NO810851L - Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel) - Google Patents
Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel)Info
- Publication number
- NO810851L NO810851L NO810851A NO810851A NO810851L NO 810851 L NO810851 L NO 810851L NO 810851 A NO810851 A NO 810851A NO 810851 A NO810851 A NO 810851A NO 810851 L NO810851 L NO 810851L
- Authority
- NO
- Norway
- Prior art keywords
- phe
- asp
- procedure
- preparation
- dipeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Fremgangsmåte for fremstilling av :. det kunstige sotningsmiddel aspartam, som er et dipeptid med formel Asp-Phe-Me, 1 ved hjelp av en klonet mikroorganisme, '..' r. DNA som koder for et stort stabilt peptid bestående av den repeterende aminosyresekvens (Asp-Phe) ,innfores i en klonebefordrer som i sin tur innfores i en passende verts-mikroorganisme. Verts-mikroorganismen dyrkes og det store peptid inneholdende den gjentagende Asp-Phe-sekvens hostes derfra. Den fri karboksylgruppe av det store peptid benzyleres og hydrolyseres deretter til benzyl Asp-Phe-dipeptider. Dette dipeptid metyleres og debenzyleres deretter til å danne aspartam.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13046280A | 1980-03-14 | 1980-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO810851L true NO810851L (no) | 1981-09-15 |
Family
ID=22444802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO810851A NO810851L (no) | 1980-03-14 | 1981-03-12 | Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel) |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0036258A3 (no) |
JP (1) | JPS56140897A (no) |
AU (1) | AU6800481A (no) |
DK (1) | DK114681A (no) |
FI (1) | FI810777L (no) |
IL (1) | IL62343A0 (no) |
NO (1) | NO810851L (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE50833B1 (en) * | 1980-01-30 | 1986-07-23 | Searle & Co | Recombinant dna techniques |
DE3326520A1 (de) * | 1983-07-22 | 1985-01-31 | Hubert Prof. Dr. 2000 Hamburg Köster | Verfahren zur definierten verknuepfung doppelhelikaler dna-fragmente mittels einer linker-dna sowie als linker-dna geeignete oligonucletide |
AU577334B2 (en) * | 1983-10-11 | 1988-09-22 | International Genetic Engineering, Inc. | Synthetic thaumatin genes |
GB2153363B (en) * | 1983-12-07 | 1988-05-05 | Univ Manchester | Method of preparation of cloning vector |
CA1213537A (en) * | 1984-05-01 | 1986-11-04 | Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee | Polypeptide expression method |
JPH02502604A (ja) * | 1987-01-07 | 1990-08-23 | アライド・コーポレーション | ペプチドオリゴマーの微生物生産法 |
CZ321497A3 (cs) * | 1995-04-11 | 1998-06-17 | Merck And Co., Inc. | Způsob vhodný pro produkci látek, jejichž základ tvoří dipeptid |
JPH10136992A (ja) * | 1996-11-07 | 1998-05-26 | Ajinomoto Co Inc | α−L−アスパルチル−L−フェニルアラニンメチルエステルの製造方法 |
RU2012129311A (ru) | 2012-07-11 | 2014-01-20 | Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3492131A (en) * | 1966-04-18 | 1970-01-27 | Searle & Co | Peptide sweetening agents |
CA1201668A (en) * | 1977-11-08 | 1986-03-11 | Genentech, Inc. | Synthetic dna and method therefor |
GB2068971B (en) * | 1980-01-30 | 1983-06-08 | Searle & Co | Recombinant dna techniques |
-
1981
- 1981-03-02 EP EP81300857A patent/EP0036258A3/en not_active Withdrawn
- 1981-03-03 AU AU68004/81A patent/AU6800481A/en not_active Abandoned
- 1981-03-10 IL IL62343A patent/IL62343A0/xx unknown
- 1981-03-12 JP JP3592681A patent/JPS56140897A/ja active Pending
- 1981-03-12 NO NO810851A patent/NO810851L/no unknown
- 1981-03-13 FI FI810777A patent/FI810777L/fi not_active Application Discontinuation
- 1981-03-13 DK DK114681A patent/DK114681A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPS56140897A (en) | 1981-11-04 |
EP0036258A2 (en) | 1981-09-23 |
EP0036258A3 (en) | 1982-02-10 |
IL62343A0 (en) | 1981-05-20 |
DK114681A (da) | 1981-09-15 |
AU6800481A (en) | 1981-09-17 |
FI810777L (fi) | 1981-09-15 |
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