NO20100584L - Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on - Google Patents

Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on

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Publication number
NO20100584L
NO20100584L NO20100584A NO20100584A NO20100584L NO 20100584 L NO20100584 L NO 20100584L NO 20100584 A NO20100584 A NO 20100584A NO 20100584 A NO20100584 A NO 20100584A NO 20100584 L NO20100584 L NO 20100584L
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NO
Norway
Prior art keywords
chloroethyl
dihydro
indolone
hplc
chloro
Prior art date
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NO20100584A
Other languages
English (en)
Inventor
Frank Robert Busch
Jr Harry Ralph Howard
Adam Worth Grobin
Kyle Robert Leeman
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Pfizer Prod Inc
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Publication of NO20100584L publication Critical patent/NO20100584L/no
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det beskrives en fremgangsmåte ved bruk av HPLC for å måle mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3-dihydro-2H-indol-2-on.
NO20100584A 2002-02-20 2010-04-22 Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on NO20100584L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35880602P 2002-02-20 2002-02-20
US35903802P 2002-02-21 2002-02-21
US36045902P 2002-02-27 2002-02-27
PCT/IB2003/000642 WO2003070246A1 (en) 2002-02-20 2003-02-17 Controlled synthesis of ziprasidone and compositions thereof

Publications (1)

Publication Number Publication Date
NO20100584L true NO20100584L (no) 2004-09-17

Family

ID=27761437

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20043902A NO20043902L (no) 2002-02-20 2004-09-17 Kontrollert syntese av ziprasidon og sammensetninger derav
NO20100584A NO20100584L (no) 2002-02-20 2010-04-22 Fremgangsmate ved bruk av HPLC for a male mengden 5-(2-kloretyl)-1,3-dihydro-2H-indol-on i et preparat omfattende 6-klor-5-(2-kloretyl)-1,3 dihydro-2H-indol-2-on

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20043902A NO20043902L (no) 2002-02-20 2004-09-17 Kontrollert syntese av ziprasidon og sammensetninger derav

Country Status (41)

Country Link
EP (1) EP1476162B1 (no)
JP (1) JP4554938B2 (no)
KR (1) KR100773622B1 (no)
CN (2) CN1635892A (no)
AP (1) AP2004003103A0 (no)
AR (1) AR038563A1 (no)
AT (1) ATE359787T1 (no)
AU (2) AU2003206035A1 (no)
BR (1) BR0307833A (no)
CA (1) CA2475302C (no)
CO (1) CO5611138A2 (no)
CY (1) CY1106467T1 (no)
DE (1) DE60313289T2 (no)
DK (1) DK1476162T3 (no)
EA (1) EA007866B1 (no)
EC (1) ECSP045239A (no)
ES (1) ES2283745T3 (no)
GE (1) GEP20074030B (no)
GT (1) GT200300040A (no)
HR (1) HRP20040711A2 (no)
IL (1) IL163277A (no)
IS (1) IS7344A (no)
MA (1) MA27177A1 (no)
MX (1) MXPA04006993A (no)
MY (1) MY139523A (no)
NO (2) NO20043902L (no)
NZ (1) NZ534443A (no)
OA (1) OA12774A (no)
PA (1) PA8567001A1 (no)
PE (1) PE20030942A1 (no)
PL (1) PL372238A1 (no)
PT (1) PT1476162E (no)
RS (1) RS60404A (no)
SI (1) SI1476162T1 (no)
SV (1) SV2004001485A (no)
TN (1) TNSN04159A1 (no)
TW (1) TW200307546A (no)
UA (1) UA77057C2 (no)
UY (1) UY27668A1 (no)
WO (1) WO2003070246A1 (no)
ZA (1) ZA200406276B (no)

