NO2379115T3 - - Google Patents
Info
- Publication number
- NO2379115T3 NO2379115T3 NO09774794A NO09774794A NO2379115T3 NO 2379115 T3 NO2379115 T3 NO 2379115T3 NO 09774794 A NO09774794 A NO 09774794A NO 09774794 A NO09774794 A NO 09774794A NO 2379115 T3 NO2379115 T3 NO 2379115T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13842108P | 2008-12-17 | 2008-12-17 | |
| US24518209P | 2009-09-23 | 2009-09-23 | |
| PCT/US2009/068012 WO2010077853A2 (fr) | 2008-12-17 | 2009-12-15 | Production d'il-10 mono- et di-pégylé et ses utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2379115T3 true NO2379115T3 (fr) | 2018-03-24 |
Family
ID=42224354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO09774794A NO2379115T3 (fr) | 2008-12-17 | 2009-12-15 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8691205B2 (fr) |
| EP (2) | EP2379115B1 (fr) |
| JP (5) | JP5888980B2 (fr) |
| CN (2) | CN102256625B (fr) |
| AU (1) | AU2009333325B2 (fr) |
| CA (1) | CA2745443C (fr) |
| DK (1) | DK2379115T3 (fr) |
| ES (2) | ES2655364T3 (fr) |
| HK (2) | HK1190736A1 (fr) |
| HU (1) | HUE037936T2 (fr) |
| NO (1) | NO2379115T3 (fr) |
| PL (1) | PL2379115T3 (fr) |
| PT (1) | PT2379115T (fr) |
| RU (1) | RU2549702C2 (fr) |
| WO (1) | WO2010077853A2 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2379115T (pt) * | 2008-12-17 | 2018-01-03 | Merck Sharp & Dohme | Produção de mono- e di-peg-il-10; e utilizações |
| WO2014172392A1 (fr) * | 2013-04-18 | 2014-10-23 | Armo Biosciences, Inc. | Méthodes d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
| ES2688206T3 (es) * | 2013-06-17 | 2018-10-31 | Armo Biosciences, Inc. | Procedimiento de evaluación de la identidad y la estabilidad de proteínas |
| US10010588B2 (en) | 2013-08-30 | 2018-07-03 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating hyperlipidemia |
| RU2016122957A (ru) | 2013-11-11 | 2017-12-19 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
| US10293043B2 (en) * | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| US10350270B2 (en) | 2014-10-14 | 2019-07-16 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
| CA2963995A1 (fr) | 2014-10-22 | 2016-04-28 | Armo Biosciences, Inc. | Procedes d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
| CN105777892A (zh) * | 2014-12-17 | 2016-07-20 | 深圳翰宇药业股份有限公司 | 普兰林肽聚乙二醇衍生物、其制备方法及其应用 |
| WO2016126615A1 (fr) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Procédés d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
| CN107847583A (zh) | 2015-05-28 | 2018-03-27 | 阿尔莫生物科技股份有限公司 | 用于治疗癌症的聚乙二醇化白细胞介素‑10 |
| EP3302528A1 (fr) | 2015-05-29 | 2018-04-11 | Armo Biosciences, Inc. | Procédés d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
| CN108025040A (zh) | 2015-08-25 | 2018-05-11 | 阿尔莫生物科技股份有限公司 | 使用白介素-10治疗疾病和病症的方法 |
| JP7082051B2 (ja) | 2016-01-11 | 2022-06-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | 抗原特異的ｃｄ８＋ｔ細胞の産生におけるインターロイキン－１０及びその使用方法 |
| EP4252629A3 (fr) | 2016-12-07 | 2023-12-27 | Biora Therapeutics, Inc. | Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal |
| US11596670B2 (en) | 2017-03-30 | 2023-03-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with IL-10 or an IL-10 agonist |
| WO2019057180A1 (fr) * | 2017-09-25 | 2019-03-28 | Dingfu Biotarget Co., Ltd. | Hétérodimère protéique et utilisation de celui-ci |
| US20200353050A1 (en) | 2017-11-10 | 2020-11-12 | Armo Biosciences, Inc. | Compositions and methods of use of interleukin-10 in combination with immune check-point pathway inhibitors |
| US20210347842A1 (en) | 2018-06-19 | 2021-11-11 | Eli Lilly And Company | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
| KR20210095165A (ko) | 2018-11-19 | 2021-07-30 | 프로제너티, 인크. | 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스 |
| WO2020108426A1 (fr) * | 2018-11-26 | 2020-06-04 | 江苏恒瑞医药股份有限公司 | Variant d'interleukine 10 humaine et dérivé correspondant |
| CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
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| JPS63152393A (ja) | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
| US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
| US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| JP3260368B2 (ja) | 1991-01-16 | 2002-02-25 | シェリング・コーポレーション | インターロイキン−１０による腫瘍性疾患の処置 |
| DE69203443T2 (de) | 1991-01-16 | 1995-12-07 | Schering Corp | Verwendung von interleukin-10 in der adoptive immunotherapie von krebs. |
| US5783415A (en) | 1991-03-29 | 1998-07-21 | Genentech, Inc. | Method of producing an IL-8 receptor polypeptide |
| US5624823A (en) | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
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| CZ23396A3 (en) | 1993-07-26 | 1996-05-15 | Schering Corp | Antagonists and agonists of human interleukin-10 |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
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| AU707019B2 (en) | 1994-01-20 | 1999-07-01 | Schering Corporation | Use of IL-10 to stimulate peripheral blood mononuclear cell cytolytic activity |
| US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
| US5650232A (en) | 1994-10-07 | 1997-07-22 | Warner-Lambert Company | Method for making seamless capsules |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5866134A (en) | 1995-03-24 | 1999-02-02 | Schering Corporation | Method for enhancing the antibody response to specific antigens with Interleukin-10 |
