ZA200609638B - Polymer conjugate releasable under mild thiolytic conditions - Google Patents
Polymer conjugate releasable under mild thiolytic conditionsInfo
- Publication number
- ZA200609638B ZA200609638B ZA200609638A ZA200609638A ZA200609638B ZA 200609638 B ZA200609638 B ZA 200609638B ZA 200609638 A ZA200609638 A ZA 200609638A ZA 200609638 A ZA200609638 A ZA 200609638A ZA 200609638 B ZA200609638 B ZA 200609638B
- Authority
- ZA
- South Africa
- Prior art keywords
- under mild
- polymer conjugate
- releasable under
- thiolytic conditions
- mild thiolytic
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
- C07C329/10—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0039—Coumarin dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
- C07C329/02—Monothiocarbonic acids; Derivatives thereof
- C07C329/04—Esters of monothiocarbonic acids
- C07C329/08—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to carbon atoms of rings other than six-membered aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56456504P | 2004-04-21 | 2004-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200609638B true ZA200609638B (en) | 2008-02-27 |
Family
ID=37450607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200609638A ZA200609638B (en) | 2004-04-21 | 2005-04-20 | Polymer conjugate releasable under mild thiolytic conditions |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050265925A1 (xx) |
| EP (1) | EP1748795A1 (xx) |
| KR (1) | KR20070010175A (xx) |
| CN (1) | CN1997399A (xx) |
| AU (1) | AU2005238015A1 (xx) |
| CA (1) | CA2562527A1 (xx) |
| IL (1) | IL178561A0 (xx) |
| MX (1) | MXPA06012144A (xx) |
| NO (1) | NO20065270L (xx) |
| WO (1) | WO2005105154A1 (xx) |
| ZA (1) | ZA200609638B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100255050A1 (en) * | 2007-07-24 | 2010-10-07 | James Klein Leonard | Polyethylene Based Bioactive Agents |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| PT2344478T (pt) | 2008-11-03 | 2017-11-28 | Syntarga Bv | Análogos de cc-1065 e seus conjugados |
| DK3056203T3 (da) | 2010-04-21 | 2018-01-29 | Syntarga Bv | Konjugater af cc-1065-analoger og bifunktionelle linkere. |
| RU2632199C2 (ru) | 2012-04-05 | 2017-10-03 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Функционализированные производные тиеноиндола для лечения ракового заболевания |
| DK2836494T3 (da) | 2012-04-05 | 2019-11-11 | Nerviano Medical Sciences Srl | Nye alkyleringsmidler |
| JP2016504272A (ja) | 2012-10-30 | 2016-02-12 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 官能化９−ブロモ−カンプトテシン誘導体 |
| EP3049420B1 (en) | 2013-09-25 | 2019-05-15 | Nerviano Medical Sciences S.r.l. | Thieno[2,3-e]indole derivatives as new antitumor agents |
| PL3092010T3 (pl) | 2014-01-10 | 2019-01-31 | Synthon Biopharmaceuticals B.V. | Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek |
| EP3215513B1 (en) | 2014-11-05 | 2019-05-08 | Nerviano Medical Sciences S.r.l. | Functionalized morpholinyl anthracycline derivatives |
| EP3604386B1 (en) | 2017-03-30 | 2022-04-06 | NOF Corporation | Degradable polyethylene glycol derivative having disulfide linker |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| GB8430252D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US5103556A (en) * | 1988-05-05 | 1992-04-14 | Circon Corporation | Method of manufacturing an electrohydraulic probe |
| US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| EP0470128B2 (en) * | 1989-04-19 | 2003-08-13 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| JP2001503396A (ja) * | 1996-10-11 | 2001-03-13 | アルザ コーポレイション | 治療用リポソーム組成物および方法 |
| US6214330B1 (en) * | 1998-07-13 | 2001-04-10 | Enzon, Inc. | Coumarin and related aromatic-based polymeric prodrugs |
| ATE340592T1 (de) * | 1999-04-23 | 2006-10-15 | Alza Corp | Konjugate enthaltend eine spaltbare bindung zur anwendung in einem liposom |
-
2005
- 2005-04-20 CA CA002562527A patent/CA2562527A1/en not_active Abandoned
- 2005-04-20 CN CNA2005800126244A patent/CN1997399A/zh active Pending
- 2005-04-20 EP EP05738176A patent/EP1748795A1/en not_active Withdrawn
- 2005-04-20 US US11/110,272 patent/US20050265925A1/en not_active Abandoned
- 2005-04-20 ZA ZA200609638A patent/ZA200609638B/xx unknown
- 2005-04-20 MX MXPA06012144A patent/MXPA06012144A/es not_active Application Discontinuation
- 2005-04-20 KR KR1020067023899A patent/KR20070010175A/ko not_active Application Discontinuation
- 2005-04-20 WO PCT/US2005/013367 patent/WO2005105154A1/en active Application Filing
- 2005-04-20 AU AU2005238015A patent/AU2005238015A1/en not_active Abandoned
-
2006
- 2006-10-15 IL IL178561A patent/IL178561A0/en unknown
- 2006-11-16 NO NO20065270A patent/NO20065270L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070010175A (ko) | 2007-01-22 |
| AU2005238015A1 (en) | 2005-11-10 |
| WO2005105154A1 (en) | 2005-11-10 |
| CA2562527A1 (en) | 2005-11-10 |
| MXPA06012144A (es) | 2007-01-31 |
| NO20065270L (no) | 2007-01-17 |
| US20050265925A1 (en) | 2005-12-01 |
| CN1997399A (zh) | 2007-07-11 |
| WO2005105154A8 (en) | 2007-02-15 |
| IL178561A0 (en) | 2007-02-11 |
| EP1748795A1 (en) | 2007-02-07 |
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