NO317485B1 - Fremgangsmate for fremstilling av ZME-018 gelonin immunokonjugat for behandling av melanom - Google Patents
Fremgangsmate for fremstilling av ZME-018 gelonin immunokonjugat for behandling av melanom Download PDFInfo
- Publication number
- NO317485B1 NO317485B1 NO19924025A NO924025A NO317485B1 NO 317485 B1 NO317485 B1 NO 317485B1 NO 19924025 A NO19924025 A NO 19924025A NO 924025 A NO924025 A NO 924025A NO 317485 B1 NO317485 B1 NO 317485B1
- Authority
- NO
- Norway
- Prior art keywords
- zme
- melanoma
- preparation
- treatment
- gelonin
- Prior art date
Links
- 201000001441 melanoma Diseases 0.000 title claims abstract 4
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 title claims 2
- 229940127121 immunoconjugate Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title 1
- 101710160107 Outer membrane protein A Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
- A61K47/6823—Double chain ricin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51092390A | 1990-04-19 | 1990-04-19 | |
PCT/US1991/002696 WO1991016071A1 (en) | 1990-04-19 | 1991-04-19 | Antibody conjugates for treatment of neoplastic disease |
Publications (3)
Publication Number | Publication Date |
---|---|
NO924025L NO924025L (no) | 1992-10-16 |
NO924025D0 NO924025D0 (no) | 1992-10-16 |
NO317485B1 true NO317485B1 (no) | 2004-11-08 |
Family
ID=24032743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19924025A NO317485B1 (no) | 1990-04-19 | 1992-10-16 | Fremgangsmate for fremstilling av ZME-018 gelonin immunokonjugat for behandling av melanom |
Country Status (23)
Country | Link |
---|---|
US (1) | US20050214307A1 (da) |
EP (1) | EP0525119B1 (da) |
JP (1) | JP3340127B2 (da) |
KR (1) | KR100212372B1 (da) |
CN (1) | CN1071579C (da) |
AT (1) | ATE164078T1 (da) |
AU (1) | AU650267B2 (da) |
CA (1) | CA2079902C (da) |
DE (1) | DE69129109T2 (da) |
DK (1) | DK0525119T3 (da) |
ES (1) | ES2113376T3 (da) |
FI (1) | FI104234B1 (da) |
HK (1) | HK1008418A1 (da) |
IE (1) | IE62496B1 (da) |
IL (1) | IL97776A (da) |
NO (1) | NO317485B1 (da) |
NZ (1) | NZ237688A (da) |
PT (1) | PT97423B (da) |
RU (1) | RU2119352C1 (da) |
SA (1) | SA91120208B1 (da) |
TW (1) | TW211573B (da) |
WO (1) | WO1991016071A1 (da) |
ZA (1) | ZA912490B (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
US6787153B1 (en) | 1991-06-28 | 2004-09-07 | Mitsubishi Chemical Corporation | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
US5632982A (en) * | 1994-06-07 | 1997-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Cytotoxic enhancement of TNF with copper |
ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
JP2004535202A (ja) | 2001-07-17 | 2004-11-25 | リサーチ ディベロップメント ファンデーション | アポトーシス促進性蛋白質を含む治療剤 |
EP1572170A4 (en) * | 2002-06-12 | 2007-02-28 | Res Dev Foundation | IMMUNOTOXIN AS THERAPEUTIC AGENT AND USES THEREOF |
US20060057145A1 (en) * | 2002-10-25 | 2006-03-16 | Government Of The United States Of America As Represented By The Secretary, Dept. Of Health | Methods to prevent tumor recurrence by blockade of tgf-beta |
EP1855724A2 (en) * | 2005-02-01 | 2007-11-21 | Research Development Foundation | Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders |
CA2598090A1 (en) * | 2005-02-17 | 2006-08-24 | The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services | Synergistic effect of tgf-beta blockade and immunogenic agents on tumors |
WO2007109193A2 (en) * | 2006-03-16 | 2007-09-27 | Health Research Inc. | Inhibition of breast carcinoma stem cell growth and metastasis |
EP2844300B1 (en) | 2012-05-01 | 2018-10-17 | Genentech, Inc. | Anti-pmel17 antibodies and immunoconjugates |
CN105377307B (zh) | 2013-06-24 | 2019-09-24 | Abl生物公司 | 具有改进的稳定性的抗体-药物缀合物及其用途 |
BR112017015582A2 (pt) * | 2015-01-23 | 2018-03-13 | Helix Biopharma Corp | conjugados de anticorpo-urease para propósitos terapêuticos |
CN111278978B (zh) | 2017-09-08 | 2023-08-18 | 新实有限公司 | 使细菌能够通过葡萄糖依赖性生存力特异性靶向实体肿瘤的核酸系统 |
CN110455903A (zh) * | 2018-05-07 | 2019-11-15 | 天士力生物医药股份有限公司 | 一种注射用重组人尿激酶原杂质分析的梯度电泳检测方法 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4263279A (en) * | 1975-08-19 | 1981-04-21 | Yeda Research & Development Co. Ltd | Pharmaceutically active compositions containing adriamycin and daunomycin |
FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
US4522918A (en) * | 1981-12-15 | 1985-06-11 | Jeffery Schlom | Process for producing monoclonal antibodies reactive with human breast cancer |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
FR2546756B1 (fr) * | 1983-06-03 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux derives immunostimulants, leur preparation et leur application comme medicament |
US4894443A (en) * | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
US4753894A (en) * | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
FR2566271B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
US4650674A (en) * | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
US4590071A (en) * | 1984-09-25 | 1986-05-20 | Xoma Corporation | Human melanoma specific immunotoxins |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
US5032521A (en) * | 1984-12-05 | 1991-07-16 | The Salk Institute For Biological Studies | Monoclonal antibody specific for a mammary tumor cell surface antigen |
US4888415A (en) * | 1985-03-04 | 1989-12-19 | Dana-Farber Cancer Institute, Inc. | Gelonin immunotoxin |
US6084073A (en) * | 1985-03-25 | 2000-07-04 | Chiron Corporation | Recombinant ricin toxin |
US4870163A (en) * | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US4962188A (en) * | 1985-12-06 | 1990-10-09 | Cetus Corporation | Recombinant ricin toxin A chain conjugates |
US4831122A (en) * | 1986-01-09 | 1989-05-16 | Regents Of The University Of Minnesota | Radioimmunotoxins |
US4894227A (en) * | 1986-08-01 | 1990-01-16 | Cetus Corporation | Composition of immunotoxins with interleukin-2 |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4771128A (en) * | 1986-10-10 | 1988-09-13 | Cetus Corporation | Method of purifying toxin conjugates using hydrophobic interaction chromatography |
US5019368A (en) * | 1989-02-23 | 1991-05-28 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
US4963354A (en) * | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
US4863726A (en) * | 1987-05-29 | 1989-09-05 | Cetus Corporation | Combination therapy using immunotoxins with interleukin-2 |
US5017371A (en) * | 1988-01-06 | 1991-05-21 | Amarillo Cell Culture Company, Incorporated | Method for reducing side effects of cancer therapy |
WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
IE62463B1 (en) * | 1988-07-07 | 1995-02-08 | Res Dev Foundation | Immunoconjugates for cancer diagnosis and therapy |
US5134075A (en) * | 1989-02-17 | 1992-07-28 | Oncogen Limited Partnership | Monoclonal antibody to novel antigen associated with human tumors |
IE63847B1 (en) * | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
US6750329B1 (en) * | 1989-05-05 | 2004-06-15 | Research Development Foundation | Antibody delivery system for biological response modifiers |
US6306626B1 (en) * | 1990-04-27 | 2001-10-23 | Research Development Foundation | Anti-IgM monoclonal antibodies and methods of their use |
IE912716A1 (en) * | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
US6099842A (en) * | 1990-12-03 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin |
CA2074825C (en) * | 1990-12-14 | 2005-04-12 | Daniel J. Capon | Chimeric chains for receptor-associated signal transduction pathways |
US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US6599505B1 (en) * | 1992-04-10 | 2003-07-29 | Research Development Foundation | Immunotoxins directed against CD33 related surface antigens |
IL112372A (en) * | 1994-02-07 | 2001-08-26 | Res Dev Foundation | Non-viral vector for the delivery of genetic information to cells |
US5513296A (en) * | 1994-06-08 | 1996-04-30 | Holmes Products Corp. | Air heater with angled PTC heaters producing diverging heated airflow |
AU3548799A (en) * | 1998-04-03 | 1999-10-25 | Invitrogen Corporation | Libraries of expressible gene sequences |
WO2001080880A2 (de) * | 2000-04-22 | 2001-11-01 | Stefan Barth | Apoptotika |
ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
JP2004535202A (ja) * | 2001-07-17 | 2004-11-25 | リサーチ ディベロップメント ファンデーション | アポトーシス促進性蛋白質を含む治療剤 |
EP1572170A4 (en) * | 2002-06-12 | 2007-02-28 | Res Dev Foundation | IMMUNOTOXIN AS THERAPEUTIC AGENT AND USES THEREOF |
-
1991
- 1991-04-04 IL IL9777691A patent/IL97776A/xx not_active IP Right Cessation
- 1991-04-04 ZA ZA912490A patent/ZA912490B/xx unknown
- 1991-04-04 NZ NZ237688A patent/NZ237688A/xx unknown
- 1991-04-04 IE IE112291A patent/IE62496B1/en not_active IP Right Cessation
- 1991-04-12 TW TW080102833A patent/TW211573B/zh active
- 1991-04-19 JP JP50922891A patent/JP3340127B2/ja not_active Expired - Fee Related
- 1991-04-19 ES ES91909732T patent/ES2113376T3/es not_active Expired - Lifetime
- 1991-04-19 CA CA002079902A patent/CA2079902C/en not_active Expired - Fee Related
- 1991-04-19 PT PT97423A patent/PT97423B/pt not_active IP Right Cessation
- 1991-04-19 KR KR1019920702569A patent/KR100212372B1/ko not_active IP Right Cessation
- 1991-04-19 CN CN91102606A patent/CN1071579C/zh not_active Expired - Fee Related
- 1991-04-19 DE DE69129109T patent/DE69129109T2/de not_active Expired - Fee Related
- 1991-04-19 AU AU78922/91A patent/AU650267B2/en not_active Ceased
- 1991-04-19 DK DK91909732T patent/DK0525119T3/da active
- 1991-04-19 EP EP91909732A patent/EP0525119B1/en not_active Expired - Lifetime
- 1991-04-19 AT AT91909732T patent/ATE164078T1/de not_active IP Right Cessation
- 1991-04-19 WO PCT/US1991/002696 patent/WO1991016071A1/en active IP Right Grant
- 1991-04-19 RU RU92016354A patent/RU2119352C1/ru not_active IP Right Cessation
- 1991-10-23 SA SA91120208A patent/SA91120208B1/ar unknown
-
1992
- 1992-10-12 FI FI924605A patent/FI104234B1/fi not_active IP Right Cessation
- 1992-10-16 NO NO19924025A patent/NO317485B1/no unknown
-
1998
- 1998-07-14 HK HK98109132A patent/HK1008418A1/xx not_active IP Right Cessation
-
2004
- 2004-08-26 US US10/926,731 patent/US20050214307A1/en not_active Abandoned
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