NO306735B1 - Fremgangsmåte for fremstilling av en vaksine for å forhindre furunkulose i fisk - Google Patents
Fremgangsmåte for fremstilling av en vaksine for å forhindre furunkulose i fisk Download PDFInfo
- Publication number
- NO306735B1 NO306735B1 NO923550A NO923550A NO306735B1 NO 306735 B1 NO306735 B1 NO 306735B1 NO 923550 A NO923550 A NO 923550A NO 923550 A NO923550 A NO 923550A NO 306735 B1 NO306735 B1 NO 306735B1
- Authority
- NO
- Norway
- Prior art keywords
- strain
- salmonicida
- aroa
- aeromonas
- mutation
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims description 19
- 241000251468 Actinopterygii Species 0.000 title claims description 18
- 206010017553 Furuncle Diseases 0.000 title claims description 10
- 208000003512 furunculosis Diseases 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 8
- 101150037081 aroA gene Proteins 0.000 claims description 46
- 241000607525 Aeromonas salmonicida Species 0.000 claims description 38
- 230000035772 mutation Effects 0.000 claims description 26
- 241000894006 Bacteria Species 0.000 claims description 20
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 241000607534 Aeromonas Species 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 230000001851 biosynthetic effect Effects 0.000 claims description 9
- 230000037361 pathway Effects 0.000 claims description 9
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- 229930027917 kanamycin Natural products 0.000 claims description 6
- 229960000318 kanamycin Drugs 0.000 claims description 6
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims description 6
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- 239000003381 stabilizer Substances 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims 1
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- 101100491986 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aromA gene Proteins 0.000 description 27
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- 230000036039 immunity Effects 0.000 description 6
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- 241000277288 Salmo trutta Species 0.000 description 3
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 3
- 241000277331 Salmonidae Species 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
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- 239000011724 folic acid Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 3
- 235000013923 monosodium glutamate Nutrition 0.000 description 3
- 239000004223 monosodium glutamate Substances 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 230000000087 stabilizing effect Effects 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- QUTYKIXIUDQOLK-PRJMDXOYSA-N 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid Chemical compound O[C@H]1[C@H](OC(=C)C(O)=O)CC(C(O)=O)=C[C@H]1OP(O)(O)=O QUTYKIXIUDQOLK-PRJMDXOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101100270568 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) aroA gene Proteins 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 206010039438 Salmonella Infections Diseases 0.000 description 2
- 101100163491 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) aroA1 gene Proteins 0.000 description 2
- 101100163494 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) aroA2 gene Proteins 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 101150019042 aroA1 gene Proteins 0.000 description 2
- 101150083124 aroA2 gene Proteins 0.000 description 2
- 150000001491 aromatic compounds Chemical class 0.000 description 2
- 229960005091 chloramphenicol Drugs 0.000 description 2
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
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- 239000003814 drug Substances 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229940124590 live attenuated vaccine Drugs 0.000 description 2
- 229940023012 live-attenuated vaccine Drugs 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 2
- 229960000210 nalidixic acid Drugs 0.000 description 2
- 239000013600 plasmid vector Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000006798 recombination Effects 0.000 description 2
- 238000005215 recombination Methods 0.000 description 2
- 206010039447 salmonellosis Diseases 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
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- 150000003522 tetracyclines Chemical class 0.000 description 2
- 108010050327 trypticase-soy broth Proteins 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 108700028369 Alleles Proteins 0.000 description 1
- 241000908115 Bolivar Species 0.000 description 1
- 241000819038 Chichester Species 0.000 description 1
- NGHMDNPXVRFFGS-IUYQGCFVSA-N D-erythrose 4-phosphate Chemical compound O=C[C@H](O)[C@H](O)COP(O)(O)=O NGHMDNPXVRFFGS-IUYQGCFVSA-N 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 101710105714 Outer surface protein A Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000277263 Salmo Species 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- -1 aromatic amino acids Chemical class 0.000 description 1
- 229940031567 attenuated vaccine Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
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- 230000002503 metabolic effect Effects 0.000 description 1
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- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 229930029653 phosphoenolpyruvate Natural products 0.000 description 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
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- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE88790A IE61635B1 (en) | 1990-03-13 | 1990-03-13 | Improvements in vaccines |
| PCT/EP1991/000490 WO1991013978A1 (fr) | 1990-03-13 | 1991-03-12 | Vaccins pour la prevention de la furonculose chez les poissons |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923550D0 NO923550D0 (no) | 1992-09-11 |
| NO923550L NO923550L (no) | 1992-11-09 |
| NO306735B1 true NO306735B1 (no) | 1999-12-13 |
Family
ID=11019383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923550A NO306735B1 (no) | 1990-03-13 | 1992-09-11 | Fremgangsmåte for fremstilling av en vaksine for å forhindre furunkulose i fisk |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0520011B1 (fr) |
| JP (1) | JP2997056B2 (fr) |
| CA (1) | CA2078128A1 (fr) |
| DK (1) | DK0520011T3 (fr) |
| IE (1) | IE61635B1 (fr) |
| NO (1) | NO306735B1 (fr) |
| NZ (1) | NZ237421A (fr) |
| WO (1) | WO1991013978A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498414A (en) * | 1992-10-05 | 1996-03-12 | University Of Victoria | Attenuated strains of Aeromonas salmonicida useful as fish vaccines |
| IL132327A0 (en) * | 1997-04-11 | 2001-03-19 | Univ Louisiana State | Attenuated invasive vaccines against fish pathogens |
| US6010705A (en) * | 1997-04-11 | 2000-01-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Attenuated, invasive vaccines against fish pathogens |
| JP4905649B2 (ja) * | 2006-03-08 | 2012-03-28 | 国立大学法人 長崎大学 | 魚用ワクチン、その製造方法、および魚類感染症の予防方法 |
| JP4892296B2 (ja) | 2006-08-24 | 2012-03-07 | 川崎製薬株式会社 | 魚類のエドワジェラ症及び連鎖球菌症用ワクチン |
| CN115152665B (zh) * | 2022-07-26 | 2023-10-20 | 郝雅 | 一种水生生态系统捕食信息素生态效应研究装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735801A (en) * | 1982-09-07 | 1988-04-05 | Board Of Trustees Of Leland Stanford Jr. University | Novel non-reverting salmonella live vaccines |
| US5077044A (en) * | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| GB8730037D0 (en) * | 1987-12-23 | 1988-02-03 | Wellcome Found | Vaccines |
| DK189788D0 (da) * | 1988-04-07 | 1988-04-07 | Wolf Watz Hans | Vaccine |
-
1990
- 1990-03-13 IE IE88790A patent/IE61635B1/en not_active IP Right Cessation
-
1991
- 1991-03-12 CA CA002078128A patent/CA2078128A1/fr not_active Abandoned
- 1991-03-12 EP EP91906645A patent/EP0520011B1/fr not_active Expired - Lifetime
- 1991-03-12 WO PCT/EP1991/000490 patent/WO1991013978A1/fr active IP Right Grant
- 1991-03-12 JP JP3506773A patent/JP2997056B2/ja not_active Expired - Lifetime
- 1991-03-12 DK DK91906645.6T patent/DK0520011T3/da active
- 1991-03-13 NZ NZ237421A patent/NZ237421A/en unknown
-
1992
- 1992-09-11 NO NO923550A patent/NO306735B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2078128A1 (fr) | 1991-09-14 |
| JP2997056B2 (ja) | 2000-01-11 |
| NZ237421A (en) | 1992-07-28 |
| NO923550L (no) | 1992-11-09 |
| IE900887A1 (en) | 1991-09-25 |
| JPH06503946A (ja) | 1994-05-12 |
| EP0520011A1 (fr) | 1992-12-30 |
| IE61635B1 (en) | 1994-11-16 |
| NO923550D0 (no) | 1992-09-11 |
| WO1991013978A1 (fr) | 1991-09-19 |
| DK0520011T3 (da) | 1995-07-10 |
| EP0520011B1 (fr) | 1995-03-01 |
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