FI924605A - Antikroppkonjugater foer behandling av neoplastiska sjukdomar - Google Patents

Antikroppkonjugater foer behandling av neoplastiska sjukdomar Download PDF

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Publication number
FI924605A
FI924605A FI924605A FI924605A FI924605A FI 924605 A FI924605 A FI 924605A FI 924605 A FI924605 A FI 924605A FI 924605 A FI924605 A FI 924605A FI 924605 A FI924605 A FI 924605A
Authority
FI
Finland
Prior art keywords
neoplastiska
antikropponjugater
sjukdomar
foer behandling
zme
Prior art date
Application number
FI924605A
Other languages
English (en)
Other versions
FI924605A0 (fi
FI104234B (fi
FI104234B1 (fi
Inventor
Michael G Rosenblum
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of FI924605A0 publication Critical patent/FI924605A0/fi
Publication of FI924605A publication Critical patent/FI924605A/fi
Application granted granted Critical
Publication of FI104234B publication Critical patent/FI104234B/fi
Publication of FI104234B1 publication Critical patent/FI104234B1/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
    • A61K47/6823—Double chain ricin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI924605A 1990-04-19 1992-10-12 Menetelmä vasta-ainekonjugaattien valmistamiseksi neoplastisten sairauksien hoitoon FI104234B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51092390A 1990-04-19 1990-04-19
US51092390 1990-04-19
US9102696 1991-04-19
PCT/US1991/002696 WO1991016071A1 (en) 1990-04-19 1991-04-19 Antibody conjugates for treatment of neoplastic disease

Publications (4)

Publication Number Publication Date
FI924605A0 FI924605A0 (fi) 1992-10-12
FI924605A true FI924605A (fi) 1992-10-12
FI104234B FI104234B (fi) 1999-12-15
FI104234B1 FI104234B1 (fi) 1999-12-15

Family

ID=24032743

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924605A FI104234B1 (fi) 1990-04-19 1992-10-12 Menetelmä vasta-ainekonjugaattien valmistamiseksi neoplastisten sairauksien hoitoon

Country Status (23)

Country Link
US (1) US20050214307A1 (fi)
EP (1) EP0525119B1 (fi)
JP (1) JP3340127B2 (fi)
KR (1) KR100212372B1 (fi)
CN (1) CN1071579C (fi)
AT (1) ATE164078T1 (fi)
AU (1) AU650267B2 (fi)
CA (1) CA2079902C (fi)
DE (1) DE69129109T2 (fi)
DK (1) DK0525119T3 (fi)
ES (1) ES2113376T3 (fi)
FI (1) FI104234B1 (fi)
HK (1) HK1008418A1 (fi)
IE (1) IE62496B1 (fi)
IL (1) IL97776A (fi)
NO (1) NO317485B1 (fi)
NZ (1) NZ237688A (fi)
PT (1) PT97423B (fi)
RU (1) RU2119352C1 (fi)
SA (1) SA91120208B1 (fi)
TW (1) TW211573B (fi)
WO (1) WO1991016071A1 (fi)
ZA (1) ZA912490B (fi)

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US5632982A (en) * 1994-06-07 1997-05-27 The Board Of Trustees Of The Leland Stanford Junior University Cytotoxic enhancement of TNF with copper
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2004535202A (ja) * 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
WO2003105761A2 (en) * 2002-06-12 2003-12-24 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
EP1556071B1 (en) * 2002-10-25 2011-01-19 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods to prevent tumor recurrence by blockade of tgf-beta
CA2595904A1 (en) * 2005-02-01 2006-08-10 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
CA2598090A1 (en) * 2005-02-17 2006-08-24 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services Synergistic effect of tgf-beta blockade and immunogenic agents on tumors
WO2007109193A2 (en) * 2006-03-16 2007-09-27 Health Research Inc. Inhibition of breast carcinoma stem cell growth and metastasis
RU2014148162A (ru) 2012-05-01 2016-06-20 Дженентек, Инк. Анти-pmel17 антитела и их иммуноконъюгаты
RU2670748C9 (ru) * 2013-06-24 2018-12-13 Аблбио Конъюгаты антител с лекарственными агентами, обладающие улучшенной стабильностью, и их применение
BR112017015582A2 (pt) * 2015-01-23 2018-03-13 Helix Biopharma Corp conjugados de anticorpo-urease para propósitos terapêuticos
US11458172B2 (en) 2017-09-08 2022-10-04 New Portal Limited Nucleic acid systems that enable bacteria to specifically target solid tumors via glucose-dependent viability
CN110455903A (zh) * 2018-05-07 2019-11-15 天士力生物医药股份有限公司 一种注射用重组人尿激酶原杂质分析的梯度电泳检测方法

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Also Published As

Publication number Publication date
ATE164078T1 (de) 1998-04-15
DE69129109T2 (de) 1998-07-02
SA91120208B1 (ar) 2006-03-01
NO924025L (no) 1992-10-16
RU2119352C1 (ru) 1998-09-27
WO1991016071A1 (en) 1991-10-31
FI924605A0 (fi) 1992-10-12
IL97776A (en) 2000-10-31
FI104234B (fi) 1999-12-15
NZ237688A (en) 1993-01-27
DK0525119T3 (da) 1998-11-23
NO924025D0 (no) 1992-10-16
IE911122A1 (en) 1991-10-23
TW211573B (fi) 1993-08-21
PT97423B (pt) 1998-10-30
CN1071579C (zh) 2001-09-26
KR930700140A (ko) 1993-03-13
ZA912490B (en) 1992-12-30
KR100212372B1 (ko) 1999-08-02
CA2079902A1 (en) 1991-10-20
AU650267B2 (en) 1994-06-16
JPH06502617A (ja) 1994-03-24
DE69129109D1 (de) 1998-04-23
NO317485B1 (no) 2004-11-08
EP0525119B1 (en) 1998-03-18
IE62496B1 (en) 1995-02-08
JP3340127B2 (ja) 2002-11-05
CN1055879A (zh) 1991-11-06
ES2113376T3 (es) 1998-05-01
IL97776A0 (en) 1992-06-21
US20050214307A1 (en) 2005-09-29
AU7892291A (en) 1991-11-11
EP0525119A1 (en) 1993-02-03
CA2079902C (en) 2001-08-28
FI104234B1 (fi) 1999-12-15
PT97423A (pt) 1992-01-31
EP0525119A4 (en) 1993-09-15
HK1008418A1 (en) 1999-05-07

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