NO20081037L - Fremgangsmate for oppnaelse av 3,3-difenylpropylaminer - Google Patents
Fremgangsmate for oppnaelse av 3,3-difenylpropylaminerInfo
- Publication number
- NO20081037L NO20081037L NO20081037A NO20081037A NO20081037L NO 20081037 L NO20081037 L NO 20081037L NO 20081037 A NO20081037 A NO 20081037A NO 20081037 A NO20081037 A NO 20081037A NO 20081037 L NO20081037 L NO 20081037L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- diphenylpropylamines
- compounds
- obtaining
- coor6
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- KISZTEOELCMZPY-UHFFFAOYSA-N 3,3-diphenylpropylamine Chemical class C=1C=CC=CC=1C(CCN)C1=CC=CC=C1 KISZTEOELCMZPY-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- HHORIIVYWGOMNE-UHFFFAOYSA-N aniline;prop-1-ene Chemical compound CC=C.NC1=CC=CC=C1 HHORIIVYWGOMNE-UHFFFAOYSA-N 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 abstract 1
- 229960004045 tolterodine Drugs 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200501990A ES2268987B1 (es) | 2005-08-05 | 2005-08-05 | Procedimiento para la obtencion de 3,3-difenilpropilaminas. |
| PCT/ES2006/000458 WO2007017544A2 (fr) | 2005-08-05 | 2006-08-03 | Procede d'obtention de 3,3-diphenyl-propylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081037L true NO20081037L (no) | 2008-04-23 |
Family
ID=37727675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081037A NO20081037L (no) | 2005-08-05 | 2008-02-27 | Fremgangsmate for oppnaelse av 3,3-difenylpropylaminer |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8039672B2 (fr) |
| EP (1) | EP1927585B1 (fr) |
| JP (1) | JP2009503035A (fr) |
| KR (1) | KR20080043811A (fr) |
| CN (1) | CN101277926A (fr) |
| AU (1) | AU2006277906A1 (fr) |
| BR (1) | BRPI0614387A2 (fr) |
| CA (1) | CA2618446A1 (fr) |
| ES (2) | ES2268987B1 (fr) |
| NO (1) | NO20081037L (fr) |
| WO (1) | WO2007017544A2 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20050249A1 (it) | 2005-02-18 | 2006-08-19 | Dipharma Spa | Procedimento per la preparazione di tolterodina |
| WO2007147547A1 (fr) * | 2006-06-20 | 2007-12-27 | Lek Pharmaceuticals D.D. | Procédé de préparation de 3-(2-hydroxy-5-(phényle substitué))-n-alkyl-3-phénylpropylamines |
| EP2281801B1 (fr) | 2009-07-27 | 2014-01-08 | Crystal Pharma, S.A.U. | Procédé pour la préparation de 3,3-diphénylpropylamines |
| IT1396373B1 (it) * | 2009-10-29 | 2012-11-19 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina. |
| IT1397521B1 (it) | 2009-12-21 | 2013-01-16 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina con un basso contenuto di impurezze. |
| EP2364966A1 (fr) * | 2010-03-09 | 2011-09-14 | LEK Pharmaceuticals d.d. | Procédé pour la préparation de 3-(2-hydroxy-5-substitue phényl)-3-phénylpropylamines, intermédiaires pour la préparation de tolterodine |
| IT1403094B1 (it) | 2010-12-09 | 2013-10-04 | Dipharma Francis Srl | Procedimento per la preparazione di fesoterodina o un suo sale |
| ITMI20121232A1 (it) | 2012-07-16 | 2014-01-17 | Cambrex Profarmaco Milano Srl | Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati |
| CN103044274B (zh) * | 2012-11-29 | 2014-10-22 | 珠海保税区丽珠合成制药有限公司 | 一种无溶剂合成酒石酸托特罗定的方法 |
| CN103044273B (zh) * | 2012-11-29 | 2014-12-24 | 珠海保税区丽珠合成制药有限公司 | 一种酒石酸托特罗定的合成方法 |
| CN111470971B (zh) * | 2020-05-09 | 2023-06-16 | 浙江大学衢州研究院 | 防止二异丙基乙胺生产中催化剂ZnCl2结块的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239908A (en) * | 1979-12-10 | 1980-12-16 | G.D. Searle & Co. | N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines |
| US5382600A (en) | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| EP0924983A4 (fr) | 1996-07-19 | 1999-08-25 | Gunnar Aberg | S(-)-tolterodine pour le traitement des troubles urinaires et gastro-intestinaux |
| KR20000057548A (ko) * | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
| DE19722373A1 (de) * | 1997-05-28 | 1998-12-03 | Hoechst Ag | Verwendung eines Rhodiumkatalysators sowie ein neues Verfahren zur Herstellung von 2-arylsubstituierten Ethylen- und Ethylaminen |
| SE9904850D0 (sv) | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
| PE20020547A1 (es) | 2000-10-24 | 2002-06-12 | Upjohn Co | Uso de la tolterodina en tratamientos del asma |
| IN191835B (fr) | 2001-08-03 | 2004-01-10 | Ranbaxy Lab Ltd | |
| ES2235648B1 (es) | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
| WO2007147547A1 (fr) * | 2006-06-20 | 2007-12-27 | Lek Pharmaceuticals D.D. | Procédé de préparation de 3-(2-hydroxy-5-(phényle substitué))-n-alkyl-3-phénylpropylamines |
-
2005
- 2005-08-05 ES ES200501990A patent/ES2268987B1/es not_active Expired - Fee Related
-
2006
- 2006-08-03 US US11/989,962 patent/US8039672B2/en not_active Expired - Fee Related
- 2006-08-03 ES ES06807906.0T patent/ES2592885T3/es active Active
- 2006-08-03 KR KR1020087005419A patent/KR20080043811A/ko not_active Application Discontinuation
- 2006-08-03 EP EP06807906.0A patent/EP1927585B1/fr not_active Not-in-force
- 2006-08-03 AU AU2006277906A patent/AU2006277906A1/en not_active Abandoned
- 2006-08-03 JP JP2008524533A patent/JP2009503035A/ja active Pending
- 2006-08-03 WO PCT/ES2006/000458 patent/WO2007017544A2/fr active Application Filing
- 2006-08-03 CA CA002618446A patent/CA2618446A1/fr not_active Abandoned
- 2006-08-03 BR BRPI0614387-3A patent/BRPI0614387A2/pt not_active Application Discontinuation
- 2006-08-03 CN CNA2006800368322A patent/CN101277926A/zh active Pending
-
2008
- 2008-02-27 NO NO20081037A patent/NO20081037L/no not_active Application Discontinuation
-
2011
- 2011-09-07 US US13/227,067 patent/US20110319666A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110319666A1 (en) | 2011-12-29 |
| ES2592885T3 (es) | 2016-12-02 |
| US8039672B2 (en) | 2011-10-18 |
| EP1927585A2 (fr) | 2008-06-04 |
| CA2618446A1 (fr) | 2007-02-15 |
| AU2006277906A1 (en) | 2007-02-15 |
| WO2007017544A3 (fr) | 2007-04-19 |
| EP1927585B1 (fr) | 2016-07-27 |
| ES2268987B1 (es) | 2008-02-01 |
| EP1927585A4 (fr) | 2010-08-18 |
| WO2007017544A2 (fr) | 2007-02-15 |
| US20100286446A1 (en) | 2010-11-11 |
| KR20080043811A (ko) | 2008-05-19 |
| BRPI0614387A2 (pt) | 2011-03-22 |
| CN101277926A (zh) | 2008-10-01 |
| JP2009503035A (ja) | 2009-01-29 |
| ES2268987A1 (es) | 2007-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |