NO20071245L - Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer. - Google Patents
Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer.Info
- Publication number
- NO20071245L NO20071245L NO20071245A NO20071245A NO20071245L NO 20071245 L NO20071245 L NO 20071245L NO 20071245 A NO20071245 A NO 20071245A NO 20071245 A NO20071245 A NO 20071245A NO 20071245 L NO20071245 L NO 20071245L
- Authority
- NO
- Norway
- Prior art keywords
- raf inhibitors
- quinazolinone derivatives
- marrow
- chemical compounds
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60653504P | 2004-09-01 | 2004-09-01 | |
PCT/GB2005/003336 WO2006024836A1 (en) | 2004-09-01 | 2005-08-26 | Quinazolinone derivatives and their use as b-raf inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20071245L true NO20071245L (no) | 2007-05-24 |
Family
ID=35149373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20071245A NO20071245L (no) | 2004-09-01 | 2007-03-07 | Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20090054469A1 (ko) |
EP (1) | EP1789400A1 (ko) |
JP (1) | JP2008511600A (ko) |
KR (1) | KR20070055575A (ko) |
CN (1) | CN101010303A (ko) |
AR (1) | AR050545A1 (ko) |
AU (1) | AU2005278961A1 (ko) |
BR (1) | BRPI0514679A (ko) |
CA (1) | CA2577278A1 (ko) |
IL (1) | IL181213A0 (ko) |
MX (1) | MX2007002433A (ko) |
NO (1) | NO20071245L (ko) |
TW (1) | TW200621259A (ko) |
UY (1) | UY29092A1 (ko) |
WO (1) | WO2006024836A1 (ko) |
ZA (1) | ZA200701366B (ko) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1957461B1 (en) * | 2005-11-14 | 2016-11-02 | Genentech, Inc. | Bisamide inhibitors of hedgehog signaling |
CN101415688A (zh) * | 2006-04-05 | 2009-04-22 | 阿斯利康(瑞典)有限公司 | 具有b-raf抑制活性的喹唑啉酮衍生物 |
CN101421253A (zh) * | 2006-04-18 | 2009-04-29 | 阿斯利康(瑞典)有限公司 | 喹唑啉-4-酮衍生物、其制备方法及含有它们的药用组合物 |
WO2008020203A1 (en) * | 2006-08-17 | 2008-02-21 | Astrazeneca Ab | Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors |
SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
CL2009000447A1 (es) * | 2008-02-29 | 2010-01-04 | Array Biopharma Inc Y Genentech Inc | Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf. |
JP2011513329A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | RAF阻害化合物として使用されるイミダゾ[4,5−b]ピリジン誘導体 |
AR072657A1 (es) * | 2008-02-29 | 2010-09-15 | Genentech Inc | Compuestos inhibidores de raf y metodos para su uso |
JP2011513332A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | 癌の治療のためのraf阻害剤としてのn−(6−アミノピリジン−3−イル)−3−(スルホンアミド)ベンズアミド誘導体 |
JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Mek阻害剤に対する耐性を付与するmek突然変異 |
JP5985401B2 (ja) | 2010-03-09 | 2016-09-06 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 第一の癌療法に対する耐性を現に有するか、または、そのような耐性を生じる患者において癌を診断および治療する方法 |
US8669256B2 (en) | 2010-05-28 | 2014-03-11 | Merck Sharp & Dohme B.V. | Substituted thieno[2,3-b]pyrazine compounds as modulators of B-Raf kinase activity |
ES2873933T3 (es) | 2010-06-09 | 2021-11-04 | Dana Farber Cancer Inst Inc | Una mutación de MEK1 que confiere resistencia a inhibidores de RAF y de MEK |
WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
WO2014160438A1 (en) * | 2013-03-13 | 2014-10-02 | Bioasis Technologies Inc. | Fragments of p97 and uses thereof |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
WO2015041533A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
JP6038212B2 (ja) * | 2015-03-18 | 2016-12-07 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 甲状腺刺激ホルモン受容体(tshr)の低分子量アゴニスト |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2444605A (en) * | 1945-12-15 | 1948-07-06 | Gen Aniline & Film Corp | Stabilizers for photographic emulsions |
GB9623833D0 (en) * | 1996-11-16 | 1997-01-08 | Zeneca Ltd | Chemical compound |
HUP0103019A3 (en) * | 1998-08-04 | 2002-01-28 | Astrazeneca Ab | Amide derivatives useful as inhibitors of the production of cytokines, process for producing them and pharmaceutical compositions containing them |
GB0005357D0 (en) * | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
NZ535985A (en) * | 2002-03-29 | 2007-04-27 | Chiron Corp | Substituted benzazoles and use thereof as RAF kinase inhibitors |
-
2005
- 2005-08-26 AU AU2005278961A patent/AU2005278961A1/en not_active Abandoned
- 2005-08-26 MX MX2007002433A patent/MX2007002433A/es not_active Application Discontinuation
- 2005-08-26 CA CA002577278A patent/CA2577278A1/en not_active Abandoned
- 2005-08-26 KR KR1020077007040A patent/KR20070055575A/ko not_active Application Discontinuation
- 2005-08-26 WO PCT/GB2005/003336 patent/WO2006024836A1/en active Application Filing
- 2005-08-26 JP JP2007528984A patent/JP2008511600A/ja active Pending
- 2005-08-26 BR BRPI0514679-8A patent/BRPI0514679A/pt not_active Application Discontinuation
- 2005-08-26 EP EP05775543A patent/EP1789400A1/en not_active Withdrawn
- 2005-08-26 CN CNA2005800293196A patent/CN101010303A/zh active Pending
- 2005-08-28 US US11/574,036 patent/US20090054469A1/en not_active Abandoned
- 2005-08-30 UY UY29092A patent/UY29092A1/es not_active Application Discontinuation
- 2005-08-30 AR ARP050103625A patent/AR050545A1/es unknown
- 2005-09-02 TW TW094130101A patent/TW200621259A/zh unknown
-
2007
- 2007-02-07 IL IL181213A patent/IL181213A0/en unknown
- 2007-02-15 ZA ZA200701366A patent/ZA200701366B/xx unknown
- 2007-03-07 NO NO20071245A patent/NO20071245L/no unknown
Also Published As
Publication number | Publication date |
---|---|
KR20070055575A (ko) | 2007-05-30 |
TW200621259A (en) | 2006-07-01 |
UY29092A1 (es) | 2006-04-28 |
EP1789400A1 (en) | 2007-05-30 |
WO2006024836A1 (en) | 2006-03-09 |
CN101010303A (zh) | 2007-08-01 |
ZA200701366B (en) | 2008-09-25 |
JP2008511600A (ja) | 2008-04-17 |
US20090054469A1 (en) | 2009-02-26 |
IL181213A0 (en) | 2007-07-04 |
MX2007002433A (es) | 2007-05-04 |
BRPI0514679A (pt) | 2008-06-17 |
AU2005278961A1 (en) | 2006-03-09 |
CA2577278A1 (en) | 2006-03-09 |
AR050545A1 (es) | 2006-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20071245L (no) | Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer. | |
NO20071246L (no) | Kinazolinonderivater og deres anvendelse som B-RAF-inhibitorer. | |
NO20071776L (no) | Kinoksaliner som B RAF inhibitorer. | |
NO20084202L (no) | 4-anilinoquinolin-3-carboksamider som CSF-1R kinase inhibitorer | |
NO20072784L (no) | Pyridenkarboksamidderivater for anvendelse som anticancer midler | |
NO20091683L (no) | Kjemiske forbindelser | |
NO20070199L (no) | Substituerte kinazoloner som anti-kreftmidler | |
NO20082709L (no) | Kjemiske forbindelser | |
NO20073719L (no) | Kjemiske forbindelser | |
NO20081729L (no) | Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer | |
NO20070655L (no) | 2,4,6-Trisubstituerte pyrimidiner som fosfotidylinositol-(PI)-3-kinaseinhibitorer og disses anvendelse ved behandling av kreft | |
NO20071504L (no) | Pyrimidinderivanter. | |
NO20083214L (no) | Pyrimidinylarylurea-derivater som omdannes til FGF-inhibitorer | |
WO2008145688A3 (en) | Pyrrolopyridine compounds, process for their preparation, and their use as medicaments | |
TW200635899A (en) | Chemical compounds | |
NO20070656L (no) | 2,4,6-Trisubstituerte pyrimidiner som fosfotidylinositol-(PI)-3-kinaseinhibitorer og disses anvendelse ved behandling av kreft | |
TN2009000128A1 (en) | Dihydropyridine derivatives useful as protein kinase inhibitors | |
NO20090631L (no) | Morpholin pyrimidin derivativer anvendelige i behandlingen av proliferative lidelser | |
TW200616974A (en) | Chemical compounds | |
NO20082730L (no) | Morfolinopyrimidinderivater og deres anvendelse i terapi | |
NO20073859L (no) | Pyrrolopyrazoler, potente kinaseinhibitorer | |
NO20072259L (no) | Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer | |
NO20085218L (no) | Nye pyridinanaloger | |
WO2008068507A3 (en) | 2 -phenylamino, 6- (pyrid-3-yl) quinazoline derivatives as raf-protein kinase inhibitors in cancer treatment | |
NO20091703L (no) | Heterocykliske sylfonamider med EDG-I antagonistisk aktivitet |