NO313196B1 - Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette - Google Patents
Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette Download PDFInfo
- Publication number
- NO313196B1 NO313196B1 NO19971384A NO971384A NO313196B1 NO 313196 B1 NO313196 B1 NO 313196B1 NO 19971384 A NO19971384 A NO 19971384A NO 971384 A NO971384 A NO 971384A NO 313196 B1 NO313196 B1 NO 313196B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- hydrochloride
- methyl
- pyrimidinyl
- pyrazolyl
- Prior art date
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- 239000002246 antineoplastic agent Substances 0.000 title claims description 11
- BWIHJLOBZMKPKS-UHFFFAOYSA-N 2-(1h-pyrazol-5-yl)pyrimidine Chemical class N1C=CC(C=2N=CC=CN=2)=N1 BWIHJLOBZMKPKS-UHFFFAOYSA-N 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 105
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 20
- 125000005843 halogen group Chemical group 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000003277 amino group Chemical group 0.000 claims abstract description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 3
- 125000001424 substituent group Chemical group 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 7
- 125000004429 atom Chemical group 0.000 claims description 7
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- 239000004480 active ingredient Substances 0.000 claims description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
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- FRHZLLOCJRJYMZ-UHFFFAOYSA-N 3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-ylpyrazol-4-yl)propan-1-one;hydrochloride Chemical compound Cl.CC1=C(C(=O)CCN2CCN(CC2)C=2C=C(Cl)C=C(Cl)C=2)C=NN1C1=NC=CC=N1 FRHZLLOCJRJYMZ-UHFFFAOYSA-N 0.000 description 1
- UBHMPVLVPATDMN-UHFFFAOYSA-N 3-[4-(3,5-dichlorophenyl)piperazin-1-yl]-1-[1-(4,6-dimethylpyrimidin-2-yl)-5-methylpyrazol-4-yl]propan-1-one;hydrochloride Chemical compound Cl.CC1=C(C(=O)CCN2CCN(CC2)C=2C=C(Cl)C=C(Cl)C=2)C=NN1C1=NC(C)=CC(C)=N1 UBHMPVLVPATDMN-UHFFFAOYSA-N 0.000 description 1
- RJWVFKIYDPDYMZ-UHFFFAOYSA-N 3-[4-(3-chlorophenyl)piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-ylpyrazol-4-yl)propan-1-one;hydrochloride Chemical compound Cl.CC1=C(C(=O)CCN2CCN(CC2)C=2C=C(Cl)C=CC=2)C=NN1C1=NC=CC=N1 RJWVFKIYDPDYMZ-UHFFFAOYSA-N 0.000 description 1
- HHNBBNXHXDVDFB-UHFFFAOYSA-N 3-[4-(3-chlorophenyl)piperazin-1-yl]-1-[1-(4-methoxypyrimidin-2-yl)-5-methylpyrazol-4-yl]propan-1-one;hydrochloride Chemical compound Cl.COC1=CC=NC(N2C(=C(C(=O)CCN3CCN(CC3)C=3C=C(Cl)C=CC=3)C=N2)C)=N1 HHNBBNXHXDVDFB-UHFFFAOYSA-N 0.000 description 1
- MMERRUCVYKTNCB-UHFFFAOYSA-N 3-[4-(4-fluorophenyl)piperazin-1-yl]-1-(5-methyl-1-pyrimidin-2-ylpyrazol-4-yl)propan-1-one;hydrochloride Chemical compound Cl.CC1=C(C(=O)CCN2CCN(CC2)C=2C=CC(F)=CC=2)C=NN1C1=NC=CC=N1 MMERRUCVYKTNCB-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- DHYHYLGCQVVLOQ-UHFFFAOYSA-N 3-bromoaniline Chemical compound NC1=CC=CC(Br)=C1 DHYHYLGCQVVLOQ-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 101150041968 CDC13 gene Proteins 0.000 description 1
- 101100005766 Caenorhabditis elegans cdf-1 gene Proteins 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical group O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000007868 Raney catalyst Substances 0.000 description 1
