NO302754B1 - Fremgangsmåte ved fremstilling av ergolinderivater - Google Patents
Fremgangsmåte ved fremstilling av ergolinderivaterInfo
- Publication number
- NO302754B1 NO302754B1 NO934077A NO934077A NO302754B1 NO 302754 B1 NO302754 B1 NO 302754B1 NO 934077 A NO934077 A NO 934077A NO 934077 A NO934077 A NO 934077A NO 302754 B1 NO302754 B1 NO 302754B1
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- formula
- ergoline derivatives
- ergoline
- image
- Prior art date
Links
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 title abstract 2
- -1 ergoline amide Chemical class 0.000 abstract 2
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 229940125688 antiparkinson agent Drugs 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Control Of Electric Motors In General (AREA)
- Emergency Protection Circuit Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929205439A GB9205439D0 (en) | 1992-03-12 | 1992-03-12 | Process for the synthesis of ergoline derivatives |
| PCT/EP1993/000360 WO1993018034A1 (en) | 1992-03-12 | 1993-02-15 | Process for the preparation of ergoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO934077L NO934077L (no) | 1993-11-11 |
| NO934077D0 NO934077D0 (no) | 1993-11-11 |
| NO302754B1 true NO302754B1 (no) | 1998-04-20 |
Family
ID=10712024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO934077A NO302754B1 (no) | 1992-03-12 | 1993-11-11 | Fremgangsmåte ved fremstilling av ergolinderivater |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5382669A (cs) |
| EP (1) | EP0593692B1 (cs) |
| JP (1) | JP3339858B2 (cs) |
| KR (1) | KR100274102B1 (cs) |
| CN (1) | CN1038510C (cs) |
| AT (1) | ATE180783T1 (cs) |
| AU (1) | AU653099B2 (cs) |
| CA (1) | CA2106371C (cs) |
| CZ (1) | CZ281708B6 (cs) |
| DE (1) | DE69325138D1 (cs) |
| FI (1) | FI113473B (cs) |
| GB (1) | GB9205439D0 (cs) |
| HU (1) | HU210407B (cs) |
| IL (1) | IL104973A (cs) |
| MX (1) | MX9301297A (cs) |
| MY (1) | MY109152A (cs) |
| NO (1) | NO302754B1 (cs) |
| NZ (1) | NZ249115A (cs) |
| PH (1) | PH30138A (cs) |
| RU (1) | RU2118323C1 (cs) |
| SK (1) | SK279039B6 (cs) |
| TW (1) | TW215089B (cs) |
| UA (1) | UA26400C2 (cs) |
| WO (1) | WO1993018034A1 (cs) |
| ZA (1) | ZA931720B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0007308D0 (en) | 2000-03-24 | 2000-05-17 | Pharmacia & Upjohn Spa | Process for preparing crystalline form | of cabergoline |
| US6696568B2 (en) | 2001-04-16 | 2004-02-24 | Finetech Ltd. | Process and intermediates for production of cabergoline and related compounds |
| US7517853B2 (en) * | 2003-04-11 | 2009-04-14 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
| IL155545A (en) * | 2003-04-21 | 2009-12-24 | Finetech Pharmaceutical Ltd | Solvate form of cabergoline |
| HUP0400517A3 (en) * | 2004-03-04 | 2006-05-29 | Richter Gedeon Vegyeszet | Process for producing cabergoline |
| GB0409785D0 (en) * | 2004-04-30 | 2004-06-09 | Resolution Chemicals Ltd | Preparation of cabergoline |
| FR2877945A1 (fr) * | 2004-11-18 | 2006-05-19 | Archemis Sa | Procede de la preparation de la cabergoline |
| EP1858894A1 (en) | 2005-03-17 | 2007-11-28 | Synthon Argentina S.A. | Improved process for making cabergoline |
| GB0505965D0 (en) * | 2005-03-23 | 2005-04-27 | Resolution Chemicals Ltd | Preparation of cabergoline |
| EP1925616A1 (en) * | 2006-10-26 | 2008-05-28 | LEK Pharmaceuticals D.D. | Process for the preparation of crystal forms of cabergoline via stable solvates of cabergoline |
| US7939665B2 (en) * | 2007-05-04 | 2011-05-10 | Apotex Pharmachem Inc. | Efficient process for the preparation of cabergoline and its intermediates |
| US9670199B2 (en) | 2012-11-19 | 2017-06-06 | Regents Of The University Of Minnesota | Ergoline derivatives as dopamine receptor modulators |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2074566B (en) * | 1980-04-03 | 1983-11-02 | Erba Farmitalia | Ergoline derivatives |
| GB2103603B (en) * | 1981-08-11 | 1985-04-11 | Erba Farmitalia | Ergoline derivatives |
-
1992
- 1992-03-12 GB GB929205439A patent/GB9205439D0/en active Pending
-
1993
- 1993-02-15 AU AU34974/93A patent/AU653099B2/en not_active Ceased
- 1993-02-15 KR KR1019930703386A patent/KR100274102B1/ko not_active Expired - Fee Related
- 1993-02-15 HU HU9303541A patent/HU210407B/hu unknown
- 1993-02-15 NZ NZ249115A patent/NZ249115A/en not_active IP Right Cessation
- 1993-02-15 DE DE69325138T patent/DE69325138D1/de not_active Expired - Lifetime
- 1993-02-15 UA UA93003963A patent/UA26400C2/uk unknown
- 1993-02-15 CZ CZ932715A patent/CZ281708B6/cs not_active IP Right Cessation
- 1993-02-15 WO PCT/EP1993/000360 patent/WO1993018034A1/en not_active Ceased
- 1993-02-15 JP JP51527993A patent/JP3339858B2/ja not_active Expired - Fee Related
- 1993-02-15 EP EP93903972A patent/EP0593692B1/en not_active Expired - Lifetime
- 1993-02-15 CA CA002106371A patent/CA2106371C/en not_active Expired - Fee Related
- 1993-02-15 RU RU93058546A patent/RU2118323C1/ru not_active IP Right Cessation
- 1993-02-15 AT AT93903972T patent/ATE180783T1/de active
- 1993-02-15 SK SK1401-93A patent/SK279039B6/sk unknown
- 1993-02-16 TW TW082101067A patent/TW215089B/zh active
- 1993-03-08 IL IL104973A patent/IL104973A/xx not_active IP Right Cessation
- 1993-03-09 US US08/028,286 patent/US5382669A/en not_active Expired - Lifetime
- 1993-03-09 MX MX9301297A patent/MX9301297A/es not_active IP Right Cessation
- 1993-03-09 PH PH45839A patent/PH30138A/en unknown
- 1993-03-09 CN CN93102663A patent/CN1038510C/zh not_active Expired - Fee Related
- 1993-03-10 ZA ZA931720A patent/ZA931720B/xx unknown
- 1993-03-11 MY MYPI93000439A patent/MY109152A/en unknown
- 1993-11-08 FI FI934933A patent/FI113473B/fi active
- 1993-11-11 NO NO934077A patent/NO302754B1/no unknown
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