NO324796B1 - Anvendelse av fosfolipidkomplekser ekstrahert fra Vitis vinifera ved fremstilling av antiaterosklerotiske midler. - Google Patents
Anvendelse av fosfolipidkomplekser ekstrahert fra Vitis vinifera ved fremstilling av antiaterosklerotiske midler. Download PDFInfo
- Publication number
- NO324796B1 NO324796B1 NO20002827A NO20002827A NO324796B1 NO 324796 B1 NO324796 B1 NO 324796B1 NO 20002827 A NO20002827 A NO 20002827A NO 20002827 A NO20002827 A NO 20002827A NO 324796 B1 NO324796 B1 NO 324796B1
- Authority
- NO
- Norway
- Prior art keywords
- vitis vinifera
- phospholipid complexes
- preparation
- atherosclerotic agents
- drug
- Prior art date
Links
- 235000014787 Vitis vinifera Nutrition 0.000 title claims abstract description 11
- 240000006365 Vitis vinifera Species 0.000 title claims abstract description 11
- 235000002532 grape seed extract Nutrition 0.000 title claims abstract description 11
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 10
- 230000000879 anti-atherosclerotic effect Effects 0.000 title description 2
- 238000002360 preparation method Methods 0.000 title description 2
- 239000003814 drug Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 229920002770 condensed tannin Polymers 0.000 claims description 4
- 125000004403 catechin group Chemical group 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 206010008118 cerebral infarction Diseases 0.000 claims description 2
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000002107 myocardial effect Effects 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 210000004165 myocardium Anatomy 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 7
- 230000003143 atherosclerotic effect Effects 0.000 abstract description 6
- 238000011282 treatment Methods 0.000 abstract description 5
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 230000000260 hypercholesteremic effect Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 210000002376 aorta thoracic Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 description 1
- UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 229920001991 Proanthocyanidin Polymers 0.000 description 1
- 108010069201 VLDL Cholesterol Proteins 0.000 description 1
- 239000003529 anticholesteremic agent Substances 0.000 description 1
- 229940127226 anticholesterol agent Drugs 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- GGCLNOIGPMGLDB-GYKMGIIDSA-N cholest-5-en-3-one Chemical compound C1C=C2CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 GGCLNOIGPMGLDB-GYKMGIIDSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000009552 doppler ultrasonography Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
- 235000012734 epicatechin Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 229940038487 grape extract Drugs 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002690A IT1296920B1 (it) | 1997-12-04 | 1997-12-04 | Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici |
| PCT/EP1998/007662 WO1999029331A1 (en) | 1997-12-04 | 1998-11-30 | The use of phospholipid complexes of extracts of vitis vinifera as anti-atherosclerotic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20002827L NO20002827L (no) | 2000-06-02 |
| NO20002827D0 NO20002827D0 (no) | 2000-06-02 |
| NO324796B1 true NO324796B1 (no) | 2007-12-10 |
Family
ID=11378312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002827A NO324796B1 (no) | 1997-12-04 | 2000-06-02 | Anvendelse av fosfolipidkomplekser ekstrahert fra Vitis vinifera ved fremstilling av antiaterosklerotiske midler. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6297218B1 (da) |
| EP (1) | EP1035859B1 (da) |
| JP (1) | JP4456267B2 (da) |
| KR (1) | KR100567867B1 (da) |
| CN (1) | CN1126564C (da) |
| AT (1) | ATE258802T1 (da) |
| AU (1) | AU743031B2 (da) |
| BR (1) | BR9805813B1 (da) |
| CA (1) | CA2312795C (da) |
| CZ (1) | CZ299555B6 (da) |
| DE (1) | DE69821524T2 (da) |
| DK (1) | DK1035859T3 (da) |
| ES (1) | ES2214755T3 (da) |
| HK (1) | HK1033267A1 (da) |
| HU (1) | HU228109B1 (da) |
| IT (1) | IT1296920B1 (da) |
| NO (1) | NO324796B1 (da) |
| PL (1) | PL191023B1 (da) |
| PT (1) | PT1035859E (da) |
| RU (1) | RU2207866C2 (da) |
| SI (1) | SI1035859T1 (da) |
| SK (1) | SK284865B6 (da) |
| WO (1) | WO1999029331A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1304183B1 (it) | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| JP2001122791A (ja) * | 1999-10-20 | 2001-05-08 | Boehringer Ingelheim Internatl Gmbh | 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤 |
| JP4574788B2 (ja) | 2000-03-24 | 2010-11-04 | 協和発酵バイオ株式会社 | プロアントシアニジン含有組成物 |
| IT1320080B1 (it) * | 2000-10-25 | 2003-11-18 | Giuliani Spa | Composizione per uso farmaceutico o dietetico. |
| FR2836337B1 (fr) * | 2002-02-28 | 2004-11-19 | Bio Serae Laboratoires | Utilisation des polymeres procyanidoliques a titre d'agents inhibuteurs des alpha-amylases et application dans des compositions a visees dietetiques |
| KR20050095834A (ko) * | 2002-12-31 | 2005-10-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 레드바인 잎 추출물을 포함하는 필름 코팅 정제 |
| US20040151769A1 (en) * | 2002-12-31 | 2004-08-05 | Boehringer Ingelheim International Gmbh | Film coated tablet containing an extract of red vine leaves |
| ITMI20031313A1 (it) * | 2003-06-27 | 2004-12-28 | Indena Spa | Associazioni di agenti vasoprotettori e formulazioni che li contengono. |
| EP1550450A1 (en) * | 2003-12-29 | 2005-07-06 | Boehringer Ingelheim International GmbH | Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies |
| RU2367464C2 (ru) | 2004-02-19 | 2009-09-20 | Берингер Ингельхайм Интернациональ Гмбх | Состав для лечения хронических венозных недостаточностей, содержащий водный экстракт листьев красного винограда и противовоспалительное средство |
| US20060088617A1 (en) * | 2004-10-23 | 2006-04-27 | Mccurry James M | Chocolate composition and method for benefiting the cardiovascular system |
| AT501682A1 (de) | 2005-01-14 | 2006-10-15 | Hermine Dr Engl | Verfahren zur herstellung einer wirkstoffmischung |
| EP1837030A1 (en) | 2006-03-09 | 2007-09-26 | INDENA S.p.A. | Phospholipid complexes of curcumin having improved bioavailability |
| EP2829277A1 (en) | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
| EP3703724A1 (en) | 2017-11-02 | 2020-09-09 | NatureCeuticals Sdn. Bhd. | Extract of orthosiphon stamineus, formulations, and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092743A1 (en) * | 1970-06-15 | 1972-01-28 | Aquitaine Invest Pharma | Complete extraction of total flavanol gomers from plats -peripheral - venous activity |
| GB1541469A (en) * | 1976-12-01 | 1979-02-28 | Inverni Della Beffa Spa | Method of obtaining flavonolic oligomers |
| IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
| US5484594A (en) * | 1988-06-28 | 1996-01-16 | Tecnofarmaci S.P.A. | Process for preparing grapeseed extracts enriched in procyanidol oligomers |
| FI955691A (fi) | 1994-11-28 | 1996-05-29 | Suntory Ltd | Lipoproteiini(a):ta alentava aine, kolesterolia alentava aine ja näitä aineita sisältävät lääkkeet |
-
1997
- 1997-12-04 IT IT97MI002690A patent/IT1296920B1/it active IP Right Grant
-
1998
- 1998-11-30 SK SK827-2000A patent/SK284865B6/sk not_active IP Right Cessation
- 1998-11-30 AT AT98959890T patent/ATE258802T1/de active
- 1998-11-30 JP JP2000524000A patent/JP4456267B2/ja not_active Expired - Fee Related
- 1998-11-30 PL PL340884A patent/PL191023B1/pl not_active IP Right Cessation
- 1998-11-30 HU HU0100522A patent/HU228109B1/hu not_active IP Right Cessation
- 1998-11-30 CA CA002312795A patent/CA2312795C/en not_active Expired - Fee Related
- 1998-11-30 KR KR1020007005420A patent/KR100567867B1/ko not_active IP Right Cessation
- 1998-11-30 AU AU15627/99A patent/AU743031B2/en not_active Ceased
- 1998-11-30 DK DK98959890T patent/DK1035859T3/da active
- 1998-11-30 EP EP98959890A patent/EP1035859B1/en not_active Expired - Lifetime
- 1998-11-30 RU RU2000114174/14A patent/RU2207866C2/ru not_active IP Right Cessation
- 1998-11-30 DE DE69821524T patent/DE69821524T2/de not_active Expired - Lifetime
- 1998-11-30 CN CN98811768A patent/CN1126564C/zh not_active Expired - Fee Related
- 1998-11-30 CZ CZ20002038A patent/CZ299555B6/cs not_active IP Right Cessation
- 1998-11-30 ES ES98959890T patent/ES2214755T3/es not_active Expired - Lifetime
- 1998-11-30 SI SI9830609T patent/SI1035859T1/xx unknown
- 1998-11-30 WO PCT/EP1998/007662 patent/WO1999029331A1/en active IP Right Grant
- 1998-11-30 PT PT98959890T patent/PT1035859E/pt unknown
- 1998-12-29 BR BRPI9805813-4A patent/BR9805813B1/pt not_active IP Right Cessation
-
2000
- 2000-05-31 US US09/580,906 patent/US6297218B1/en not_active Expired - Lifetime
- 2000-06-02 NO NO20002827A patent/NO324796B1/no not_active IP Right Cessation
-
2001
- 2001-06-08 HK HK01103945A patent/HK1033267A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |