NO20065270L - Polymerkonjugat som kan frigjores ved milde tiolyttiske betingelser - Google Patents

Polymerkonjugat som kan frigjores ved milde tiolyttiske betingelser

Info

Publication number
NO20065270L
NO20065270L NO20065270A NO20065270A NO20065270L NO 20065270 L NO20065270 L NO 20065270L NO 20065270 A NO20065270 A NO 20065270A NO 20065270 A NO20065270 A NO 20065270A NO 20065270 L NO20065270 L NO 20065270L
Authority
NO
Norway
Prior art keywords
conditions
under mild
thiolite
polymer conjugate
released under
Prior art date
Application number
NO20065270A
Other languages
English (en)
Inventor
Samuel Zalipsky
Paramjeet Subramony
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO20065270L publication Critical patent/NO20065270L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/10—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/08—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to carbon atoms of rings other than six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)

Abstract

Konjugater med formelen (I) som omfatter et lipid eller en hydrofil polymer, slik som polyetylenglykol, koblet til en ligand avledet fra en amin- eller hydroksylinneholdende forbindelse, slik som et medikament eller et protein, er stabilt under lagringsbetingelser, og er spaltbar under milde tiolytiske betingelser for å regenerere den amin- eller hydroksylinneholdende forbindelsen i dens native form, uten dannelsen av uønskede biprodukter.
NO20065270A 2004-04-21 2006-11-16 Polymerkonjugat som kan frigjores ved milde tiolyttiske betingelser NO20065270L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56456504P 2004-04-21 2004-04-21
PCT/US2005/013367 WO2005105154A1 (en) 2004-04-21 2005-04-20 Polymer conjugate releasable under mild thiolytic conditions

Publications (1)

Publication Number Publication Date
NO20065270L true NO20065270L (no) 2007-01-17

Family

ID=37450607

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065270A NO20065270L (no) 2004-04-21 2006-11-16 Polymerkonjugat som kan frigjores ved milde tiolyttiske betingelser

Country Status (11)

Country Link
US (1) US20050265925A1 (no)
EP (1) EP1748795A1 (no)
KR (1) KR20070010175A (no)
CN (1) CN1997399A (no)
AU (1) AU2005238015A1 (no)
CA (1) CA2562527A1 (no)
IL (1) IL178561A0 (no)
MX (1) MXPA06012144A (no)
NO (1) NO20065270L (no)
WO (1) WO2005105154A1 (no)
ZA (1) ZA200609638B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100255050A1 (en) * 2007-07-24 2010-10-07 James Klein Leonard Polyethylene Based Bioactive Agents
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
PT2344478T (pt) 2008-11-03 2017-11-28 Syntarga Bv Análogos de cc-1065 e seus conjugados
DK3056203T3 (da) 2010-04-21 2018-01-29 Syntarga Bv Konjugater af cc-1065-analoger og bifunktionelle linkere.
RU2632199C2 (ru) 2012-04-05 2017-10-03 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Функционализированные производные тиеноиндола для лечения ракового заболевания
DK2836494T3 (da) 2012-04-05 2019-11-11 Nerviano Medical Sciences Srl Nye alkyleringsmidler
JP2016504272A (ja) 2012-10-30 2016-02-12 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 官能化９−ブロモ−カンプトテシン誘導体
EP3049420B1 (en) 2013-09-25 2019-05-15 Nerviano Medical Sciences S.r.l. Thieno[2,3-e]indole derivatives as new antitumor agents
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
EP3215513B1 (en) 2014-11-05 2019-05-08 Nerviano Medical Sciences S.r.l. Functionalized morpholinyl anthracycline derivatives
EP3604386B1 (en) 2017-03-30 2022-04-06 NOF Corporation Degradable polyethylene glycol derivative having disulfide linker

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5103556A (en) * 1988-05-05 1992-04-14 Circon Corporation Method of manufacturing an electrohydraulic probe
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
EP0470128B2 (en) * 1989-04-19 2003-08-13 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
JP2001503396A (ja) * 1996-10-11 2001-03-13 アルザ コーポレイション 治療用リポソーム組成物および方法
US6214330B1 (en) * 1998-07-13 2001-04-10 Enzon, Inc. Coumarin and related aromatic-based polymeric prodrugs
ATE340592T1 (de) * 1999-04-23 2006-10-15 Alza Corp Konjugate enthaltend eine spaltbare bindung zur anwendung in einem liposom

Also Published As

Publication number Publication date
KR20070010175A (ko) 2007-01-22
AU2005238015A1 (en) 2005-11-10
WO2005105154A1 (en) 2005-11-10
CA2562527A1 (en) 2005-11-10
ZA200609638B (en) 2008-02-27
MXPA06012144A (es) 2007-01-31
US20050265925A1 (en) 2005-12-01
CN1997399A (zh) 2007-07-11
WO2005105154A8 (en) 2007-02-15
IL178561A0 (en) 2007-02-11
EP1748795A1 (en) 2007-02-07

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application