NO320555B1 - Fremgangsmate og innretning for a separere en komponent fra plasma. - Google Patents
Fremgangsmate og innretning for a separere en komponent fra plasma. Download PDFInfo
- Publication number
- NO320555B1 NO320555B1 NO19972492A NO972492A NO320555B1 NO 320555 B1 NO320555 B1 NO 320555B1 NO 19972492 A NO19972492 A NO 19972492A NO 972492 A NO972492 A NO 972492A NO 320555 B1 NO320555 B1 NO 320555B1
- Authority
- NO
- Norway
- Prior art keywords
- chamber
- reaction chamber
- reagent
- plasma
- stated
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 56
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical group CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 85
- 239000003153 chemical reaction reagent Substances 0.000 claims description 57
- 238000006243 chemical reaction Methods 0.000 claims description 55
- 239000002775 capsule Substances 0.000 claims description 52
- 108010073385 Fibrin Proteins 0.000 claims description 49
- 102000009123 Fibrin Human genes 0.000 claims description 49
- 229950003499 fibrin Drugs 0.000 claims description 49
- 210000004369 blood Anatomy 0.000 claims description 32
- 239000008280 blood Substances 0.000 claims description 32
- 229920000642 polymer Polymers 0.000 claims description 30
- 238000000926 separation method Methods 0.000 claims description 27
- 239000012530 fluid Substances 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 12
- 238000004891 communication Methods 0.000 claims description 11
- 108010049003 Fibrinogen Proteins 0.000 claims description 8
- 102000008946 Fibrinogen Human genes 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229940012952 fibrinogen Drugs 0.000 claims description 8
- 108090001008 Avidin Proteins 0.000 claims description 7
- 229960002685 biotin Drugs 0.000 claims description 6
- 235000020958 biotin Nutrition 0.000 claims description 6
- 239000011616 biotin Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 108090000190 Thrombin Proteins 0.000 claims description 4
- 229960004072 thrombin Drugs 0.000 claims description 4
- 101000772006 Bombus ignitus Venom serine protease Bi-VSP Proteins 0.000 claims description 3
- 239000012876 carrier material Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 description 42
- 108010073651 fibrinmonomer Proteins 0.000 description 36
- 239000000243 solution Substances 0.000 description 30
- 238000005119 centrifugation Methods 0.000 description 29
- 239000007788 liquid Substances 0.000 description 20
- 229960002210 batroxobin Drugs 0.000 description 19
- 239000000306 component Substances 0.000 description 19
- 108010027612 Batroxobin Proteins 0.000 description 15
- 108090000790 Enzymes Proteins 0.000 description 15
- 102000004190 Enzymes Human genes 0.000 description 15
- 229940088598 enzyme Drugs 0.000 description 15
- 238000007789 sealing Methods 0.000 description 15
- 239000000203 mixture Substances 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- 108010063086 avidin-agarose Proteins 0.000 description 10
- 239000000872 buffer Substances 0.000 description 10
- 230000008878 coupling Effects 0.000 description 10
- 238000010168 coupling process Methods 0.000 description 10
- 238000005859 coupling reaction Methods 0.000 description 10
- 239000007853 buffer solution Substances 0.000 description 9
- 206010001497 Agitation Diseases 0.000 description 8
- 238000013019 agitation Methods 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 239000012503 blood component Substances 0.000 description 4
- 229920000936 Agarose Polymers 0.000 description 3
- -1 KCNS Chemical compound 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 229940127219 anticoagulant drug Drugs 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 208000019838 Blood disease Diseases 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 230000004323 axial length Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000003196 chaotropic effect Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000018706 hematopoietic system disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000565 sealant Substances 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 108010001779 Ancrod Proteins 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 108010035108 acutin Proteins 0.000 description 1
- NNRQRIKGBJBXDO-UHFFFAOYSA-N acutine Natural products C1=CC=C2NC(CCCC=CCC)=CC(=O)C2=C1 NNRQRIKGBJBXDO-UHFFFAOYSA-N 0.000 description 1
- 229960004233 ancrod Drugs 0.000 description 1
- 108010044458 asperase Proteins 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 108010046562 botropase Proteins 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 108010056533 gabonase Proteins 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 229960000789 guanidine hydrochloride Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- SCUZVMOVTVSBLE-UHFFFAOYSA-N prop-2-enenitrile;styrene Chemical compound C=CC#N.C=CC1=CC=CC=C1 SCUZVMOVTVSBLE-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 229920000638 styrene acrylonitrile Polymers 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2405—Feed mechanisms for settling tanks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/24—Feed or discharge mechanisms for settling tanks
- B01D21/2427—The feed or discharge opening located at a distant position from the side walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B1/00—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles
- B04B1/02—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles without inserted separating walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/0485—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with a displaceable piston in the centrifuge chamber
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87571—Multiple inlet with single outlet
- Y10T137/87676—With flow control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/111666—Utilizing a centrifuge or compartmented rotor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34916694A | 1994-12-02 | 1994-12-02 | |
| PCT/US1995/015667 WO1996016713A1 (en) | 1994-12-02 | 1995-12-01 | Centrifuge reagent delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972492D0 NO972492D0 (no) | 1997-05-30 |
| NO972492L NO972492L (no) | 1997-07-30 |
| NO320555B1 true NO320555B1 (no) | 2005-12-19 |
Family
ID=23371175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19972492A NO320555B1 (no) | 1994-12-02 | 1997-05-30 | Fremgangsmate og innretning for a separere en komponent fra plasma. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US5830352A (pt) |
| EP (1) | EP0794823A4 (pt) |
| JP (1) | JPH10510810A (pt) |
| CN (1) | CN1174515A (pt) |
| AU (1) | AU695602B2 (pt) |
| BR (1) | BR9509860A (pt) |
| CA (1) | CA2206516C (pt) |
| CZ (1) | CZ164697A3 (pt) |
| FI (1) | FI972338A (pt) |
| HU (1) | HUT77810A (pt) |
| NO (1) | NO320555B1 (pt) |
| NZ (1) | NZ298283A (pt) |
| PL (1) | PL320512A1 (pt) |
| WO (1) | WO1996016713A1 (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ336396A (en) * | 1997-01-08 | 2000-12-22 | Bristol Myers Squibb Co | Apparatus for preparing blood or plasma component solutions of known concentration |
| US6846298B1 (en) * | 1997-07-25 | 2005-01-25 | Bristol-Myers Squibb Company | Blood product delivery system |
| WO1999029338A1 (en) * | 1997-12-09 | 1999-06-17 | Bristol-Myers Squibb Company | Fibrinolytic inhibitor for sealant |
| US6393369B1 (en) * | 1999-04-30 | 2002-05-21 | Bristol-Myers Squibb Company | System for control of blood processor |
| JP3253290B2 (ja) * | 1999-10-29 | 2002-02-04 | 照明 伊藤 | 検体処理システム |
| PT1289618E (pt) * | 2000-04-28 | 2008-04-11 | Harvest Technologies Corp | Disco separador de componentes do sangue |
| US6605028B2 (en) | 2001-04-09 | 2003-08-12 | Medtronic, Inc. | Blood centrifuge having integral heating to control cellular component temperature |
| US6790371B2 (en) * | 2001-04-09 | 2004-09-14 | Medtronic, Inc. | System and method for automated separation of blood components |
| US6835316B2 (en) | 2001-04-09 | 2004-12-28 | Medtronic, Inc. | Clam shell blood reservoir holder with index line |
| US6589155B2 (en) | 2001-04-09 | 2003-07-08 | Medtronic, Inc. | Miniaturized blood centrifuge having side mounted motor with belt drive |
| US20020144939A1 (en) * | 2001-04-09 | 2002-10-10 | Dolecek Victor D. | Miniaturized blood centrifuge having side mounted motor with belt drive |
| US6612975B2 (en) | 2001-04-09 | 2003-09-02 | Medtronic, Inc. | Blood centrifuge with an enhanced internal drive assembly |
| US6589153B2 (en) | 2001-09-24 | 2003-07-08 | Medtronic, Inc. | Blood centrifuge with exterior mounted, self-balancing collection chambers |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| KR100624458B1 (ko) * | 2005-01-17 | 2006-09-19 | 삼성전자주식회사 | 휴대용 원심분리기 |
| EP1848473B1 (en) * | 2005-02-07 | 2013-05-22 | Hanuman LLC | Plasma concentrator device |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US7771590B2 (en) * | 2005-08-23 | 2010-08-10 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
| US8048297B2 (en) | 2005-08-23 | 2011-11-01 | Biomet Biologics, Llc | Method and apparatus for collecting biological materials |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7666620B2 (en) * | 2006-11-08 | 2010-02-23 | Richard-Allan Scientific Company | Rapid tissue processing system |
| NL1033365C2 (nl) * | 2007-02-09 | 2008-08-12 | Medavinci Dev B V | Inrichting en werkwijze voor scheiden en analyseren van bloed. |
| US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| WO2009111338A1 (en) * | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
| US8158381B2 (en) * | 2008-03-27 | 2012-04-17 | Richard-Allan Scientific Company | Methods for integrated tissue processing and staining |
| US8187475B2 (en) * | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US8870733B2 (en) | 2010-11-19 | 2014-10-28 | Kensey Nash Corporation | Centrifuge |
| US8469871B2 (en) | 2010-11-19 | 2013-06-25 | Kensey Nash Corporation | Centrifuge |
| US8317672B2 (en) | 2010-11-19 | 2012-11-27 | Kensey Nash Corporation | Centrifuge method and apparatus |
| US8394006B2 (en) | 2010-11-19 | 2013-03-12 | Kensey Nash Corporation | Centrifuge |
| US8556794B2 (en) | 2010-11-19 | 2013-10-15 | Kensey Nash Corporation | Centrifuge |
| DE102011077124A1 (de) * | 2011-06-07 | 2012-12-13 | Robert Bosch Gmbh | Kartusche, Zentrifuge sowie Verfahren |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| ES2754326T3 (es) | 2014-01-31 | 2020-04-17 | Dsm Ip Assets Bv | Centrifugadora de tejido adiposo y procedimiento de uso |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3064647A (en) * | 1957-06-13 | 1962-11-20 | Baxter Laboratories Inc | Blood component separation method and apparatus |
| US3078847A (en) * | 1959-05-06 | 1963-02-26 | Baxter Laboratories Inc | Blood handling method and apparatus |
| US3799342A (en) * | 1970-07-27 | 1974-03-26 | Medical Res & Dev Inc | Method of using a serum separator |
| US3911918A (en) * | 1972-04-13 | 1975-10-14 | Ralph D Turner | Blood collection, storage and administering bag |
| US3838809A (en) * | 1973-04-16 | 1974-10-01 | M Williams | Automatic serum preparation station |
| US3932277A (en) * | 1974-03-29 | 1976-01-13 | Bio-Logics Products, Inc. | Method and apparatus for separating blood fractions |
| DE2624373C2 (de) * | 1976-05-31 | 1983-02-03 | Arnold Dr. 8782 Karlstadt Seufert | Verfahren zur Herstellung von steril filtriertem Kryopräzipilat mit einer Anreicherung des Faktors VIII |
| US4086924A (en) * | 1976-10-06 | 1978-05-02 | Haemonetics Corporation | Plasmapheresis apparatus |
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| DE3017707A1 (de) * | 1980-05-08 | 1981-11-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zum nachweis von fibrinmonomer |
| DE3128611C2 (de) * | 1981-07-20 | 1994-07-14 | Hilti Ag | Dosiergerät für Mehrkomponenten-Massen |
| US4735726A (en) * | 1981-07-22 | 1988-04-05 | E. I. Du Pont De Nemours And Company | Plasmapheresis by reciprocatory pulsatile filtration |
| US4729829A (en) * | 1981-07-22 | 1988-03-08 | E. I. Du Pont De Nemours And Company | Hollow fiber plasmapheresis module |
| US4668399A (en) * | 1982-02-16 | 1987-05-26 | E. I. Du Pont De Nemours And Company | Hollow fiber plasmapheresis process |
| US4596657A (en) * | 1982-06-04 | 1986-06-24 | Miles Laboratories, Inc. | Blood bag system with integral filtering means |
| DE3234250A1 (de) * | 1982-09-15 | 1984-03-15 | Hilti AG, 9494 Schaan | Handgeraet zum abgeben von mehrkomponenten-massen |
| US4530691A (en) * | 1983-12-13 | 1985-07-23 | Baxter Travenol Laboratories, Inc. | Centrifuge with movable mandrel |
| US4729529A (en) * | 1985-12-19 | 1988-03-08 | Pneumo Corporation | Landing gear mechanism including bypass valve assembly for reducing damping loads during taxiing |
| GB8602732D0 (en) * | 1986-02-04 | 1986-03-12 | Univ Brunel | Taking samples from patients |
| US4666429A (en) * | 1986-02-26 | 1987-05-19 | Intelligent Medicine, Inc. | Infusion device having improved valving apparatus |
| US4810378A (en) * | 1986-04-21 | 1989-03-07 | Miles Laboratories, Inc. | Red blood cell filtering system |
| IT1192015B (it) * | 1986-06-27 | 1988-03-31 | Tecnocar Spa | Filtro per lubrificanti di motori a combustione interna con riserva di additivi |
| US4944883A (en) * | 1987-01-13 | 1990-07-31 | Schoendorfer Donald W | Continuous centrifugation system and method for directly deriving intermediate density material from a suspension |
| US4767396A (en) * | 1987-03-03 | 1988-08-30 | Haemonetics Corporation | Method and apparatus for processing biological fluids |
| US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
| US4795441A (en) * | 1987-04-16 | 1989-01-03 | Bhatt Kunjlata M | Medication administration system |
| DE3723517A1 (de) * | 1987-07-16 | 1989-01-26 | Licentia Gmbh | Handgefuehrtes, motorisch angetriebenes elektrowerkzeug |
| US4818386A (en) * | 1987-10-08 | 1989-04-04 | Becton, Dickinson And Company | Device for separating the components of a liquid sample having higher and lower specific gravities |
| SE467713B (sv) * | 1988-07-12 | 1992-08-31 | U & I Engineering Handelsbolag | Foerfarande och anordning foer att i ett i huvudsak konstant floede av en fluid under en kort tidsperiod utmana en doserad volym av naemnda fluid |
| US4902281A (en) * | 1988-08-16 | 1990-02-20 | Corus Medical Corporation | Fibrinogen dispensing kit |
| DE3920694A1 (de) * | 1989-06-24 | 1991-01-10 | Friedhelm Schneider | Dosierpistole fuer zwei komponenten mit dynamischer mischkammer |
| US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
| US5100372A (en) * | 1990-03-02 | 1992-03-31 | Haemonetics Corporation | Core for blood processing apparatus |
| US5102407A (en) * | 1990-03-13 | 1992-04-07 | Miles Inc. | Blood separation system |
| DK119490D0 (da) * | 1990-05-14 | 1990-05-14 | Unes As | Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion |
| US5061381A (en) * | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
| EP0532591A4 (en) * | 1990-06-04 | 1993-07-21 | Abaxis, Inc. | Analytical rotors and methods for analysis of biological fluids |
| US5137181A (en) * | 1990-07-18 | 1992-08-11 | Wilhelm A. Keller | Manually operated appliance, in particular for a double dispensing cartridge for two-component substances |
| IT1246530B (it) * | 1991-03-29 | 1994-11-24 | Miramed Spa | Metodo e corredo pre-assemblato per l'ottenimento di colla di fibrina in ambiente completamente sterile. |
| US5304348A (en) * | 1992-02-11 | 1994-04-19 | Abaxis, Inc. | Reagent container for analytical rotor |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| ZA948564B (en) | 1993-11-19 | 1995-07-26 | Bristol Myers Squibb Co | Liquid separation apparatus and method |
-
1995
- 1995-12-01 CZ CZ971646A patent/CZ164697A3/cs unknown
- 1995-12-01 PL PL32051295A patent/PL320512A1/xx unknown
- 1995-12-01 JP JP51910896A patent/JPH10510810A/ja not_active Ceased
- 1995-12-01 CA CA002206516A patent/CA2206516C/en not_active Expired - Fee Related
- 1995-12-01 NZ NZ29828395A patent/NZ298283A/xx unknown
- 1995-12-01 US US08/566,195 patent/US5830352A/en not_active Expired - Fee Related
- 1995-12-01 BR BR9509860A patent/BR9509860A/pt not_active Application Discontinuation
- 1995-12-01 HU HU9801003A patent/HUT77810A/hu unknown
- 1995-12-01 EP EP95942532A patent/EP0794823A4/en not_active Withdrawn
- 1995-12-01 WO PCT/US1995/015667 patent/WO1996016713A1/en not_active Application Discontinuation
- 1995-12-01 CN CN95197450A patent/CN1174515A/zh active Pending
- 1995-12-01 AU AU43729/96A patent/AU695602B2/en not_active Ceased
-
1997
- 1997-05-30 NO NO19972492A patent/NO320555B1/no unknown
- 1997-06-02 FI FI972338A patent/FI972338A/fi not_active Application Discontinuation
- 1997-11-06 US US08/965,430 patent/US5935432A/en not_active Expired - Fee Related
- 1997-11-06 US US08/965,216 patent/US5958253A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ164697A3 (cs) | 1998-03-18 |
| BR9509860A (pt) | 1997-09-30 |
| NO972492D0 (no) | 1997-05-30 |
| FI972338A (fi) | 1997-08-01 |
| CA2206516C (en) | 2007-04-17 |
| CN1174515A (zh) | 1998-02-25 |
| FI972338A0 (fi) | 1997-06-02 |
| US5935432A (en) | 1999-08-10 |
| JPH10510810A (ja) | 1998-10-20 |
| US5958253A (en) | 1999-09-28 |
| US5830352A (en) | 1998-11-03 |
| AU4372996A (en) | 1996-06-19 |
| AU695602B2 (en) | 1998-08-20 |
| NO972492L (no) | 1997-07-30 |
| NZ298283A (en) | 1999-01-28 |
| CA2206516A1 (en) | 1996-06-06 |
| HUT77810A (hu) | 1998-08-28 |
| EP0794823A4 (en) | 1998-12-30 |
| PL320512A1 (en) | 1997-10-13 |
| MX9704016A (es) | 1998-05-31 |
| EP0794823A1 (en) | 1997-09-17 |
| WO1996016713A1 (en) | 1996-06-06 |
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