NO327283B1 - Serinproteaser fra torsk og deres farmasoytiske og kosmetiske anvendelser. - Google Patents
Serinproteaser fra torsk og deres farmasoytiske og kosmetiske anvendelser. Download PDFInfo
- Publication number
- NO327283B1 NO327283B1 NO20016159A NO20016159A NO327283B1 NO 327283 B1 NO327283 B1 NO 327283B1 NO 20016159 A NO20016159 A NO 20016159A NO 20016159 A NO20016159 A NO 20016159A NO 327283 B1 NO327283 B1 NO 327283B1
- Authority
- NO
- Norway
- Prior art keywords
- trypsin
- cod
- proteinase
- infections
- infection
- Prior art date
Links
- 102000012479 Serine Proteases Human genes 0.000 title claims abstract description 21
- 108010022999 Serine Proteases Proteins 0.000 title claims abstract description 21
- 239000002537 cosmetic Substances 0.000 title claims abstract description 12
- 241000276438 Gadus morhua Species 0.000 claims abstract description 136
- 102000035195 Peptidases Human genes 0.000 claims abstract description 45
- 108091005804 Peptidases Proteins 0.000 claims abstract description 45
- 239000000203 mixture Substances 0.000 claims abstract description 45
- 108090000317 Chymotrypsin Proteins 0.000 claims abstract description 42
- 235000019833 protease Nutrition 0.000 claims abstract description 36
- 229960002376 chymotrypsin Drugs 0.000 claims abstract description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
- 201000010099 disease Diseases 0.000 claims abstract description 20
- 241000894006 Bacteria Species 0.000 claims abstract 2
- 241000700605 Viruses Species 0.000 claims abstract 2
- 108090000631 Trypsin Proteins 0.000 claims description 99
- 102000004142 Trypsin Human genes 0.000 claims description 98
- 239000012588 trypsin Substances 0.000 claims description 88
- 238000011282 treatment Methods 0.000 claims description 69
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 51
- 208000015181 infectious disease Diseases 0.000 claims description 48
- 239000000017 hydrogel Substances 0.000 claims description 29
- 208000010668 atopic eczema Diseases 0.000 claims description 27
- 201000004624 Dermatitis Diseases 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 24
- 206010052428 Wound Diseases 0.000 claims description 23
- 208000027418 Wounds and injury Diseases 0.000 claims description 22
- 208000002193 Pain Diseases 0.000 claims description 19
- 230000036407 pain Effects 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 241000251468 Actinopterygii Species 0.000 claims description 17
- 201000004681 Psoriasis Diseases 0.000 claims description 16
- 206010017533 Fungal infection Diseases 0.000 claims description 15
- 206010003246 arthritis Diseases 0.000 claims description 14
- 230000002265 prevention Effects 0.000 claims description 14
- 201000008482 osteoarthritis Diseases 0.000 claims description 13
- 230000000699 topical effect Effects 0.000 claims description 13
- 210000001503 joint Anatomy 0.000 claims description 12
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 12
- 206010006811 Bursitis Diseases 0.000 claims description 11
- 208000010201 Exanthema Diseases 0.000 claims description 11
- 208000031888 Mycoses Diseases 0.000 claims description 11
- 201000005884 exanthem Diseases 0.000 claims description 11
- 208000026278 immune system disease Diseases 0.000 claims description 11
- 206010037844 rash Diseases 0.000 claims description 11
- 206010053555 Arthritis bacterial Diseases 0.000 claims description 10
- 208000023275 Autoimmune disease Diseases 0.000 claims description 10
- 208000001640 Fibromyalgia Diseases 0.000 claims description 10
- 208000004575 Infectious Arthritis Diseases 0.000 claims description 10
- 102100034396 Trypsin-3 Human genes 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 230000000813 microbial effect Effects 0.000 claims description 10
- 201000001223 septic arthritis Diseases 0.000 claims description 10
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 9
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 9
- 102100032491 Serine protease 1 Human genes 0.000 claims description 9
- 101710151387 Serine protease 1 Proteins 0.000 claims description 9
- 101710119665 Trypsin-1 Proteins 0.000 claims description 9
- 208000038016 acute inflammation Diseases 0.000 claims description 9
- 230000006022 acute inflammation Effects 0.000 claims description 9
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 9
- 230000006020 chronic inflammation Effects 0.000 claims description 9
- 208000037976 chronic inflammation Diseases 0.000 claims description 9
- 208000014617 hemorrhoid Diseases 0.000 claims description 9
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 9
- 206010007134 Candida infections Diseases 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- 208000025865 Ulcer Diseases 0.000 claims description 8
- 201000003984 candidiasis Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 208000001297 phlebitis Diseases 0.000 claims description 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 8
- 231100000397 ulcer Toxicity 0.000 claims description 8
- 206010016717 Fistula Diseases 0.000 claims description 7
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 7
- 208000000491 Tendinopathy Diseases 0.000 claims description 7
- 206010043255 Tendonitis Diseases 0.000 claims description 7
- 102100034392 Trypsin-2 Human genes 0.000 claims description 7
- 101710119666 Trypsin-2 Proteins 0.000 claims description 7
- 101710119642 Trypsin-3 Proteins 0.000 claims description 7
- 206010048038 Wound infection Diseases 0.000 claims description 7
- 230000003890 fistula Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 7
- 201000004415 tendinitis Diseases 0.000 claims description 7
- 208000032544 Cicatrix Diseases 0.000 claims description 6
- 208000002260 Keloid Diseases 0.000 claims description 6
- 208000003251 Pruritus Diseases 0.000 claims description 6
- 206010040954 Skin wrinkling Diseases 0.000 claims description 6
- 230000000172 allergic effect Effects 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 230000001815 facial effect Effects 0.000 claims description 6
- 210000003953 foreskin Anatomy 0.000 claims description 6
- 230000036074 healthy skin Effects 0.000 claims description 6
- 230000007803 itching Effects 0.000 claims description 6
- 210000001117 keloid Anatomy 0.000 claims description 6
- 210000004761 scalp Anatomy 0.000 claims description 6
- 231100000241 scar Toxicity 0.000 claims description 6
- 230000037387 scars Effects 0.000 claims description 6
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 claims description 6
- 201000004647 tinea pedis Diseases 0.000 claims description 6
- 230000037303 wrinkles Effects 0.000 claims description 6
- 210000003739 neck Anatomy 0.000 claims description 5
- 230000009885 systemic effect Effects 0.000 claims description 5
- 206010034016 Paronychia Diseases 0.000 claims description 4
- 108010027597 alpha-chymotrypsin Proteins 0.000 claims description 4
- 208000006454 hepatitis Diseases 0.000 claims description 4
- 231100000283 hepatitis Toxicity 0.000 claims description 4
- 208000035143 Bacterial infection Diseases 0.000 claims description 3
- 241000711573 Coronaviridae Species 0.000 claims description 3
- 206010012735 Diarrhoea Diseases 0.000 claims description 3
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 3
- 241000588748 Klebsiella Species 0.000 claims description 3
- 241000589516 Pseudomonas Species 0.000 claims description 3
- 241000191940 Staphylococcus Species 0.000 claims description 3
- 241000194017 Streptococcus Species 0.000 claims description 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 206010022000 influenza Diseases 0.000 claims description 3
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000606790 Haemophilus Species 0.000 claims description 2
- 208000001688 Herpes Genitalis Diseases 0.000 claims description 2
- 208000007514 Herpes zoster Diseases 0.000 claims description 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 2
- 208000009608 Papillomavirus Infections Diseases 0.000 claims description 2
- 201000004946 genital herpes Diseases 0.000 claims description 2
- 208000006379 syphilis Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 108010057788 chymotrypsin B Proteins 0.000 claims 2
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 abstract description 2
- 208000037765 diseases and disorders Diseases 0.000 abstract description 2
- 230000002538 fungal effect Effects 0.000 abstract description 2
- 102000005962 receptors Human genes 0.000 abstract description 2
- 108020003175 receptors Proteins 0.000 abstract description 2
- 230000008275 binding mechanism Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 description 81
- 102000004190 Enzymes Human genes 0.000 description 80
- 108090000790 Enzymes Proteins 0.000 description 80
- 239000000499 gel Substances 0.000 description 34
- 230000000694 effects Effects 0.000 description 24
- 208000024891 symptom Diseases 0.000 description 23
- 108010044467 Isoenzymes Proteins 0.000 description 13
- 239000000758 substrate Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000002674 ointment Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 11
- 241000239366 Euphausiacea Species 0.000 description 11
- 239000000872 buffer Substances 0.000 description 11
- 239000001110 calcium chloride Substances 0.000 description 11
- 229910001628 calcium chloride Inorganic materials 0.000 description 11
- 206010061218 Inflammation Diseases 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- 230000000069 prophylactic effect Effects 0.000 description 8
- 241000283690 Bos taurus Species 0.000 description 7
- 239000004365 Protease Substances 0.000 description 7
- 206010000496 acne Diseases 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- 235000008504 concentrate Nutrition 0.000 description 7
- 108010047290 Multifunctional Enzymes Proteins 0.000 description 6
- 102000006833 Multifunctional Enzymes Human genes 0.000 description 6
- 206010040070 Septic Shock Diseases 0.000 description 6
- 239000007983 Tris buffer Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 6
- 239000003446 ligand Substances 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 210000001835 viscera Anatomy 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WPANETAWYGDRLL-UHFFFAOYSA-N 4-aminobenzenecarboximidamide Chemical compound NC(=N)C1=CC=C(N)C=C1 WPANETAWYGDRLL-UHFFFAOYSA-N 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 4
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 4
- 108010029485 Protein Isoforms Proteins 0.000 description 4
- 102000001708 Protein Isoforms Human genes 0.000 description 4
- 229920002684 Sepharose Polymers 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000001042 affinity chromatography Methods 0.000 description 4
- 206010009887 colitis Diseases 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- 239000000829 suppository Substances 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 3
- 241000709661 Enterovirus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 206010044248 Toxic shock syndrome Diseases 0.000 description 3
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 3
- 206010046914 Vaginal infection Diseases 0.000 description 3
- 206010047115 Vasculitis Diseases 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000007664 blowing Methods 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- -1 carbobenzoxy Gly-pro Chemical compound 0.000 description 3
- 230000021164 cell adhesion Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000006806 disease prevention Effects 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 238000001155 isoelectric focusing Methods 0.000 description 3
- 210000002414 leg Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 150000003077 polyols Chemical class 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000036303 septic shock Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 206010010741 Conjunctivitis Diseases 0.000 description 2
- 208000028006 Corneal injury Diseases 0.000 description 2
- 201000003883 Cystic fibrosis Diseases 0.000 description 2
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 2
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 2
- 101001018097 Homo sapiens L-selectin Proteins 0.000 description 2
- 101000847952 Homo sapiens Trypsin-3 Proteins 0.000 description 2
- 102000004157 Hydrolases Human genes 0.000 description 2
- 108090000604 Hydrolases Proteins 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- 102100025390 Integrin beta-2 Human genes 0.000 description 2
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 2
- 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 2
- 102100033467 L-selectin Human genes 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 206010058803 Oesophageal infection Diseases 0.000 description 2
- 206010048685 Oral infection Diseases 0.000 description 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 2
- 101000795023 Rattus norvegicus Trypsin-4 Proteins 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 208000031737 Tissue Adhesions Diseases 0.000 description 2
- 238000005571 anion exchange chromatography Methods 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229940049638 carbomer homopolymer type c Drugs 0.000 description 2
- 229940043234 carbomer-940 Drugs 0.000 description 2
- 238000011098 chromatofocusing Methods 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000007910 systemic administration Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 210000001635 urinary tract Anatomy 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- LGKDEBYYRWXEDL-UHFFFAOYSA-N 2-aminobenzenecarboximidamide Chemical compound NC(=N)C1=CC=CC=C1N LGKDEBYYRWXEDL-UHFFFAOYSA-N 0.000 description 1
- LKDMKWNDBAVNQZ-WJNSRDFLSA-N 4-[[(2s)-1-[[(2s)-1-[(2s)-2-[[(2s)-1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-WJNSRDFLSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 102100039501 Chymotrypsinogen B Human genes 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 208000004678 Elbow Tendinopathy Diseases 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- 206010019973 Herpes virus infection Diseases 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030154 Oesophageal candidiasis Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 206010061494 Rhinovirus infection Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040030 Sensory loss Diseases 0.000 description 1
- 206010056518 Septic phlebitis Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000324401 Superba Species 0.000 description 1
- 239000004784 Superba Substances 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000004732 Systemic Vasculitis Diseases 0.000 description 1
- 208000002240 Tennis Elbow Diseases 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 206010046996 Varicose vein Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- ZPQZRIJTQNWNLG-VXKWHMMOSA-N benzyl n-[2-[(2s)-2-[[(2s)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]carbamate Chemical compound C([C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC=2C=CC(=CC=2)[N+]([O-])=O)CCN1C(=O)CNC(=O)OCC1=CC=CC=C1 ZPQZRIJTQNWNLG-VXKWHMMOSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000003593 chromogenic compound Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229940066758 endopeptidases Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000147 enterotoxin Substances 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 108010077515 glycylproline Proteins 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 201000005060 thrombophlebitis Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 208000027185 varicose disease Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IS5086 | 1999-06-18 | ||
PCT/IS2000/000005 WO2000078332A2 (en) | 1999-06-18 | 2000-06-15 | Fish serine proteinases and their pharmaceutical and cosmetic use |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20016159D0 NO20016159D0 (no) | 2001-12-17 |
NO20016159L NO20016159L (no) | 2001-12-17 |
NO327283B1 true NO327283B1 (no) | 2009-06-02 |
Family
ID=36700558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20016159A NO327283B1 (no) | 1999-06-18 | 2001-12-17 | Serinproteaser fra torsk og deres farmasoytiske og kosmetiske anvendelser. |
Country Status (19)
Country | Link |
---|---|
US (1) | US6846485B2 (is) |
EP (1) | EP1202743B1 (is) |
JP (1) | JP2003502071A (is) |
KR (1) | KR100699084B1 (is) |
CN (1) | CN1197617C (is) |
AT (1) | ATE278417T1 (is) |
AU (1) | AU779700B2 (is) |
CA (1) | CA2377357C (is) |
DE (1) | DE60014659T2 (is) |
DK (1) | DK1202743T3 (is) |
ES (1) | ES2231200T3 (is) |
IS (1) | IS2782B (is) |
MX (1) | MXPA01013246A (is) |
NO (1) | NO327283B1 (is) |
NZ (1) | NZ516632A (is) |
PL (1) | PL202532B1 (is) |
PT (1) | PT1202743E (is) |
RU (1) | RU2264824C2 (is) |
WO (1) | WO2000078332A2 (is) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1227736T3 (da) * | 1999-10-20 | 2004-05-24 | Nordur Ehf | Proteinhydrolysater fremstillet under anvendelse af marine proteaser |
US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US7026111B2 (en) * | 2001-10-15 | 2006-04-11 | Beckman Coulter, Inc. | Methods and reagents for improved cell-based assays |
JP2006527738A (ja) * | 2003-06-18 | 2006-12-07 | ディレボ・ビオテク・アーゲー | 新規生物学的実体およびその薬学的または診断的使用 |
GB2403146B (en) * | 2003-06-23 | 2007-07-11 | Johnson & Johnson Medical Ltd | Method of making a wound dressing comprising lactate oxidase |
US7758902B2 (en) * | 2003-09-12 | 2010-07-20 | Access Business Group International Llc | Cytokine modulators and related methods of use |
CN102309573B (zh) * | 2003-09-12 | 2013-11-20 | 捷通国际有限公司 | 细胞因子调节剂及相关用法 |
US7758903B2 (en) | 2003-09-12 | 2010-07-20 | Access Business Group International Llc | Cytokine modulators and related methods of use |
GB0326194D0 (en) * | 2003-11-10 | 2003-12-17 | Univ Kent Canterbury | Proteins involved in signal transduction |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
EP1971365A4 (en) * | 2005-12-20 | 2010-01-13 | Swiss American Products Inc | PROTEASE COMPOSITIONS FOR THE TREATMENT OF DAMAGED TISSUE |
RU2355383C2 (ru) * | 2007-06-26 | 2009-05-20 | Открытое акционерное общество "Московский комитет по науке и технологиям" ОАО "МКНТ" | Косметическое средство на основе коллагеназы микробного происхождения |
AU2009207394B2 (en) * | 2008-01-21 | 2015-01-22 | Dermadis Sa | Use of serine protease inhibitors in the treatment of skin diseases |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
FR2930727B1 (fr) * | 2008-04-30 | 2012-10-05 | Evolution Dermatologique Lab | Composition pour le traitement des etats seborrheiques. |
US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
WO2010002972A1 (en) | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
JP2010130920A (ja) * | 2008-12-03 | 2010-06-17 | Shiseido Co Ltd | ヒアルロン酸酵素複合体ゲル |
NZ593823A (en) | 2009-01-06 | 2013-09-27 | Curelon Llc | Compositions and methods for the treatment or the prevention of infections by e. coli |
ES2668909T3 (es) | 2009-01-06 | 2018-05-23 | Galenagen, Llc | Composiciones que comprenden proteasa, amilasa y lipasa para su uso en el tratamiento de infecciones por Staphylococcus aureus |
EP2226382A1 (en) | 2009-03-03 | 2010-09-08 | B.R.A.I.N. Biotechnology Research and Information Network AG | Protease for wound conditioning and skin care |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
US9511125B2 (en) * | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
MX347770B (es) | 2011-04-21 | 2017-05-12 | Curemark Llc | Compuesto para el tratamiento de alteraciones neuropsiquiatricas. |
CN103007258A (zh) * | 2011-09-22 | 2013-04-03 | 安淇生物控释技术(苏州)有限公司 | 含鱼丝氨酸蛋白酶和抗菌化合物的医用组合物及其用途 |
EP2691069B1 (en) | 2012-01-23 | 2016-09-28 | Restorsea, LLC | Cosmetic |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
CN103509809B (zh) * | 2013-09-25 | 2015-02-04 | 中山大学 | 文昌鱼识别几丁质的丝氨酸蛋白酶casp基因及其应用 |
AU2014361780B2 (en) | 2013-12-13 | 2016-11-24 | Restorsea, Llc | Exfoliative hair retention-promoting formulation |
AU2015212554B2 (en) * | 2014-01-29 | 2020-09-03 | Enzymatica Ab | Novel treatments |
GB201405784D0 (en) * | 2014-03-31 | 2014-05-14 | Enzymatica Ab | Novel methods, polypeptides and uses thereof |
MX2016014982A (es) | 2014-05-16 | 2017-03-31 | Restorsea Llc | Cosmetico bifasico. |
LT6177B (lt) | 2014-10-10 | 2015-07-27 | Uab "Biocentras" | Fermentų kompleksų išskyrimas iš steptomyces gougerotii 101, daugiafermentinių biopreparatų ruošimas bei taikymas |
EP3120866A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Use of marine serine proteases for removal, prevention and inhibition of formation and growth of biofilms |
EP3121272A1 (en) * | 2015-07-24 | 2017-01-25 | Zymetech ehf. | Novel fish trypsin isoforms and their use |
RU2610669C1 (ru) * | 2015-10-16 | 2017-02-14 | Общество с ограниченной ответственностью "Научно-исследовательский институт средств противоожоговой терапии" | Способ получения протеолитического препарата для медицинского применения |
GB201701315D0 (en) | 2017-01-26 | 2017-03-15 | Enzymatica Ab | Novel treatments |
GB201800274D0 (en) * | 2018-01-08 | 2018-02-21 | Enzymatica Ab | Novel treatments |
GB201801982D0 (en) | 2018-02-07 | 2018-03-28 | Enzymatica Ab | Novel treatments |
US20220204922A1 (en) * | 2019-05-13 | 2022-06-30 | Bioseutica B.V. | Purified fish proteases with high specific activities and its process of production |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
US11441261B2 (en) | 2020-09-10 | 2022-09-13 | WABESO Enhanced Enzymatics, Inc. | Self-sterilizing fabrics incorporating anti-viral cold-active proteases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE454566B (sv) * | 1984-04-24 | 1988-05-16 | Lars G I Hellgren | Farmaceutisk komposition innehallande en verksam mengd av vattenlosliga proteinaser som extraherats fran ett vattenlevande djur valt av ordningen euphausiaceae eller slektet mallotus |
US6030612A (en) * | 1994-11-22 | 2000-02-29 | Phairson Medical Inc. | Antimicrobial uses of multifunctional enzyme |
US5958406A (en) * | 1994-11-22 | 1999-09-28 | Phairson Medical Inc. | Acne treatment with multifunctional enzyme |
US6232088B1 (en) * | 1995-02-08 | 2001-05-15 | Phairson Medical, Inc. | Treatment and prevention of immune rejection reactions |
JP2002515903A (ja) * | 1997-02-12 | 2002-05-28 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | セリンプロテアーゼと局所レチノイドの組成物 |
AU2845400A (en) * | 1998-12-24 | 2000-07-31 | Phairson Medical Inc. | Treatment and prevention of immune rejection reactions |
-
2000
- 2000-06-15 PT PT00931530T patent/PT1202743E/pt unknown
- 2000-06-15 PL PL352318A patent/PL202532B1/pl unknown
- 2000-06-15 CA CA2377357A patent/CA2377357C/en not_active Expired - Lifetime
- 2000-06-15 AT AT00931530T patent/ATE278417T1/de active
- 2000-06-15 DE DE60014659T patent/DE60014659T2/de not_active Expired - Lifetime
- 2000-06-15 ES ES00931530T patent/ES2231200T3/es not_active Expired - Lifetime
- 2000-06-15 AU AU49478/00A patent/AU779700B2/en not_active Expired
- 2000-06-15 RU RU2002101125/15A patent/RU2264824C2/ru active
- 2000-06-15 JP JP2001504395A patent/JP2003502071A/ja active Pending
- 2000-06-15 CN CNB008091110A patent/CN1197617C/zh not_active Expired - Lifetime
- 2000-06-15 DK DK00931530T patent/DK1202743T3/da active
- 2000-06-15 KR KR1020017016291A patent/KR100699084B1/ko active IP Right Grant
- 2000-06-15 NZ NZ516632A patent/NZ516632A/en not_active IP Right Cessation
- 2000-06-15 MX MXPA01013246A patent/MXPA01013246A/es active IP Right Grant
- 2000-06-15 EP EP00931530A patent/EP1202743B1/en not_active Expired - Lifetime
- 2000-06-15 WO PCT/IS2000/000005 patent/WO2000078332A2/en active IP Right Grant
-
2001
- 2001-12-10 IS IS6194A patent/IS2782B/is unknown
- 2001-12-17 NO NO20016159A patent/NO327283B1/no not_active IP Right Cessation
-
2002
- 2002-01-07 US US10/036,371 patent/US6846485B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1202743A2 (en) | 2002-05-08 |
US6846485B2 (en) | 2005-01-25 |
DK1202743T3 (da) | 2005-02-14 |
PL202532B1 (pl) | 2009-07-31 |
JP2003502071A (ja) | 2003-01-21 |
AU779700B2 (en) | 2005-02-10 |
PL352318A1 (en) | 2003-08-11 |
ES2231200T3 (es) | 2005-05-16 |
WO2000078332A2 (en) | 2000-12-28 |
WO2000078332A3 (en) | 2001-07-05 |
RU2264824C2 (ru) | 2005-11-27 |
DE60014659D1 (de) | 2004-11-11 |
AU4947800A (en) | 2001-01-09 |
ATE278417T1 (de) | 2004-10-15 |
KR100699084B1 (ko) | 2007-03-23 |
US20020141987A1 (en) | 2002-10-03 |
MXPA01013246A (es) | 2003-08-20 |
NO20016159D0 (no) | 2001-12-17 |
NO20016159L (no) | 2001-12-17 |
PT1202743E (pt) | 2005-02-28 |
IS6194A (is) | 2001-12-10 |
CA2377357A1 (en) | 2000-12-28 |
DE60014659T2 (de) | 2006-03-02 |
CN1356907A (zh) | 2002-07-03 |
IS2782B (is) | 2012-05-15 |
CN1197617C (zh) | 2005-04-20 |
NZ516632A (en) | 2004-04-30 |
KR20020025082A (ko) | 2002-04-03 |
EP1202743B1 (en) | 2004-10-06 |
CA2377357C (en) | 2013-07-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO327283B1 (no) | Serinproteaser fra torsk og deres farmasoytiske og kosmetiske anvendelser. | |
US6030612A (en) | Antimicrobial uses of multifunctional enzyme | |
RU2739945C2 (ru) | Новые изоформы трипсина и их применение | |
US5945102A (en) | Crustacean and fish derived multifunctional enzyme | |
US5958406A (en) | Acne treatment with multifunctional enzyme | |
US20060134641A1 (en) | Treating viral infections with krill enzymes | |
US7947270B2 (en) | Removing dental plaque with krill enzymes | |
RU2814729C2 (ru) | Новая изоформа трипсина и ее применение | |
NZ503162A (en) | Use of a krill- or atlantic cod-derived hydrolase with chymotrypsin, collagenase, elastase and/or exo peptidase activity to inactivate call adhesion components including ICAM-1 (CD54), CD4, CD8, CD11 and CD28. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |