NO313934B1 - Skin care agent in the form of an emulsion, process for making said skin care agent, and use thereof - Google Patents
Skin care agent in the form of an emulsion, process for making said skin care agent, and use thereof Download PDFInfo
- Publication number
- NO313934B1 NO313934B1 NO20011327A NO20011327A NO313934B1 NO 313934 B1 NO313934 B1 NO 313934B1 NO 20011327 A NO20011327 A NO 20011327A NO 20011327 A NO20011327 A NO 20011327A NO 313934 B1 NO313934 B1 NO 313934B1
- Authority
- NO
- Norway
- Prior art keywords
- emulsion
- oil
- omega
- fatty acids
- skin care
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title claims description 93
- 238000000034 method Methods 0.000 title claims description 8
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 41
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 38
- 239000006014 omega-3 oil Substances 0.000 claims description 38
- 239000003921 oil Substances 0.000 claims description 23
- 235000019198 oils Nutrition 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 150000002632 lipids Chemical class 0.000 claims description 13
- 235000021323 fish oil Nutrition 0.000 claims description 12
- 239000007762 w/o emulsion Substances 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 235000012716 cod liver oil Nutrition 0.000 claims description 9
- 239000003026 cod liver oil Substances 0.000 claims description 9
- 239000007764 o/w emulsion Substances 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 230000001590 oxidative effect Effects 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- LSTDYDRCKUBPDI-UHFFFAOYSA-N palmityl acetate Chemical compound CCCCCCCCCCCCCCCCOC(C)=O LSTDYDRCKUBPDI-UHFFFAOYSA-N 0.000 claims description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 3
- 235000021314 Palmitic acid Nutrition 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 235000010323 ascorbic acid Nutrition 0.000 claims description 3
- 239000011668 ascorbic acid Substances 0.000 claims description 3
- 229960005070 ascorbic acid Drugs 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
- 235000019438 castor oil Nutrition 0.000 claims description 3
- 229940049297 cetyl acetate Drugs 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 3
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 239000002304 perfume Substances 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 3
- 229960003415 propylparaben Drugs 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- 102000002322 Egg Proteins Human genes 0.000 claims 2
- 108010000912 Egg Proteins Proteins 0.000 claims 2
- 235000019501 Lemon oil Nutrition 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- 235000013345 egg yolk Nutrition 0.000 claims 2
- 210000002969 egg yolk Anatomy 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 239000010501 lemon oil Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 12
- 230000003647 oxidation Effects 0.000 description 12
- 238000007254 oxidation reaction Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 239000002884 skin cream Substances 0.000 description 11
- 239000000194 fatty acid Substances 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 6
- 235000013877 carbamide Nutrition 0.000 description 6
- 239000006071 cream Substances 0.000 description 4
- -1 fatty acid compounds Chemical class 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006388 chemical passivation reaction Methods 0.000 description 1
- 230000008131 children development Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Description
Foreliggende oppfinnelse omhandler et hudpleiemiddel (hudkrem) i form av en emulsjon, hvori emulsjonen emulsjon (III) utgjøres av to andre emulsjoner, emulsjon I og emulsjon II, der emulsjon I er en vann-i-olje-emulsjon uten omega-3-fettsyrer og emulsjon II er en olje-i-vann-emulsjon med omega-3-fettsyrer, og der en del av oljen i emulsjon II ut fjøres av omega-3-fettsyrer som er forhindret fra å oksidere. Videre omhandler oppfinnelsen en fremgangsmåte til å fremstille et slik hudpleiemiddel, samt anvendelse derav. The present invention relates to a skin care agent (skin cream) in the form of an emulsion, in which the emulsion emulsion (III) is made up of two other emulsions, emulsion I and emulsion II, where emulsion I is a water-in-oil emulsion without omega-3 fatty acids and emulsion II is an oil-in-water emulsion with omega-3 fatty acids, and where part of the oil in emulsion II is carried out by omega-3 fatty acids which are prevented from oxidizing. Furthermore, the invention relates to a method for producing such a skin care agent, as well as its use.
I Norge er det lang tradisjon for å anvende torskelevertran som kosttilskudd, spesielt fordi tran er ansett for å være en verdifull vitaminkilde. I den senere tid har man imidlertid i økende grad også blitt oppmerksom på fiskeoljenes viktige rolle som kilde til flerumettede fettsyrer ( Dyrberg et al., Lancet ii, 117- 119, 1978), og fiskeolje anses i dag for å være den beste kilden for de såkalte omega-3-fettsyrene (omega-3; fettsyrer der den siste dobbeltbindingen er plassert ved det tredje siste karbonatomet i karbonkjeden). Forskning har vist at disse fettsyrene reduserer risikoen for å få hjertekarsykdommer og at de har en positiv virkning på barns utvikling. In Norway, there is a long tradition of using cod liver oil as a dietary supplement, especially because cod liver oil is considered to be a valuable source of vitamins. In recent times, however, people have increasingly become aware of the important role of fish oils as a source of polyunsaturated fatty acids (Dyrberg et al., Lancet ii, 117-119, 1978), and fish oil is now considered to be the best source of the so-called omega-3 fatty acids (omega-3; fatty acids where the last double bond is located at the third last carbon atom in the carbon chain). Research has shown that these fatty acids reduce the risk of cardiovascular disease and that they have a positive effect on children's development.
Det har lenge vært kjent at tran har en helbredende virkning på ulike typer av hud-lidelser. Senere tids forskning har vist at det er omega-3-fettsyrene i tranen som bidrar til dette, uten at virkningsmekanismen(e) er kartlagt. I kroppen benyttes omega-3-fettsyrene blant annet til membranoppbygging, og de er kjent for å ha en gunstig virkning på huden samt være betennelseshemmende. It has long been known that cod liver oil has a healing effect on various types of skin disorders. Recent research has shown that it is the omega-3 fatty acids in cod liver oil that contribute to this, without the mechanism(s) of action being mapped. In the body, omega-3 fatty acids are used, among other things, for membrane building, and they are known to have a beneficial effect on the skin and to be anti-inflammatory.
Et problem ved å anvende omega-3-fettsyrer i hudpleiemidler/kremer har imidlertid vært at de ved oksidasjon utvikler en uunngåelig harsk tranlukt, og en slik anvendelse har derfor ikke vært forsøkt i særlig grad. A problem with using omega-3 fatty acids in skin care products/creams has, however, been that they develop an inevitable rancid cod liver odor upon oxidation, and such use has therefore not been attempted to any great extent.
En patentsøknad som imidlertid beskriver anvendelsen av omega-3-fettsyrer i et hudpleiemiddel er NO-A-19980711 som omhandler et hudpleiemiddel som forutset-ter at det er urinstoff (karbamid) til stede i middelet. I følge patentet er hensikten med oppfinnelsen å nyttiggjøre bruken av karbamidet i hudpleiemiddelet. Dette oppnås i følge krav 1 ved at karbamid omslutter fettsyrer og/eller fettsyreforbind-elser på en slik måte at fettet i hudpleiekremen blir gjort tilgjengelig, samtidig som det beskyttes mot oksidasjon. Et slikt produkt er imidlertid, som allerede nevnt, helt avhengig av at det er karbamid til stede i sammensetningen. I tillegg står det i patentsøknad NO-A-19980711 (side 4) at den fremgangsmåten som er beskrevet fører til at bare omlag halvparten av omega-3-fettsyrene omsluttes i en slik blanding med karbamid, noe som trolig betyr at ikke all omega-3-fettsyrene som er til stede er beskyttet fra oksidasjon. A patent application which, however, describes the use of omega-3 fatty acids in a skin care agent is NO-A-19980711 which deals with a skin care agent which requires that urea (urea) is present in the agent. According to the patent, the purpose of the invention is to exploit the use of the carbamide in skin care products. This is achieved according to claim 1 by carbamide enclosing fatty acids and/or fatty acid compounds in such a way that the fat in the skin care cream is made available, while at the same time protecting it from oxidation. However, as already mentioned, such a product is entirely dependent on carbamide being present in the composition. In addition, it is stated in patent application NO-A-19980711 (page 4) that the method described leads to only about half of the omega-3 fatty acids being enclosed in such a mixture with carbamide, which probably means that not all omega- The 3-fatty acids present are protected from oxidation.
Videre beskriver US-patent nr.5,985,177 en multippel emulsjon som kan forhindre oksidering av de oljeløselige forbindelsene i emulsjonen. Nærmere angitt oppnås oksidasjonsinhiberingen ved anvendelse av en leire som skiller vanndråpene i emulsjonen fra hverandre. Leiren hindrer dermed blandingen av den indre og ytre oljefasen og derigjennom beskyttes den indre oljefasen mot oksidasjon. Emulsjonen som beskrives i US 5,985,177 er ikke tilsatt antioksidanter. C. Laugel et al. (1998), International Journal o/ Cosmetic Science, 20, 183- 191 omhandler en multippel emulsjon inneholdende triterpenderivater for stimulering av den totale kollagensyntesen i fibroblaster i huden, og hvor studien omfatter under-søkelser av hvorvidt triterpinderivatene er beskyttet mot oksidasjon i den angitte emulsjonen. Emulsjonen som beskrives av C. Laugel et al.(1998), supra, inneholder ikke fettsyrer, så som for eksempel omega-3-fettsyrer. Furthermore, US patent no. 5,985,177 describes a multiple emulsion which can prevent oxidation of the oil-soluble compounds in the emulsion. In more detail, the oxidation inhibition is achieved by using a clay that separates the water droplets in the emulsion from each other. The clay thus prevents the mixing of the inner and outer oil phase and thereby protects the inner oil phase from oxidation. The emulsion described in US 5,985,177 has no added antioxidants. C. Laugel et al. (1998), International Journal o/ Cosmetic Science, 20, 183-191 deals with a multiple emulsion containing triterpene derivatives for stimulating the total collagen synthesis in fibroblasts in the skin, and where the study includes investigations of whether the triterpene derivatives are protected against oxidation in the indicated the emulsion. The emulsion described by C. Laugel et al. (1998), supra, does not contain fatty acids, such as, for example, omega-3 fatty acids.
I Gallarate et al. (1999), International Journal of Pharmaceutics, 188, 233- 241 beskrives det hvordan man kan unngå oksidativ degradering av vitamin C ved å isolere denne i en indre oljefase i en olje-i-vann-emulsjon. In Gallarate et al. (1999), International Journal of Pharmaceutics, 188, 233-241, it is described how to avoid oxidative degradation of vitamin C by isolating this in an inner oil phase in an oil-in-water emulsion.
I US patent nr. 6,419,900 beskrives en vann-i-olje-i-vann-emulsjon som forhindrer oksidering av angitte bestanddeler ved at disse isoleres i en fase slik at de ikke er tilgjengelige for oksidasjon. In US patent no. 6,419,900, a water-in-oil-in-water emulsion is described which prevents oxidation of specified components by isolating them in a phase so that they are not available for oxidation.
US patent nr. 5,935,588 omfatter også en vann-i-olje-i-vann-trippelemulsjon som beskytter de aktive bestanddelene fra degradering. US Patent No. 5,935,588 also includes a water-in-oil-in-water triple emulsion that protects the active ingredients from degradation.
Det er imidlertid ikke kjent egnede hudpleiemidler inneholdende omega-3-fettsyrer som i tilstrekkelig grad er beskyttet mot oksidasjon. However, there are no known suitable skin care products containing omega-3 fatty acids that are sufficiently protected against oxidation.
Det er derfor en hensikt med den foreliggende oppfinnelsen å tilveiebringe et hudpleiemiddel (hudkrem) som omfatter fettsyrer, spesielt omega-3-fettsyrer, som er beskyttet mot oksidasjon, slik at hudkremen ikke lukter etter påsmøring på huden. Det er videre en hensikt å tilveiebringe en hudkrem med et mye høyere innhold av omega-3-fettsyrer enn det som har vært gjort tidligere, men likevel uten at produktet oksiderer og utvikler en harsk lukt, samt en fremgangsmåte til å fremstille et slikt produkt og anvendelse derav. It is therefore an aim of the present invention to provide a skin care agent (skin cream) which comprises fatty acids, especially omega-3 fatty acids, which are protected against oxidation, so that the skin cream does not smell after being applied to the skin. It is further an aim to provide a skin cream with a much higher content of omega-3 fatty acids than has been done previously, but still without the product oxidizing and developing a rancid smell, as well as a method for producing such a product and application thereof.
