NO20091571L - Markorgener for anvendelse ved identifisering av kondrocyttfenotypiskstabilitet og ved screeningav faktorer som innvirker pabruskdannelse - Google Patents

Markorgener for anvendelse ved identifisering av kondrocyttfenotypiskstabilitet og ved screeningav faktorer som innvirker pabruskdannelse

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Publication number
NO20091571L
NO20091571L NO20091571A NO20091571A NO20091571L NO 20091571 L NO20091571 L NO 20091571L NO 20091571 A NO20091571 A NO 20091571A NO 20091571 A NO20091571 A NO 20091571A NO 20091571 L NO20091571 L NO 20091571L
Authority
NO
Norway
Prior art keywords
screening
pabrus
identifying
formation
marker genes
Prior art date
Application number
NO20091571A
Other languages
English (en)
Other versions
NO342020B1 (no
Inventor
Frank Luyten
Cosimo De Bari
Francesco Dell'accio
Original Assignee
Tigenix Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix Nv filed Critical Tigenix Nv
Publication of NO20091571L publication Critical patent/NO20091571L/no
Publication of NO342020B1 publication Critical patent/NO342020B1/no

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Det beskrives et sett av gener som kan benyttes for å predikere potensialet for en cellepopulasjon til å danne brusk etter implantering in vivo. Settet av markører benyttes blant annet som en kvalitetskontroll for celler og i screeninganalyser for å evaluere innvirkningen av forbindelser og betingelser på cellenes bruskdannende evne.
NO20091571A 2006-11-24 2009-04-21 Markørgener for anvendelse ved identifisering av kondrocyttfenotypisk stabilitet og ved screening av faktorer som innvirker på bruskdannelse NO342020B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86715206P 2006-11-24 2006-11-24
PCT/EP2007/010285 WO2008061804A2 (en) 2006-11-24 2007-11-23 Marker genes for use in the identification of chondrocyte phenotypic stability and in the screening of factors influencing cartilage production

Publications (2)

Publication Number Publication Date
NO20091571L true NO20091571L (no) 2009-08-14
NO342020B1 NO342020B1 (no) 2018-03-12

Family

ID=39323853

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091571A NO342020B1 (no) 2006-11-24 2009-04-21 Markørgener for anvendelse ved identifisering av kondrocyttfenotypisk stabilitet og ved screening av faktorer som innvirker på bruskdannelse

Country Status (13)

Country Link
US (1) US20100068715A1 (no)
EP (1) EP2094310B1 (no)
JP (1) JP5455219B2 (no)
CN (1) CN101616693A (no)
AU (1) AU2007324705B2 (no)
CA (1) CA2670419C (no)
ES (1) ES2452825T3 (no)
HK (1) HK1136964A1 (no)
IL (1) IL198799A (no)
NO (1) NO342020B1 (no)
NZ (1) NZ576360A (no)
RU (1) RU2508548C2 (no)
WO (1) WO2008061804A2 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0902793D0 (en) 2009-02-20 2009-04-08 Univ Gent GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes
US9593385B2 (en) * 2011-01-26 2017-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selective detection of Haemophilus influenzae
US20140255364A1 (en) * 2011-10-28 2014-09-11 Tufts University 3d culture system for culturing cells in synovial fluid, cells cultured in synovial fluid and their use
DE102014201528A1 (de) * 2013-03-27 2014-10-02 Tetec Tissue Engineering Technologies Ag In vitro-Verfahren zur prognostischen Beurteilung der Erfolgsaussichten einer Implantation und/oder Transplantation
JP2014230493A (ja) * 2013-05-28 2014-12-11 三菱レイヨン株式会社 間葉系幹細胞からの分化状態を識別する遺伝子群及び分化状態の評価方法
CN106581666A (zh) * 2016-11-23 2017-04-26 新乡医学院 Pedf在制备治疗糖尿病骨组织并发症药物中的应用
EP3417888A1 (de) * 2017-06-25 2018-12-26 co.don AG Verfahren zum herstellen von transplantierbarem knorpelgewebe
RU2765437C1 (ru) * 2021-08-17 2022-01-31 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Способ определения уровня экспрессии гена, кодирующего PEDF, в тканях глаза кролика Oryctolagus cuniculus и набор для его определения

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4981797A (en) * 1996-10-11 1998-05-11 Government Of The United States Of America, The Isolation and method of using tissue growth-inducing frzb protein
DE10048710A1 (de) 1999-09-27 2001-10-04 Gabriele Pecher Pharmazeutische Zusammensetzung zur Behandlung und Prophylaxe von humanen Tumoren, die das Tumorantigen Muzin und/oder das Carcinoembryonale Antigen (CEA) exprimieren und ihre Verwendung
US7482114B2 (en) * 1999-10-06 2009-01-27 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation
WO2001024833A2 (en) 1999-10-06 2001-04-12 Tigenix N.V. In vivo assay for testing the phenotypic stability
DE20023640U1 (de) 1999-10-06 2005-06-23 Tigenix N.V. Isolierung von Vorläuferzellen und deren Verwendung zum Wiederaufbau von Bindegewebe
US20020009730A1 (en) * 1999-11-17 2002-01-24 Alex Chenchik Human stress array
RU2209433C2 (ru) * 2000-06-19 2003-07-27 Российский научный центр "Восстановительная травматология и ортопедия" им. акад. Г.А.Илизарова Способ определения показаний к внутрисуставному введению хондропротекторов на основе гидролизата гликозаминогликанов хряща
US20020061514A1 (en) 2000-09-21 2002-05-23 Underhill Tully Michael Assay for identifying modulators of chondrogenesis
US20040265808A1 (en) 2001-04-05 2004-12-30 Teresa Garcia Genes involved in osteogenesis, and methods of use
GB0301977D0 (en) 2003-01-28 2003-02-26 Daniolabs Ltd Method for creating a model amenable to high-throughput screening

Also Published As

Publication number Publication date
WO2008061804A3 (en) 2008-07-17
JP5455219B2 (ja) 2014-03-26
CA2670419C (en) 2018-07-17
IL198799A0 (en) 2011-08-01
JP2010509927A (ja) 2010-04-02
CN101616693A (zh) 2009-12-30
IL198799A (en) 2013-08-29
NZ576360A (en) 2011-07-29
US20100068715A1 (en) 2010-03-18
AU2007324705B2 (en) 2013-09-05
HK1136964A1 (en) 2010-07-16
CA2670419A1 (en) 2008-05-29
WO2008061804A2 (en) 2008-05-29
RU2009123960A (ru) 2010-12-27
NO342020B1 (no) 2018-03-12
ES2452825T3 (es) 2014-04-02
EP2094310B1 (en) 2013-12-25
RU2508548C2 (ru) 2014-02-27
EP2094310A2 (en) 2009-09-02
AU2007324705A1 (en) 2008-05-29

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