NO802592L - Fremgangsmaate ved fremstilling av 1,2,4-triazol-3-thioler - Google Patents
Fremgangsmaate ved fremstilling av 1,2,4-triazol-3-thiolerInfo
- Publication number
- NO802592L NO802592L NO802592A NO802592A NO802592L NO 802592 L NO802592 L NO 802592L NO 802592 A NO802592 A NO 802592A NO 802592 A NO802592 A NO 802592A NO 802592 L NO802592 L NO 802592L
- Authority
- NO
- Norway
- Prior art keywords
- acid
- triazole
- thiol
- amino
- compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 34
- LJTFFORYSFGNCT-UHFFFAOYSA-N Thiocarbohydrazide Chemical compound NNC(=S)NN LJTFFORYSFGNCT-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 13
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 6
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 5
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims description 4
- 125000005544 phthalimido group Chemical group 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- AFBBKYQYNPNMAT-UHFFFAOYSA-N 1h-1,2,4-triazol-1-ium-3-thiolate Chemical compound SC=1N=CNN=1 AFBBKYQYNPNMAT-UHFFFAOYSA-N 0.000 claims description 3
- DNXIQMQGKSQHPC-UHFFFAOYSA-N 7-methoxy-3,4,5,6-tetrahydro-2h-azepine Chemical compound COC1=NCCCCC1 DNXIQMQGKSQHPC-UHFFFAOYSA-N 0.000 claims description 3
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 claims description 3
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 claims description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 3
- -1 triazole thiol Chemical class 0.000 claims description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
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- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000001452 natriuretic effect Effects 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/071,814 US4230715A (en) | 1979-09-04 | 1979-09-04 | 1,2,4-Triazole-3-thiols as antisecretory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO802592L true NO802592L (no) | 1981-03-05 |
Family
ID=22103760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO802592A NO802592L (no) | 1979-09-04 | 1980-09-03 | Fremgangsmaate ved fremstilling av 1,2,4-triazol-3-thioler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4230715A (xx) |
| JP (1) | JPS5640672A (xx) |
| AU (1) | AU6108980A (xx) |
| BE (1) | BE885015A (xx) |
| DE (1) | DE3031320A1 (xx) |
| DK (1) | DK375480A (xx) |
| ES (1) | ES494226A0 (xx) |
| FR (1) | FR2464257A1 (xx) |
| GB (1) | GB2057446A (xx) |
| IL (1) | IL60763A0 (xx) |
| IT (1) | IT1145443B (xx) |
| NL (1) | NL8004630A (xx) |
| NO (1) | NO802592L (xx) |
| SE (1) | SE8006142L (xx) |
| ZA (1) | ZA804668B (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0232382U (xx) * | 1988-08-22 | 1990-02-28 | ||
| US5489598A (en) * | 1994-06-08 | 1996-02-06 | Warner-Lambert Company | Cytoprotection utilizing aryltriazol-3-thiones |
| EP0821676B1 (en) * | 1995-04-20 | 2000-07-05 | Aventis Pharmaceuticals Inc. | 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as antidepressants |
| US20030125562A1 (en) * | 1999-08-21 | 2003-07-03 | Heindel Ned H. | Methods of producing 4-amino-3-mercapto-triazoles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB928919A (en) * | 1960-08-16 | 1963-06-19 | Bellon Labor Sa Roger | Triazole derivatives and a process for their preparation |
| DE1620506A1 (de) * | 1965-07-07 | 1970-01-02 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen 1,2,4-Triazolin-Thionen-(5) |
| US3701784A (en) * | 1968-09-04 | 1972-10-31 | Rohm & Haas | 1,2,4-4h-triazole derivatives |
| US3818097A (en) * | 1969-10-29 | 1974-06-18 | Smith Kline French Lab | Method of inhibiting histamine activity with isothioureas |
| IL49200A0 (en) * | 1975-03-27 | 1976-05-31 | Pfizer | Novel heterocyclic thiols and their preparation |
-
1979
- 1979-09-04 US US06/071,814 patent/US4230715A/en not_active Expired - Lifetime
-
1980
- 1980-07-31 ZA ZA00804668A patent/ZA804668B/xx unknown
- 1980-08-05 IL IL60763A patent/IL60763A0/xx unknown
- 1980-08-05 AU AU61089/80A patent/AU6108980A/en not_active Abandoned
- 1980-08-13 ES ES494226A patent/ES494226A0/es active Granted
- 1980-08-15 NL NL8004630A patent/NL8004630A/nl not_active Application Discontinuation
- 1980-08-20 DE DE19803031320 patent/DE3031320A1/de not_active Withdrawn
- 1980-08-21 JP JP11411880A patent/JPS5640672A/ja active Pending
- 1980-08-22 IT IT49543/80A patent/IT1145443B/it active
- 1980-09-01 BE BE0/201936A patent/BE885015A/fr unknown
- 1980-09-02 GB GB8028289A patent/GB2057446A/en not_active Withdrawn
- 1980-09-03 NO NO802592A patent/NO802592L/no unknown
- 1980-09-03 DK DK375480A patent/DK375480A/da unknown
- 1980-09-03 SE SE8006142A patent/SE8006142L/xx not_active Application Discontinuation
- 1980-09-04 FR FR8019132A patent/FR2464257A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5640672A (en) | 1981-04-16 |
| IL60763A0 (en) | 1980-10-26 |
| ES8106147A1 (es) | 1981-08-01 |
| ZA804668B (en) | 1981-07-29 |
| ES494226A0 (es) | 1981-08-01 |
| IT1145443B (it) | 1986-11-05 |
| BE885015A (fr) | 1980-12-31 |
| GB2057446A (en) | 1981-04-01 |
| IT8049543A0 (it) | 1980-08-22 |
| DE3031320A1 (de) | 1981-03-26 |
| DK375480A (da) | 1981-03-05 |
| FR2464257A1 (fr) | 1981-03-06 |
| AU6108980A (en) | 1981-03-12 |
| NL8004630A (nl) | 1981-03-06 |
| SE8006142L (sv) | 1981-03-05 |
| US4230715A (en) | 1980-10-28 |
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