PL2379115T3 - Wytwarzanie i zastosowania mono- i di-peg il-10 - Google Patents
Wytwarzanie i zastosowania mono- i di-peg il-10Info
- Publication number
- PL2379115T3 PL2379115T3 PL09774794T PL09774794T PL2379115T3 PL 2379115 T3 PL2379115 T3 PL 2379115T3 PL 09774794 T PL09774794 T PL 09774794T PL 09774794 T PL09774794 T PL 09774794T PL 2379115 T3 PL2379115 T3 PL 2379115T3
- Authority
- PL
- Poland
- Prior art keywords
- peg
- mono
- production
- Prior art date
Links
- 230000031261 interleukin-10 production Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyethers (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13842108P | 2008-12-17 | 2008-12-17 | |
| US24518209P | 2009-09-23 | 2009-09-23 | |
| EP09774794.3A EP2379115B1 (en) | 2008-12-17 | 2009-12-15 | Mono- and di-peg il-10 production; and uses |
| PCT/US2009/068012 WO2010077853A2 (en) | 2008-12-17 | 2009-12-15 | Mono- and di-peg il-10 production; and uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2379115T3 true PL2379115T3 (pl) | 2018-03-30 |
Family
ID=42224354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09774794T PL2379115T3 (pl) | 2008-12-17 | 2009-12-15 | Wytwarzanie i zastosowania mono- i di-peg il-10 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8691205B2 (pl) |
| EP (2) | EP3348281B1 (pl) |
| JP (5) | JP5888980B2 (pl) |
| CN (2) | CN103601800B (pl) |
| AU (1) | AU2009333325B2 (pl) |
| CA (1) | CA2745443C (pl) |
| DK (1) | DK2379115T3 (pl) |
| ES (2) | ES2655364T3 (pl) |
| HU (1) | HUE037936T2 (pl) |
| NO (1) | NO2379115T3 (pl) |
| PL (1) | PL2379115T3 (pl) |
| PT (1) | PT2379115T (pl) |
| RU (1) | RU2549702C2 (pl) |
| WO (1) | WO2010077853A2 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037936T2 (hu) * | 2008-12-17 | 2018-09-28 | Merck Sharp & Dohme | Mono- és di-pegil IL-10 elõállítása és alkalmazása |
| HK1215681A1 (zh) * | 2013-04-18 | 2016-09-09 | Armo Biosciences, Inc. | 使用白细胞介素-10治疗疾病和病症的方法 |
| EP3010527B1 (en) | 2013-06-17 | 2018-08-08 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| CA2920679A1 (en) * | 2013-08-30 | 2015-03-05 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EP3068425B1 (en) | 2013-11-11 | 2021-01-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN106573072A (zh) | 2014-06-02 | 2017-04-19 | 阿尔莫生物科技股份有限公司 | 降低血清胆固醇的方法 |
| CN107001438A (zh) | 2014-10-14 | 2017-08-01 | 阿尔莫生物科技股份有限公司 | 白细胞介素‑15组合物及其用途 |
| KR20170084033A (ko) | 2014-10-22 | 2017-07-19 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위해 인터루킨-10을 사용하는 방법 |
| CN105777892A (zh) * | 2014-12-17 | 2016-07-20 | 深圳翰宇药业股份有限公司 | 普兰林肽聚乙二醇衍生物、其制备方法及其应用 |
| US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
| CA2986755A1 (en) | 2015-05-28 | 2016-12-01 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
| HK1245671A1 (zh) | 2015-05-29 | 2018-08-31 | Armo Biosciences, Inc. | 使用白细胞介素-10治疗疾病和病症的方法 |
| ES3039640T3 (en) * | 2015-08-25 | 2025-10-23 | Armo Biosciences Inc | Methods of using interleukin-10 for treating diseases and disorders |
| CN108697776A (zh) | 2016-01-11 | 2018-10-23 | 阿尔莫生物科技股份有限公司 | 在产生抗原特异性cd8+t细胞中的白介素-10及其使用方法 |
| EP3551034A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| EP3600414A1 (en) | 2017-03-30 | 2020-02-05 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist |
| EP3688036A4 (en) * | 2017-09-25 | 2021-06-23 | Dingfu Biotarget Co., Ltd | HETERODIMER PROTEIN AND USE OF IT |
| ES2939112T3 (es) | 2017-11-10 | 2023-04-19 | Armo Biosciences Inc | Composiciones y métodos de uso de interleucina-10 en combinación con inhibidores de vías de puntos de control inmunitario |
| US20210347842A1 (en) | 2018-06-19 | 2021-11-11 | Eli Lilly And Company | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
| US20240252795A1 (en) | 2018-11-19 | 2024-08-01 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| WO2020108426A1 (zh) * | 2018-11-26 | 2020-06-04 | 江苏恒瑞医药股份有限公司 | 一种人白细胞介素10变体及其衍生物 |
| US20220105190A1 (en) * | 2019-02-04 | 2022-04-07 | Lipoxen Technologies Limited | Methods of using glycopolysialylated therapeutic proteins |
| EP4054644A1 (en) * | 2019-11-04 | 2022-09-14 | Synthorx, Inc. | Interleukin 10 conjugates and uses thereof |
| EP3870261B1 (en) | 2019-12-13 | 2024-01-31 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| JPS63152393A (ja) | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
| US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
| US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| IL100667A0 (en) | 1991-01-16 | 1992-09-06 | Schering Corp | Use of interleukin-10 in adoptive immunotherapy of cancer |
| KR100207766B1 (ko) | 1991-01-16 | 1999-07-15 | 둘락 노먼 씨. | 신생물 질환 치료용 인터루킨-10 조성물 |
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| US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
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| US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
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| DE602006018969D1 (de) * | 2005-10-04 | 2011-01-27 | Bristol Myers Squibb Co | Herstellung und reinigung von il-29 |
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-
2009
- 2009-12-15 HU HUE09774794A patent/HUE037936T2/hu unknown
- 2009-12-15 RU RU2011129638/10A patent/RU2549702C2/ru active
- 2009-12-15 DK DK09774794.3T patent/DK2379115T3/da active
- 2009-12-15 NO NO09774794A patent/NO2379115T3/no unknown
- 2009-12-15 EP EP17187274.0A patent/EP3348281B1/en active Active
- 2009-12-15 ES ES09774794.3T patent/ES2655364T3/es active Active
- 2009-12-15 CN CN201310480573.4A patent/CN103601800B/zh active Active
- 2009-12-15 JP JP2011542332A patent/JP5888980B2/ja active Active
- 2009-12-15 PT PT97747943T patent/PT2379115T/pt unknown
- 2009-12-15 EP EP09774794.3A patent/EP2379115B1/en active Active
- 2009-12-15 CA CA2745443A patent/CA2745443C/en active Active
- 2009-12-15 AU AU2009333325A patent/AU2009333325B2/en active Active
- 2009-12-15 CN CN2009801506728A patent/CN102256625B/zh active Active
- 2009-12-15 PL PL09774794T patent/PL2379115T3/pl unknown
- 2009-12-15 ES ES17187274T patent/ES2957546T3/es active Active
- 2009-12-15 WO PCT/US2009/068012 patent/WO2010077853A2/en not_active Ceased
- 2009-12-15 US US13/140,390 patent/US8691205B2/en active Active
-
2014
- 2014-02-18 US US14/183,302 patent/US9259478B2/en active Active
-
2015
- 2015-07-16 JP JP2015141963A patent/JP2015221817A/ja active Pending
-
2016
- 2016-01-06 US US14/989,068 patent/US9566345B2/en active Active
- 2016-11-04 JP JP2016216681A patent/JP6349371B2/ja active Active
- 2016-12-28 US US15/393,013 patent/US10639353B2/en active Active
-
2018
- 2018-06-04 JP JP2018107216A patent/JP6791906B2/ja active Active
-
2019
- 2019-10-08 JP JP2019185061A patent/JP6905024B2/ja active Active
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