NO310031B1 - Nukleinsyremolekyl som koder for en human 5-HT1D-reseptor, vektorer og vertceller som omfatter denne, fremgangsmåte for fremstilling og anvendelse derav - Google Patents
Nukleinsyremolekyl som koder for en human 5-HT1D-reseptor, vektorer og vertceller som omfatter denne, fremgangsmåte for fremstilling og anvendelse derav Download PDFInfo
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- NO310031B1 NO310031B1 NO924289A NO924289A NO310031B1 NO 310031 B1 NO310031 B1 NO 310031B1 NO 924289 A NO924289 A NO 924289A NO 924289 A NO924289 A NO 924289A NO 310031 B1 NO310031 B1 NO 310031B1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/82—Subcellular parts of microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/520,716 US5155218A (en) | 1990-05-08 | 1990-05-08 | Dna encoding human 5-ht1d receptors |
| PCT/US1991/003200 WO1991017174A1 (en) | 1990-05-08 | 1991-05-08 | Dna encoding human 5-ht1d receptors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO924289D0 NO924289D0 (no) | 1992-11-06 |
| NO924289L NO924289L (no) | 1992-12-18 |
| NO310031B1 true NO310031B1 (no) | 2001-05-07 |
Family
ID=24073787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924289A NO310031B1 (no) | 1990-05-08 | 1992-11-06 | Nukleinsyremolekyl som koder for en human 5-HT1D-reseptor, vektorer og vertceller som omfatter denne, fremgangsmåte for fremstilling og anvendelse derav |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5155218A (de) |
| EP (2) | EP0530265B1 (de) |
| JP (2) | JP3319596B2 (de) |
| AT (1) | ATE171211T1 (de) |
| CA (2) | CA2374571A1 (de) |
| DE (2) | DE69130219T2 (de) |
| DK (1) | DK0530265T3 (de) |
| ES (1) | ES2059298T3 (de) |
| FI (1) | FI110692B (de) |
| NO (1) | NO310031B1 (de) |
| WO (1) | WO1991017174A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5661024A (en) | 1989-10-31 | 1997-08-26 | Synaptic Pharmaceutical Corporation | DNA encoding a human serotonic (5-HT2) receptor and uses thereof |
| US5935925A (en) * | 1990-05-08 | 1999-08-10 | Synaptic Pharmaceutical Corporation | Methods of treating migraine and compounds useful for such methods |
| US5155218A (en) * | 1990-05-08 | 1992-10-13 | Neurogenetic Corporation | Dna encoding human 5-ht1d receptors |
| AU671417B2 (en) * | 1991-03-15 | 1996-08-29 | Merck Serono Sa | Human follicle stimulating hormone receptor |
| ES2237747T3 (es) * | 1991-11-14 | 2005-08-01 | Prionics Ag | Animales transgenicos no humanos que carecen de proteinas prionicas. |
| DE585415T1 (de) * | 1991-12-02 | 1996-10-10 | Synaptic Pharma Corp | Dns-kodierend für den menschlichen 5-ht 1e rezeptor und seine verwendung. |
| US5670113A (en) | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
| US6406859B1 (en) * | 1992-01-08 | 2002-06-18 | Synaptic Pharmaceutical Corporation | DNA encoding a 5-HT 1F receptor and uses thereof |
| US5360735A (en) * | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
| DE4216319A1 (de) * | 1992-05-16 | 1993-11-18 | Basf Ag | Serotonin Rezeptor, Verfahren zur Herstellung und seine Verwendung |
| FR2693200B1 (fr) * | 1992-07-01 | 1994-08-19 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polypeptides et utilisations. |
| FR2693201B1 (fr) * | 1992-07-01 | 1994-08-19 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polyptides et utilisations. |
| EP0663014B1 (de) | 1992-09-25 | 2004-08-18 | Synaptic Pharmaceutical Corporation | Für menschliche alpha-1-adrenerge rezeptoren kodierende dns und ihre verwendung |
| AU5452294A (en) * | 1992-10-26 | 1994-05-24 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | The st-b17 serotonin receptor |
| ATE279515T1 (de) * | 1992-10-26 | 2004-10-15 | Us Gov Health & Human Serv | Pct-65 serotonin rezeptor |
| EP0624100B1 (de) | 1992-11-03 | 2000-05-03 | Synaptic Pharmaceutical Corporation | Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung |
| US6300087B1 (en) | 1992-11-03 | 2001-10-09 | Synaptic Pharmaceutical Corporation | DNA encoding a human serotonin receptor (5-HT4B) and uses thereof |
| US5472866A (en) * | 1992-12-24 | 1995-12-05 | Synaptic Pharmaceutical Corporation | DNA encoding 5-HT4A serotonin receptors |
| FR2699922B1 (fr) * | 1992-12-30 | 1995-02-10 | Inst Nat Sante Rech Med | Polypeptides à activité de récepteur sérotoninergique, médicaments les comprenant, séquences codant pour eux, sondes vecteurs et hôtes les exprimant, et application au criblage des médicaments. |
| US20020115149A1 (en) * | 1993-01-08 | 2002-08-22 | Synaptic Pharmaceutical Corporation | DNA encoding human 5-HT1D receptors and uses thereof |
| US5807711A (en) * | 1993-03-23 | 1998-09-15 | Taisho Pharmaceutical Co., Ltd. | Parenchymal hepatocyte growth factors |
| AU1550195A (en) * | 1994-11-18 | 1996-06-17 | Human Genome Sciences, Inc. | G-protein coupled receptor |
| WO1996030406A1 (en) * | 1995-03-30 | 1996-10-03 | Human Genome Sciences, Inc. | Human g-protein coupled receptors |
| US6090575A (en) * | 1995-03-30 | 2000-07-18 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein coupled receptor GPR1 |
| US5998164A (en) * | 1995-03-30 | 1999-12-07 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein coupled receptor GPRZ |
| US5698766A (en) * | 1995-04-05 | 1997-12-16 | The Regents Of The University Of California | Transgenic animal model for testing drugs for treating eating disorders and epilepsy |
| US5942414A (en) * | 1995-06-06 | 1999-08-24 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein coupled receptor HIBEF51 |
| AU7434996A (en) * | 1995-10-19 | 1997-05-07 | Smithkline Beecham Corporation | A novel human b cell surface molecule |
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| JP2000506365A (ja) * | 1996-01-11 | 2000-05-30 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | ヒトｇタンパク質ケモカインレセプターｈｓａｔｕ６８ |
| CA2242908A1 (en) * | 1996-01-11 | 1997-07-17 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor hsatu68 |
| US6673535B1 (en) | 1996-05-08 | 2004-01-06 | Cedars-Sinai Medical Center | Methods of detecting spinocerebellar Ataxia-2 nucleic acids |
| US6844431B1 (en) * | 1996-05-08 | 2005-01-18 | Cedars-Sinai Medical Center | Nucleic acid encoding spinocerebellar ataxia-2 and products related thereto |
| US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| US6362009B1 (en) | 1997-11-21 | 2002-03-26 | Merck & Co., Inc. | Solid phase synthesis of heterocycles |
| US6462188B1 (en) | 1998-04-16 | 2002-10-08 | The Institute For Genomic Research | Human 5-HT3 receptor |
| WO2000012707A1 (en) * | 1998-09-02 | 2000-03-09 | Millennium Pharmaceuticals, Inc. | 14926 receptor, a novel g-protein coupled receptor |
| US7449338B2 (en) * | 1998-10-02 | 2008-11-11 | Ischemia Technologies, Inc. | Tests for the rapid evaluation of ischemic states and kits |
| US6221660B1 (en) | 1999-02-22 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding SNORF25 receptor |
| US6664373B1 (en) | 1999-03-01 | 2003-12-16 | Millennium Pharmaceuticals, Inc. | TWIK-5 potassium channel polypeptides and uses therefor |
| US6670149B1 (en) | 1999-03-01 | 2003-12-30 | Millennium Pharmaceuticals, Inc. | TWIK-5 potassium channel nucleic acids and uses therefor |
| US7179886B1 (en) * | 1999-06-08 | 2007-02-20 | Merck & Co., Inc. | Cloning and identification of the motilin receptor |
| JP2003506042A (ja) | 1999-08-03 | 2003-02-18 | ミレニアム ファーマシューティカルズ インク． | セクレチン様ファミリーの新規ｇｐｃｒ様分子１５５７１及びその使用 |
| UA77650C2 (en) * | 1999-12-06 | 2007-01-15 | Lundbeck & Co As H | Use of serotonin reuptake inhibitor in combination with deramcyclane |
| ES2426915T3 (es) | 2003-09-10 | 2013-10-25 | Brentwood Equities Ltd. | Diastereoisómeros de 4-ariloxi-3-hidroxipiperidinas |
| US20070270339A1 (en) * | 2004-04-23 | 2007-11-22 | Serono, Inc. | Use of GPCR54 Ligands for the Treatment of Infertility |
| US20080014172A1 (en) * | 2004-05-28 | 2008-01-17 | Applied Research Systems Ars Holding N.V. | Use of Il-17 in the Treatment of Fertility-Related Disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR79215B (de) * | 1982-06-07 | 1984-10-22 | Glaxo Group Ltd | |
| WO1985001961A1 (en) | 1983-10-28 | 1985-05-09 | Genetics Institute | Production of factor viii and related products |
| GB2162522B (en) * | 1984-08-01 | 1988-02-24 | Glaxo Group Ltd | An indole derivative |
| GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
| US4985352A (en) * | 1988-02-29 | 1991-01-15 | The Trustees Of Columbia University In The City Of New York | DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof |
| EP0351921A3 (de) * | 1988-07-22 | 1991-07-17 | Merck & Co. Inc. | Modifizierter beta-adrenergischer Rezeptor |
| FR2642075B1 (fr) | 1989-01-25 | 1991-04-26 | Pasteur Institut | Polypeptides ayant une activite de recepteur (beta)-adrenergique chez l'homme, impliques dans la reponse lipolytique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substance active sur ces polypeptides |
| US5155218A (en) * | 1990-05-08 | 1992-10-13 | Neurogenetic Corporation | Dna encoding human 5-ht1d receptors |
| DE585415T1 (de) * | 1991-12-02 | 1996-10-10 | Synaptic Pharma Corp | Dns-kodierend für den menschlichen 5-ht 1e rezeptor und seine verwendung. |
| US5360735A (en) * | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
| US5472866A (en) * | 1992-12-24 | 1995-12-05 | Synaptic Pharmaceutical Corporation | DNA encoding 5-HT4A serotonin receptors |
-
1990
- 1990-05-08 US US07/520,716 patent/US5155218A/en not_active Expired - Lifetime
-
1991
- 1991-05-08 AT AT91909881T patent/ATE171211T1/de not_active IP Right Cessation
- 1991-05-08 DK DK91909881T patent/DK0530265T3/da active
- 1991-05-08 DE DE69130219T patent/DE69130219T2/de not_active Expired - Lifetime
- 1991-05-08 CA CA002374571A patent/CA2374571A1/en not_active Abandoned
- 1991-05-08 DE DE91909881T patent/DE530265T1/de active Pending
- 1991-05-08 JP JP50985691A patent/JP3319596B2/ja not_active Expired - Lifetime
- 1991-05-08 CA CA002082390A patent/CA2082390C/en not_active Expired - Lifetime
- 1991-05-08 EP EP91909881A patent/EP0530265B1/de not_active Expired - Lifetime
- 1991-05-08 EP EP96118890A patent/EP0787797A1/de not_active Withdrawn
- 1991-05-08 ES ES91909881T patent/ES2059298T3/es not_active Expired - Lifetime
- 1991-05-08 WO PCT/US1991/003200 patent/WO1991017174A1/en active IP Right Grant
-
1992
- 1992-11-06 NO NO924289A patent/NO310031B1/no not_active IP Right Cessation
- 1992-11-06 FI FI925034A patent/FI110692B/fi active
-
1994
- 1994-05-02 US US08/236,686 patent/US5786157A/en not_active Expired - Lifetime
-
1999
- 1999-08-09 US US09/371,705 patent/US6475746B1/en not_active Expired - Fee Related
-
2001
- 2001-11-21 JP JP2001356183A patent/JP2002212103A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FI925034A (fi) | 1992-11-06 |
| NO924289L (no) | 1992-12-18 |
| EP0787797A1 (de) | 1997-08-06 |
| NO924289D0 (no) | 1992-11-06 |
| JP2002212103A (ja) | 2002-07-31 |
| US5786157A (en) | 1998-07-28 |
| ES2059298T1 (es) | 1994-11-16 |
| DE69130219D1 (de) | 1998-10-22 |
| EP0530265B1 (de) | 1998-09-16 |
| DE530265T1 (de) | 1994-03-31 |
| AU657686B2 (en) | 1995-03-23 |
| ATE171211T1 (de) | 1998-10-15 |
| AU7879891A (en) | 1991-11-27 |
| WO1991017174A1 (en) | 1991-11-14 |
| CA2374571A1 (en) | 1991-11-14 |
| ES2059298T3 (es) | 1999-02-01 |
| JP3319596B2 (ja) | 2002-09-03 |
| US5155218A (en) | 1992-10-13 |
| FI925034A0 (fi) | 1992-11-06 |
| FI110692B (fi) | 2003-03-14 |
| CA2082390C (en) | 2002-06-11 |
| EP0530265A1 (de) | 1993-03-10 |
| DE69130219T2 (de) | 1999-05-12 |
| CA2082390A1 (en) | 1991-11-09 |
| DK0530265T3 (da) | 1999-06-14 |
| EP0530265A4 (en) | 1993-06-16 |
| US6475746B1 (en) | 2002-11-05 |
| JPH06502297A (ja) | 1994-03-17 |
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