NO328929B1 - Nye fluorenkarboksylsyre-estere, fremgangsmate for fremstilling derav, mellomprodukter, farmasoytiske preparater inneholdende slike, anvendelse derav som legemidler samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom - Google Patents
Nye fluorenkarboksylsyre-estere, fremgangsmate for fremstilling derav, mellomprodukter, farmasoytiske preparater inneholdende slike, anvendelse derav som legemidler samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom Download PDFInfo
- Publication number
- NO328929B1 NO328929B1 NO20043612A NO20043612A NO328929B1 NO 328929 B1 NO328929 B1 NO 328929B1 NO 20043612 A NO20043612 A NO 20043612A NO 20043612 A NO20043612 A NO 20043612A NO 328929 B1 NO328929 B1 NO 328929B1
- Authority
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- Norway
- Prior art keywords
- compounds
- methyl
- hydroxy
- general formula
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims description 28
- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000003814 drug Substances 0.000 title claims description 5
- 239000000543 intermediate Substances 0.000 title claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 4
- 201000010099 disease Diseases 0.000 title claims description 3
- 150000002148 esters Chemical class 0.000 title description 17
- 238000000034 method Methods 0.000 title description 8
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 88
- 150000003839 salts Chemical class 0.000 claims description 38
- -1 hydroxy, methyl Chemical group 0.000 claims description 37
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- 239000013543 active substance Substances 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
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- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
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- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10203741A DE10203741A1 (de) | 2002-01-31 | 2002-01-31 | Neue Fluorencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| PCT/EP2003/000534 WO2003064419A1 (de) | 2002-01-31 | 2003-01-21 | Neue fluorencarbonsäureester, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20043612L NO20043612L (no) | 2004-08-30 |
| NO328929B1 true NO328929B1 (no) | 2010-06-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043612A NO328929B1 (no) | 2002-01-31 | 2004-08-30 | Nye fluorenkarboksylsyre-estere, fremgangsmate for fremstilling derav, mellomprodukter, farmasoytiske preparater inneholdende slike, anvendelse derav som legemidler samt anvendelse av slike for fremstilling av medikamenter for behandling av sykdom |
Country Status (29)
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|---|---|
| EP (2) | EP1472251B1 (sr) |
| JP (1) | JP4484522B2 (sr) |
| KR (1) | KR100950869B1 (sr) |
| CN (1) | CN100348598C (sr) |
| AR (1) | AR038379A1 (sr) |
| AT (1) | ATE299880T1 (sr) |
| AU (1) | AU2003210172C1 (sr) |
| BR (1) | BR0307294A (sr) |
| CA (1) | CA2472149C (sr) |
| DE (2) | DE10203741A1 (sr) |
| EA (1) | EA006966B1 (sr) |
| EC (1) | ECSP045209A (sr) |
| ES (1) | ES2245443T3 (sr) |
| HK (1) | HK1082376A1 (sr) |
| HR (1) | HRP20040690B1 (sr) |
| IL (1) | IL162527A0 (sr) |
| ME (1) | MEP43408A (sr) |
| MX (1) | MXPA04007245A (sr) |
| MY (1) | MY134582A (sr) |
| NO (1) | NO328929B1 (sr) |
| NZ (1) | NZ534784A (sr) |
| PE (1) | PE20031029A1 (sr) |
| PL (1) | PL209037B1 (sr) |
| PT (1) | PT1472251E (sr) |
| RS (1) | RS50918B (sr) |
| TW (1) | TWI352077B (sr) |
| UA (1) | UA78544C2 (sr) |
| UY (1) | UY27633A1 (sr) |
| WO (1) | WO2003064419A1 (sr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2533791C (en) * | 2003-07-28 | 2012-05-22 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising betamimetics and an anticholinergic agent |
| CA2533786A1 (en) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders |
| ES2326320T3 (es) * | 2003-07-28 | 2009-10-07 | Boehringer Ingelheim International Gmbh | Medicamentos para inhalacion que comprenden esteroides y nuevo ester del acido fluorencarboxilico. |
| JP2007500676A (ja) * | 2003-07-31 | 2007-01-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗コリン作用薬とベータ受容体刺激薬を含む吸入用薬剤 |
| DE102004001607A1 (de) * | 2004-01-09 | 2005-08-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen auf der Basis von Scopin- oder Tropensäureestern mit EGFR-Kinase-Hemmern |
| US7507745B2 (en) * | 2004-02-20 | 2009-03-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins |
| WO2005079794A1 (en) * | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on anticholinergics and pegsunercept |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| US20060034776A1 (en) * | 2004-08-10 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Inhalable medicaments containing a new anticholinergic, corticosteroids, and betamimetics |
