | 1990-02-09 |
| US4755458A (en) | 1988-07-05 |
| EP0173339B1 (en) | 1992-01-22 |
| CA1260368A (en) | 1989-09-26 |
| JPH0634758B2 (ja) | 1994-05-11 |
| AU597874B2 (en) | 1990-06-14 |
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