NO331779B1 - Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol - Google Patents

Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol Download PDF

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Publication number
NO331779B1
NO331779B1 NO20014657A NO20014657A NO331779B1 NO 331779 B1 NO331779 B1 NO 331779B1 NO 20014657 A NO20014657 A NO 20014657A NO 20014657 A NO20014657 A NO 20014657A NO 331779 B1 NO331779 B1 NO 331779B1
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NO
Norway
Prior art keywords
lipg
cholesterol
cells
polypeptide
lipase
Prior art date
Application number
NO20014657A
Other languages
English (en)
Norwegian (no)
Other versions
NO20014657D0 (no
NO20014657L (no
Inventor
John A Krawiec
Dilip V Amin
Victoria J South
Michael Jaye
Kevin J Lynch
Kim-Anh Thi Doan
Dawn Marchadier
Cyrille Maugeais
Daniel J Rader
Original Assignee
Univ Pennsylvania
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/277,401 external-priority patent/US7008776B1/en
Application filed by Univ Pennsylvania, Aventis Pharma Inc filed Critical Univ Pennsylvania
Publication of NO20014657D0 publication Critical patent/NO20014657D0/no
Publication of NO20014657L publication Critical patent/NO20014657L/no
Publication of NO331779B1 publication Critical patent/NO331779B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
NO20014657A 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol NO331779B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/277,401 US7008776B1 (en) 1996-12-06 1999-03-26 Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
PCT/US2000/007870 WO2000057837A2 (en) 1999-03-26 2000-03-24 Compositions and methods for effecting the levels of cholesterol

Publications (3)

Publication Number Publication Date
NO20014657D0 NO20014657D0 (no) 2001-09-25
NO20014657L NO20014657L (no) 2001-11-21
NO331779B1 true NO331779B1 (no) 2012-03-26

Family

ID=23060703

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20014657A NO331779B1 (no) 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol
NO20100214A NO331784B1 (no) 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20100214A NO331784B1 (no) 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient.

Country Status (13)

Country Link
EP (1) EP1171078A4 (https=)
JP (1) JP2002540127A (https=)
KR (2) KR20050044812A (https=)
AU (1) AU776684B2 (https=)
BR (1) BR0009333A (https=)
CA (1) CA2363486C (https=)
HK (1) HK1043309A1 (https=)
IL (2) IL145526A0 (https=)
MX (1) MXPA01009727A (https=)
NO (2) NO331779B1 (https=)
NZ (2) NZ531180A (https=)
WO (1) WO2000057837A2 (https=)
ZA (1) ZA200107598B (https=)

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Also Published As

Publication number Publication date
WO2000057837A8 (en) 2001-09-27
KR20020029651A (ko) 2002-04-19
IL145526A0 (en) 2002-06-30
NO20014657D0 (no) 2001-09-25
AU776684B2 (en) 2004-09-16
NO20014657L (no) 2001-11-21
AU3918700A (en) 2000-10-16
HK1043309A1 (zh) 2002-09-13
JP2002540127A (ja) 2002-11-26
CA2363486C (en) 2012-12-18
NO331784B1 (no) 2012-03-26
EP1171078A4 (en) 2002-11-06
WO2000057837A3 (en) 2001-01-25
NZ531180A (en) 2005-06-24
CA2363486A1 (en) 2000-10-05
EP1171078A2 (en) 2002-01-16
KR100887164B1 (ko) 2009-03-10
BR0009333A (pt) 2002-01-08
NZ514350A (en) 2004-12-24
ZA200107598B (en) 2003-05-28
NO20100214L (no) 2001-11-21
WO2000057837A2 (en) 2000-10-05
IL145526A (en) 2010-11-30
KR20050044812A (ko) 2005-05-12
MXPA01009727A (es) 2002-07-22
WO2000057837A9 (en) 2001-10-18

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