| US5770190A (en) | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
| AU6501296A (en) | 1995-07-21 | 1997-02-18 | General Hospital Corporation, The | Method and apparatus of enhancing the delivery of a pharmaceutical formulation |
| GB2304047A (en) | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| US5989867A (en) | 1996-09-23 | 1999-11-23 | Knappe; Andrea | DNA encoding IL-10-like homologue; related reagents |
| US6660258B1 (en) | 1997-05-09 | 2003-12-09 | Pharma Pacific Pty Ltd | Oromucosal cytokine compositions and uses thereof |
| US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US6326482B1 (en) | 1999-04-23 | 2001-12-04 | Genentech, Inc. | SH2 domain-containing peptides |
| US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| WO2001005821A2 (fr) | 1999-07-16 | 2001-01-25 | Maria Teresa Bejarano | Utilisations de l'il-10 virale |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| EP1257574A1 (fr) | 2000-02-11 | 2002-11-20 | Maxygen Aps | Interleukine-10 amelioree |
| US20030186386A1 (en) | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
| JP3894118B2 (ja) | 2000-09-20 | 2007-03-14 | 株式会社日立製作所 | イオントラップ質量分析計を用いた探知方法及び探知装置 |
| EP2295450B1 (fr) * | 2000-09-29 | 2015-01-28 | Merck Sharp & Dohme Corp. | Interleukine 10 pegylee |
| GB0212648D0 (en) | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
| WO2004022593A2 (fr) | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Evolution rationnelle de cytokines pour une plus grande stabilite, les cytokines et molecules d'acide nucleique codant |
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| US20060127357A1 (en) | 2002-11-29 | 2006-06-15 | Roncarolo Maria G | Rapamycin and il-10 for the treatment of immune diseases |
| JP2006519170A (ja) * | 2002-12-26 | 2006-08-24 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | サイトカイン、ケモカイン、増殖因子、ポリペプチドホルモン、およびレセプター結合活性が保存されたそのアンタゴニストのポリマー結合体 |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| US8133700B2 (en) | 2003-11-28 | 2012-03-13 | The University Of Sydney | Latent phase viral interleukin-10-(VII-10) and uses thereof |
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| DE602006011311D1 (de) | 2005-05-31 | 2010-02-04 | Univ Colorado | Il-10 mutante |
| ES2357152T3 (es) * | 2005-10-04 | 2011-04-19 | Zymogenetics, L.L.C. | Producción y purificación de il-29. |
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| NZ597098A (en) * | 2006-09-28 | 2013-05-31 | Merck Sharp & Dohme | Use of pegylated il-10 to treat cancer |
| EP2078201A2 (fr) | 2006-10-05 | 2009-07-15 | Agency for Science, Technology and Research | Diagnostic et traitement de la dingue |
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| EP2959917A3 (fr) | 2007-10-19 | 2016-02-24 | The Regents of The University of California | Compositions et procédés permettant d'améliorer l'inflammation du sn, la psychose, le délire, le ptsd ou le sspt |
| PT2379115T (pt) * | 2008-12-17 | 2018-01-03 | Merck Sharp & Dohme | Produção de mono- e di-peg-il-10; e utilizações |
| WO2014172392A1 (fr) * | 2013-04-18 | 2014-10-23 | Armo Biosciences, Inc. | Méthodes d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
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2009
- 2009-12-15 PT PT97747943T patent/PT2379115T/pt unknown
- 2009-12-15 US US13/140,390 patent/US8691205B2/en active Active
- 2009-12-15 CN CN2009801506728A patent/CN102256625B/zh active Active
- 2009-12-15 DK DK09774794.3T patent/DK2379115T3/da active
- 2009-12-15 ES ES09774794.3T patent/ES2655364T3/es active Active
- 2009-12-15 EP EP09774794.3A patent/EP2379115B1/fr active Active
- 2009-12-15 WO PCT/US2009/068012 patent/WO2010077853A2/fr active Application Filing
- 2009-12-15 HU HUE09774794A patent/HUE037936T2/hu unknown
- 2009-12-15 CN CN201310480573.4A patent/CN103601800B/zh active Active
- 2009-12-15 JP JP2011542332A patent/JP5888980B2/ja active Active
- 2009-12-15 AU AU2009333325A patent/AU2009333325B2/en active Active
- 2009-12-15 PL PL09774794T patent/PL2379115T3/pl unknown
- 2009-12-15 CA CA2745443A patent/CA2745443C/fr active Active
- 2009-12-15 EP EP17187274.0A patent/EP3348281B1/fr active Active
- 2009-12-15 ES ES17187274T patent/ES2957546T3/es active Active
- 2009-12-15 NO NO09774794A patent/NO2379115T3/no unknown
- 2009-12-15 RU RU2011129638/10A patent/RU2549702C2/ru active
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2014
- 2014-02-18 US US14/183,302 patent/US9259478B2/en active Active
- 2014-04-24 HK HK14103942.7A patent/HK1190736A1/zh unknown
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2015
- 2015-07-16 JP JP2015141963A patent/JP2015221817A/ja active Pending
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2016
- 2016-01-06 US US14/989,068 patent/US9566345B2/en active Active
- 2016-11-04 JP JP2016216681A patent/JP6349371B2/ja active Active
- 2016-12-28 US US15/393,013 patent/US10639353B2/en active Active
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2018
- 2018-06-04 JP JP2018107216A patent/JP6791906B2/ja active Active
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2019
- 2019-01-17 HK HK19100810.7A patent/HK1258403A1/zh unknown
- 2019-10-08 JP JP2019185061A patent/JP6905024B2/ja active Active