NO310446B1 - Biokompatibel hydrogel - Google Patents
Biokompatibel hydrogel Download PDFInfo
- Publication number
- NO310446B1 NO310446B1 NO19970330A NO970330A NO310446B1 NO 310446 B1 NO310446 B1 NO 310446B1 NO 19970330 A NO19970330 A NO 19970330A NO 970330 A NO970330 A NO 970330A NO 310446 B1 NO310446 B1 NO 310446B1
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- Prior art keywords
- hydrogel
- paa
- biocompatible
- tissue
- acrylamide
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Cosmetics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA94086726A UA10911C2 (ru) | 1994-08-10 | 1994-08-10 | Биосовместимых гидрогель |
| PCT/UA1994/000022 WO1996004943A1 (fr) | 1994-08-10 | 1994-08-12 | Hyrogel biocompatible |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO970330D0 NO970330D0 (no) | 1997-01-24 |
| NO970330L NO970330L (no) | 1997-02-10 |
| NO310446B1 true NO310446B1 (no) | 2001-07-09 |
Family
ID=21689009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19970330A NO310446B1 (no) | 1994-08-10 | 1997-01-24 | Biokompatibel hydrogel |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | USRE38913E1 (ru) |
| EP (1) | EP0742022B1 (ru) |
| JP (1) | JP3359036B2 (ru) |
| KR (1) | KR100316212B1 (ru) |
| CN (1) | CN1058639C (ru) |
| AT (1) | ATE190508T1 (ru) |
| AU (1) | AU696773B2 (ru) |
| BG (1) | BG62915B1 (ru) |
| BR (1) | BR9408609A (ru) |
| CA (1) | CA2195957C (ru) |
| CZ (1) | CZ297126B6 (ru) |
| DE (1) | DE69423520T2 (ru) |
| DK (1) | DK0742022T3 (ru) |
| ES (1) | ES2145841T3 (ru) |
| FI (1) | FI970315A (ru) |
| GR (1) | GR3033694T3 (ru) |
| HU (1) | HU9603434D0 (ru) |
| NO (1) | NO310446B1 (ru) |
| PT (1) | PT742022E (ru) |
| RU (1) | RU2067873C1 (ru) |
| UA (1) | UA10911C2 (ru) |
| WO (1) | WO1996004943A1 (ru) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA10911C2 (ru) | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Биосовместимых гидрогель |
| US5658329A (en) * | 1995-02-14 | 1997-08-19 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| US5941909A (en) * | 1995-02-14 | 1999-08-24 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| US6800278B1 (en) | 1996-10-28 | 2004-10-05 | Ballard Medical Products, Inc. | Inherently antimicrobial quaternary amine hydrogel wound dressings |
| BG102375A (en) * | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
| USRE38614E1 (en) | 1998-01-30 | 2004-10-05 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| US6660301B1 (en) | 1998-03-06 | 2003-12-09 | Biosphere Medical, Inc. | Injectable microspheres for dermal augmentation and tissue bulking |
| CA2338881C (en) | 1998-08-03 | 2005-03-15 | Synthes (U.S.A.) | Intervertebral allograft spacer |
| FR2784580B1 (fr) | 1998-10-16 | 2004-06-25 | Biosepra Inc | Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci |
| US6025538A (en) * | 1998-11-20 | 2000-02-15 | Musculoskeletal Transplant Foundation | Compound bone structure fabricated from allograft tissue |
| CN1068612C (zh) * | 1999-01-15 | 2001-07-18 | 吉林富华医用高分子材料有限公司 | 医用交联聚丙烯酰胺水凝胶的制备方法 |
| DE60033633T2 (de) * | 1999-12-08 | 2007-11-15 | Vercell Biotechnology Bv | Kit aus polyacrylamidgel zur herstellung einer kapsel im gewebe eines säugetierorganismus und tierischen allogenen oder xenogenen zellen , zur behandlung von onkologischen krankheiten und diabetes mellitus |
| WO2001049336A1 (en) * | 1999-12-29 | 2001-07-12 | Progen S.R.L. | Biocompatible hydrogel and method of its production |
| AU2001249221A1 (en) | 2000-03-20 | 2001-10-03 | Biosphere Medical, Inc. | Injectable and swellable microspheres for tissue bulking |
| ES2551164T3 (es) | 2000-03-24 | 2015-11-16 | Biosphere Medical, Inc. | Microesferas para embolización activa |
