NO20081036L - Fremgangsmater for oppnaelse av fenylkarbamater - Google Patents

Fremgangsmater for oppnaelse av fenylkarbamater

Info

Publication number
NO20081036L
NO20081036L NO20081036A NO20081036A NO20081036L NO 20081036 L NO20081036 L NO 20081036L NO 20081036 A NO20081036 A NO 20081036A NO 20081036 A NO20081036 A NO 20081036A NO 20081036 L NO20081036 L NO 20081036L
Authority
NO
Norway
Prior art keywords
phenylcarbamates
obtaining
reaction
ethyl
methods
Prior art date
Application number
NO20081036A
Other languages
English (en)
Inventor
Nn
Original Assignee
Interquim Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081036(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Interquim Sa filed Critical Interquim Sa
Publication of NO20081036L publication Critical patent/NO20081036L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives en fremgangsmåte for å oppnå fenylkarbamater (I), der R1 er lavere alkyl C1 -C5 eller benzyl og R2 er metyl, etyl eller propyl. Fremgangsmåten omfatter omsetning av L-(S)-3-[(l-metylamino)etyl]fenol i nærvær av en base, med et karbamoylhalogenid for å oppnå et intermediat og deretter, å underkaste dette en reduserende amineringsreaksjon eller en metyleringsreaksjon ved omsetning med et metylhalogenid. Forbindelsene (I) inkluderer rivastigmin, en forbindelse som inhiberer kolinsterase i sentralnervesystemet, og som kan benyttes ved behandling av neurodegenerative sykdommer som senil demens eller Alzheimers sykdom.
NO20081036A 2005-08-04 2008-02-27 Fremgangsmater for oppnaelse av fenylkarbamater NO20081036L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200501969A ES2267399B1 (es) 2005-08-04 2005-08-04 Procedimiento para la obtencion de carbamatos de fenilo.
PCT/ES2006/000459 WO2007014973A2 (es) 2005-08-04 2006-08-03 Procedimiento para la obtención de carbamatos de fenilo

Publications (1)

Publication Number Publication Date
NO20081036L true NO20081036L (no) 2008-04-23

Family

ID=37709657

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081036A NO20081036L (no) 2005-08-04 2008-02-27 Fremgangsmater for oppnaelse av fenylkarbamater

Country Status (11)

Country Link
EP (1) EP1939172B1 (no)
JP (1) JP2009503036A (no)
KR (1) KR20080046176A (no)
CN (1) CN101277929A (no)
AU (1) AU2006274824A1 (no)
BR (1) BRPI0614395A2 (no)
CA (1) CA2618452A1 (no)
ES (2) ES2267399B1 (no)
NO (1) NO20081036L (no)
RU (1) RU2008108169A (no)
WO (1) WO2007014973A2 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7884121B2 (en) 2007-06-11 2011-02-08 Apotex Pharmachem Inc. Process for the preparation of phenylcarbamates
WO2009086705A1 (zh) 2008-01-10 2009-07-16 Shanghai Institute Of Pharmaceutical Industry 利凡斯的明的制备方法、其中间体以及中间体的制备方法
EP2349976B1 (en) * 2008-08-25 2012-12-26 Jubilant Life Sciences Limited A process for producing (s)-3-[(1-dimethylamino)ethyl]phenyl-n-ethyl-n-methyl-carbamate via novel intermediates
CN104151176B (zh) * 2014-08-29 2016-08-24 大连韦德生化科技有限公司 一种卡巴拉汀手性中间体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6504208A (no) * 1964-04-03 1965-10-04
IL74497A (en) 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
HU201906B (en) 1987-03-04 1991-01-28 Sandoz Ag Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
WO2003101917A2 (en) 2002-05-31 2003-12-11 Sun Pharmaceutical Industries Limited A process for the preparation of phenylcarbamates
CZ293014B6 (cs) * 2002-10-24 2004-01-14 Léčiva, A.S. Způsob výroby (-)-(S)-3-[1-(dimethylamino)ethyl]fenyl-N-ethyl-N-methylkarbamátu
ES2615487T3 (es) * 2004-11-08 2017-06-07 Emcure Pharmaceuticals Limited un método eficaz para la preparación de (S)-3-[(1-dimetilamino)etil]-fenil-N-etil-N-metil-carbamato
KR20060072326A (ko) * 2004-12-23 2006-06-28 동국제약 주식회사 페닐카바메이트 유도체의 새로운 합성 방법

Also Published As

Publication number Publication date
BRPI0614395A2 (pt) 2011-03-29
ES2267399A1 (es) 2007-03-01
EP1939172B1 (en) 2012-07-11
WO2007014973A2 (es) 2007-02-08
CA2618452A1 (en) 2007-02-08
EP1939172A4 (en) 2011-03-23
WO2007014973A3 (es) 2007-05-03
KR20080046176A (ko) 2008-05-26
ES2391032T3 (es) 2012-11-20
AU2006274824A1 (en) 2007-02-08
CN101277929A (zh) 2008-10-01
ES2267399B1 (es) 2008-02-01
JP2009503036A (ja) 2009-01-29
EP1939172A2 (en) 2008-07-02
RU2008108169A (ru) 2009-09-10

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