NO319698B1 - Hestearteritt-virus peptid eller peptidkonjugat omfattende en eller flere epitoper i stand til a fremkalle en immunrespons i dyr - Google Patents
Hestearteritt-virus peptid eller peptidkonjugat omfattende en eller flere epitoper i stand til a fremkalle en immunrespons i dyr Download PDFInfo
- Publication number
- NO319698B1 NO319698B1 NO19962927A NO962927A NO319698B1 NO 319698 B1 NO319698 B1 NO 319698B1 NO 19962927 A NO19962927 A NO 19962927A NO 962927 A NO962927 A NO 962927A NO 319698 B1 NO319698 B1 NO 319698B1
- Authority
- NO
- Norway
- Prior art keywords
- peptide
- stated
- protein
- seq
- acid sequence
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 57
- 239000000863 peptide conjugate Substances 0.000 title claims description 39
- 241001465754 Metazoa Species 0.000 title claims description 10
- 230000028993 immune response Effects 0.000 title claims description 8
- 241000283073 Equus caballus Species 0.000 title description 11
- 241000700605 Viruses Species 0.000 title description 7
- 210000001367 artery Anatomy 0.000 title 1
- 241000710803 Equine arteritis virus Species 0.000 claims description 58
- 150000001413 amino acids Chemical group 0.000 claims description 34
- 102000004169 proteins and genes Human genes 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 238000002965 ELISA Methods 0.000 claims description 19
- 230000003472 neutralizing effect Effects 0.000 claims description 15
- 238000004458 analytical method Methods 0.000 claims description 10
- 239000011230 binding agent Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000013612 plasmid Substances 0.000 claims description 9
- 229960005486 vaccine Drugs 0.000 claims description 9
- 108020004511 Recombinant DNA Proteins 0.000 claims description 8
- 108020004414 DNA Proteins 0.000 claims description 7
- 102000005720 Glutathione transferase Human genes 0.000 claims description 7
- 108010070675 Glutathione transferase Proteins 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 5
- 239000000032 diagnostic agent Substances 0.000 claims description 5
- 229940039227 diagnostic agent Drugs 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 230000009870 specific binding Effects 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000010998 test method Methods 0.000 claims 2
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000000562 conjugate Substances 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 102000004196 processed proteins & peptides Human genes 0.000 description 13
- 238000012360 testing method Methods 0.000 description 11
- 230000010530 Virus Neutralization Effects 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 8
- 241000283086 Equidae Species 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 102000037865 fusion proteins Human genes 0.000 description 5
- 108020001507 fusion proteins Proteins 0.000 description 5
- 238000009395 breeding Methods 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- RIIWUGSYXOBDMC-UHFFFAOYSA-N benzene-1,2-diamine;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=CC=C1N RIIWUGSYXOBDMC-UHFFFAOYSA-N 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 125000006853 reporter group Chemical group 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 206010003230 arteritis Diseases 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- 208000031973 Conjunctivitis infective Diseases 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 101710126256 Hydrolase in agr operon Proteins 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 241000711517 Torovirus Species 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 201000001028 acute contagious conjunctivitis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000007981 phosphate-citrate buffer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9400656A GB9400656D0 (en) | 1994-01-14 | 1994-01-14 | The Vaccine and diagnostic test kit |
| PCT/GB1995/000066 WO1995019438A1 (fr) | 1994-01-14 | 1995-01-13 | Peptides de virus de l'arterite equine, anticorps contre ces peptides et leur utilisation dans des tests diagnostiques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962927L NO962927L (no) | 1996-07-12 |
| NO962927D0 NO962927D0 (no) | 1996-07-12 |
| NO319698B1 true NO319698B1 (no) | 2005-09-05 |
Family
ID=10748801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19962927A NO319698B1 (no) | 1994-01-14 | 1996-07-12 | Hestearteritt-virus peptid eller peptidkonjugat omfattende en eller flere epitoper i stand til a fremkalle en immunrespons i dyr |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5773235A (fr) |
| EP (1) | EP0811067B1 (fr) |
| JP (1) | JP3662927B2 (fr) |
| AT (1) | ATE234358T1 (fr) |
| AU (1) | AU692213B2 (fr) |
| BR (1) | BR9506512A (fr) |
| CA (1) | CA2181159A1 (fr) |
| DE (1) | DE69529920T2 (fr) |
| DK (1) | DK0811067T3 (fr) |
| ES (1) | ES2194900T3 (fr) |
| GB (2) | GB9400656D0 (fr) |
| NO (1) | NO319698B1 (fr) |
| NZ (1) | NZ278430A (fr) |
| PT (1) | PT811067E (fr) |
| WO (1) | WO1995019438A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9512464D0 (en) * | 1995-06-20 | 1995-08-23 | Animal Health Trust | Diagnostic test for equine arteritis virus mediated disease |
| NL1003579C2 (nl) * | 1996-07-12 | 1998-01-15 | Univ Leiden | Recombinant DNA-vector. |
| ATE373675T1 (de) * | 2002-01-30 | 2007-10-15 | Giese Matthias Dr | Impfstoff gegen pferdearteritisvirus |
| US20050070700A1 (en) * | 2003-09-30 | 2005-03-31 | Matthias Giese | Equine arteritis virus vaccine |
| WO2009008924A2 (fr) | 2007-04-05 | 2009-01-15 | Mount Sinai School Of Medicine Of New York University | Procédés permettant de prévenir et de traiter les infections virales en inhibant l'activité de suppression de l'isg des protéines virales contenant le domaine otu |
-
1994
- 1994-01-14 GB GB9400656A patent/GB9400656D0/en active Pending
-
1995
- 1995-01-13 JP JP51891495A patent/JP3662927B2/ja not_active Expired - Fee Related
- 1995-01-13 AU AU13907/95A patent/AU692213B2/en not_active Ceased
- 1995-01-13 NZ NZ278430A patent/NZ278430A/en unknown
- 1995-01-13 WO PCT/GB1995/000066 patent/WO1995019438A1/fr active IP Right Grant
- 1995-01-13 BR BR9506512A patent/BR9506512A/pt not_active Application Discontinuation
- 1995-01-13 ES ES95905212T patent/ES2194900T3/es not_active Expired - Lifetime
- 1995-01-13 US US08/676,169 patent/US5773235A/en not_active Expired - Fee Related
- 1995-01-13 DK DK95905212T patent/DK0811067T3/da active
- 1995-01-13 GB GB9614219A patent/GB2299994B/en not_active Revoked
- 1995-01-13 DE DE69529920T patent/DE69529920T2/de not_active Expired - Fee Related
- 1995-01-13 PT PT95905212T patent/PT811067E/pt unknown
- 1995-01-13 AT AT95905212T patent/ATE234358T1/de not_active IP Right Cessation
- 1995-01-13 CA CA002181159A patent/CA2181159A1/fr not_active Abandoned
- 1995-01-13 EP EP95905212A patent/EP0811067B1/fr not_active Expired - Lifetime
-
1996
- 1996-07-12 NO NO19962927A patent/NO319698B1/no unknown
-
1998
- 1998-04-21 US US09/063,431 patent/US6342222B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69529920T2 (de) | 2004-01-15 |
| EP0811067B1 (fr) | 2003-03-12 |
| NO962927L (no) | 1996-07-12 |
| JP3662927B2 (ja) | 2005-06-22 |
| DK0811067T3 (da) | 2003-07-07 |
| GB2299994A (en) | 1996-10-23 |
| ES2194900T3 (es) | 2003-12-01 |
| BR9506512A (pt) | 1997-09-09 |
| AU692213B2 (en) | 1998-06-04 |
| GB9614219D0 (en) | 1996-09-04 |
| CA2181159A1 (fr) | 1995-07-20 |
| NZ278430A (en) | 1997-04-24 |
| ATE234358T1 (de) | 2003-03-15 |
| DE69529920D1 (de) | 2003-04-17 |
| US6342222B1 (en) | 2002-01-29 |
| WO1995019438A1 (fr) | 1995-07-20 |
| NO962927D0 (no) | 1996-07-12 |
| AU1390795A (en) | 1995-08-01 |
| PT811067E (pt) | 2003-08-29 |
| JPH09508014A (ja) | 1997-08-19 |
| GB9400656D0 (en) | 1994-03-09 |
| EP0811067A1 (fr) | 1997-12-10 |
| US5773235A (en) | 1998-06-30 |
| GB2299994B (en) | 1998-04-29 |
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