Disse hensikter er oppnådd med foreliggende oppfinnelse, kjennetegnet ved det som fremgår av de vedlagte kravene. These purposes have been achieved with the present invention, characterized by what appears in the attached claims.
Foreliggende oppfinnelse omhandler følgelig et hudpleiemiddel (hudkrem) som blant annet omfatter umettede fettsyrer (omega-3-fettsyrer), og som er fremstilt på en slik måte at omega-3-fettsyrene ikke oksiderer, selv ikke etter påsmøring på huden. Dette oppnås ved å blande to emulsjoner der den ene er en vann-i-olje-emulsjon (emulsjon I) uten omega-3-fettsyrer, og den andre er en olje-i-vann-emulsjon (emulsjon II) med omega-3-fettsyrer. Det fremkommer da en ny type emulsjon (emulsjon III) som vil være en vann-i-olje-emulsjon. Uten at virknings-mekanismen er eksperimentelt bevist, og uten å måtte binde seg til en bestemt teori, er det oppfinnerens mening at omega-3-fettsyrene i denne nye emulsjonen The present invention therefore relates to a skin care agent (skin cream) which, among other things, comprises unsaturated fatty acids (omega-3 fatty acids), and which is produced in such a way that the omega-3 fatty acids do not oxidize, even after application to the skin. This is achieved by mixing two emulsions where one is a water-in-oil emulsion (emulsion I) without omega-3 fatty acids, and the other is an oil-in-water emulsion (emulsion II) with omega-3 - fatty acids. A new type of emulsion (emulsion III) is then produced which will be a water-in-oil emulsion. Without the mechanism of action being experimentally proven, and without having to commit to a specific theory, it is the inventor's opinion that the omega-3 fatty acids in this new emulsion
(emulsjon III) er beskyttet mot oksidasjon ved at de befinner seg inne i midten av små vannpartikler, som i sin tur er omgitt av/er dispergert i den homogene og kontinuerlige lipidfasen fra emulsjon I, slik at harskning av produktet ikke forekommer. (emulsion III) are protected against oxidation by being located in the center of small water particles, which in turn are surrounded by/are dispersed in the homogeneous and continuous lipid phase from emulsion I, so that rancidity of the product does not occur.
Oppfinnelsen vil nå bli beskrevet i mer detalj, med henvisning til figurer og eksempler. The invention will now be described in more detail, with reference to figures and examples.
Figur 1 Figuren viser emulsjon III, som er en vann-i-olje-emulsjon. Vannet er i emulsjonen er i form av en dispergert fase (dråper) 2, 3, som befinner seg i en kontinuerlig lipidfase 1. Omlag 15% av vannpartiklene stammer fra emulsjon II 3, og inneholder omega-3-fettsyrer 4. Figure 1 The figure shows emulsion III, which is a water-in-oil emulsion. The water in the emulsion is in the form of a dispersed phase (droplets) 2, 3, which is in a continuous lipid phase 1. Around 15% of the water particles originate from emulsion II 3, and contain omega-3 fatty acids 4.
For å fremstille et hudpleiemiddel (hudkrem) med omega-3-fettsyrer som ikke oksideres, slik at en harsk tranlukt kan unngås, har det i følge foreliggende oppfinnelse blitt fremstilt en emulsjon (emulsjon III) ved å blande sammen to andre emulsjoner (emulsjon I og emulsjon II). In order to produce a skin care agent (skin cream) with omega-3 fatty acids that do not oxidize, so that a rancid cod liver oil smell can be avoided, according to the present invention, an emulsion (emulsion III) has been produced by mixing together two other emulsions (emulsion I and emulsion II).
Emulsjon I er en vann-i-olje-emulsjon, f.eks. en hudkrem, som ikke inneholder omega-3-fettsyrer, og der lipidinnholdet er relativt lavt, det vil si 15-20%, fortrinnsvis 17%. Vannfasen i denne emulsjonen utgjør fra 80-85%, fortrinnsvis 83%. Emulsion I is a water-in-oil emulsion, e.g. a skin cream, which does not contain omega-3 fatty acids, and where the lipid content is relatively low, i.e. 15-20%, preferably 17%. The water phase in this emulsion makes up from 80-85%, preferably 83%.
Emulsjon II er en olje-i-vann-emulsjon der oljen utgjør fra 66-80%, fortrinnsvis 80%, mens vannfasen utgjør fra 20-34%, fortrinnsvis 20%. Oljefasen i emulsjonen utgjøres av marine oljer eller konsentrater eller blandinger av slike, eller en blanding av marine oljer og planteoljer. Som marin olje benyttes fortrinnsvis torskeleverolje, og mer fortrinnsvis omega-3-fettsyrer. Dersom oljen er fiskeolje kan innholdet av omega-3-fettsyrer i fiskeoljen være fra 10-85%, fortrinnsvis 20-60%, og mer fortrinnsvis 40 %. Det høye oljeinnholdet gir en slik emulsjon høy viskositet, noe som synes å bidra til at de flerumettede fettsyrene ikke autooksideres. Emulsion II is an oil-in-water emulsion where the oil makes up from 66-80%, preferably 80%, while the water phase makes up from 20-34%, preferably 20%. The oil phase in the emulsion consists of marine oils or concentrates or mixtures thereof, or a mixture of marine oils and plant oils. Cod liver oil is preferably used as marine oil, and more preferably omega-3 fatty acids. If the oil is fish oil, the content of omega-3 fatty acids in the fish oil can be from 10-85%, preferably 20-60%, and more preferably 40%. The high oil content gives such an emulsion a high viscosity, which seems to contribute to the polyunsaturated fatty acids not autoxidizing.
For å fremstille en ny type hudkrem i henhold til foreliggende oppfinnelse, kan man blande emulsjon I og emulsjon II i et gitt forhold, f.eks. i et forhold på hhv. (80-90):(20-10), fortrinnsvis i forholdet 85:15. De to emulsjonene blandes ved at emulsjon II tilsettes emulsjon I en ved romtemperatur, hvoretter det hele røres forsiktig sammen, fortrinnsvis uten lufttilgang, inntil det forekommer en synlig homogenitet. Det fremkommer da en ny emulsjon kalt emulsjon III, som vil være en vann-i-olje-emulsjon (Figur 1). I emulsjon III vil oljefasen fra emulsjon I danne en homogen og kontinuerlig lipidfase 1. Vannet i emulsjon III vil være dispergert i den kontinuerlige lipidfasen i fonn av små dråper 2, 3, og er følgelig forhindret fra å komme i kontakt med hverandre. En overveiende del av dråpene 2 er vann fra emulsjon I. Dråpene 3 som stammer fra emulsjon II utgjør en vesentlig mindre del av emulsjon III som en følge av blandingsforholdet, og fettsyrene 4 fra emulsjon II befinner seg inne i disse 3 vanndråpene, og er i følge oppfinneren således forhindret fra å oksidere. Lipidfasene i emulsjon I og II er inkompatible, og har derfor ingen mulighet til å danne en homogen lipidfase. Så langt oppfinneren kjenner til har en slik emulsjon ikke tidligere blitt beskrevet. To prepare a new type of skin cream according to the present invention, emulsion I and emulsion II can be mixed in a given ratio, e.g. in a ratio of (80-90):(20-10), preferably in the ratio 85:15. The two emulsions are mixed by adding emulsion II to emulsion I at room temperature, after which the whole is carefully stirred together, preferably without access to air, until a visible homogeneity occurs. A new emulsion called emulsion III then appears, which will be a water-in-oil emulsion (Figure 1). In emulsion III, the oil phase from emulsion I will form a homogeneous and continuous lipid phase 1. The water in emulsion III will be dispersed in the continuous lipid phase in the form of small droplets 2, 3, and is consequently prevented from coming into contact with each other. A predominant part of the droplets 2 is water from emulsion I. The droplets 3 originating from emulsion II make up a significantly smaller part of emulsion III as a result of the mixing ratio, and the fatty acids 4 from emulsion II are located inside these 3 water droplets, and are in according to the inventor thus prevented from oxidizing. The lipid phases in emulsion I and II are incompatible, and therefore have no possibility of forming a homogeneous lipid phase. As far as the inventor knows, such an emulsion has not previously been described.
Oppfinnelsen vil i det følgende bli nærmere belyst ved hjelp av eksempler. In the following, the invention will be explained in more detail with the help of examples.
EKSEMPLER EXAMPLES
Eksempel 1 Example 1
Eksempelet illustrerer et hudpleiemiddel i henhold til foreliggende oppfinnelse som inneholder omega-3-fettsyrer. The example illustrates a skin care agent according to the present invention which contains omega-3 fatty acids.
Fremstillingen av et slikt hudpleiemiddel foregår på følgende måte: (i) det fremstilles først en hudkrem i form av en vann-i-olje-emulsjon (emulsjon I) som ikke inneholder omega-3-fettsyrer, og der forholdet mellom lipid- og vannfase er hhv. 17 og 83%; (ii) det fremstilles en olje-i-vann-emulsjon (emulsjon II) der oljen utgjøres av fiskeolje som inneholder omega-3-fettsyrer, og der forholdet mellom lipid- og vannfase er hhv. 80 og 20%; (iii) emulsjon I og emulsjon II blandes sammen ved forsiktig røring. The production of such a skin care product takes place in the following way: (i) a skin cream is first produced in the form of a water-in-oil emulsion (emulsion I) which does not contain omega-3 fatty acids, and where the ratio between lipid and water phase are respectively 17 and 83%; (ii) an oil-in-water emulsion (emulsion II) is produced where the oil consists of fish oil containing omega-3 fatty acids, and where the ratio between lipid and water phase is respectively 80 and 20%; (iii) emulsion I and emulsion II are mixed together by gentle stirring.
Eksempel 2 Example 2
Eksempelet illustrerer et hudpleiemiddel i henhold til foreliggende oppfinnelse som inneholder omega-3-fettsyrer. The example illustrates a skin care agent according to the present invention which contains omega-3 fatty acids.
Det fremstilles en emulsjon I (hudkrem; Hudpleiekrem, ScanHall A.s) som nevnt i eksempel 1, der hudkremen består av ca. 83% renset vann samt følgende komponenter: stearinsyre, palmitinsyre, isopropylen myristat, propylen glycol, ceryl alkohol, glycol distearat, polysorbat 80, cetyl acetat, acetylat lanolin alkohol, stearyl alkohol, alkohol denat, trietanolamin, metylparben, tocoferyl acetat, melkesyre, propyl paraben, parfyme, allantoin og polyetylenglykol-40 hydrogenert lakserolje. An emulsion I (skin cream; Hudpleiekrem, ScanHall A.s) is prepared as mentioned in example 1, where the skin cream consists of approx. 83% purified water and the following components: stearic acid, palmitic acid, isopropylene myristate, propylene glycol, ceryl alcohol, glycol distearate, polysorbate 80, cetyl acetate, acetylated lanolin alcohol, stearyl alcohol, alcohol denat, triethanolamine, methyl parbene, tocopheryl acetate, lactic acid, propyl paraben, perfume, allantoin and polyethylene glycol-40 hydrogenated castor oil.
Videre benyttes det som emulsjon II en olje-i-vann-emulsjon med viskositet som pasta. Dette produktet har under fremstilling ikke vært i kontakt med luft, slik at det har ikke foregått noen oksidasjon av fiskeoljen i produktet. Denne emulsjonen inneholder i tillegg vitamin E og C, som virker som antioksidanter og spiller en viktig rolle i forsvaret mot frie radikaler. Emulsjon II (Coromar™, ScanHall A.s) inneholder fiskeolje med 40% omega-3-fettsyrer, i tillegg til vann, egg, vitaminer (ascorbinsyre, alfa-tokoferol, folsyre), aroma (vanilin), konserveringsmiddel (kaliumsorbat, natriumbenzoat), søtstoff (acesulfam K, natriumcyclamat, natrium-sakkarinat), surhetsregulerende middel (sitronsyre), stabilisator (guarkjernemel, xantangummi) og beta-karoten). Furthermore, an oil-in-water emulsion with a paste-like viscosity is used as emulsion II. This product has not been in contact with air during manufacture, so that no oxidation of the fish oil in the product has taken place. This emulsion also contains vitamins E and C, which act as antioxidants and play an important role in the defense against free radicals. Emulsion II (Coromar™, ScanHall A.s) contains fish oil with 40% omega-3 fatty acids, in addition to water, eggs, vitamins (ascorbic acid, alpha-tocopherol, folic acid), aroma (vanillin), preservative (potassium sorbate, sodium benzoate), sweetener (acesulfame K, sodium cyclamate, sodium saccharinate), acidity regulator (citric acid), stabilizer (guar gum, xanthan gum) and beta-carotene).
Eksempel 3 Example 3
Et hudpleiemiddel som angitt i eksempel 2 ble testet for lukt etter påsmøring på hud. A skin care agent as indicated in example 2 was tested for odor after application to the skin.
Fem personer smurte seg på hendene med hudpleiemiddelet, og selv etter 5-8 timer var det ikke utviklet noen harsk tranlukt. Dette skyldes at fettsyrene/fiskeoljen i kremen er forhindret i å oksidere, til tross for at mengden fiskeolje som er tilsatt hudpleiemiddel et er betydelig øket i forhold til det som er kjent fra andre kremer/salver. Five people smeared their hands with the skin care product, and even after 5-8 hours no rancid cod liver oil smell had developed. This is because the fatty acids/fish oil in the cream are prevented from oxidizing, despite the fact that the amount of fish oil added to the skin care product is significantly increased compared to what is known from other creams/ointments.
Claims (16)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20011327A NO313934B1 (en) | 2001-03-15 | 2001-03-15 | Skin care agent in the form of an emulsion, process for making said skin care agent, and use thereof |
| PCT/NO2002/000104 WO2002080882A1 (en) | 2001-03-15 | 2002-03-13 | Skin care cream containing omega-3 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20011327A NO313934B1 (en) | 2001-03-15 | 2001-03-15 | Skin care agent in the form of an emulsion, process for making said skin care agent, and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20011327D0 NO20011327D0 (en) | 2001-03-15 |
| NO20011327L NO20011327L (en) | 2002-09-16 |
| NO313934B1 true NO313934B1 (en) | 2002-12-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011327A NO313934B1 (en) | 2001-03-15 | 2001-03-15 | Skin care agent in the form of an emulsion, process for making said skin care agent, and use thereof |
Country Status (2)
| Country | Link |
|---|---|
| NO (1) | NO313934B1 (en) |
| WO (1) | WO2002080882A1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3734147C2 (en) * | 1987-10-09 | 1998-10-29 | Braun Melsungen Ag | Isotonic omega-3 fatty acid-containing fat emulsion and its use |
| DE4133694C2 (en) * | 1991-10-11 | 1993-10-07 | Fresenius Ag | Use of an emulsion with polyunsaturated fatty acids for i.v. administration for the treatment of skin diseases |
| FR2769224B1 (en) * | 1997-10-03 | 2000-01-28 | Oreal | STABLE W / O / W EMULSION AND ITS USE AS A COSMETIC AND / OR DERMATOLOGICAL COMPOSITION |
-
2001
- 2001-03-15 NO NO20011327A patent/NO313934B1/en not_active IP Right Cessation
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- 2002-03-13 WO PCT/NO2002/000104 patent/WO2002080882A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20011327L (en) | 2002-09-16 |
| WO2002080882A1 (en) | 2002-10-17 |
| NO20011327D0 (en) | 2001-03-15 |
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