- 229910000564 Raney nickel Inorganic materials 0.000 description 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- 238000007239 Wittig reaction Methods 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- TXFLGZOGNOOEFZ-UHFFFAOYSA-N bis(2-chloroethyl)amine Chemical compound ClCCNCCCl TXFLGZOGNOOEFZ-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- NWVNXDKZIQLBNM-UHFFFAOYSA-N diphenylmethylpiperazine Chemical compound C1CNCCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 NWVNXDKZIQLBNM-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 description 1
- 229960002064 kanamycin sulfate Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NHKJPPKXDNZFBJ-UHFFFAOYSA-N phenyllithium Chemical compound [Li]C1=CC=CC=C1 NHKJPPKXDNZFBJ-UHFFFAOYSA-N 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- HPOKESDSMZRZLC-UHFFFAOYSA-N propan-2-one;hydrochloride Chemical compound Cl.CC(C)=O HPOKESDSMZRZLC-UHFFFAOYSA-N 0.000 description 1
- 230000000506 psychotropic effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Photoreceptors In Electrophotography (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22942294 | 1994-09-26 | ||
| JP13501095 | 1995-06-01 | ||
| PCT/JP1995/001934 WO1996010024A1 (fr) | 1994-09-26 | 1995-09-25 | Derive pyrimidinylpyrazole |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO971384D0 NO971384D0 (no) | 1997-03-24 |
| NO971384L NO971384L (no) | 1997-05-23 |
| NO313196B1 true NO313196B1 (no) | 2002-08-26 |
Family
ID=26468965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19971384A NO313196B1 (no) | 1994-09-26 | 1997-03-24 | Pyrimidinylpyrazol-derivat, og antitumormiddel inneholdende dette |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5852019A (fr) |
| EP (1) | EP0784055B1 (fr) |
| KR (1) | KR100388568B1 (fr) |
| CN (1) | CN1071754C (fr) |
| AT (1) | ATE232528T1 (fr) |
| CA (1) | CA2201110A1 (fr) |
| DE (2) | DE69529619D1 (fr) |
| DK (1) | DK0784055T3 (fr) |
| ES (1) | ES2192584T3 (fr) |
| FI (1) | FI971227A (fr) |
| HK (1) | HK1001396A1 (fr) |
| NO (1) | NO313196B1 (fr) |
| TW (1) | TW312694B (fr) |
| WO (1) | WO1996010024A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA002101B1 (ru) * | 1997-01-27 | 2001-12-24 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
| US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| AU4800299A (en) * | 1998-07-24 | 2000-02-14 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives and salts thereof |
| AU3078000A (en) * | 1999-01-25 | 2000-08-07 | Zenyaku Kogyo Kabushiki Kaisha | Heterocyclic compounds and antitumor agents containing the same as the active ingredient |
| WO2002088112A1 (fr) * | 2001-04-27 | 2002-11-07 | Zenyaku Kogyo Kabushiki Kaisha | Compose heterocyclique et agent antitumoral contenant ce dernier en tant qu'ingredient actif |
| US7109204B2 (en) * | 2001-08-01 | 2006-09-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| BRPI0407088A (pt) * | 2003-01-28 | 2006-01-24 | Aventis Pharma Sa | Produtos n-aril-heteroaromáticos, composições contendo os mesmos e seu uso |
| FR2850379B1 (fr) * | 2003-01-28 | 2006-11-17 | Aventis Pharma Sa | Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation |
| US20050130989A1 (en) * | 2003-01-28 | 2005-06-16 | Aventis Pharma S. A. | N-arylheteroaromatic products compositions containing them and use thereof |
| WO2005028467A1 (fr) * | 2003-09-15 | 2005-03-31 | Anadys Pharmaceuticals, Inc. | Composes heteroaromatiques et aromatiques a substitution 3,5-diaminopiperidine antibacteriens |
| ES2400056T3 (es) | 2004-03-31 | 2013-04-05 | Zenyaku Kogyo Kabushikikaisha | Compuesto heterocíclico y agente anti tumores malignos que comprende el mismo como componente eficaz |
| AU2006221285B2 (en) | 2005-03-11 | 2011-03-31 | Zenyaku Kogyo Kabushikikaisha | Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient |
| US20070244110A1 (en) * | 2006-04-14 | 2007-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Treatment of prostate cancer, melanoma or hepatic cancer |
| US8022061B2 (en) | 2006-10-10 | 2011-09-20 | Amgen Inc. | N-aryl pyrazole compounds, compositions, and methods for their use |
| US10287269B2 (en) * | 2015-03-26 | 2019-05-14 | Merck Sharp & Dohme Corp. | Pyrazolyl pyrimidinone compounds as PDE2 inhibitors |
| JP6896715B2 (ja) | 2015-09-30 | 2021-06-30 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ヴィッセンシャフテン エーファウ −ジェネラルフェルヴァルトゥング | セピアプテリン還元酵素としてのヘテロアリール誘導体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
| JPS4842072A (fr) * | 1971-09-29 | 1973-06-19 | ||
| JPS61129129A (ja) * | 1984-11-28 | 1986-06-17 | Kureha Chem Ind Co Ltd | 抗腫瘍剤 |
| US5102893A (en) * | 1986-07-07 | 1992-04-07 | Warner-Lambert Company | Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- or ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
-
1995
- 1995-09-19 TW TW084109880A patent/TW312694B/zh active
- 1995-09-25 EP EP95932229A patent/EP0784055B1/fr not_active Expired - Lifetime
- 1995-09-25 DE DE69529619A patent/DE69529619D1/de not_active Expired - Fee Related
- 1995-09-25 AT AT95932229T patent/ATE232528T1/de not_active IP Right Cessation
- 1995-09-25 CN CN95196449A patent/CN1071754C/zh not_active Expired - Fee Related
- 1995-09-25 ES ES95932229T patent/ES2192584T3/es not_active Expired - Lifetime
- 1995-09-25 US US08/821,076 patent/US5852019A/en not_active Expired - Fee Related
- 1995-09-25 DE DE69529619T patent/DE69529619T4/de not_active Expired - Lifetime
- 1995-09-25 DK DK95932229T patent/DK0784055T3/da active
- 1995-09-25 CA CA002201110A patent/CA2201110A1/fr not_active Abandoned
- 1995-09-25 KR KR1019970701964A patent/KR100388568B1/ko not_active IP Right Cessation
- 1995-09-25 WO PCT/JP1995/001934 patent/WO1996010024A1/fr active IP Right Grant
-
1997
- 1997-03-24 NO NO19971384A patent/NO313196B1/no not_active IP Right Cessation
- 1997-03-24 FI FI971227A patent/FI971227A/fi unknown
-
1998
- 1998-01-12 HK HK98100241A patent/HK1001396A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE232528T1 (de) | 2003-02-15 |
| DK0784055T3 (da) | 2003-06-02 |
| WO1996010024A1 (fr) | 1996-04-04 |
| TW312694B (fr) | 1997-08-11 |
| DE69529619T4 (de) | 2005-01-27 |
| DE69529619T2 (de) | 2003-12-18 |
| FI971227A0 (fi) | 1997-03-24 |
| HK1001396A1 (en) | 1998-06-19 |
| NO971384L (no) | 1997-05-23 |
| CA2201110A1 (fr) | 1996-04-04 |
| KR970706275A (ko) | 1997-11-03 |
| CN1071754C (zh) | 2001-09-26 |
| US5852019A (en) | 1998-12-22 |
| KR100388568B1 (ko) | 2003-10-04 |
| FI971227A (fi) | 1997-05-23 |
| DE69529619D1 (en) | 2003-03-20 |
| CN1166833A (zh) | 1997-12-03 |
| EP0784055A1 (fr) | 1997-07-16 |
| EP0784055B1 (fr) | 2003-02-12 |
| NO971384D0 (no) | 1997-03-24 |
| ES2192584T3 (es) | 2003-10-16 |
| EP0784055A4 (fr) | 1998-01-07 |
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