| US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| CN1116321C (zh) * | 2000-04-21 | 2003-07-30 | 郑永碧 | 一种医用聚丙烯酰胺水凝胶的提纯测试方法 |
| MY130475A (en) * | 2000-08-25 | 2007-06-29 | Contura As | Polyacrylamide hydrogel and its use as an endoprosthesis |
| US7186419B2 (en) | 2000-08-25 | 2007-03-06 | Contura Sa | Polyacrylamide hydrogel for arthritis |
| WO2002016453A1 (en) * | 2000-08-25 | 2002-02-28 | Contura S.A. | Polyacrylamide hydrogel and its use as an endoprosthesis |
| WO2003026711A1 (fr) * | 2001-09-28 | 2003-04-03 | Biopharma Development Ltd | Hydrogel biocompatible polyfonctionnel et procede de production associe |
| IL163941A0 (en) * | 2002-04-10 | 2005-12-18 | Obschestvo S Ogranichennoy Otv | Polyfunctional biocompatible hydrogel and method for the production thereof |
| US7632291B2 (en) | 2003-06-13 | 2009-12-15 | Trivascular2, Inc. | Inflatable implant |
| US20050065616A1 (en) * | 2003-08-08 | 2005-03-24 | Contura Sa | Implantable hydrogel with resorbable shell for use as an endoprothesis |
| JP4210231B2 (ja) * | 2004-03-25 | 2009-01-14 | 株式会社資生堂 | 皮膚のシワを改善する美容方法及びシワ改善具 |
| US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
| US7641688B2 (en) | 2004-09-16 | 2010-01-05 | Evera Medical, Inc. | Tissue augmentation device |
| US7244270B2 (en) | 2004-09-16 | 2007-07-17 | Evera Medical | Systems and devices for soft tissue augmentation |
| EP1879554B2 (en) | 2005-05-09 | 2018-03-07 | Biosphere Medical, S.A. | Compositions and methods using microspheres and non-ionic contrast agents |
| US20070048249A1 (en) | 2005-08-24 | 2007-03-01 | Purdue Research Foundation | Hydrophilized bactericidal polymers |
| CN1322032C (zh) * | 2005-10-20 | 2007-06-20 | 北京科技大学 | 一种采用波聚合技术制备多孔水凝胶的方法 |
| EP1986706B1 (en) * | 2006-01-30 | 2011-08-17 | Biosphere Medical, Inc. | Porous intravascular embolization particles and methods of making them |
| US20080033366A1 (en) | 2006-01-30 | 2008-02-07 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
| US8043377B2 (en) | 2006-09-02 | 2011-10-25 | Osprey Biomedical, Inc. | Implantable intervertebral fusion device |
| JP5271288B2 (ja) | 2007-03-15 | 2013-08-21 | オーソ−スペース リミテッド | プロテーゼ装置およびその使用方法 |
| EP2144672A4 (en) * | 2007-05-04 | 2012-08-08 | Perth Bone & Tissue Bank | PROCESS FOR TREATMENT OF IGNITIONS AND MATERIALS WITH CONTROLLED RELEASE FOR THIS PROCEDURE |
| HU228872B1 (hu) * | 2007-05-31 | 2013-06-28 | Univ Szegedi | N-izopropil-akrilamid, akrilamid és akrilsav polimerizációjával szintetizált hidrogélek rétegszilikátokkal készült nanokompozitjai, eljárás ezek elõállítására és alkalmazásuk ozmotikusan aktív hidrogél szövettágító expanderekben bõr nyerésére |
| CN101230135B (zh) * | 2007-08-27 | 2010-09-22 | 重庆大学 | 一类基于乙二胺四乙酸酐的水凝胶材料及用途 |
| US20090198329A1 (en) | 2008-02-01 | 2009-08-06 | Kesten Randy J | Breast implant with internal flow dampening |
| EP2249877B1 (en) | 2008-02-22 | 2012-12-19 | Battelle Memorial Institute | Absorbent protein meal base hydrogels |
| EP2172236A1 (en) * | 2008-10-03 | 2010-04-07 | Koninklijke Philips Electronics N.V. | Breast pump system |
| JP2012507562A (ja) * | 2008-10-30 | 2012-03-29 | ダビド リウ | 微小球性多孔質生体適合性足場並びにその製造方法及び装置 |
| EP2263710A1 (en) * | 2009-06-18 | 2010-12-22 | Koninklijke Philips Electronics N.V. | An insert for a breast pump |
| RU2457792C1 (ru) * | 2011-04-27 | 2012-08-10 | Игорь Леонидович Бабанин | Способ эндоскопической коррекции пузырно-мочеточникового рефлюкса |
| RU2514093C2 (ru) * | 2011-08-09 | 2014-04-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО СибГМУ Минздравсоцразвития России) | Средство для инъекционной терапии гастроэзофагеальной рефлюксной болезни |
| US9289307B2 (en) | 2011-10-18 | 2016-03-22 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
| RU2470589C1 (ru) * | 2011-10-27 | 2012-12-27 | Федеральное государственное бюджетное учреждение "Московский научно-исследовательский институт глазных болезней имени Гельмгольца" Министерства здравоохранения и социального развития Российской Федерации | Иммерсионная среда для проведения объемной эхографии орбиты при анофтальме и субатрофии глаза и способ проведения объемной эхографии орбиты при анофтальме и субатрофии глаза |
| EP2703018A1 (en) | 2012-08-31 | 2014-03-05 | Ludwig Boltzmann Gesellschaft GmbH | One step method for casting hydrogels for tissue engineering |
| RU2523879C2 (ru) * | 2012-11-23 | 2014-07-27 | Общество с ограниченной ответственностью "Кардиоплант" | Способ модификации биоткани для протезирования |
| CN103583512B (zh) * | 2013-11-14 | 2016-05-11 | 大连民族学院 | 植物标本保存凝胶及其制作方法和用途 |
| LT6227B (lt) | 2014-01-17 | 2015-10-26 | Oleksiiovych Ivan Zavgorodnii | Biologiškai suderinamas poliakrilamido hidrogelis ir jo gavimo būdas |
| CN103977458B (zh) * | 2014-05-28 | 2016-10-05 | 苏州恒瑞迦俐生生物医药科技有限公司 | 多羟基聚合体栓塞微球及其制备工艺 |
| US10959761B2 (en) | 2015-09-18 | 2021-03-30 | Ortho-Space Ltd. | Intramedullary fixated subacromial spacers |
| RU2622430C1 (ru) * | 2016-01-27 | 2017-06-15 | Майя Валерьевна УСПЕНСКАЯ | Способ получения нанокомпозитного сорбента для засушливых почв |
| US11045981B2 (en) | 2017-01-30 | 2021-06-29 | Ortho-Space Ltd. | Processing machine and methods for processing dip-molded articles |
| WO2018222622A1 (en) | 2017-05-27 | 2018-12-06 | Poly Group LLC | Dispersible antimicrobial complex and coatings therefrom |
| US20180362678A1 (en) | 2017-06-16 | 2018-12-20 | Poly Group LLC | Polymeric antimicrobial surfactant |
| RU2681212C1 (ru) * | 2018-07-09 | 2019-03-05 | Давид Севанович Давтян | Способ получения полиакриламидных гидрогелей путем непрерывной фронтальной полимеризации |
| FR3089115B1 (fr) | 2018-11-30 | 2020-11-20 | Nvd | Hydrogel biocompatible, procede de preparation et utilisation dans un systeme de visco-supplementation mecanique |
| KR102166153B1 (ko) * | 2020-01-20 | 2020-10-15 | 박형준 | 조직수복용 폴리아크릴아마이드 하이드로겔의 제조방법 |
| CN113461979A (zh) * | 2021-07-19 | 2021-10-01 | 吉林大学 | 一种通过血红蛋白催化交联的仿贻贝类水凝胶的制备方法 |
| CN114246983B (zh) * | 2021-12-31 | 2022-11-18 | 华南理工大学 | 一种双层结构阴茎白膜修复补片及其制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE742022C (de) | 1940-03-30 | 1943-11-20 | Boehmische Waffenfabrik Ag | Patronenmagazin, bei dem ein von einer Triebkraft belasteter Patronenstoessel eine Patronenreihe in kreisfoermigen oder spiralfoermigen Fuehrungen verschiebt und die Fortbewegungsbahn der Patronen im Magazin erfolgt |
| GB727232A (en) | 1949-10-13 | 1955-03-30 | Stin | Improvements in or relating to railway interlocking apparatus |
| DE2048039A1 (de) * | 1969-10-23 | 1971-04-29 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung on Gegen standen, die zu wiederholtem oder langfn stigem Kontakt mit lebendigen Geweben be stimmt sind |
| DE3050012A1 (de) * | 1979-11-06 | 1982-05-06 | I Bilko | Polyacrylamide gel for medical and biological application and method of its preparation |
| JPS56160992A (en) * | 1980-05-17 | 1981-12-11 | Nitto Electric Ind Co Ltd | Enzymic pharmaceutical of sustained release type |
| US4540568A (en) | 1982-10-14 | 1985-09-10 | Trager Seymour F | Injectionable viscoelastic ophthalmic gel |
| US4631188A (en) * | 1983-08-31 | 1986-12-23 | S.K.Y. Polymers, Ltd. (Kingston Technologies) | Injectable physiologically-acceptable polymeric composition |
| JPS6060548A (ja) * | 1983-09-14 | 1985-04-08 | Fuji Photo Film Co Ltd | 電気泳動用媒体 |
| GB8418772D0 (en) * | 1984-07-24 | 1984-08-30 | Geistlich Soehne Ag | Chemical substances |
| US4746551A (en) * | 1985-11-20 | 1988-05-24 | Micro-Map, Inc. | Rehydratable polyacrylamide gels |
| US4873086A (en) * | 1986-03-03 | 1989-10-10 | Ciba-Geigy Corporation | Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof |
| IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
| US5244799A (en) * | 1987-05-20 | 1993-09-14 | Anderson David M | Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate |
| JPH02503205A (ja) * | 1988-02-12 | 1990-10-04 | ドゥ ツァープフェル，ブリギット | 医用及びパラメディカル用の架橋親水性コポリマー |
| SU1697756A1 (ru) * | 1988-06-20 | 1991-12-15 | Киевский Научно-Исследовательский Институт Отоларингологии Им.Проф.А.Коломийченко | Способ лечени заболеваний гортани со стойким несмыканием голосовых складок |
| JP3071926B2 (ja) * | 1992-01-28 | 2000-07-31 | 第一化学薬品株式会社 | ポリアクリルアミド系電気泳動用ゲルプレートの製造方法 |
| US5344451A (en) * | 1992-06-24 | 1994-09-06 | Dayton Michael P | Synthetic reconstructive implant device |
| US5482719A (en) * | 1992-10-30 | 1996-01-09 | Guillet; James E. | Drug delivery systems |
| US5589104A (en) * | 1993-12-30 | 1996-12-31 | Bambeck; Gregory S. | Electrophoresis separation gel and a method for preparing an electrophoresis separation gel |
| UA10911C2 (ru) | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Биосовместимых гидрогель |
| US5658329A (en) | 1995-02-14 | 1997-08-19 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| US5941909A (en) | 1995-02-14 | 1999-08-24 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
| BG102375A (en) | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
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1994
- 1994-08-10 UA UA94086726A patent/UA10911C2/ru unknown
- 1994-08-12 EP EP94928547A patent/EP0742022B1/en not_active Expired - Lifetime
- 1994-08-12 CA CA002195957A patent/CA2195957C/en not_active Expired - Fee Related
- 1994-08-12 ES ES94928547T patent/ES2145841T3/es not_active Expired - Lifetime
- 1994-08-12 CN CN94195147A patent/CN1058639C/zh not_active Expired - Fee Related
- 1994-08-12 AU AU77940/94A patent/AU696773B2/en not_active Ceased
- 1994-08-12 JP JP50724296A patent/JP3359036B2/ja not_active Expired - Fee Related
- 1994-08-12 DE DE69423520T patent/DE69423520T2/de not_active Expired - Lifetime
- 1994-08-12 HU HU9603434A patent/HU9603434D0/hu unknown
- 1994-08-12 PT PT94928547T patent/PT742022E/pt unknown
- 1994-08-12 BR BR9408609A patent/BR9408609A/pt not_active Application Discontinuation
- 1994-08-12 AT AT94928547T patent/ATE190508T1/de active
- 1994-08-12 US US09/648,586 patent/USRE38913E1/en not_active Expired - Lifetime
- 1994-08-12 KR KR1019970700490A patent/KR100316212B1/ko not_active IP Right Cessation
- 1994-08-12 WO PCT/UA1994/000022 patent/WO1996004943A1/ru active IP Right Grant
- 1994-08-12 CZ CZ0022497A patent/CZ297126B6/cs not_active IP Right Cessation
- 1994-08-12 DK DK94928547T patent/DK0742022T3/da active
- 1994-08-12 US US08/776,731 patent/US5798096A/en not_active Ceased
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1995
- 1995-01-25 RU RU9595100525A patent/RU2067873C1/ru not_active IP Right Cessation
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1997
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- 1997-01-24 NO NO19970330A patent/NO310446B1/no not_active IP Right Cessation
- 1997-02-20 BG BG101251A patent/BG62915B1/bg unknown
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2000
- 2000-06-15 GR GR20000401384T patent/GR3033694T3/el unknown
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