NO330243B1 - Forbindelser som er partielle og fullstendige agonister av A1-adenosinreseptorer, samt farmasoytiske preparater som omfatter slike forbindelser - Google Patents
Forbindelser som er partielle og fullstendige agonister av A1-adenosinreseptorer, samt farmasoytiske preparater som omfatter slike forbindelser Download PDFInfo
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- NO330243B1 NO330243B1 NO20043907A NO20043907A NO330243B1 NO 330243 B1 NO330243 B1 NO 330243B1 NO 20043907 A NO20043907 A NO 20043907A NO 20043907 A NO20043907 A NO 20043907A NO 330243 B1 NO330243 B1 NO 330243B1
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- tetrahydrofuran
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Diabetes (AREA)
- Cardiology (AREA)
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- Genetics & Genomics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
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- Neurology (AREA)
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US35796102P | 2002-02-19 | 2002-02-19 | |
PCT/US2003/007289 WO2003070739A1 (en) | 2002-02-19 | 2003-02-19 | Partial and full agonists of a1 adenosine receptors |
Publications (2)
Publication Number | Publication Date |
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NO20043907L NO20043907L (no) | 2004-09-17 |
NO330243B1 true NO330243B1 (no) | 2011-03-14 |
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NO20043907A NO330243B1 (no) | 2002-02-19 | 2004-09-17 | Forbindelser som er partielle og fullstendige agonister av A1-adenosinreseptorer, samt farmasoytiske preparater som omfatter slike forbindelser |
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Country | Link |
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US (3) | US7144871B2 (zh) |
EP (2) | EP1476455A1 (zh) |
JP (1) | JP2005527502A (zh) |
KR (2) | KR20040084929A (zh) |
CN (2) | CN1636009A (zh) |
AU (2) | AU2003223237C1 (zh) |
CA (1) | CA2476683C (zh) |
IL (2) | IL163613A0 (zh) |
MX (1) | MXPA04008008A (zh) |
NO (1) | NO330243B1 (zh) |
NZ (1) | NZ534801A (zh) |
PL (1) | PL372145A1 (zh) |
RU (1) | RU2317994C2 (zh) |
WO (1) | WO2003070739A1 (zh) |
ZA (1) | ZA200406607B (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US7713946B2 (en) | 2002-07-11 | 2010-05-11 | Cv Therapeutics, Inc. | Partial and full agonists A1 adenosine receptors |
US7157440B2 (en) * | 2001-07-13 | 2007-01-02 | Cv Therapeutics, Inc. | Partial and full agonists of A1 adenosine receptors |
JP2005527502A (ja) * | 2002-02-19 | 2005-09-15 | シーブイ・セラピューティクス・インコーポレイテッド | A1アデノシン受容体の部分的および全アゴニスト |
DE102004032651A1 (de) * | 2004-07-06 | 2006-02-16 | Bayer Healthcare Ag | Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen |
WO2006017052A1 (en) * | 2004-07-12 | 2006-02-16 | Cv Therapeutics, Inc. | Process for the preparation of a1 adenosine receptor agonists |
RU2443708C2 (ru) * | 2007-05-17 | 2012-02-27 | Си Ви Терапьютикс, Инк. | Способ получения агониста рецептора a2a-аденозина и его полиморфных модификаций |
US20130123345A1 (en) * | 2010-07-23 | 2013-05-16 | The Ohio State University | Method of treating a viral infection dysfunction by disrupting an adenosine receptor pathway |
JP2015172077A (ja) * | 2015-06-24 | 2015-10-01 | 中国医学科学院葯物研究所 | N6−置換アデノシン誘導体とn6−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途 |
TWI791251B (zh) * | 2015-08-26 | 2023-02-01 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
MX2018010923A (es) | 2016-03-10 | 2019-02-13 | Janssen Pharmaceutica Nv | Analogos de nucleosidos sustituidos para su uso como inhibidores de prmt5. |
CA3016096C (en) | 2016-03-10 | 2023-10-17 | Janssen Pharmaceutica Nv | Substituted nucleoside analogues for use as prmt5 inhibitors |
BR112019004764A2 (pt) | 2016-09-14 | 2019-05-28 | Janssen Pharmaceutica Nv | inibidores bicíclicos fundidos da interação menina-mll |
MX2019002962A (es) | 2016-09-14 | 2019-07-04 | Janssen Pharmaceutica Nv | Inhibidores espirobiciclicos de la interaccion de menina-mll. |
WO2018065365A1 (en) | 2016-10-03 | 2018-04-12 | Janssen Pharmaceutica Nv | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
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- 2003-02-19 AU AU2003223237A patent/AU2003223237C1/en not_active Ceased
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KR20040084929A (ko) | 2004-10-06 |
AU2003223237A1 (en) | 2003-09-09 |
NZ534801A (en) | 2006-04-28 |
KR20100046058A (ko) | 2010-05-04 |
AU2003223237B2 (en) | 2008-08-21 |
WO2003070739A1 (en) | 2003-08-28 |
AU2003223237C1 (en) | 2009-03-26 |
AU2008249143A1 (en) | 2008-12-11 |
US20030232783A1 (en) | 2003-12-18 |
RU2004125492A (ru) | 2006-01-27 |
CA2476683C (en) | 2011-11-01 |
RU2317994C2 (ru) | 2008-02-27 |
CA2476683A1 (en) | 2003-08-28 |
NO20043907L (no) | 2004-09-17 |
IL163613A (en) | 2010-12-30 |
EP2412716A1 (en) | 2012-02-01 |
PL372145A1 (en) | 2005-07-11 |
IL163613A0 (en) | 2005-12-18 |
US7144871B2 (en) | 2006-12-05 |
ZA200406607B (en) | 2006-05-31 |
US7696181B2 (en) | 2010-04-13 |
JP2005527502A (ja) | 2005-09-15 |
US20060287275A1 (en) | 2006-12-21 |
AU2008249143B2 (en) | 2011-08-25 |
CN1636009A (zh) | 2005-07-06 |
US20090325896A1 (en) | 2009-12-31 |
MXPA04008008A (es) | 2005-03-23 |
CN101392012A (zh) | 2009-03-25 |
EP1476455A1 (en) | 2004-11-17 |
KR101032005B1 (ko) | 2011-05-02 |
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