ZA816259B - 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants - Google Patents

2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants

Info

Publication number
ZA816259B
ZA816259B ZA816259A ZA816259A ZA816259B ZA 816259 B ZA816259 B ZA 816259B ZA 816259 A ZA816259 A ZA 816259A ZA 816259 A ZA816259 A ZA 816259A ZA 816259 B ZA816259 B ZA 816259B
Authority
ZA
South Africa
Prior art keywords
ylalkyl
benzodioxan
antidepressants
imidazoles
useful
Prior art date
Application number
ZA816259A
Other languages
English (en)
Inventor
A Kluge
A Strosberg
R Whiting
G Christie
L Waterbury
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of ZA816259B publication Critical patent/ZA816259B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
ZA816259A 1980-09-10 1981-09-09 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants ZA816259B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/185,832 US4302469A (en) 1980-09-10 1980-09-10 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants

Publications (1)

Publication Number Publication Date
ZA816259B true ZA816259B (en) 1983-04-27

Family

ID=22682624

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA816259A ZA816259B (en) 1980-09-10 1981-09-09 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants

Country Status (17)

Country Link
US (1) US4302469A (xx)
EP (1) EP0047531B1 (xx)
JP (1) JPS5750989A (xx)
KR (1) KR830007626A (xx)
AT (1) ATE13765T1 (xx)
AU (1) AU541413B2 (xx)
CA (1) CA1173044A (xx)
DE (1) DE3170937D1 (xx)
DK (1) DK400781A (xx)
ES (1) ES8205791A1 (xx)
FI (1) FI812804L (xx)
HU (1) HU186781B (xx)
IL (1) IL63782A (xx)
NO (1) NO813065L (xx)
NZ (1) NZ198321A (xx)
YU (1) YU217181A (xx)
ZA (1) ZA816259B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16249A (en) * 1980-02-04 1983-08-16 Reckitt & Colmann Prod Ltd Imidazoline derivatives,its pharmaceutical composition and method of use
US4402967A (en) * 1981-04-23 1983-09-06 Syntex (U.S.A.) Inc. Method for lowering intraocular pressure
US4436914A (en) * 1981-08-03 1984-03-13 Kluge Arthur F Benzodioxane-imidazoline compounds as antihypertensives
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
FI833224A (fi) * 1983-09-09 1985-03-10 Farmos Oy Foerfarande foer framstaellning av ett terapeutiskt aktivt aemne.
US4634714A (en) * 1983-12-01 1987-01-06 American Home Products Corporation Inhibition of prolactin release by a benzodioxinylimidazoline derivative
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
US4943311A (en) * 1988-05-09 1990-07-24 Uniroyal Chemical Company, Inc. Azole derivatives of spiroheterocycles
IL95760A0 (en) * 1989-09-27 1992-05-25 Rhone Poulenc Sante Imidazole derivatives,their preparation and pharmaceutical compositions containing the same
GB9020889D0 (en) * 1990-09-25 1990-11-07 May & Baker Ltd New compositions of matter
US6162455A (en) * 1997-01-22 2000-12-19 American Cyanamid Company Method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals
US20040152710A1 (en) * 2002-10-15 2004-08-05 Deecher Darlene Coleman Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms
AU2004281750A1 (en) * 2003-10-14 2005-04-28 Wyeth Use of adrenergic alphaze antagonists for the treatment of vasomotor symptoms

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA731147A (en) 1966-03-29 Charles E. Frosst And Co. 1:4 benzodioxan derivatives
US2979511A (en) * 1959-03-25 1961-04-11 Olin Mathieson Certain 1, 4-benzodioxanyl imidazolines and corresponding pyrimidines and process
US3360529A (en) * 1962-01-29 1967-12-26 Smith Kline French Lab Guanidinoalkylbenzodioxan derivatives
GB1094982A (en) 1963-05-08 1967-12-13 Ward Blenkinsop & Co Ltd 1,4-benzodioxanes
BE643853A (xx) 1964-02-20 1964-08-14
US3829411A (en) * 1972-03-29 1974-08-13 Eastman Kodak Co Thiadiazolyl-azo-indole compounds
GB1411531A (en) * 1972-10-24 1975-10-29 Lafon Labor Amino derivatives of 1,4-benzodioxan
GB1457038A (en) * 1973-10-23 1976-12-01 Lafon Labor Amino derivatives of 1,4-benzodioxan
GB1520801A (en) 1975-01-16 1978-08-09 Lafon Labor Benzodioxanyl and benzofuranylmethylamines
US4039676A (en) * 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans

Also Published As

Publication number Publication date
IL63782A0 (en) 1981-12-31
ES505329A0 (es) 1982-08-16
FI812804L (fi) 1982-03-11
NZ198321A (en) 1985-07-12
JPS5750989A (en) 1982-03-25
DK400781A (da) 1982-03-11
KR830007626A (ko) 1983-11-04
YU217181A (en) 1983-10-31
AU541413B2 (en) 1985-01-10
ATE13765T1 (de) 1985-06-15
AU7509481A (en) 1982-03-18
EP0047531B1 (en) 1985-06-12
HU186781B (en) 1985-09-30
DE3170937D1 (en) 1985-07-18
IL63782A (en) 1984-03-30
NO813065L (no) 1982-03-11
US4302469A (en) 1981-11-24
CA1173044A (en) 1984-08-21
ES8205791A1 (es) 1982-08-16
EP0047531A1 (en) 1982-03-17

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