NO304593B1 - Inhibitorer for farnesylproteintransferase - Google Patents
Inhibitorer for farnesylproteintransferaseInfo
- Publication number
- NO304593B1 NO304593B1 NO951649A NO951649A NO304593B1 NO 304593 B1 NO304593 B1 NO 304593B1 NO 951649 A NO951649 A NO 951649A NO 951649 A NO951649 A NO 951649A NO 304593 B1 NO304593 B1 NO 304593B1
- Authority
- NO
- Norway
- Prior art keywords
- protein transferase
- inhibitors
- farnesyl protein
- farnesyl
- farnesylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96802592A | 1992-10-29 | 1992-10-29 | |
| PCT/US1993/010353 WO1994010138A1 (en) | 1992-10-29 | 1993-10-28 | Inhibitors of farnesyl-protein transferase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951649D0 NO951649D0 (no) | 1995-04-28 |
| NO951649L NO951649L (no) | 1995-06-28 |
| NO304593B1 true NO304593B1 (no) | 1999-01-18 |
Family
ID=25513608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951649A NO304593B1 (no) | 1992-10-29 | 1995-04-28 | Inhibitorer for farnesylproteintransferase |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5686472A (hu) |
| EP (1) | EP0666844B1 (hu) |
| JP (1) | JPH08502972A (hu) |
| KR (1) | KR100305989B1 (hu) |
| AT (1) | ATE195727T1 (hu) |
| AU (1) | AU680850B2 (hu) |
| CA (1) | CA2147241A1 (hu) |
| CZ (1) | CZ110395A3 (hu) |
| DE (1) | DE69329291T2 (hu) |
| ES (1) | ES2149859T3 (hu) |
| FI (1) | FI952011A (hu) |
| HU (1) | HUT72966A (hu) |
| NO (1) | NO304593B1 (hu) |
| NZ (1) | NZ258303A (hu) |
| PL (1) | PL177310B1 (hu) |
| RU (1) | RU95109935A (hu) |
| SK (1) | SK53895A3 (hu) |
| WO (1) | WO1994010138A1 (hu) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504212A (en) * | 1992-10-29 | 1996-04-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5326773A (en) * | 1992-10-29 | 1994-07-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6936447B1 (en) | 2000-04-03 | 2005-08-30 | University Of Iowa Research Foundation | Autoinducer molecule |
| US5510510A (en) * | 1994-05-10 | 1996-04-23 | Bristol-Meyers Squibb Company | Inhibitors of farnesyl protein transferase |
| IT1273986B (it) * | 1994-09-28 | 1997-07-14 | Merck & Co Inc | Inibitori peptidici di farnesil proteina transferasi |
| US5523456A (en) * | 1994-09-29 | 1996-06-04 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5661161A (en) * | 1994-09-29 | 1997-08-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5585359A (en) * | 1994-09-29 | 1996-12-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| FR2729390A1 (fr) * | 1995-01-18 | 1996-07-19 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5703241A (en) * | 1995-10-16 | 1997-12-30 | Merck & Co., Inc. | Inhibitor of farnesyl-protein transferase |
| US6127366A (en) * | 1995-11-22 | 2000-10-03 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5968965A (en) * | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6028201A (en) * | 1996-01-30 | 2000-02-22 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5981562A (en) * | 1996-01-30 | 1999-11-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU704087B2 (en) * | 1996-01-30 | 1999-04-15 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6455031B1 (en) * | 1997-06-18 | 2002-09-24 | David G Davies | Methods and compositions for controlling biofilm development |
| US6756404B2 (en) | 1998-06-18 | 2004-06-29 | The Research & Development Institute, Inc. | Autoinducer compounds |
| WO2001062234A2 (en) | 2000-02-24 | 2001-08-30 | Janssen Pharmaceutica N.V. | Dosing regimen |
| US20020177715A1 (en) * | 2000-08-31 | 2002-11-28 | Pesci Everett C. | Novel autoinducer molecules and uses therefor |
| PT1815247E (pt) | 2004-11-05 | 2013-04-23 | Janssen Pharmaceutica Nv | Uso terapêutico de inibidores de farnesiltransferase e métodos para monitorizar a eficácia do mesmo |
| EP1656931A1 (en) * | 2004-11-15 | 2006-05-17 | Exonhit Therapeutics SA | Compounds which inhibits protein prenylation ( e.g. geranylgeranyltransferase or farnesyltransferase inhibitors) for treating Parkinson's disease |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| AU2007240437B2 (en) | 2006-04-20 | 2012-12-06 | Janssen Pharmaceutica N.V. | Heterocyclic compounds as inhibitors of c-fms kinase |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| MX2008013530A (es) | 2006-04-20 | 2009-01-14 | Janssen Pharmaceutica Nv | Inhibidores de c-fms cinasa. |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| WO2014025675A1 (en) | 2012-08-07 | 2014-02-13 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| EP3640345B9 (en) | 2015-08-17 | 2021-11-24 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyl transferase inhibitors |
| US20190119758A1 (en) | 2016-04-22 | 2019-04-25 | Kura Oncology, Inc. | Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors |
| LT3534885T (lt) | 2016-11-03 | 2021-07-12 | Kura Oncology, Inc. | Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui |
| TWI663974B (zh) | 2017-02-21 | 2019-07-01 | 美商庫拉腫瘤技術股份有限公司 | 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法 |
| US10137121B2 (en) | 2017-02-21 | 2018-11-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| SG11202000894TA (en) | 2017-08-07 | 2020-02-27 | Kura Oncology Inc | Methods of treating cancer with farnesyltransferase inhibitors |
| US10806730B2 (en) | 2017-08-07 | 2020-10-20 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| WO2019113269A1 (en) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
| AU2019372141A1 (en) | 2018-11-01 | 2021-05-27 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| AU2019403379A1 (en) | 2018-12-21 | 2021-07-15 | Kura Oncology, Inc. | Therapies for squamous cell carcinomas |
| WO2020180663A1 (en) | 2019-03-01 | 2020-09-10 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| EP3946338A1 (en) | 2019-03-29 | 2022-02-09 | Kura Oncology, Inc. | Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors |
| WO2020205387A1 (en) | 2019-04-01 | 2020-10-08 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
| WO2020223583A1 (en) | 2019-05-02 | 2020-11-05 | Kura Oncology, Inc. | Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT66467B (de) * | 1912-08-27 | 1914-08-25 | Theodor Johann Cavier | Schuhsohlenschoner. |
| US4720585A (en) * | 1985-09-18 | 1988-01-19 | E. R. Squibb & Sons, Inc. | Aminopeptidase inhibitors |
| US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| US5043268A (en) * | 1990-05-04 | 1991-08-27 | The Trustees Of Princeton University | Substrates and inhibitors for prenyl cysteine methyltransferase enzymes |
| US5185248A (en) * | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| US5238922A (en) * | 1991-09-30 | 1993-08-24 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5340828A (en) * | 1991-09-30 | 1994-08-23 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5352705A (en) * | 1992-06-26 | 1994-10-04 | Merck & Co., Inc. | Inhibitors of farnesyl protein transferase |
| US5326773A (en) * | 1992-10-29 | 1994-07-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US5504212A (en) * | 1992-10-29 | 1996-04-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
-
1993
- 1993-10-27 US US08/143,943 patent/US5686472A/en not_active Expired - Fee Related
- 1993-10-28 DE DE69329291T patent/DE69329291T2/de not_active Expired - Fee Related
- 1993-10-28 ES ES94901218T patent/ES2149859T3/es not_active Expired - Lifetime
- 1993-10-28 JP JP6511318A patent/JPH08502972A/ja active Pending
- 1993-10-28 WO PCT/US1993/010353 patent/WO1994010138A1/en active IP Right Grant
- 1993-10-28 SK SK538-95A patent/SK53895A3/sk unknown
- 1993-10-28 PL PL93308554A patent/PL177310B1/pl unknown
- 1993-10-28 NZ NZ258303A patent/NZ258303A/en unknown
- 1993-10-28 AU AU55882/94A patent/AU680850B2/en not_active Ceased
- 1993-10-28 EP EP94901218A patent/EP0666844B1/en not_active Expired - Lifetime
- 1993-10-28 KR KR1019950701641A patent/KR100305989B1/ko not_active IP Right Cessation
- 1993-10-28 CA CA002147241A patent/CA2147241A1/en not_active Abandoned
- 1993-10-28 HU HU9501238A patent/HUT72966A/hu unknown
- 1993-10-28 CZ CZ951103A patent/CZ110395A3/cs unknown
- 1993-10-28 AT AT94901218T patent/ATE195727T1/de not_active IP Right Cessation
- 1993-10-28 RU RU95109935/04A patent/RU95109935A/ru unknown
-
1995
- 1995-04-27 FI FI952011A patent/FI952011A/fi unknown
- 1995-04-28 NO NO951649A patent/NO304593B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994010138A1 (en) | 1994-05-11 |
| ATE195727T1 (de) | 2000-09-15 |
| KR100305989B1 (ko) | 2001-11-30 |
| RU95109935A (ru) | 1997-01-10 |
| US5686472A (en) | 1997-11-11 |
| FI952011A0 (fi) | 1995-04-27 |
| HUT72966A (en) | 1996-06-28 |
| EP0666844A1 (en) | 1995-08-16 |
| DE69329291T2 (de) | 2001-04-05 |
| EP0666844B1 (en) | 2000-08-23 |
| SK53895A3 (en) | 1995-09-13 |
| CA2147241A1 (en) | 1994-05-11 |
| ES2149859T3 (es) | 2000-11-16 |
| AU680850B2 (en) | 1997-08-14 |
| NO951649L (no) | 1995-06-28 |
| PL177310B1 (pl) | 1999-10-29 |
| FI952011A (fi) | 1995-04-27 |
| DE69329291D1 (de) | 2000-09-28 |
| KR950704248A (ko) | 1995-11-17 |
| HU9501238D0 (en) | 1995-06-28 |
| NZ258303A (en) | 1996-05-28 |
| PL308554A1 (en) | 1995-08-21 |
| CZ110395A3 (en) | 1996-04-17 |
| NO951649D0 (no) | 1995-04-28 |
| JPH08502972A (ja) | 1996-04-02 |
| AU5588294A (en) | 1994-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI952011A0 (fi) | Farnesyyliproteiinitransferaasin estäjät | |
| ATE181059T1 (de) | Inhibitoren der farnesyl-protein-transferase | |
| MX9707459A (es) | Inhibidores de farnesil-proteina transferasa, composiciones que los contienen y uso de las composiciones. | |
| NO951647L (no) | Inhibitorer for farnesylproteintransferase | |
| YU19296A (sh) | Inhibitori farnezil-protein transferaze | |
| WO1997038665A3 (en) | Inhibitors of farnesyl-protein transferase | |
| MX9705273A (es) | Inhibidores de prenil transferasas. | |
| EP0535730A3 (en) | Inhibitors of farnesyl protein transferase | |
| EP0535731A3 (en) | Inhibitors of farnesyl protein transferase | |
| WO2000034437A3 (en) | Inhibitors of prenyl-protein transferase | |
| UA29446C2 (uk) | Засіб для інгібування тромбіну | |
| MY117961A (en) | Inhibitors of farnesyl protein transferase | |
| ATE206390T1 (de) | Cyclobutan-derivate als inhibitoren der squalen- synthase und der protein farnesyltransferase | |
| FI941580A0 (fi) | Bisyklisiä ansamysiinejä | |
| FI941519A0 (fi) | Farnesyyliproteiinitransferaasin heterosyklisiä inhibiittoreita | |
| ATE409189T1 (de) | Farnesyl transferase-hemmende 6- heterocyclylmethyl-chinolin und chinazol-derivate | |
| HK1018446A1 (en) | Tricyclic antitumor compounds being farnesyl protein transferase inhibitors. | |
| EP0547669A3 (en) | Inhibitors of farnesyl protein transferase | |
| AU2867992A (en) | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors | |
| EP0547670A3 (en) | Inhibitors of farnesyl protein transferase | |
| EP0547672A3 (en) | Inhibitors of farnesyl protein transferase | |
| WO2002060868A3 (en) | Inhibitors of prenyl-protein transferase | |
| WO2000034239A3 (en) | Inhibitors of prenyl-protein transferase | |
| WO2002079147A3 (en) | Inhibitors of prenyl-protein transferase | |
| EP0547671A3 (en) | Inhibitors of farnesyl protein transferase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |