NO315517B1 - Polypeptid som er i stand til a gjenkjenne og selektivt binde humant FSH, DNA som koder for dette, rekombinant ekspresjonsvektor inneholdende dette DNA, celle transfektert med ekspresjonsvektoren, fremgangsmate for fremstilling av polypeptidet, farmasoyti - Google Patents
Polypeptid som er i stand til a gjenkjenne og selektivt binde humant FSH, DNA som koder for dette, rekombinant ekspresjonsvektor inneholdende dette DNA, celle transfektert med ekspresjonsvektoren, fremgangsmate for fremstilling av polypeptidet, farmasoyti Download PDFInfo
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- NO315517B1 NO315517B1 NO19933272A NO933272A NO315517B1 NO 315517 B1 NO315517 B1 NO 315517B1 NO 19933272 A NO19933272 A NO 19933272A NO 933272 A NO933272 A NO 933272A NO 315517 B1 NO315517 B1 NO 315517B1
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- fsh
- receptor
- polypeptide
- fragment
- mutant
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- 239000006193 liquid solution Substances 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002790 naphthalenes Chemical class 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 101150091879 neo gene Proteins 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 238000013492 plasmid preparation Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000006259 progesterone secretion Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 239000002342 ribonucleoside Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67008591A | 1991-03-15 | 1991-03-15 | |
| PCT/US1992/000122 WO1992016620A1 (en) | 1991-03-15 | 1992-01-02 | Human follicle stimulating hormone receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO933272L NO933272L (no) | 1993-09-14 |
| NO933272D0 NO933272D0 (no) | 1993-09-14 |
| NO315517B1 true NO315517B1 (no) | 2003-09-15 |
Family
ID=24688922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19933272A NO315517B1 (no) | 1991-03-15 | 1993-09-14 | Polypeptid som er i stand til a gjenkjenne og selektivt binde humant FSH, DNA som koder for dette, rekombinant ekspresjonsvektor inneholdende dette DNA, celle transfektert med ekspresjonsvektoren, fremgangsmate for fremstilling av polypeptidet, farmasoyti |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US5744448A (de) |
| EP (2) | EP1167385B1 (de) |
| JP (1) | JP3581148B2 (de) |
| KR (1) | KR100245250B1 (de) |
| AT (2) | ATE224446T1 (de) |
| AU (1) | AU671417B2 (de) |
| CA (1) | CA2106061C (de) |
| DE (2) | DE69233805D1 (de) |
| DK (1) | DK0575357T3 (de) |
| ES (1) | ES2183806T3 (de) |
| FI (1) | FI109360B (de) |
| GE (1) | GEP19991604B (de) |
| LT (1) | LT3973B (de) |
| LV (1) | LV10724B (de) |
| MX (1) | MX9203350A (de) |
| NO (1) | NO315517B1 (de) |
| RU (1) | RU2193599C2 (de) |
| UA (1) | UA43826C2 (de) |
| WO (1) | WO1992016620A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993020199A1 (en) * | 1992-03-30 | 1993-10-14 | Akzo Nobel N.V. | Human gonadotropin receptor (fsh receptor) |
| SI0894141T1 (en) | 1996-02-20 | 2005-10-31 | Applied Research Systems Ars Holding N.V. | Hybrid proteins which form heterodimers |
| CA2250975A1 (en) * | 1996-04-15 | 1997-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble 7-transmembrane domain g-protein-coupled receptor compositions and methods |
| US6521641B1 (en) | 1998-10-08 | 2003-02-18 | Allergan, Inc. | Male anti-fertility agents |
| WO2000073416A1 (en) * | 1999-05-28 | 2000-12-07 | University Of Cincinnati | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
| EP1287135A2 (de) * | 2000-05-18 | 2003-03-05 | Bayer Aktiengesellschaft | Regulation eines menschlichen, follikel-stimulierenden hormon-ähnlichen g-protein gekoppelten rezeptors |
| US20030175889A1 (en) * | 2002-01-23 | 2003-09-18 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated versions of human G protein coupled receptor: FSHR |
| EP1466620A1 (de) * | 2003-04-11 | 2004-10-13 | AXXAM S.r.l. | Modulatoren des Follikel-stimulierenden Hormon-Rezeptors und ihre therapeutische Verwendung |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652450A (en) * | 1984-08-31 | 1987-03-24 | Research Corporation | Bacterial FSH binding inhibitor |
| US4761371A (en) | 1985-02-12 | 1988-08-02 | Genentech, Inc. | Insulin receptor |
| US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
| US4921808A (en) * | 1986-06-25 | 1990-05-01 | The Albany Medical College Of Union University | Method for determining follicle stimulating hormone |
| US4960700A (en) * | 1986-12-24 | 1990-10-02 | Genentech, Inc. | Compositions and methods for the synthesis and assay of a mammalian enkephalinase |
| JPH04505103A (ja) * | 1989-05-05 | 1992-09-10 | ジェネンテク，インコーポレイテッド | 糖タンパク質ホルモン受容体分子 |
| US5155218A (en) * | 1990-05-08 | 1992-10-13 | Neurogenetic Corporation | Dna encoding human 5-ht1d receptors |
-
1992
- 1992-01-02 AU AU12514/92A patent/AU671417B2/en not_active Expired
- 1992-01-02 EP EP01202809A patent/EP1167385B1/de not_active Expired - Lifetime
- 1992-01-02 JP JP50530292A patent/JP3581148B2/ja not_active Expired - Lifetime
- 1992-01-02 CA CA002106061A patent/CA2106061C/en not_active Expired - Lifetime
- 1992-01-02 GE GEAP19921579A patent/GEP19991604B/en unknown
- 1992-01-02 DE DE69233805T patent/DE69233805D1/de not_active Expired - Lifetime
- 1992-01-02 EP EP92904833A patent/EP0575357B1/de not_active Expired - Lifetime
- 1992-01-02 WO PCT/US1992/000122 patent/WO1992016620A1/en active IP Right Grant
- 1992-01-02 ES ES92904833T patent/ES2183806T3/es not_active Expired - Lifetime
- 1992-01-02 DE DE69232779T patent/DE69232779T2/de not_active Expired - Lifetime
- 1992-01-02 RU RU93057956/13A patent/RU2193599C2/ru active
- 1992-01-02 AT AT92904833T patent/ATE224446T1/de not_active IP Right Cessation
- 1992-01-02 DK DK92904833T patent/DK0575357T3/da active
- 1992-01-02 AT AT01202809T patent/ATE505486T1/de not_active IP Right Cessation
- 1992-02-01 UA UA93004376A patent/UA43826C2/uk unknown
- 1992-06-25 MX MX9203350A patent/MX9203350A/es unknown
-
1993
- 1993-09-14 NO NO19933272A patent/NO315517B1/no not_active IP Right Cessation
- 1993-09-14 FI FI934023A patent/FI109360B/fi active
- 1993-09-15 KR KR1019930702771A patent/KR100245250B1/ko not_active IP Right Cessation
- 1993-10-11 LV LVP-93-1136A patent/LV10724B/en unknown
- 1993-12-20 LT LTIP1631A patent/LT3973B/lt not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/487,886 patent/US5744448A/en not_active Expired - Lifetime
- 1995-06-07 US US08/482,855 patent/US6121016A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,986 patent/US6372711B1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
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| CREP | Change of representative |
Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS |
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| CREP | Change of representative |
Representative=s name: ZACCO NORWAY AS, POSTBOKS 2003 VIKA, 0125 OSLO, NO |
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| MK1K | Patent expired |