NO331509B1 - Anvendelse av gammavinyl-GABA for fremstilling av et farmasoytisk preparat for anvendelse ved behandling av smerte i en vert - Google Patents
Anvendelse av gammavinyl-GABA for fremstilling av et farmasoytisk preparat for anvendelse ved behandling av smerte i en vert Download PDFInfo
- Publication number
- NO331509B1 NO331509B1 NO20035038A NO20035038A NO331509B1 NO 331509 B1 NO331509 B1 NO 331509B1 NO 20035038 A NO20035038 A NO 20035038A NO 20035038 A NO20035038 A NO 20035038A NO 331509 B1 NO331509 B1 NO 331509B1
- Authority
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- Norway
- Prior art keywords
- analgesic
- gaba
- pain
- host
- gvg
- Prior art date
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- XELXKCKNPPSFNN-BJWPBXOKSA-N morphine hydrochloride trihydrate Chemical compound O.O.O.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O XELXKCKNPPSFNN-BJWPBXOKSA-N 0.000 description 1
- QCOXCILKVHKOGO-UHFFFAOYSA-N n-(2-nitramidoethyl)nitramide Chemical compound [O-][N+](=O)NCCN[N+]([O-])=O QCOXCILKVHKOGO-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229960004013 normethadone Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 1
- 229960005118 oxymorphone Drugs 0.000 description 1
- 125000005489 p-toluenesulfonic acid group Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000003518 presynaptic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229940106773 sabril Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940067741 sodium octyl sulfate Drugs 0.000 description 1
- WFRKJMRGXGWHBM-UHFFFAOYSA-M sodium;octyl sulfate Chemical compound [Na+].CCCCCCCCOS([O-])(=O)=O WFRKJMRGXGWHBM-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000015883 synaptic transmission, dopaminergic Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 229960001402 tilidine Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 229960005318 vigabatrin Drugs 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/853,548 US20020187996A1 (en) | 2001-05-14 | 2001-05-14 | Prevention of addiction in pain management |
| PCT/US2002/011072 WO2002091990A2 (en) | 2001-05-14 | 2002-04-08 | Prevention of addiction in pain management |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20035038D0 NO20035038D0 (no) | 2003-11-13 |
| NO331509B1 true NO331509B1 (no) | 2012-01-16 |
Family
ID=25316324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20035038A NO331509B1 (no) | 2001-05-14 | 2003-11-13 | Anvendelse av gammavinyl-GABA for fremstilling av et farmasoytisk preparat for anvendelse ved behandling av smerte i en vert |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20020187996A1 (enExample) |
| EP (1) | EP1392301B1 (enExample) |
| JP (1) | JP2004534029A (enExample) |
| KR (1) | KR20040020054A (enExample) |
| CN (1) | CN100528156C (enExample) |
| AT (1) | ATE473001T1 (enExample) |
| AU (1) | AU2002342533B2 (enExample) |
| BR (1) | BR0209613A (enExample) |
| CA (1) | CA2446639C (enExample) |
| CZ (1) | CZ20033380A3 (enExample) |
| DE (1) | DE60236927D1 (enExample) |
| ES (1) | ES2348637T3 (enExample) |
| HR (1) | HRP20030892A2 (enExample) |
| HU (1) | HUP0402326A3 (enExample) |
| IL (1) | IL158762A0 (enExample) |
| MX (1) | MXPA03010407A (enExample) |
| NO (1) | NO331509B1 (enExample) |
| NZ (1) | NZ529614A (enExample) |
| PL (1) | PL368505A1 (enExample) |
| WO (1) | WO2002091990A2 (enExample) |
| YU (1) | YU89003A (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60133203T3 (de) * | 2000-07-31 | 2012-02-23 | Nycomed Danmark Aps | Fentanyl Zusammensetzung für nasale Anwendung |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN105497896A (zh) * | 2015-03-31 | 2016-04-20 | 苏州大学 | 一种肿瘤耐药的靶点及其应用 |
| WO2022119430A1 (es) | 2020-12-04 | 2022-06-09 | Laboratorios Silanes S.A. De C.V. | Composición farmacéutica sólida recubierta y estable de un analgésico opioide y un antiepiléptico para el dolor |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057368A (en) * | 1998-08-05 | 2000-05-02 | Brookhaven Science Associates Llc | Treatment of addiction and addiction-related behavior |
| US6541520B1 (en) * | 1998-08-05 | 2003-04-01 | Brookhaven Science Associates | Treatment of addiction and addiction-related behavior |
-
2001
- 2001-05-14 US US09/853,548 patent/US20020187996A1/en not_active Abandoned
-
2002
- 2002-04-08 CN CNB028098277A patent/CN100528156C/zh not_active Expired - Fee Related
- 2002-04-08 CZ CZ20033380A patent/CZ20033380A3/cs unknown
- 2002-04-08 WO PCT/US2002/011072 patent/WO2002091990A2/en not_active Ceased
- 2002-04-08 HU HU0402326A patent/HUP0402326A3/hu unknown
- 2002-04-08 BR BR0209613-7A patent/BR0209613A/pt not_active IP Right Cessation
- 2002-04-08 JP JP2002588909A patent/JP2004534029A/ja active Pending
- 2002-04-08 EP EP02769652A patent/EP1392301B1/en not_active Expired - Lifetime
- 2002-04-08 AT AT02769652T patent/ATE473001T1/de not_active IP Right Cessation
- 2002-04-08 MX MXPA03010407A patent/MXPA03010407A/es not_active Application Discontinuation
- 2002-04-08 PL PL02368505A patent/PL368505A1/xx not_active Application Discontinuation
- 2002-04-08 AU AU2002342533A patent/AU2002342533B2/en not_active Ceased
- 2002-04-08 DE DE60236927T patent/DE60236927D1/de not_active Expired - Lifetime
- 2002-04-08 HR HR20030892A patent/HRP20030892A2/xx not_active Application Discontinuation
- 2002-04-08 KR KR10-2003-7014736A patent/KR20040020054A/ko not_active Withdrawn
- 2002-04-08 CA CA2446639A patent/CA2446639C/en not_active Expired - Fee Related
- 2002-04-08 YU YU89003A patent/YU89003A/sh unknown
- 2002-04-08 ES ES02769652T patent/ES2348637T3/es not_active Expired - Lifetime
- 2002-04-08 IL IL15876202A patent/IL158762A0/xx unknown
- 2002-04-08 NZ NZ529614A patent/NZ529614A/en unknown
- 2002-04-18 US US10/124,660 patent/US6939876B2/en not_active Expired - Fee Related
-
2003
- 2003-01-02 US US10/335,800 patent/US20030134868A1/en not_active Abandoned
- 2003-11-13 NO NO20035038A patent/NO331509B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1531431A (zh) | 2004-09-22 |
| BR0209613A (pt) | 2004-12-07 |
| US20030004176A1 (en) | 2003-01-02 |
| HUP0402326A2 (hu) | 2005-02-28 |
| US20020187996A1 (en) | 2002-12-12 |
| EP1392301A2 (en) | 2004-03-03 |
| JP2004534029A (ja) | 2004-11-11 |
| CA2446639A1 (en) | 2002-11-21 |
| YU89003A (sh) | 2006-08-17 |
| HUP0402326A3 (en) | 2008-04-28 |
| US6939876B2 (en) | 2005-09-06 |
| WO2002091990A2 (en) | 2002-11-21 |
| EP1392301B1 (en) | 2010-07-07 |
| PL368505A1 (en) | 2005-04-04 |
| CN100528156C (zh) | 2009-08-19 |
| MXPA03010407A (es) | 2004-05-05 |
| NO20035038D0 (no) | 2003-11-13 |
| US20030134868A1 (en) | 2003-07-17 |
| KR20040020054A (ko) | 2004-03-06 |
| DE60236927D1 (de) | 2010-08-19 |
| WO2002091990A3 (en) | 2003-03-27 |
| AU2002342533B2 (en) | 2007-07-05 |
| HRP20030892A2 (en) | 2005-08-31 |
| CA2446639C (en) | 2010-11-02 |
| EP1392301A4 (en) | 2004-07-14 |
| ES2348637T3 (es) | 2010-12-10 |
| IL158762A0 (en) | 2004-05-12 |
| NZ529614A (en) | 2006-08-31 |
| ATE473001T1 (de) | 2010-07-15 |
| CZ20033380A3 (cs) | 2005-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |