NO813065L - 2-(1,4-benzodioksan-2-ylalkyl)imidazoler og fremgangsmaate til deres fremstilling - Google Patents
2-(1,4-benzodioksan-2-ylalkyl)imidazoler og fremgangsmaate til deres fremstillingInfo
- Publication number
- NO813065L NO813065L NO813065A NO813065A NO813065L NO 813065 L NO813065 L NO 813065L NO 813065 A NO813065 A NO 813065A NO 813065 A NO813065 A NO 813065A NO 813065 L NO813065 L NO 813065L
- Authority
- NO
- Norway
- Prior art keywords
- benzodioxan
- imidazole
- hydrogen
- acid
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 150000002460 imidazoles Chemical class 0.000 title abstract description 6
- 238000002360 preparation method Methods 0.000 title description 26
- 150000003839 salts Chemical class 0.000 claims abstract description 45
- 239000002253 acid Substances 0.000 claims abstract description 31
- 239000001257 hydrogen Substances 0.000 claims abstract description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 13
- 150000001875 compounds Chemical class 0.000 claims description 67
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- FMJHRCKHSCBACX-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1h-imidazole Chemical compound C1OC2=CC=CC=C2OC1CC1=NC=CN1 FMJHRCKHSCBACX-UHFFFAOYSA-N 0.000 claims description 8
- 239000002585 base Substances 0.000 claims description 8
- UXABARREKCJULM-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-ethylimidazole Chemical compound CCN1C=CN=C1CC1OC2=CC=CC=C2OC1 UXABARREKCJULM-UHFFFAOYSA-N 0.000 claims description 6
- 239000012458 free base Substances 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- 150000002431 hydrogen Chemical class 0.000 claims description 5
- CAMUYLMNJLOGGU-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1h-imidazole Chemical compound C1OC2=CC=CC=C2OC1C1=NC=CN1 CAMUYLMNJLOGGU-UHFFFAOYSA-N 0.000 claims description 4
- CEIPQQODRKXDSB-UHFFFAOYSA-N ethyl 3-(6-hydroxynaphthalen-2-yl)-1H-indazole-5-carboximidate dihydrochloride Chemical compound Cl.Cl.C1=C(O)C=CC2=CC(C3=NNC4=CC=C(C=C43)C(=N)OCC)=CC=C21 CEIPQQODRKXDSB-UHFFFAOYSA-N 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- PUMIRKHTZKRJBI-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-methylimidazole Chemical compound CN1C=CN=C1CC1OC2=CC=CC=C2OC1 PUMIRKHTZKRJBI-UHFFFAOYSA-N 0.000 claims description 3
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- JZVLEROUYCWKSZ-UHFFFAOYSA-N 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-propylimidazole Chemical compound CCCN1C=CN=C1CC1OC2=CC=CC=C2OC1 JZVLEROUYCWKSZ-UHFFFAOYSA-N 0.000 claims description 2
- LMWVSSDUEFXIER-UHFFFAOYSA-N 2-[2-(2,3-dihydro-1,4-benzodioxin-3-yl)ethyl]-1h-imidazole Chemical compound C1OC2=CC=CC=C2OC1CCC1=NC=CN1 LMWVSSDUEFXIER-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/185,832 US4302469A (en) | 1980-09-10 | 1980-09-10 | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO813065L true NO813065L (no) | 1982-03-11 |
Family
ID=22682624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO813065A NO813065L (no) | 1980-09-10 | 1981-09-09 | 2-(1,4-benzodioksan-2-ylalkyl)imidazoler og fremgangsmaate til deres fremstilling |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4302469A (fi) |
| EP (1) | EP0047531B1 (fi) |
| JP (1) | JPS5750989A (fi) |
| KR (1) | KR830007626A (fi) |
| AT (1) | ATE13765T1 (fi) |
| AU (1) | AU541413B2 (fi) |
| CA (1) | CA1173044A (fi) |
| DE (1) | DE3170937D1 (fi) |
| DK (1) | DK400781A (fi) |
| ES (1) | ES8205791A1 (fi) |
| FI (1) | FI812804L (fi) |
| HU (1) | HU186781B (fi) |
| IL (1) | IL63782A (fi) |
| NO (1) | NO813065L (fi) |
| NZ (1) | NZ198321A (fi) |
| YU (1) | YU217181A (fi) |
| ZA (1) | ZA816259B (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH16249A (en) * | 1980-02-04 | 1983-08-16 | Reckitt & Colmann Prod Ltd | Imidazoline derivatives,its pharmaceutical composition and method of use |
| US4402967A (en) * | 1981-04-23 | 1983-09-06 | Syntex (U.S.A.) Inc. | Method for lowering intraocular pressure |
| US4436914A (en) * | 1981-08-03 | 1984-03-13 | Kluge Arthur F | Benzodioxane-imidazoline compounds as antihypertensives |
| US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
| FI833224A (fi) * | 1983-09-09 | 1985-03-10 | Farmos Oy | Foerfarande foer framstaellning av ett terapeutiskt aktivt aemne. |
| US4634714A (en) * | 1983-12-01 | 1987-01-06 | American Home Products Corporation | Inhibition of prolactin release by a benzodioxinylimidazoline derivative |
| GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
| US4943311A (en) * | 1988-05-09 | 1990-07-24 | Uniroyal Chemical Company, Inc. | Azole derivatives of spiroheterocycles |
| IL95760A0 (en) * | 1989-09-27 | 1992-05-25 | Rhone Poulenc Sante | Imidazole derivatives,their preparation and pharmaceutical compositions containing the same |
| GB9020889D0 (en) * | 1990-09-25 | 1990-11-07 | May & Baker Ltd | New compositions of matter |
| US6162455A (en) * | 1997-01-22 | 2000-12-19 | American Cyanamid Company | Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals |
| US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
| AU2004281750A1 (en) * | 2003-10-14 | 2005-04-28 | Wyeth | Use of adrenergic alphaze antagonists for the treatment of vasomotor symptoms |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA731147A (en) | 1966-03-29 | Charles E. Frosst And Co. | 1:4 benzodioxan derivatives | |
| US2979511A (en) * | 1959-03-25 | 1961-04-11 | Olin Mathieson | Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process |
| US3360529A (en) * | 1962-01-29 | 1967-12-26 | Smith Kline French Lab | Guanidinoalkylbenzodioxan derivatives |
| GB1094982A (en) | 1963-05-08 | 1967-12-13 | Ward Blenkinsop & Co Ltd | 1,4-benzodioxanes |
| BE643853A (fi) | 1964-02-20 | 1964-08-14 | ||
| US3829411A (en) * | 1972-03-29 | 1974-08-13 | Eastman Kodak Co | Thiadiazolyl-azo-indole compounds |
| GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GB1457038A (en) * | 1973-10-23 | 1976-12-01 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
| GB1520801A (en) | 1975-01-16 | 1978-08-09 | Lafon Labor | Benzodioxanyl and benzofuranylmethylamines |
| US4039676A (en) * | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
-
1980
- 1980-09-10 US US06/185,832 patent/US4302469A/en not_active Expired - Lifetime
-
1981
- 1981-05-25 JP JP56079118A patent/JPS5750989A/ja active Pending
- 1981-09-09 CA CA000385505A patent/CA1173044A/en not_active Expired
- 1981-09-09 DK DK400781A patent/DK400781A/da not_active Application Discontinuation
- 1981-09-09 NZ NZ198321A patent/NZ198321A/en unknown
- 1981-09-09 IL IL63782A patent/IL63782A/xx unknown
- 1981-09-09 FI FI812804A patent/FI812804L/fi not_active Application Discontinuation
- 1981-09-09 EP EP81107104A patent/EP0047531B1/en not_active Expired
- 1981-09-09 YU YU02171/81A patent/YU217181A/xx unknown
- 1981-09-09 DE DE8181107104T patent/DE3170937D1/de not_active Expired
- 1981-09-09 AT AT81107104T patent/ATE13765T1/de not_active IP Right Cessation
- 1981-09-09 HU HU812591A patent/HU186781B/hu unknown
- 1981-09-09 NO NO813065A patent/NO813065L/no unknown
- 1981-09-09 ZA ZA816259A patent/ZA816259B/xx unknown
- 1981-09-09 KR KR1019810003367A patent/KR830007626A/ko unknown
- 1981-09-09 AU AU75094/81A patent/AU541413B2/en not_active Ceased
- 1981-09-09 ES ES505329A patent/ES8205791A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL63782A0 (en) | 1981-12-31 |
| ES505329A0 (es) | 1982-08-16 |
| FI812804L (fi) | 1982-03-11 |
| NZ198321A (en) | 1985-07-12 |
| JPS5750989A (en) | 1982-03-25 |
| DK400781A (da) | 1982-03-11 |
| KR830007626A (ko) | 1983-11-04 |
| YU217181A (en) | 1983-10-31 |
| ZA816259B (en) | 1983-04-27 |
| AU541413B2 (en) | 1985-01-10 |
| ATE13765T1 (de) | 1985-06-15 |
| AU7509481A (en) | 1982-03-18 |
| EP0047531B1 (en) | 1985-06-12 |
| HU186781B (en) | 1985-09-30 |
| DE3170937D1 (en) | 1985-07-18 |
| IL63782A (en) | 1984-03-30 |
| US4302469A (en) | 1981-11-24 |
| CA1173044A (en) | 1984-08-21 |
| ES8205791A1 (es) | 1982-08-16 |
| EP0047531A1 (en) | 1982-03-17 |
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