| DE102004038885A1 (de) * | 2004-08-10 | 2006-02-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
| ATE427108T1 (de) * | 2004-08-11 | 2009-04-15 | Boehringer Ingelheim Pharma | Anticholinergika enthaltende arzneimittel zur behandlung von krankheiten der ableitenden harnwege |
| DE102005001297A1 (de) * | 2005-01-12 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
| CA2597942A1 (en) * | 2005-02-16 | 2006-08-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions comprising anticholinergics and etiprednol |
| CA2600636A1 (en) * | 2005-03-09 | 2006-09-14 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors |
| CA2609429A1 (en) * | 2005-05-31 | 2006-12-07 | Boehringer Ingelheim International Gmbh | Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor |
| DE102005030733A1 (de) | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| US7423146B2 (en) | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| DE502007006951D1 (de) | 2006-08-07 | 2011-05-26 | Boehringer Ingelheim Pharma | Arzneimittelkombinationen zur behandlung von atemwegserkrankungen |
| UY30550A1 (es) | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos |
| EP1925296A1 (de) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stabile Pulverformulierung enthaltend ein neues Anticholinergikum |
| EP1997819A1 (de) * | 2007-05-25 | 2008-12-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopinestern |
| ES2569359T3 (es) | 2007-07-06 | 2016-05-10 | Vectura Delivery Devices Limited | Inhalador |
| CA2688669A1 (en) * | 2007-07-18 | 2009-01-22 | Boehringer Ingelheim International Gmbh | New combinations for the treatment of respiratory diseases |
| EP2082768A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082767A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082772A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082771A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082766A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Blister Strip Coil Forming |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
| GB0918450D0 (en) | 2009-10-21 | 2009-12-09 | Innovata Ltd | Composition |
| CN102876318B (zh) * | 2012-09-28 | 2014-07-16 | 宁波大学 | 一种芴羧酸酯荧光材料及其制备方法 |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2221828A (en) * | 1936-04-25 | 1940-11-19 | Merck & Co Inc | Esters of amino alcohols with 9-hydroxyfluorene-9-carboxylic acid and processes for their production |
| DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
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2002
- 2002-01-31 DE DE10203741A patent/DE10203741A1/de not_active Withdrawn
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2003
- 2003-01-21 CN CNB038030004A patent/CN100348598C/zh not_active Expired - Fee Related
- 2003-01-21 RS YUP-656/04A patent/RS50918B/sr unknown
- 2003-01-21 IL IL16252703A patent/IL162527A0/xx not_active IP Right Cessation
- 2003-01-21 AU AU2003210172A patent/AU2003210172C1/en not_active Ceased
- 2003-01-21 AT AT03734600T patent/ATE299880T1/de active
- 2003-01-21 ES ES03734600T patent/ES2245443T3/es not_active Expired - Lifetime
- 2003-01-21 UA UA20040807067A patent/UA78544C2/uk unknown
- 2003-01-21 JP JP2003564042A patent/JP4484522B2/ja not_active Expired - Lifetime
- 2003-01-21 CA CA2472149A patent/CA2472149C/en not_active Expired - Fee Related
- 2003-01-21 NZ NZ534784A patent/NZ534784A/en not_active IP Right Cessation
- 2003-01-21 BR BR0307294-0A patent/BR0307294A/pt active Pending
- 2003-01-21 EA EA200400878A patent/EA006966B1/ru not_active IP Right Cessation
- 2003-01-21 ME MEP-434/08A patent/MEP43408A/xx unknown
- 2003-01-21 PL PL369396A patent/PL209037B1/pl unknown
- 2003-01-21 KR KR1020047011881A patent/KR100950869B1/ko not_active IP Right Cessation
- 2003-01-21 EP EP03734600A patent/EP1472251B1/de not_active Expired - Lifetime
- 2003-01-21 EP EP05004525A patent/EP1561751A1/de not_active Withdrawn
- 2003-01-21 WO PCT/EP2003/000534 patent/WO2003064419A1/de active IP Right Grant
- 2003-01-21 MX MXPA04007245A patent/MXPA04007245A/es active IP Right Grant
- 2003-01-21 PT PT03734600T patent/PT1472251E/pt unknown
- 2003-01-21 DE DE50300813T patent/DE50300813D1/de not_active Expired - Lifetime
- 2003-01-29 TW TW092101968A patent/TWI352077B/zh active
- 2003-01-29 PE PE2003000092A patent/PE20031029A1/es not_active Application Discontinuation
- 2003-01-29 MY MYPI20030303A patent/MY134582A/en unknown
- 2003-01-30 UY UY27633A patent/UY27633A1/es not_active Application Discontinuation
- 2003-01-31 AR ARP030100288A patent/AR038379A1/es active Pending
-
2004
- 2004-07-28 EC EC2004005209A patent/ECSP045209A/es unknown
- 2004-07-29 HR HRP20040690AA patent/HRP20040690B1/xx not_active IP Right Cessation
- 2004-08-30 NO NO20043612A patent/NO328929B1/no not_active IP Right Cessation
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2005
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