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WO2003057698A2 (en) 2001-12-28 2003-07-17 Acadia Pharmaceuticals, Inc. Spiroazacyclic compounds as monoamine receptor modulators
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US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7488729B2 (en) 2002-12-04 2009-02-10 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof
WO2004050655A1 (en) * 2002-12-04 2004-06-17 Dr. Reddy's Laboratories Limited Polymorphic forms of ziprasidone and its hydrochloride
MXPA05007568A (es) 2003-01-16 2005-09-21 Acadia Pharm Inc Agonistas inversos del receptor selectivo de serotonina 2a/2c como terapeuticos para enfermedades neurodegenerativas.
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ATE393764T1 (de) 2003-03-17 2008-05-15 Teva Pharma Polymorphe formen von valsartan
WO2004094392A1 (en) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan
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WO2005040160A2 (en) 2003-10-24 2005-05-06 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
US20050197347A1 (en) * 2003-12-18 2005-09-08 Judith Aronhime Polymorphic form B2 of ziprasidone base
ATE451367T1 (de) 2004-02-27 2009-12-15 Ranbaxy Lab Ltd Verfahren zur herstellung von ziprasidon
CA2467538C (en) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
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PL2289879T3 (pl) 2004-09-27 2015-05-29 Acadia Pharm Inc Synteza formy krystalicznej soli winianowej n-(4-fluorobenzylo)-n-(1-metylopiperydyn-4-ylo)-n'-(4-(2-metylopropyloksy)fenylometylo)karbamidu
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
WO2006080025A1 (en) * 2005-01-27 2006-08-03 Hetero Drugs Limited Process for ziprasidone using novel intermediates
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
CN100491375C (zh) * 2006-07-01 2009-05-27 浙江美诺华药物化学有限公司 一种齐拉西酮的制备方法
WO2008116024A2 (en) 2007-03-19 2008-09-25 Acadia Pharmaceuticals Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
CN102234272A (zh) * 2010-04-21 2011-11-09 上海医药工业研究院 盐酸齐拉西酮半水合物的制备方法
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Also Published As

Publication number Publication date
UY27668A1 (es) 2003-10-31
EP1476162A1 (en) 2004-11-17
AR038563A1 (es) 2005-01-19
CN1635892A (zh) 2005-07-06
CA2475302A1 (en) 2003-08-28
MXPA04006993A (es) 2004-11-10
BR0307833A (pt) 2004-12-07
GT200300040A (es) 2007-01-12
IS7344A (is) 2004-07-05
OA12774A (en) 2006-07-04
EP1476162B1 (en) 2007-04-18
TNSN04159A1 (fr) 2007-03-12
TW200307546A (en) 2003-12-16
ZA200406276B (en) 2005-09-20
SV2004001485A (es) 2004-05-07
DK1476162T3 (da) 2007-07-02
DE60313289T2 (de) 2007-12-27
PE20030942A1 (es) 2003-11-08
AU2009202008A1 (en) 2009-06-11
MY139523A (en) 2009-10-30
AU2003206035A1 (en) 2003-09-09
NZ534443A (en) 2007-07-27
CA2475302C (en) 2009-05-12
MA27177A1 (fr) 2005-01-03
WO2003070246A1 (en) 2003-08-28
KR20040086417A (ko) 2004-10-08
IL163277A (en) 2010-05-31
ATE359787T1 (de) 2007-05-15
UA77057C2 (en) 2006-10-16
AP2004003103A0 (en) 2004-09-30
EA200400815A1 (ru) 2004-12-30
SI1476162T1 (sl) 2007-08-31
CO5611138A2 (es) 2006-02-28
GEP20074030B (en) 2007-02-12
PL372238A1 (en) 2005-07-11
ECSP045239A (es) 2004-09-28
DE60313289D1 (de) 2007-05-31
JP2005525347A (ja) 2005-08-25
JP4554938B2 (ja) 2010-09-29
PT1476162E (pt) 2007-06-25
CY1106467T1 (el) 2012-01-25
ES2283745T3 (es) 2007-11-01
NO20043902L (no) 2004-09-17
PA8567001A1 (es) 2003-12-10
KR100773622B1 (ko) 2007-11-05
HRP20040711A2 (en) 2004-12-31
CN101735212A (zh) 2010-06-16
EA007866B1 (ru) 2007-02-27
RS60404A (en) 2006-10-27

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