NO20063218L - Aminobenzimidazoler og benzimidazoler som hemmere av respiratorisk syncytial virusreproduksjon - Google Patents

Aminobenzimidazoler og benzimidazoler som hemmere av respiratorisk syncytial virusreproduksjon

Info

Publication number
NO20063218L
NO20063218L NO20063218A NO20063218A NO20063218L NO 20063218 L NO20063218 L NO 20063218L NO 20063218 A NO20063218 A NO 20063218A NO 20063218 A NO20063218 A NO 20063218A NO 20063218 L NO20063218 L NO 20063218L
Authority
NO
Norway
Prior art keywords
hydrogen
6alkyloxy
alkyl
ar1c1
r4ar4b
Prior art date
Application number
NO20063218A
Other languages
English (en)
Inventor
Koenraad Jozef Lodewijk Andries
Jerome Michel Claude Fortin
Philippe Muller
Frederic Marc Maurice Doublet
Jean-Francois Bonfanti
Christophe Meyer
Rudy Edmond Willebrords
Tom Valerius Josepha Gevers
Philip Maria Martha Timmerman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2004/053613 external-priority patent/WO2005058869A1/en
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20063218L publication Critical patent/NO20063218L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Aminobenzimidazoler og benzimidazoler som har hemmende aktivitet på RSV-reproduksjon, og som har formelen prodrogene, N-oksidene, addisjonssaltene, de kvaternære aminer, metallkompleksene og de stereokjemisk isomere former derav; hvori G er en direkte binding eller C1-10alkandiyl valgfritt substituert med en eller flere hydroksy, C1-6 alkyloksy, Ar1C1-6alkyloksy, C1-6alkyltio, Ar1C1-6alkyltio, HO(-CH2-CH2-O)n-, C1-6a1kyloksy(-CH2-CH2-O)n- eller Ar1C1-6alkyloksy(-CH2-CH2-O)n-; R1 er Ar1 eller en monocyklisk eller bicyklisk heterocyklus; Q er hydrogen, amino eller mono- eller di(C1-4alkyl)amino; én av R2a og R3a er valgt fra halo, valgfritt mono- eller polysubstituert C1-6alkyl, valgfritt mono- eller polysubstituert C2-6alkenyl, nitro, hydroksy, Ar2, N(R4aR4b), N(R4aR4b )sulfonyl, N(R4aR4b)karbonyl, C1-6alkyloksy, Ar2oksy, Ar2C1-6alkyloksy, karboksyl, C1-6alkyloksykarbonyl eller -C(=Z)Ar2 ; og den andre av R2a og R3a er hydrogen; i tilfelle R2a er forskjellig fra hydrogen, da er R2b hydrogen, C1-6alkyl eller halogen, og R3b er hydrogen; i tilfelle R3a er forskjellig fra hydrogen, da er R3b hydrogen, C1-6alkyl eller halogen, og R2b er hydrogen. Sammensetninger inneholdende disse forbindelser som aktiv ingrediens og prosesser for å fremstille disse forbindelser og sammensetninger.
NO20063218A 2003-12-18 2006-07-11 Aminobenzimidazoler og benzimidazoler som hemmere av respiratorisk syncytial virusreproduksjon NO20063218L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104797 2003-12-18
US56683404P 2004-04-30 2004-04-30
PCT/EP2004/053613 WO2005058869A1 (en) 2003-12-18 2004-12-20 Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication

Publications (1)

Publication Number Publication Date
NO20063218L true NO20063218L (no) 2006-07-11

Family

ID=34702355

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063218A NO20063218L (no) 2003-12-18 2006-07-11 Aminobenzimidazoler og benzimidazoler som hemmere av respiratorisk syncytial virusreproduksjon

Country Status (5)

Country Link
KR (1) KR101187441B1 (no)
DE (1) DE602004021850D1 (no)
IL (1) IL176063A0 (no)
MX (1) MXPA06007108A (no)
NO (1) NO20063218L (no)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20014574A3 (cs) * 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
EP1383760A1 (en) * 2001-04-30 2004-01-28 Fujisawa Pharmaceutical Co., Ltd. Biarylcarboxamide compounds as apolipoprotein b inhibitors

Also Published As

Publication number Publication date
IL176063A0 (en) 2006-10-05
DE602004021850D1 (de) 2009-08-13
MXPA06007108A (es) 2006-08-18
KR20060127879A (ko) 2006-12-13
KR101187441B1 (ko) 2012-10-02

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