NO833681L - 3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse - Google Patents
3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelseInfo
- Publication number
- NO833681L NO833681L NO833681A NO833681A NO833681L NO 833681 L NO833681 L NO 833681L NO 833681 A NO833681 A NO 833681A NO 833681 A NO833681 A NO 833681A NO 833681 L NO833681 L NO 833681L
- Authority
- NO
- Norway
- Prior art keywords
- chloro
- acridine
- dihydro
- gives
- dione
- Prior art date
Links
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- 239000001257 hydrogen Substances 0.000 claims abstract description 19
- 239000002253 acid Substances 0.000 claims abstract description 9
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 8
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- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241000231697 Zelus means Species 0.000 description 1
- FLMCNCMHXSWZNT-UHFFFAOYSA-N [2-(diethylamino)ethylamino]thiourea Chemical compound CCN(CC)CCNNC(N)=S FLMCNCMHXSWZNT-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940058934 aminoquinoline antimalarials Drugs 0.000 description 1
- 150000005010 aminoquinolines Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 125000000068 chlorophenyl group Chemical group 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- NRYJIKFQAFBQJF-UHFFFAOYSA-N o-(2-morpholin-4-ylethyl)hydroxylamine Chemical compound NOCCN1CCOCC1 NRYJIKFQAFBQJF-UHFFFAOYSA-N 0.000 description 1
- PYXHZSPWJIANNK-UHFFFAOYSA-N o-(2-pyrrolidin-1-ylethyl)hydroxylamine Chemical compound NOCCN1CCCC1 PYXHZSPWJIANNK-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- UNEIHNMKASENIG-UHFFFAOYSA-N para-chlorophenylpiperazine Chemical compound C1=CC(Cl)=CC=C1N1CCNCC1 UNEIHNMKASENIG-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- ZAMCTDDIJFNXOH-UHFFFAOYSA-N tributylazanium;acetate Chemical compound CC(O)=O.CCCCN(CCCC)CCCC ZAMCTDDIJFNXOH-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823237649 DE3237649A1 (de) | 1982-10-11 | 1982-10-11 | 3-aryl-7-chlor-10-hydroxy-3,4-dihydro-acridin-1,9-(2h, 10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| DE19823247908 DE3247908A1 (de) | 1982-12-24 | 1982-12-24 | 3-aryl-7-chlor-3,4-dihydro-acridin-1,9-(2h,-10h)-dion-1-oxime und -1-hydrazonderivate, deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO833681L true NO833681L (no) | 1984-04-12 |
Family
ID=25805046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO833681A NO833681L (no) | 1982-10-11 | 1983-10-10 | 3-aryl-7-klor-3,4-dihydro-akridin-1,9,(2h,10h)-dion-1-oksimer og -1-hydrazonderivater, deres salter, fremgangsmaate til deres fremstilling, midler som inneholder de og deres anvendelse |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4593027A (enExample) |
| EP (1) | EP0106284B1 (enExample) |
| AU (1) | AU561449B2 (enExample) |
| CA (1) | CA1217491A (enExample) |
| DE (1) | DE3372094D1 (enExample) |
| DK (1) | DK465583A (enExample) |
| ES (1) | ES526354A0 (enExample) |
| FI (1) | FI833651A7 (enExample) |
| GR (1) | GR78732B (enExample) |
| HU (1) | HU190854B (enExample) |
| IL (1) | IL69941A (enExample) |
| JO (1) | JO1266B1 (enExample) |
| MA (1) | MA19925A1 (enExample) |
| NO (1) | NO833681L (enExample) |
| NZ (1) | NZ205906A (enExample) |
| PH (1) | PH19108A (enExample) |
| PT (1) | PT77476B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626540A (en) * | 1983-11-08 | 1986-12-02 | Warner-Lambert Company | Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them |
| IN164921B (enExample) * | 1986-07-22 | 1989-07-08 | Hoechst India | |
| US5180717A (en) * | 1988-08-16 | 1993-01-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
| US5182303A (en) * | 1988-12-27 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Substituted semicarbazone arthropodicides |
| US5268388A (en) * | 1988-12-27 | 1993-12-07 | E. I. Du Pont De Nemours And Company | Substituted semicarbazone arthropodicides |
| US5859028A (en) * | 1997-04-28 | 1999-01-12 | Potomax Limited Partnership | Carotenoid synthesis inhibiting herbicides and fatty acid synthesis inhibiting oxime herbicides as anti-Apicomplexa protozoan parasite agents |
| US20090324580A1 (en) * | 2006-03-09 | 2009-12-31 | Cenix Bioscience Gmbh | Use of Inhibitors of Scavenger Receptor Class Proteins for the Treatment of Infectious Diseases |
| CA2673683C (en) | 2007-01-11 | 2014-07-29 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| EP2225226B1 (en) | 2007-12-26 | 2016-08-17 | Critical Outcome Technologies, Inc. | Compounds and their use in a method for treatment of cancer |
| WO2010006438A1 (en) | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
| CA2794952C (en) | 2010-04-01 | 2018-05-15 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2880210A (en) * | 1959-03-31 | Acridine n-oxides | ||
| US3184452A (en) * | 1965-05-18 | New aminoalkoxy compounds and process for theik manufacture | ||
| NL132832C (enExample) * | 1961-05-26 | |||
| US3577558A (en) * | 1968-04-15 | 1971-05-04 | Sterling Drug Inc | 1-aminoalkylamino-4-alkoxymethylthioxanthene derivatives |
| DE1811409A1 (de) * | 1968-11-28 | 1970-06-18 | Bayer Ag | Mittel zur Bekaempfung von Insekten,Milben,Hasenartigen und Nagetieren |
| DE2337474C2 (de) * | 1973-07-24 | 1982-01-21 | Hoechst Ag, 6000 Frankfurt | Chemotherapeutisch wirksame Tetrahydroacridone, Verfahren zu ihrer Herstellung und sie enthaltende Mittel |
| DE2651084A1 (de) * | 1976-11-09 | 1978-12-14 | Hoechst Ag | Basisch substituirte o-(2-hydroxypropyl) -aldoxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE2748333A1 (de) * | 1977-10-28 | 1979-05-03 | Hoechst Ag | Mittel gegen malaria |
| US4178451A (en) * | 1978-07-13 | 1979-12-11 | E. R. Squibb & Sons, Inc. | 3-(Substituted hydrazino)benzisothiazole-1,1-dioxides |
| US4266062A (en) * | 1978-09-18 | 1981-05-05 | Mcneilab, Inc. | (1-Methyl-2-pyridinylidene) derivatives of guanidine |
| US4447427A (en) * | 1979-01-04 | 1984-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones |
| US4291034A (en) * | 1980-03-20 | 1981-09-22 | Warner Lambert Company | 7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10 hydroxy acridinedioneimines having antimalarial activity |
| US4440771A (en) * | 1982-02-12 | 1984-04-03 | The United States Of America As Represented By The Secretary Of The Army | 2-Acetyl quinoline thiosemicarbazones useful in treatment of gonorrhea, malaria or bacterial infections |
-
1983
- 1983-10-07 EP EP83110035A patent/EP0106284B1/de not_active Expired
- 1983-10-07 FI FI833651A patent/FI833651A7/fi not_active Application Discontinuation
- 1983-10-07 CA CA000438636A patent/CA1217491A/en not_active Expired
- 1983-10-07 DE DE8383110035T patent/DE3372094D1/de not_active Expired
- 1983-10-10 HU HU833500A patent/HU190854B/hu not_active IP Right Cessation
- 1983-10-10 IL IL69941A patent/IL69941A/xx unknown
- 1983-10-10 DK DK465583A patent/DK465583A/da not_active Application Discontinuation
- 1983-10-10 NO NO833681A patent/NO833681L/no unknown
- 1983-10-10 ES ES526354A patent/ES526354A0/es active Granted
- 1983-10-10 NZ NZ205906A patent/NZ205906A/en unknown
- 1983-10-10 GR GR72653A patent/GR78732B/el unknown
- 1983-10-10 MA MA20145A patent/MA19925A1/fr unknown
- 1983-10-10 PT PT77476A patent/PT77476B/pt unknown
- 1983-10-10 PH PH29680A patent/PH19108A/en unknown
- 1983-10-10 AU AU20004/83A patent/AU561449B2/en not_active Ceased
- 1983-10-11 US US06/540,647 patent/US4593027A/en not_active Expired - Fee Related
- 1983-10-11 JO JO19831266A patent/JO1266B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK465583D0 (da) | 1983-10-10 |
| ES8405616A1 (es) | 1984-06-16 |
| JO1266B1 (en) | 1985-04-20 |
| CA1217491A (en) | 1987-02-03 |
| AU2000483A (en) | 1984-04-19 |
| EP0106284A1 (de) | 1984-04-25 |
| FI833651A7 (fi) | 1984-04-12 |
| US4593027A (en) | 1986-06-03 |
| ES526354A0 (es) | 1984-06-16 |
| MA19925A1 (fr) | 1984-07-01 |
| EP0106284B1 (de) | 1987-06-16 |
| FI833651A0 (fi) | 1983-10-07 |
| DK465583A (da) | 1984-04-12 |
| PH19108A (en) | 1986-01-06 |
| NZ205906A (en) | 1986-06-11 |
| IL69941A (en) | 1988-06-30 |
| GR78732B (enExample) | 1984-10-02 |
| DE3372094D1 (en) | 1987-07-23 |
| PT77476B (de) | 1986-04-16 |
| AU561449B2 (en) | 1987-05-07 |
| IL69941A0 (en) | 1984-01-31 |
| PT77476A (de) | 1983-11-01 |
| HU190854B (en) | 1986-11-28 |
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