NO842759L - Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer - Google Patents

Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer

Info

Publication number
NO842759L
NO842759L NO842759A NO842759A NO842759L NO 842759 L NO842759 L NO 842759L NO 842759 A NO842759 A NO 842759A NO 842759 A NO842759 A NO 842759A NO 842759 L NO842759 L NO 842759L
Authority
NO
Norway
Prior art keywords
carbon atoms
acid
hydrogen
alkyl
formula
Prior art date
Application number
NO842759A
Other languages
English (en)
Norwegian (no)
Inventor
Alexander Krantz
Arlindo L Castelhano
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO842759L publication Critical patent/NO842759L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Silicon Polymers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
NO842759A 1983-07-07 1984-07-06 Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer NO842759L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51169183A 1983-07-07 1983-07-07

Publications (1)

Publication Number Publication Date
NO842759L true NO842759L (no) 1985-01-08

Family

ID=24036025

Family Applications (1)

Application Number Title Priority Date Filing Date
NO842759A NO842759L (no) 1983-07-07 1984-07-06 Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer

Country Status (14)

Country Link
EP (1) EP0134481B1 (ko)
JP (1) JPS6036448A (ko)
KR (1) KR850001151A (ko)
AT (1) ATE31407T1 (ko)
AU (1) AU566709B2 (ko)
CA (1) CA1252477A (ko)
DE (1) DE3468103D1 (ko)
DK (1) DK335784A (ko)
ES (2) ES8605468A1 (ko)
FI (1) FI842723A (ko)
HU (1) HU198902B (ko)
NO (1) NO842759L (ko)
NZ (1) NZ208805A (ko)
ZA (1) ZA845237B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208345A (en) * 1990-12-17 1993-05-04 Merrell Dow Pharmaceuticals Inc. Process for the production of (S)-vinyl and allenyl gaba
IL100360A (en) * 1990-12-17 1998-08-16 Merrell Dow Pharma HISTORY OF PYROLIDINONE USED AS SUBSTANCE (S) -Vinyl and Alanyl GABA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960927A (en) * 1975-03-18 1976-06-01 Richardson-Merrell Inc. Olefinic derivatives of amino acids
US4178463A (en) * 1978-01-30 1979-12-11 Merrell Toraude Et Compagnie Process for making 4-aminohex-5-enoic acid
GB2120244B (en) * 1982-05-17 1985-05-01 Merrell Toraude & Co Aminoalkadiene derivative

Also Published As

Publication number Publication date
AU3037584A (en) 1985-01-10
ES534115A0 (es) 1986-04-01
CA1252477A (en) 1989-04-11
FI842723A (fi) 1985-01-08
DK335784D0 (da) 1984-07-06
NZ208805A (en) 1989-01-27
EP0134481B1 (en) 1987-12-16
AU566709B2 (en) 1987-10-29
ZA845237B (en) 1986-02-26
ATE31407T1 (de) 1988-01-15
HU198902B (en) 1989-12-28
DK335784A (da) 1985-01-08
ES545264A0 (es) 1986-01-01
KR850001151A (ko) 1985-03-16
HUT34435A (en) 1985-03-28
FI842723A0 (fi) 1984-07-06
EP0134481A1 (en) 1985-03-20
JPS6036448A (ja) 1985-02-25
DE3468103D1 (de) 1988-01-28
ES8605468A1 (es) 1986-04-01
ES8603169A1 (es) 1986-01-01

Similar Documents

Publication Publication Date Title
US5629322A (en) Cyclic amidine analogs as inhibitors of nitric oxide synthase
KR100365057B1 (ko) 면역억제활성을갖는신규한2,2'-비-1h-피롤유도체
CA2212007C (en) Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group
SK122595A3 (en) Hiv protease inhibitors and pharmaceutical compositions containing them
FR2606018A1 (fr) Nouveaux a-aminoacides substitues, leur preparation et leur utilisation en therapeutique comme medicaments
NO147104B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive acetylenderivater av aminosyrer
US20240279197A1 (en) Nrf2 activator
NO179249B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 4,6- disubstituerte 2,3-dikarboksylsyreindolderivater
PL109390B1 (en) Method of producing new derivatives of pyrolocarboxylic-1 acid
US4113873A (en) 8-azaprostanoic acid derivatives
NO151319B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive beta-mono-fluormetyl-beta-alanin- og beta-difluormetyl-beta-alanin-forbindelser
NO842759L (no) Fremgangsmaate ved fremstilling av nye, terapeutisk virksomme gamma-allenyl-gamma-aminosmoersyrer
US4925867A (en) Hydrocarbon substituted pyrrolidinones, intermediates therefor, and anti-convulsant use thereof
EA000380B1 (ru) 4-аминотетрагидробензизоксазоловые или -изотиазоловые соединения, их применение и фармацевтическая композиция на их основе
KR100453301B1 (ko) 1-트리플루오로메틸-4-히드록시-7-피페리디닐-아미노메틸크로만 유도체
US20160326110A1 (en) Novel substituted 5 membered heterocyclic compounds and preparation thereof
US4743691A (en) 2-halomethyl derivatives of 2-amino acids
US4668703A (en) γ-allenyl-γ-aminobutyric acids
CS230562B2 (en) Production method of halogen n-/mepkaptoacyl/proline derivatives
JPS6317884A (ja) トリシクロ化合物
NO176242B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 5-substituerte ornithinderivater
CA1132986A (en) Mercaptoacyl derivatives of 4,5-dihydro-1h- pyrrole-2-carboxylic acids and 1,4,5,6- tetrahydropyridine-2-carboxylic acids
NO323263B1 (no) Heterosyklisk derivat, fremgangsmater for dets fremstilling, farmasoytiske sammensetninger som inneholder dette, anvendelse av dette for fremstilling av et preparat for medisinsk bruk samt nevnte derivat til bruk som medikament
US4041041A (en) Acetylene derivatives of amino acids
DE69407789T2 (de) Verfahren zur herstellung von (s)-4-aminohepta-5,6-diencarbon-säure und intermediate