NO301748B1 - Fremgangsmåte for fremstilling av et farmasöytisk preparat for forhindring av fibrinavsetning eller adhesjonsdannelse eller -nydannelse - Google Patents
Fremgangsmåte for fremstilling av et farmasöytisk preparat for forhindring av fibrinavsetning eller adhesjonsdannelse eller -nydannelse Download PDFInfo
- Publication number
- NO301748B1 NO301748B1 NO895338A NO895338A NO301748B1 NO 301748 B1 NO301748 B1 NO 301748B1 NO 895338 A NO895338 A NO 895338A NO 895338 A NO895338 A NO 895338A NO 301748 B1 NO301748 B1 NO 301748B1
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- Norway
- Prior art keywords
- plasminogen activator
- tissue plasminogen
- preparation
- formation
- adhesions
- Prior art date
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- 229960003957 dexamethasone Drugs 0.000 description 1
- 238000011026 diafiltration Methods 0.000 description 1
- DOBMPNYZJYQDGZ-UHFFFAOYSA-N dicoumarol Chemical compound C1=CC=CC2=C1OC(=O)C(CC=1C(OC3=CC=CC=C3C=1O)=O)=C2O DOBMPNYZJYQDGZ-UHFFFAOYSA-N 0.000 description 1
- 229960001912 dicoumarol Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
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- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- IRYFCWPNDIUQOW-UHFFFAOYSA-N fluanisone Chemical compound COC1=CC=CC=C1N1CCN(CCCC(=O)C=2C=CC(F)=CC=2)CC1 IRYFCWPNDIUQOW-UHFFFAOYSA-N 0.000 description 1
- 229960005220 fluanisone Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
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- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 231100000021 irritant Toxicity 0.000 description 1
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- 210000000281 joint capsule Anatomy 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
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- 238000002684 laminectomy Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000002747 omentum Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
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- 239000002797 plasminogen activator inhibitor Substances 0.000 description 1
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- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
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- 239000002244 precipitate Substances 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
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- 229960003910 promethazine Drugs 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- 229960002244 promethazine hydrochloride Drugs 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- 230000004044 response Effects 0.000 description 1
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- 239000012266 salt solution Substances 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940071117 starch glycolate Drugs 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229960004533 streptodornase Drugs 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
- 238000013316 zoning Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6887287A | 1987-07-01 | 1987-07-01 | |
| US12531987A | 1987-11-25 | 1987-11-25 | |
| US21089588A | 1988-06-24 | 1988-06-24 | |
| PCT/US1988/002194 WO1989000049A1 (en) | 1987-07-01 | 1988-06-30 | Method and therapeutic compositions for the prevention of fibrin deposition or adhesions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO895338D0 NO895338D0 (no) | 1989-12-29 |
| NO895338L NO895338L (no) | 1990-02-28 |
| NO301748B1 true NO301748B1 (no) | 1997-12-08 |
Family
ID=27371438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO895338A NO301748B1 (no) | 1987-07-01 | 1989-12-29 | Fremgangsmåte for fremstilling av et farmasöytisk preparat for forhindring av fibrinavsetning eller adhesjonsdannelse eller -nydannelse |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0297860B1 (ko) |
| JP (1) | JP2756131B2 (ko) |
| KR (1) | KR0131330B1 (ko) |
| AU (1) | AU621305B2 (ko) |
| DE (1) | DE3883645T2 (ko) |
| DK (1) | DK175597B1 (ko) |
| FI (1) | FI103868B1 (ko) |
| IE (1) | IE65658B1 (ko) |
| IL (2) | IL86933A (ko) |
| NO (1) | NO301748B1 (ko) |
| NZ (1) | NZ225260A (ko) |
| PH (1) | PH26527A (ko) |
| PT (1) | PT87886B (ko) |
| WO (1) | WO1989000049A1 (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364622A (en) * | 1987-12-04 | 1994-11-15 | Dr. Karl Thomae Gmbh | Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydroxyethylcellulose hydrogel |
| DE3741149A1 (de) * | 1987-12-04 | 1989-06-15 | Thomae Gmbh Dr K | Zubereitungsformen zur verhinderung von adhaesionen von organen und organteilen |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| WO1995001292A1 (en) * | 1993-07-02 | 1995-01-12 | Quest International Bv. | Packaging of enzymes |
| US5869810A (en) * | 1995-05-23 | 1999-02-09 | Victor Reynolds | Impedance-heated furnace |
| DE19529223A1 (de) * | 1995-08-09 | 1997-02-13 | Boehringer Mannheim Gmbh | Verwendung von Plasminogenaktivatoren zum lokalen Knochenaufbau |
| US5837688A (en) * | 1996-11-27 | 1998-11-17 | Gelfand; Mathew I. | Use of thrombolytic reagents for prevention of vascular disease |
| US7067485B2 (en) | 1997-11-07 | 2006-06-27 | Chiron Corporation | IGF-I composition and its use |
| WO1999024062A1 (en) * | 1997-11-07 | 1999-05-20 | Chiron Corporation | Novel igf-i composition and its use |
| FR2918276B1 (fr) | 2007-07-02 | 2010-01-22 | Anteis Sa | "utilisation d'un gel de polysaccharide(s)naturel(s)pour la preparation d'une formulation injectable de traitement des degenerescences articulaires" |
| DE102014112212A1 (de) | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
| DE3500268A1 (de) * | 1985-01-05 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Praeparate mit verzoegerter wirkung, verfahren zu deren herstellung sowie entsprechende mittel zur human- bzw. veterinaermedizinischen anwendung |
| JPS6218742A (ja) * | 1985-07-18 | 1987-01-27 | Sony Corp | ヒ−トシンクの製造方法 |
| NZ217844A (en) * | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
| KR870005646A (ko) * | 1985-12-16 | 1987-07-06 | 로버트 엘. 미니어 | 수술후 유착형성 억제방법 |
-
1988
- 1988-06-30 EP EP88305935A patent/EP0297860B1/en not_active Expired - Lifetime
- 1988-06-30 KR KR1019890700376A patent/KR0131330B1/ko not_active IP Right Cessation
- 1988-06-30 JP JP63505978A patent/JP2756131B2/ja not_active Expired - Lifetime
- 1988-06-30 PT PT87886A patent/PT87886B/pt not_active IP Right Cessation
- 1988-06-30 WO PCT/US1988/002194 patent/WO1989000049A1/en active IP Right Grant
- 1988-06-30 IL IL86933A patent/IL86933A/xx not_active IP Right Cessation
- 1988-06-30 AU AU19985/88A patent/AU621305B2/en not_active Expired
- 1988-06-30 DE DE88305935T patent/DE3883645T2/de not_active Expired - Lifetime
- 1988-07-01 PH PH37149A patent/PH26527A/en unknown
- 1988-07-01 NZ NZ225260A patent/NZ225260A/en unknown
- 1988-07-01 IE IE202388A patent/IE65658B1/en not_active IP Right Cessation
-
1989
- 1989-12-29 DK DK198906753A patent/DK175597B1/da not_active IP Right Cessation
- 1989-12-29 NO NO895338A patent/NO301748B1/no not_active IP Right Cessation
- 1989-12-29 FI FI896359A patent/FI103868B1/fi active IP Right Grant
-
1992
- 1992-07-23 IL IL102625A patent/IL102625A0/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR890701124A (ko) | 1989-12-19 |
| NO895338D0 (no) | 1989-12-29 |
| JP2756131B2 (ja) | 1998-05-25 |
| DK675389D0 (da) | 1989-12-29 |
| DE3883645T2 (de) | 1994-02-03 |
| PH26527A (en) | 1992-08-07 |
| DE3883645D1 (de) | 1993-10-07 |
| FI896359A0 (fi) | 1989-12-29 |
| IE65658B1 (en) | 1995-11-15 |
| IL102625A0 (en) | 1993-01-14 |
| FI103868B (fi) | 1999-10-15 |
| FI103868B1 (fi) | 1999-10-15 |
| PT87886A (pt) | 1989-06-30 |
| WO1989000049A1 (en) | 1989-01-12 |
| JPH04502753A (ja) | 1992-05-21 |
| NO895338L (no) | 1990-02-28 |
| NZ225260A (en) | 1991-03-26 |
| KR0131330B1 (ko) | 1998-04-17 |
| DK675389A (da) | 1990-02-28 |
| EP0297860B1 (en) | 1993-09-01 |
| IL86933A (en) | 1993-07-08 |
| IE882023L (en) | 1989-01-01 |
| DK175597B1 (da) | 2004-12-13 |
| AU1998588A (en) | 1989-01-30 |
| PT87886B (pt) | 1993-09-30 |
| EP0297860A1 (en) | 1989-01-04 |
| AU621305B2 (en) | 1992-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |